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Q9CQV7

- TIM14_MOUSE

UniProt

Q9CQV7 - TIM14_MOUSE

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Protein

Mitochondrial import inner membrane translocase subunit TIM14

Gene

Dnajc19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).By similarity

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_199101. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM14
Alternative name(s):
DnaJ homolog subfamily C member 19
Gene namesi
Name:Dnajc19
Synonyms:Tim14, Timm14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1914963. Dnajc19.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 116115Mitochondrial import inner membrane translocase subunit TIM14PRO_0000071101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei70 – 701PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CQV7.
PaxDbiQ9CQV7.
PRIDEiQ9CQV7.

PTM databases

PhosphoSiteiQ9CQV7.

Expressioni

Gene expression databases

BgeeiQ9CQV7.
CleanExiMM_DNAJC19.
ExpressionAtlasiQ9CQV7. baseline and differential.
GenevestigatoriQ9CQV7.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011029.

Structurei

3D structure databases

ProteinModelPortaliQ9CQV7.
SMRiQ9CQV7. Positions 48-111.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 32Mitochondrial intermembraneSequence Analysis
Topological domaini25 – 11692Mitochondrial matrixSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 11655JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TIM14 family.Curated
Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250674.
GeneTreeiENSGT00390000017303.
HOGENOMiHOG000115841.
HOVERGENiHBG057483.
InParanoidiQ9CQV7.
KOiK09539.
OMAiHRKLMIL.
PhylomeDBiQ9CQV7.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9CQV7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTVVAVGL TIAAAGFAGR YVLQAMKHVE PQVKQVFQSL PKSAFGGGYY
60 70 80 90 100
RGGFEPKMTK REAALILGVS PTANKGKIRD AHRRIMLLNH PDKGGSPYIA
110
AKINEAKDLL EGQAKK
Length:116
Mass (Da):12,437
Last modified:January 23, 2007 - v3
Checksum:i51E4313DB4F6083E
GO
Isoform 2 (identifier: Q9CQV7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-116: GSPYIAAKINEAKDLLEGQAKK → PLVEEGLKPI...TPVKPCETTM

Note: No experimental confirmation available.

Show »
Length:157
Mass (Da):16,956
Checksum:i7D8BC9DF54F2BDAA
GO
Isoform 3 (identifier: Q9CQV7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-116: GSPYIAAKINEAKDLLEGQAKK → KQLLLLYWTVNGIANSWCYECLCVSSFPVVDHIVVS

Note: No experimental confirmation available.

Show »
Length:130
Mass (Da):14,193
Checksum:iA7EE66196A6A7B2F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei95 – 11622GSPYI…GQAKK → PLVEEGLKPIPICRSCSSIC RRSILSCSTSYDQNKNPFTV CVCVHSSAHTGIHTPVKPCE TTM in isoform 2. 1 PublicationVSP_016390Add
BLAST
Alternative sequencei95 – 11622GSPYI…GQAKK → KQLLLLYWTVNGIANSWCYE CLCVSSFPVVDHIVVS in isoform 3. 1 PublicationVSP_016391Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007866 mRNA. Translation: BAB25317.1.
AK008267 mRNA. Translation: BAB25565.1.
AK010204 mRNA. Translation: BAB26767.1.
AK012051 mRNA. Translation: BAB27993.1.
BC024335 mRNA. Translation: AAH24335.1.
CCDSiCCDS38411.1. [Q9CQV7-2]
CCDS38412.1. [Q9CQV7-1]
CCDS71233.1. [Q9CQV7-3]
RefSeqiNP_001021382.1. NM_001026211.2.
NP_001273901.1. NM_001286972.1. [Q9CQV7-3]
NP_001273902.1. NM_001286973.1.
NP_080608.3. NM_026332.4. [Q9CQV7-1]
XP_003084767.1. XM_003084719.2. [Q9CQV7-1]
UniGeneiMm.274266.

Genome annotation databases

EnsembliENSMUST00000108195; ENSMUSP00000103830; ENSMUSG00000027679. [Q9CQV7-1]
ENSMUST00000117223; ENSMUSP00000113484; ENSMUSG00000027679. [Q9CQV7-3]
GeneIDi100503724.
67713.
KEGGimmu:100503724.
mmu:67713.
UCSCiuc008oxo.1. mouse. [Q9CQV7-1]
uc008oxp.1. mouse. [Q9CQV7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007866 mRNA. Translation: BAB25317.1 .
AK008267 mRNA. Translation: BAB25565.1 .
AK010204 mRNA. Translation: BAB26767.1 .
AK012051 mRNA. Translation: BAB27993.1 .
BC024335 mRNA. Translation: AAH24335.1 .
CCDSi CCDS38411.1. [Q9CQV7-2 ]
CCDS38412.1. [Q9CQV7-1 ]
CCDS71233.1. [Q9CQV7-3 ]
RefSeqi NP_001021382.1. NM_001026211.2.
NP_001273901.1. NM_001286972.1. [Q9CQV7-3 ]
NP_001273902.1. NM_001286973.1.
NP_080608.3. NM_026332.4. [Q9CQV7-1 ]
XP_003084767.1. XM_003084719.2. [Q9CQV7-1 ]
UniGenei Mm.274266.

3D structure databases

ProteinModelPortali Q9CQV7.
SMRi Q9CQV7. Positions 48-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000011029.

PTM databases

PhosphoSitei Q9CQV7.

Proteomic databases

MaxQBi Q9CQV7.
PaxDbi Q9CQV7.
PRIDEi Q9CQV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108195 ; ENSMUSP00000103830 ; ENSMUSG00000027679 . [Q9CQV7-1 ]
ENSMUST00000117223 ; ENSMUSP00000113484 ; ENSMUSG00000027679 . [Q9CQV7-3 ]
GeneIDi 100503724.
67713.
KEGGi mmu:100503724.
mmu:67713.
UCSCi uc008oxo.1. mouse. [Q9CQV7-1 ]
uc008oxp.1. mouse. [Q9CQV7-3 ]

Organism-specific databases

CTDi 100503724.
131118.
MGIi MGI:1914963. Dnajc19.

Phylogenomic databases

eggNOGi NOG250674.
GeneTreei ENSGT00390000017303.
HOGENOMi HOG000115841.
HOVERGENi HBG057483.
InParanoidi Q9CQV7.
KOi K09539.
OMAi HRKLMIL.
PhylomeDBi Q9CQV7.

Enzyme and pathway databases

Reactomei REACT_199101. Mitochondrial protein import.

Miscellaneous databases

NextBioi 325345.
PROi Q9CQV7.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQV7.
CleanExi MM_DNAJC19.
ExpressionAtlasi Q9CQV7. baseline and differential.
Genevestigatori Q9CQV7.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR001623. DnaJ_domain.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
[Graphical view ]
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
PROSITEi PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Pancreas, Small intestine and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiTIM14_MOUSE
AccessioniPrimary (citable) accession number: Q9CQV7
Secondary accession number(s): Q8R1N1, Q9D896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3