ID   MLP3B_MOUSE             Reviewed;         125 AA.
AC   Q9CQV6; Q3U9W5; Q9D1R0;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   09-FEB-2010, entry version 72.
DE   RecName: Full=Microtubule-associated proteins 1A/1B light chain 3B;
DE   AltName: Full=Microtubule-associated protein 1 light chain 3 beta;
DE   AltName: Full=MAP1A/MAP1B light chain 3 B;
DE            Short=MAP1A/MAP1B LC3 B;
DE   AltName: Full=MAP1 light chain 3-like protein 2;
DE   AltName: Full=Autophagy-related protein LC3 B;
DE   AltName: Full=Autophagy-related ubiquitin-like modifier LC3 B;
DE   Flags: Precursor;
GN   Name=Map1lc3b; Synonyms=Map1alc3, Map1lc3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yu L.;
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, Embryo, Head, Heart, and Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 31-37 AND 52-65, AND MASS SPECTROMETRY.
RC   STRAIN=C57BL/6; TISSUE=Brain;
RA   Lubec G., Kang S.U.;
RL   Submitted (APR-2007) to UniProtKB.
RN   [5]
RP   REVIEW.
RX   PubMed=15325588; DOI=10.1016/j.biocel.2004.05.009;
RA   Tanida I., Ueno T., Kominami E.;
RT   "LC3 conjugation system in mammalian autophagy.";
RL   Int. J. Biochem. Cell Biol. 36:2503-2518(2004).
CC   -!- FUNCTION: Probably involved in formation of autophagosomal
CC       vacuoles (autophagosomes).
CC   -!- SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate
CC       with MAP1A and MAP1B proteins (By similarity). Interacts with
CC       CABP1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system; Lipid-
CC       anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor
CC       (By similarity). Note=LC3-II binds to the autophagic membranes (By
CC       similarity).
CC   -!- PTM: The precursor molecule is cleaved by APG4B/ATG4B to form LC3-
CC       I. This is activated by APG7L/ATG7, transferred to ATG3 and
CC       conjugated to phospholipid to form LC3-II (By similarity).
CC   -!- SIMILARITY: Belongs to the MAP1 LC3 family.
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DR   EMBL; AF255953; AAL83723.1; -; mRNA.
DR   EMBL; AK002795; BAB22364.1; -; mRNA.
DR   EMBL; AK003106; BAB22569.1; -; mRNA.
DR   EMBL; AK003205; BAB22641.1; -; mRNA.
DR   EMBL; AK003558; BAB22855.1; -; mRNA.
DR   EMBL; AK012604; BAB28350.1; -; mRNA.
DR   EMBL; AK132329; BAE21108.1; -; mRNA.
DR   EMBL; AK151614; BAE30551.1; -; mRNA.
DR   EMBL; BC068180; AAH68180.1; -; mRNA.
DR   IPI; IPI00230349; -.
DR   RefSeq; NP_080436.1; -.
DR   UniGene; Mm.28357; -.
DR   SMR; Q9CQV6; 5-122.
DR   STRING; Q9CQV6; -.
DR   PRIDE; Q9CQV6; -.
DR   Ensembl; ENSMUST00000034270; ENSMUSP00000034270; ENSMUSG00000031812; Mus musculus.
DR   GeneID; 67443; -.
DR   KEGG; mmu:67443; -.
DR   UCSC; uc009nrw.1; mouse.
DR   CTD; 67443; -.
DR   MGI; MGI:1914693; Map1lc3b.
DR   HOGENOM; HBG592694; -.
DR   HOVERGEN; Q9CQV6; -.
DR   InParanoid; Q9CQV6; -.
DR   OMA; EEIRSQQ; -.
DR   OrthoDB; EOG9WM7DJ; -.
DR   PhylomeDB; Q9CQV6; -.
DR   NextBio; 324582; -.
DR   ArrayExpress; Q9CQV6; -.
DR   Bgee; Q9CQV6; -.
DR   Genevestigator; Q9CQV6; -.
DR   GermOnline; ENSMUSG00000031812; Mus musculus.
DR   GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   InterPro; IPR004241; MAP1_LC3.
DR   PANTHER; PTHR10969; MAP1_LC3; 1.
DR   Pfam; PF02991; MAP1_LC3; 1.
PE   1: Evidence at protein level;
KW   Autophagy; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing;
KW   Lipoprotein; Membrane; Microtubule; Ubl conjugation pathway.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    120       Microtubule-associated proteins 1A/1B
FT                                light chain 3B.
FT                                /FTId=PRO_0000017200.
FT   PROPEP      121    125       Removed in mature form (By similarity).
FT                                /FTId=PRO_0000017201.
FT   LIPID       120    120       Phosphatidylethanolamine amidated glycine
FT                                (By similarity).
FT   CONFLICT     89     89       V -> L (in Ref. 2; BAB22641).
SQ   SEQUENCE   125 AA;  14617 MW;  520E29028163FA8D CRC64;
     MPSEKTFKQR RSFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM
     SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE SERDEDGFLY MVYASQETFG
     TAMAV
//