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Protein

Protein FAM134C

Gene

Fam134c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM134C
Gene namesi
Name:Fam134c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915248. Fam134c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 18618HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 466465Protein FAM134CPRO_0000288470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineBy similarity
Modified residuei258 – 2581PhosphoserineBy similarity
Modified residuei260 – 2601PhosphoserineBy similarity
Modified residuei283 – 2831Phosphothreonine1 Publication
Modified residuei285 – 2851Phosphoserine1 Publication
Modified residuei288 – 2881Phosphoserine1 Publication
Modified residuei303 – 3031Phosphoserine1 Publication
Modified residuei307 – 3071PhosphothreonineBy similarity
Modified residuei310 – 3101Phosphothreonine1 Publication
Modified residuei313 – 3131Phosphoserine1 Publication
Modified residuei320 – 3201Phosphoserine1 Publication
Modified residuei360 – 3601PhosphoserineBy similarity
Modified residuei440 – 4401PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CQV4.
PaxDbiQ9CQV4.
PRIDEiQ9CQV4.

PTM databases

PhosphoSiteiQ9CQV4.

Expressioni

Tissue specificityi

Mainly expressed in the central nervous system and in parenchymatous organs including liver, lung and kidney.1 Publication

Gene expression databases

BgeeiQ9CQV4.
GenevestigatoriQ9CQV4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017946.

Structurei

3D structure databases

ProteinModelPortaliQ9CQV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM134 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26663.
GeneTreeiENSGT00530000063240.
HOGENOMiHOG000050246.
HOVERGENiHBG096339.
InParanoidiQ9CQV4.
OMAiFCLLSCG.
OrthoDBiEOG7J70FV.
PhylomeDBiQ9CQV4.
TreeFamiTF329111.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEAEGVAAA PGPASGLAFR GRRAMSGSWE RDQQVEAAQR TLVEVLGPYE
60 70 80 90 100
PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRFV FLLAFSLMII
110 120 130 140 150
VCIDQWKNKI WPEINVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS
160 170 180 190 200
GTIFIRNLLL FKKQNPGKFC LLSCGVLTFL AMLGRYIPGL LLSYLMLVII
210 220 230 240 250
MMWPLAVYHR LWDRAYVRLK PVLQRLDFSV RGYMMSKQRE RQLRRRALHS
260 270 280 290 300
ERATDSHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTENGTF
310 320 330 340 350
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINVDP AGLDDEDDTS
360 370 380 390 400
IGMPSLMYRS PPGAGDTQVL PASRNEAALP ELLLSSLPGG SNLTSNLASL
410 420 430 440 450
VSQGMIQLAL SEASQTDPSG PPPRRATRGF LRAPSSDLDT DAEGDDFELL
460
DQSELNQLDP ASSRSH
Length:466
Mass (Da):51,638
Last modified:June 1, 2001 - v1
Checksum:i5333A7910F023A6C
GO
Isoform 2 (identifier: Q9CQV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.

Note: No experimental confirmation available.

Show »
Length:285
Mass (Da):31,332
Checksum:iEF201FE7E4D426E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401P → H in BAE37364 (PubMed:16141072).Curated
Sequence conflicti360 – 3601S → T in BAE30609 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 181181Missing in isoform 2. 1 PublicationVSP_025689Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004960 mRNA. Translation: BAB23700.1.
AK004979 mRNA. Translation: BAB23715.1.
AK051025 mRNA. Translation: BAC34501.1.
AK151685 mRNA. Translation: BAE30609.1.
AK160000 mRNA. Translation: BAE35548.1.
AK163482 mRNA. Translation: BAE37364.1.
BX255926 Genomic DNA. Translation: CAM24470.1.
BC006712 mRNA. Translation: AAH06712.1.
BC016089 mRNA. Translation: AAH16089.1.
CCDSiCCDS25449.1. [Q9CQV4-1]
CCDS25450.1. [Q9CQV4-2]
RefSeqiNP_080777.1. NM_026501.2. [Q9CQV4-1]
NP_083209.1. NM_028933.3. [Q9CQV4-2]
UniGeneiMm.33881.

Genome annotation databases

EnsembliENSMUST00000017946; ENSMUSP00000017946; ENSMUSG00000017802. [Q9CQV4-1]
ENSMUST00000107295; ENSMUSP00000102916; ENSMUSG00000017802. [Q9CQV4-2]
GeneIDi67998.
KEGGimmu:67998.
UCSCiuc007lni.1. mouse. [Q9CQV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004960 mRNA. Translation: BAB23700.1.
AK004979 mRNA. Translation: BAB23715.1.
AK051025 mRNA. Translation: BAC34501.1.
AK151685 mRNA. Translation: BAE30609.1.
AK160000 mRNA. Translation: BAE35548.1.
AK163482 mRNA. Translation: BAE37364.1.
BX255926 Genomic DNA. Translation: CAM24470.1.
BC006712 mRNA. Translation: AAH06712.1.
BC016089 mRNA. Translation: AAH16089.1.
CCDSiCCDS25449.1. [Q9CQV4-1]
CCDS25450.1. [Q9CQV4-2]
RefSeqiNP_080777.1. NM_026501.2. [Q9CQV4-1]
NP_083209.1. NM_028933.3. [Q9CQV4-2]
UniGeneiMm.33881.

3D structure databases

ProteinModelPortaliQ9CQV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017946.

PTM databases

PhosphoSiteiQ9CQV4.

Proteomic databases

MaxQBiQ9CQV4.
PaxDbiQ9CQV4.
PRIDEiQ9CQV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017946; ENSMUSP00000017946; ENSMUSG00000017802. [Q9CQV4-1]
ENSMUST00000107295; ENSMUSP00000102916; ENSMUSG00000017802. [Q9CQV4-2]
GeneIDi67998.
KEGGimmu:67998.
UCSCiuc007lni.1. mouse. [Q9CQV4-1]

Organism-specific databases

CTDi162427.
MGIiMGI:1915248. Fam134c.

Phylogenomic databases

eggNOGiNOG26663.
GeneTreeiENSGT00530000063240.
HOGENOMiHOG000050246.
HOVERGENiHBG096339.
InParanoidiQ9CQV4.
OMAiFCLLSCG.
OrthoDBiEOG7J70FV.
PhylomeDBiQ9CQV4.
TreeFamiTF329111.

Miscellaneous databases

ChiTaRSiFam134c. mouse.
NextBioi326174.
PROiQ9CQV4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQV4.
GenevestigatoriQ9CQV4.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow, Corpora quadrigemina and Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Eye and Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-283; SER-285; SER-288; SER-303; THR-310; SER-313 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiF134C_MOUSE
AccessioniPrimary (citable) accession number: Q9CQV4
Secondary accession number(s): Q3TQL8
, Q3U9Q7, Q8BQC4, Q922X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.