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Q9CQV4

- F134C_MOUSE

UniProt

Q9CQV4 - F134C_MOUSE

Protein

Protein FAM134C

Gene

Fam134c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM134C
    Gene namesi
    Name:Fam134c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1915248. Fam134c.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 466465Protein FAM134CPRO_0000288470Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261PhosphoserineBy similarity
    Modified residuei258 – 2581PhosphoserineBy similarity
    Modified residuei260 – 2601PhosphoserineBy similarity
    Modified residuei283 – 2831Phosphothreonine1 Publication
    Modified residuei285 – 2851Phosphoserine1 Publication
    Modified residuei288 – 2881Phosphoserine1 Publication
    Modified residuei303 – 3031Phosphoserine1 Publication
    Modified residuei307 – 3071PhosphothreonineBy similarity
    Modified residuei310 – 3101Phosphothreonine1 Publication
    Modified residuei313 – 3131Phosphoserine1 Publication
    Modified residuei320 – 3201Phosphoserine1 Publication
    Modified residuei360 – 3601PhosphoserineBy similarity
    Modified residuei440 – 4401PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9CQV4.
    PRIDEiQ9CQV4.

    PTM databases

    PhosphoSiteiQ9CQV4.

    Expressioni

    Tissue specificityi

    Mainly expressed in the central nervous system and in parenchymatous organs including liver, lung and kidney.1 Publication

    Gene expression databases

    BgeeiQ9CQV4.
    GenevestigatoriQ9CQV4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000017946.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQV4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 18618HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM134 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26663.
    GeneTreeiENSGT00530000063240.
    HOGENOMiHOG000050246.
    HOVERGENiHBG096339.
    InParanoidiQ9CQV4.
    OMAiFCLLSCG.
    OrthoDBiEOG7J70FV.
    PhylomeDBiQ9CQV4.
    TreeFamiTF329111.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CQV4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEAEGVAAA PGPASGLAFR GRRAMSGSWE RDQQVEAAQR TLVEVLGPYE    50
    PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRFV FLLAFSLMII 100
    VCIDQWKNKI WPEINVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS 150
    GTIFIRNLLL FKKQNPGKFC LLSCGVLTFL AMLGRYIPGL LLSYLMLVII 200
    MMWPLAVYHR LWDRAYVRLK PVLQRLDFSV RGYMMSKQRE RQLRRRALHS 250
    ERATDSHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTENGTF 300
    NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINVDP AGLDDEDDTS 350
    IGMPSLMYRS PPGAGDTQVL PASRNEAALP ELLLSSLPGG SNLTSNLASL 400
    VSQGMIQLAL SEASQTDPSG PPPRRATRGF LRAPSSDLDT DAEGDDFELL 450
    DQSELNQLDP ASSRSH 466
    Length:466
    Mass (Da):51,638
    Last modified:June 1, 2001 - v1
    Checksum:i5333A7910F023A6C
    GO
    Isoform 2 (identifier: Q9CQV4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-181: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:286
    Mass (Da):31,463
    Checksum:i0D2A49D2BDC73D43
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti340 – 3401P → H in BAE37364. (PubMed:16141072)Curated
    Sequence conflicti360 – 3601S → T in BAE30609. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 181180Missing in isoform 2. 1 PublicationVSP_025689Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004960 mRNA. Translation: BAB23700.1.
    AK004979 mRNA. Translation: BAB23715.1.
    AK051025 mRNA. Translation: BAC34501.1.
    AK151685 mRNA. Translation: BAE30609.1.
    AK160000 mRNA. Translation: BAE35548.1.
    AK163482 mRNA. Translation: BAE37364.1.
    BX255926 Genomic DNA. Translation: CAM24470.1.
    BC006712 mRNA. Translation: AAH06712.1.
    BC016089 mRNA. Translation: AAH16089.1.
    CCDSiCCDS25449.1. [Q9CQV4-1]
    RefSeqiNP_080777.1. NM_026501.2. [Q9CQV4-1]
    NP_083209.1. NM_028933.3.
    XP_006534096.1. XM_006534033.1.
    UniGeneiMm.33881.

    Genome annotation databases

    EnsembliENSMUST00000017946; ENSMUSP00000017946; ENSMUSG00000017802. [Q9CQV4-1]
    ENSMUST00000107295; ENSMUSP00000102916; ENSMUSG00000017802.
    GeneIDi67998.
    KEGGimmu:67998.
    UCSCiuc007lni.1. mouse. [Q9CQV4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004960 mRNA. Translation: BAB23700.1 .
    AK004979 mRNA. Translation: BAB23715.1 .
    AK051025 mRNA. Translation: BAC34501.1 .
    AK151685 mRNA. Translation: BAE30609.1 .
    AK160000 mRNA. Translation: BAE35548.1 .
    AK163482 mRNA. Translation: BAE37364.1 .
    BX255926 Genomic DNA. Translation: CAM24470.1 .
    BC006712 mRNA. Translation: AAH06712.1 .
    BC016089 mRNA. Translation: AAH16089.1 .
    CCDSi CCDS25449.1. [Q9CQV4-1 ]
    RefSeqi NP_080777.1. NM_026501.2. [Q9CQV4-1 ]
    NP_083209.1. NM_028933.3.
    XP_006534096.1. XM_006534033.1.
    UniGenei Mm.33881.

    3D structure databases

    ProteinModelPortali Q9CQV4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000017946.

    PTM databases

    PhosphoSitei Q9CQV4.

    Proteomic databases

    PaxDbi Q9CQV4.
    PRIDEi Q9CQV4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017946 ; ENSMUSP00000017946 ; ENSMUSG00000017802 . [Q9CQV4-1 ]
    ENSMUST00000107295 ; ENSMUSP00000102916 ; ENSMUSG00000017802 .
    GeneIDi 67998.
    KEGGi mmu:67998.
    UCSCi uc007lni.1. mouse. [Q9CQV4-1 ]

    Organism-specific databases

    CTDi 162427.
    MGIi MGI:1915248. Fam134c.

    Phylogenomic databases

    eggNOGi NOG26663.
    GeneTreei ENSGT00530000063240.
    HOGENOMi HOG000050246.
    HOVERGENi HBG096339.
    InParanoidi Q9CQV4.
    OMAi FCLLSCG.
    OrthoDBi EOG7J70FV.
    PhylomeDBi Q9CQV4.
    TreeFami TF329111.

    Miscellaneous databases

    NextBioi 326174.
    PROi Q9CQV4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQV4.
    Genevestigatori Q9CQV4.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Bone marrow, Corpora quadrigemina and Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Eye and Mammary tumor.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-283; SER-285; SER-288; SER-303; THR-310; SER-313 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiF134C_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQV4
    Secondary accession number(s): Q3TQL8
    , Q3U9Q7, Q8BQC4, Q922X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3