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Q9CQV4 (F134C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM134C
Gene names
Name:Fam134c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Mainly expressed in the central nervous system and in parenchymatous organs including liver, lung and kidney. Ref.5

Sequence similarities

Belongs to the FAM134 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9CQV4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9CQV4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-181: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 466465Protein FAM134C
PRO_0000288470

Regions

Transmembrane81 – 10121Helical; Potential
Transmembrane169 – 18618Helical; Potential
Transmembrane187 – 20721Helical; Potential

Amino acid modifications

Modified residue261Phosphoserine By similarity
Modified residue2581Phosphoserine By similarity
Modified residue2601Phosphoserine By similarity
Modified residue2831Phosphothreonine Ref.4
Modified residue2851Phosphoserine Ref.4
Modified residue2881Phosphoserine Ref.4
Modified residue3031Phosphoserine Ref.4
Modified residue3071Phosphothreonine By similarity
Modified residue3101Phosphothreonine Ref.4
Modified residue3131Phosphoserine Ref.4
Modified residue3201Phosphoserine Ref.4
Modified residue3601Phosphoserine By similarity
Modified residue4401Phosphothreonine By similarity

Natural variations

Alternative sequence2 – 181180Missing in isoform 2.
VSP_025689

Experimental info

Sequence conflict3401P → H in BAE37364. Ref.1
Sequence conflict3601S → T in BAE30609. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 5333A7910F023A6C

FASTA46651,638
        10         20         30         40         50         60 
MEEAEGVAAA PGPASGLAFR GRRAMSGSWE RDQQVEAAQR TLVEVLGPYE PLLSRVQAAL 

        70         80         90        100        110        120 
VWERPARSAL WCLGLNAAFW FFALTSLRFV FLLAFSLMII VCIDQWKNKI WPEINVPRPD 

       130        140        150        160        170        180 
ALDNESWGFV HPRLLSVPEL CHHVAEVWVS GTIFIRNLLL FKKQNPGKFC LLSCGVLTFL 

       190        200        210        220        230        240 
AMLGRYIPGL LLSYLMLVII MMWPLAVYHR LWDRAYVRLK PVLQRLDFSV RGYMMSKQRE 

       250        260        270        280        290        300 
RQLRRRALHS ERATDSHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTENGTF 

       310        320        330        340        350        360 
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINVDP AGLDDEDDTS IGMPSLMYRS 

       370        380        390        400        410        420 
PPGAGDTQVL PASRNEAALP ELLLSSLPGG SNLTSNLASL VSQGMIQLAL SEASQTDPSG 

       430        440        450        460 
PPPRRATRGF LRAPSSDLDT DAEGDDFELL DQSELNQLDP ASSRSH 

« Hide

Isoform 2 [UniParc].

Checksum: 0D2A49D2BDC73D43
Show »

FASTA28631,463

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Bone marrow, Corpora quadrigemina and Liver.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Eye and Mammary tumor.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-283; SER-285; SER-288; SER-303; THR-310; SER-313 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[5]"Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy."
Kurth I., Pamminger T., Hennings J.C., Soehendra D., Huebner A.K., Rotthier A., Baets J., Senderek J., Topaloglu H., Farrell S.A., Nuernberg G., Nurnberg P., De Jonghe P., Gal A., Kaether C., Timmerman V., Huebner C.A.
Nat. Genet. 41:1179-1181(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004960 mRNA. Translation: BAB23700.1.
AK004979 mRNA. Translation: BAB23715.1.
AK051025 mRNA. Translation: BAC34501.1.
AK151685 mRNA. Translation: BAE30609.1.
AK160000 mRNA. Translation: BAE35548.1.
AK163482 mRNA. Translation: BAE37364.1.
BX255926 Genomic DNA. Translation: CAM24470.1.
BC006712 mRNA. Translation: AAH06712.1.
BC016089 mRNA. Translation: AAH16089.1.
RefSeqNP_080777.1. NM_026501.2.
NP_083209.1. NM_028933.3.
XP_006534096.1. XM_006534033.1.
UniGeneMm.33881.

3D structure databases

ProteinModelPortalQ9CQV4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000017946.

PTM databases

PhosphoSiteQ9CQV4.

Proteomic databases

PaxDbQ9CQV4.
PRIDEQ9CQV4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000017946; ENSMUSP00000017946; ENSMUSG00000017802. [Q9CQV4-1]
ENSMUST00000107295; ENSMUSP00000102916; ENSMUSG00000017802.
GeneID67998.
KEGGmmu:67998.
UCSCuc007lni.1. mouse. [Q9CQV4-1]

Organism-specific databases

CTD162427.
MGIMGI:1915248. Fam134c.

Phylogenomic databases

eggNOGNOG26663.
GeneTreeENSGT00530000063240.
HOGENOMHOG000050246.
HOVERGENHBG096339.
InParanoidQ9CQV4.
OMAFCLLSCG.
OrthoDBEOG7J70FV.
PhylomeDBQ9CQV4.
TreeFamTF329111.

Gene expression databases

BgeeQ9CQV4.
GenevestigatorQ9CQV4.

Family and domain databases

ProtoNetSearch...

Other

NextBio326174.
PROQ9CQV4.
SOURCESearch...

Entry information

Entry nameF134C_MOUSE
AccessionPrimary (citable) accession number: Q9CQV4
Secondary accession number(s): Q3TQL8 expand/collapse secondary AC list , Q3U9Q7, Q8BQC4, Q922X3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot