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Protein

Reticulophagy regulator 3

Gene

Retreg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates NRF1-enhanced neurite outgrowth.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulophagy regulator 3
Gene namesi
Name:Retreg3
Synonyms:Fam134c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915248. Retreg3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei169 – 186HelicalSequence analysisAdd BLAST18
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884701 – 466Reticulophagy regulator 3Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Modified residuei254PhosphothreonineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei283PhosphothreonineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei310PhosphothreonineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei360PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CQV4.
PaxDbiQ9CQV4.
PeptideAtlasiQ9CQV4.
PRIDEiQ9CQV4.

PTM databases

iPTMnetiQ9CQV4.
PhosphoSitePlusiQ9CQV4.

Expressioni

Tissue specificityi

Mainly expressed in the central nervous system and in parenchymatous organs including liver, lung and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000017802.
GenevisibleiQ9CQV4. MM.

Interactioni

Subunit structurei

Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP and GABARAPL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017946.

Structurei

3D structure databases

ProteinModelPortaliQ9CQV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi445 – 450LIR motifBy similarity6

Domaini

The LIR motif interacts with ATG8 family proteins.By similarity

Sequence similaritiesi

Belongs to the RETREG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHB8. Eukaryota.
ENOG4110GB7. LUCA.
GeneTreeiENSGT00530000063240.
HOGENOMiHOG000050246.
HOVERGENiHBG096339.
InParanoidiQ9CQV4.
OMAiWPLAVYH.
OrthoDBiEOG091G08S3.
PhylomeDBiQ9CQV4.
TreeFamiTF329111.

Family and domain databases

InterProiView protein in InterPro
IPR033361. RETREG3.
PANTHERiPTHR28659:SF4. PTHR28659:SF4. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEAEGVAAA PGPASGLAFR GRRAMSGSWE RDQQVEAAQR TLVEVLGPYE
60 70 80 90 100
PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRFV FLLAFSLMII
110 120 130 140 150
VCIDQWKNKI WPEINVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS
160 170 180 190 200
GTIFIRNLLL FKKQNPGKFC LLSCGVLTFL AMLGRYIPGL LLSYLMLVII
210 220 230 240 250
MMWPLAVYHR LWDRAYVRLK PVLQRLDFSV RGYMMSKQRE RQLRRRALHS
260 270 280 290 300
ERATDSHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTENGTF
310 320 330 340 350
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINVDP AGLDDEDDTS
360 370 380 390 400
IGMPSLMYRS PPGAGDTQVL PASRNEAALP ELLLSSLPGG SNLTSNLASL
410 420 430 440 450
VSQGMIQLAL SEASQTDPSG PPPRRATRGF LRAPSSDLDT DAEGDDFELL
460
DQSELNQLDP ASSRSH
Length:466
Mass (Da):51,638
Last modified:June 1, 2001 - v1
Checksum:i5333A7910F023A6C
GO
Isoform 2 (identifier: Q9CQV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):31,332
Checksum:iEF201FE7E4D426E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340P → H in BAE37364 (PubMed:16141072).Curated1
Sequence conflicti360S → T in BAE30609 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0256891 – 181Missing in isoform 2. 1 PublicationAdd BLAST181

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004960 mRNA. Translation: BAB23700.1.
AK004979 mRNA. Translation: BAB23715.1.
AK051025 mRNA. Translation: BAC34501.1.
AK151685 mRNA. Translation: BAE30609.1.
AK160000 mRNA. Translation: BAE35548.1.
AK163482 mRNA. Translation: BAE37364.1.
BX255926 Genomic DNA. Translation: CAM24470.1.
BC006712 mRNA. Translation: AAH06712.1.
BC016089 mRNA. Translation: AAH16089.1.
CCDSiCCDS25449.1. [Q9CQV4-1]
CCDS25450.1. [Q9CQV4-2]
RefSeqiNP_080777.1. NM_026501.2. [Q9CQV4-1]
NP_083209.1. NM_028933.3. [Q9CQV4-2]
UniGeneiMm.33881.

Genome annotation databases

EnsembliENSMUST00000017946; ENSMUSP00000017946; ENSMUSG00000017802. [Q9CQV4-1]
ENSMUST00000107295; ENSMUSP00000102916; ENSMUSG00000017802. [Q9CQV4-2]
GeneIDi67998.
KEGGimmu:67998.
UCSCiuc007lni.1. mouse. [Q9CQV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRETR3_MOUSE
AccessioniPrimary (citable) accession number: Q9CQV4
Secondary accession number(s): Q3TQL8
, Q3U9Q7, Q8BQC4, Q922X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families