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Protein

Mitochondrial inner membrane protease subunit 1

Gene

Immp1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401By similarity
Active sitei83 – 831By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protease subunit 1 (EC:3.4.21.-)
Alternative name(s):
IMP1-like protein
Gene namesi
Name:Immp1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913791. Immp1l.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane peptidase complex Source: GO_Central
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Mitochondrial inner membrane protease subunit 1PRO_0000259574Add
BLAST

Proteomic databases

MaxQBiQ9CQU8.
PaxDbiQ9CQU8.
PeptideAtlasiQ9CQU8.
PRIDEiQ9CQU8.

PTM databases

PhosphoSiteiQ9CQU8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042670.
GenevisibleiQ9CQU8. MM.

Interactioni

Subunit structurei

Heterodimer of 2 subunits, IMMPL1 and IMMPL2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049044.

Structurei

3D structure databases

ProteinModelPortaliQ9CQU8.
SMRiQ9CQU8. Positions 28-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family. IMP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0171. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00550000075025.
HOGENOMiHOG000003673.
HOVERGENiHBG080010.
InParanoidiQ9CQU8.
KOiK09647.
OMAiRCYGPVP.
OrthoDBiEOG091G0TXV.
PhylomeDBiQ9CQU8.
TreeFamiTF315083.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR026730. Mitochondrial_IMP1.
IPR000223. Pept_S26A_signal_pept_1.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PTHR12383:SF16. PTHR12383:SF16. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
PF10502. Peptidase_S26. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGVLGKAF RLAGYTIQYG CIAHCAFEYV GGVVMCSGPS MEPTIQNSDI
60 70 80 90 100
VFAENLSRHF YGIQRGDIVI AKSPSDPKSN ICKRVIGLEG DKILSTSPSD
110 120 130 140 150
VFKSRSYVPT GHVWLEGDNL QNSTDSRYYG PIPYGLIRGR IFFKIWPFSD
160
FGFLRDSPNG QRFSDD
Length:166
Mass (Da):18,502
Last modified:June 1, 2001 - v1
Checksum:i5627EE1F1BD80E3D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941L → F in BAE40162 (PubMed:16141072).Curated
Sequence conflicti166 – 1661D → A in BAE40162 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005356 mRNA. Translation: BAB23971.1.
AK009570 mRNA. Translation: BAB26367.1.
AK010075 mRNA. Translation: BAB26684.1.
AK011278 mRNA. Translation: BAB27512.1.
AK011382 mRNA. Translation: BAB27582.1.
AK011420 mRNA. Translation: BAB27608.1.
AK011466 mRNA. Translation: BAB27637.1.
AK011618 mRNA. Translation: BAB27737.1.
AK011872 mRNA. Translation: BAB27891.1.
AK012181 mRNA. Translation: BAB28082.1.
AK015978 mRNA. Translation: BAB30062.1.
AK078300 mRNA. Translation: BAC37210.1.
AK135670 mRNA. Translation: BAE22608.1.
AK168202 mRNA. Translation: BAE40162.1.
BC008259 mRNA. Translation: AAH08259.1.
BC081433 mRNA. Translation: AAH81433.1.
CCDSiCCDS38192.1.
RefSeqiNP_082536.1. NM_028260.2.
UniGeneiMm.272253.

Genome annotation databases

EnsembliENSMUST00000037499; ENSMUSP00000049044; ENSMUSG00000042670.
GeneIDi66541.
KEGGimmu:66541.
UCSCiuc008lle.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005356 mRNA. Translation: BAB23971.1.
AK009570 mRNA. Translation: BAB26367.1.
AK010075 mRNA. Translation: BAB26684.1.
AK011278 mRNA. Translation: BAB27512.1.
AK011382 mRNA. Translation: BAB27582.1.
AK011420 mRNA. Translation: BAB27608.1.
AK011466 mRNA. Translation: BAB27637.1.
AK011618 mRNA. Translation: BAB27737.1.
AK011872 mRNA. Translation: BAB27891.1.
AK012181 mRNA. Translation: BAB28082.1.
AK015978 mRNA. Translation: BAB30062.1.
AK078300 mRNA. Translation: BAC37210.1.
AK135670 mRNA. Translation: BAE22608.1.
AK168202 mRNA. Translation: BAE40162.1.
BC008259 mRNA. Translation: AAH08259.1.
BC081433 mRNA. Translation: AAH81433.1.
CCDSiCCDS38192.1.
RefSeqiNP_082536.1. NM_028260.2.
UniGeneiMm.272253.

3D structure databases

ProteinModelPortaliQ9CQU8.
SMRiQ9CQU8. Positions 28-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049044.

PTM databases

PhosphoSiteiQ9CQU8.

Proteomic databases

MaxQBiQ9CQU8.
PaxDbiQ9CQU8.
PeptideAtlasiQ9CQU8.
PRIDEiQ9CQU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037499; ENSMUSP00000049044; ENSMUSG00000042670.
GeneIDi66541.
KEGGimmu:66541.
UCSCiuc008lle.1. mouse.

Organism-specific databases

CTDi196294.
MGIiMGI:1913791. Immp1l.

Phylogenomic databases

eggNOGiKOG0171. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00550000075025.
HOGENOMiHOG000003673.
HOVERGENiHBG080010.
InParanoidiQ9CQU8.
KOiK09647.
OMAiRCYGPVP.
OrthoDBiEOG091G0TXV.
PhylomeDBiQ9CQU8.
TreeFamiTF315083.

Miscellaneous databases

PROiQ9CQU8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042670.
GenevisibleiQ9CQU8. MM.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR026730. Mitochondrial_IMP1.
IPR000223. Pept_S26A_signal_pept_1.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PTHR12383:SF16. PTHR12383:SF16. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
PF10502. Peptidase_S26. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIMP1L_MOUSE
AccessioniPrimary (citable) accession number: Q9CQU8
Secondary accession number(s): Q3THN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.