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Q9CQU5 (ZWINT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ZW10 interactor
Alternative name(s):
ZW10-interacting protein 1
Short name=Zwint-1
Gene names
Name:Zwint
Synonyms:D10Ertd749e
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase By similarity.

Subunit structure

Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1 By similarity.

Subcellular location

Nucleus By similarity. Chromosomecentromerekinetochore By similarity. Note: Localizes to kinetochores from late prophase to anaphase By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252ZW10 interactor
PRO_0000066595

Regions

Region86 – 16176Interaction with NDC80 and ZW10 By similarity
Coiled coil120 – 221102 Potential

Experimental info

Sequence conflict1 – 77MADAEKN → PTRP in AAH13559. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9CQU5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 56CF28F7493CD4E8

FASTA25228,713
        10         20         30         40         50         60 
MADAEKNAVA EKNNAVATKE VLAEAAAILE PVGLQEEAEL PAKIMEEFMR NSRKKDKLLC 

        70         80         90        100        110        120 
SQLQVVNFLQ TFLAQEDTEQ SPDALASEDA SRQKATETKE QWKDMKATYM DHVDVIKCAL 

       130        140        150        160        170        180 
SEALPQVKEA HRKYTELQKA FEQLEAKKRV LEEKLQLAQK QWVLQQKRLQ NLTKISAEVK 

       190        200        210        220        230        240 
RRRKRALEKL DGSHQELETL KQQAGQEQEK LQRNQSYLQL LCSLQNKLVI SEGKAEDKDV 

       250 
KGRALTAKSK SP 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Hippocampus, Small intestine and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Mammary gland and Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004305 mRNA. Translation: BAB23256.1.
AK008144 mRNA. Translation: BAB25492.1.
AK013556 mRNA. Translation: BAB28904.1.
AK075977 mRNA. Translation: BAC36090.1.
AK134380 mRNA. Translation: BAE22123.1.
BC013559 mRNA. Translation: AAH13559.1.
BC027100 mRNA. Translation: AAH27100.1.
BC034870 mRNA. Translation: AAH34870.1.
CCDSCCDS23920.1.
RefSeqNP_079911.1. NM_025635.3.
XP_006513947.1. XM_006513884.1.
XP_006513948.1. XM_006513885.1.
XP_006513949.1. XM_006513886.1.
XP_006513950.1. XM_006513887.1.
UniGeneMm.62876.

3D structure databases

ProteinModelPortalQ9CQU5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206739. 19 interactions.
IntActQ9CQU5. 21 interactions.
STRING10090.ENSMUSP00000020081.

PTM databases

PhosphoSiteQ9CQU5.

Proteomic databases

MaxQBQ9CQU5.
PaxDbQ9CQU5.
PRIDEQ9CQU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020081; ENSMUSP00000020081; ENSMUSG00000019923.
ENSMUST00000105431; ENSMUSP00000101071; ENSMUSG00000019923.
ENSMUST00000160337; ENSMUSP00000124429; ENSMUSG00000019923.
GeneID52696.
KEGGmmu:52696.
UCSCuc007foy.1. mouse.

Organism-specific databases

CTD11130.
MGIMGI:1289227. Zwint.

Phylogenomic databases

eggNOGNOG39831.
GeneTreeENSGT00390000017639.
HOGENOMHOG000293254.
HOVERGENHBG079391.
InParanoidQ9CQU5.
OMAIAAKEQW.
OrthoDBEOG783MW9.
PhylomeDBQ9CQU5.
TreeFamTF338101.

Gene expression databases

BgeeQ9CQU5.
CleanExMM_ZWINT.
GenevestigatorQ9CQU5.

Family and domain databases

InterProIPR029092. Zwint-1.
[Graphical view]
PANTHERPTHR31504. PTHR31504. 1 hit.
PfamPF15556. Zwint. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZWINT. mouse.
NextBio309357.
PROQ9CQU5.
SOURCESearch...

Entry information

Entry nameZWINT_MOUSE
AccessionPrimary (citable) accession number: Q9CQU5
Secondary accession number(s): Q3UYT8, Q91VI4, Q9D0W9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot