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Protein

ZW10 interactor

Gene

Zwint

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity).By similarity

GO - Molecular functioni

  1. protein N-terminus binding Source: MGI

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. establishment of localization in cell Source: MGI
  3. mitotic cell cycle checkpoint Source: MGI
  4. mitotic sister chromatid segregation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_306375. Mitotic Prometaphase.
REACT_321346. Separation of Sister Chromatids.
REACT_329805. Resolution of Sister Chromatid Cohesion.

Names & Taxonomyi

Protein namesi
Recommended name:
ZW10 interactor
Alternative name(s):
ZW10-interacting protein 1
Short name:
Zwint-1
Gene namesi
Name:Zwint
Synonyms:D10Ertd749e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1289227. Zwint.

Subcellular locationi

Nucleus By similarity. Chromosomecentromerekinetochore By similarity
Note: Localizes to kinetochores from late prophase to anaphase.By similarity

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytoplasm Source: MGI
  3. dendrite Source: Ensembl
  4. kinetochore Source: MGI
  5. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252ZW10 interactorPRO_0000066595Add
BLAST

Proteomic databases

MaxQBiQ9CQU5.
PaxDbiQ9CQU5.
PRIDEiQ9CQU5.

PTM databases

PhosphoSiteiQ9CQU5.

Expressioni

Gene expression databases

BgeeiQ9CQU5.
CleanExiMM_ZWINT.
GenevestigatoriQ9CQU5.

Interactioni

Subunit structurei

Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi206739. 19 interactions.
IntActiQ9CQU5. 21 interactions.
STRINGi10090.ENSMUSP00000020081.

Structurei

3D structure databases

ProteinModelPortaliQ9CQU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 16176Interaction with NDC80 and ZW10By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili120 – 221102Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39831.
GeneTreeiENSGT00390000017639.
HOGENOMiHOG000293254.
HOVERGENiHBG079391.
InParanoidiQ9CQU5.
OMAiIAAKEQW.
OrthoDBiEOG783MW9.
PhylomeDBiQ9CQU5.
TreeFamiTF338101.

Family and domain databases

InterProiIPR029092. Zwint-1.
[Graphical view]
PANTHERiPTHR31504. PTHR31504. 1 hit.
PfamiPF15556. Zwint. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAEKNAVA EKNNAVATKE VLAEAAAILE PVGLQEEAEL PAKIMEEFMR
60 70 80 90 100
NSRKKDKLLC SQLQVVNFLQ TFLAQEDTEQ SPDALASEDA SRQKATETKE
110 120 130 140 150
QWKDMKATYM DHVDVIKCAL SEALPQVKEA HRKYTELQKA FEQLEAKKRV
160 170 180 190 200
LEEKLQLAQK QWVLQQKRLQ NLTKISAEVK RRRKRALEKL DGSHQELETL
210 220 230 240 250
KQQAGQEQEK LQRNQSYLQL LCSLQNKLVI SEGKAEDKDV KGRALTAKSK

SP
Length:252
Mass (Da):28,713
Last modified:June 1, 2001 - v1
Checksum:i56CF28F7493CD4E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 77MADAEKN → PTRP in AAH13559 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004305 mRNA. Translation: BAB23256.1.
AK008144 mRNA. Translation: BAB25492.1.
AK013556 mRNA. Translation: BAB28904.1.
AK075977 mRNA. Translation: BAC36090.1.
AK134380 mRNA. Translation: BAE22123.1.
BC013559 mRNA. Translation: AAH13559.1.
BC027100 mRNA. Translation: AAH27100.1.
BC034870 mRNA. Translation: AAH34870.1.
CCDSiCCDS23920.1.
RefSeqiNP_001280612.1. NM_001293683.1.
NP_001280613.1. NM_001293684.1.
NP_079911.1. NM_025635.4.
UniGeneiMm.62876.

Genome annotation databases

EnsembliENSMUST00000020081; ENSMUSP00000020081; ENSMUSG00000019923.
ENSMUST00000105431; ENSMUSP00000101071; ENSMUSG00000019923.
ENSMUST00000160337; ENSMUSP00000124429; ENSMUSG00000019923.
GeneIDi52696.
KEGGimmu:52696.
UCSCiuc007foy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004305 mRNA. Translation: BAB23256.1.
AK008144 mRNA. Translation: BAB25492.1.
AK013556 mRNA. Translation: BAB28904.1.
AK075977 mRNA. Translation: BAC36090.1.
AK134380 mRNA. Translation: BAE22123.1.
BC013559 mRNA. Translation: AAH13559.1.
BC027100 mRNA. Translation: AAH27100.1.
BC034870 mRNA. Translation: AAH34870.1.
CCDSiCCDS23920.1.
RefSeqiNP_001280612.1. NM_001293683.1.
NP_001280613.1. NM_001293684.1.
NP_079911.1. NM_025635.4.
UniGeneiMm.62876.

3D structure databases

ProteinModelPortaliQ9CQU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206739. 19 interactions.
IntActiQ9CQU5. 21 interactions.
STRINGi10090.ENSMUSP00000020081.

PTM databases

PhosphoSiteiQ9CQU5.

Proteomic databases

MaxQBiQ9CQU5.
PaxDbiQ9CQU5.
PRIDEiQ9CQU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020081; ENSMUSP00000020081; ENSMUSG00000019923.
ENSMUST00000105431; ENSMUSP00000101071; ENSMUSG00000019923.
ENSMUST00000160337; ENSMUSP00000124429; ENSMUSG00000019923.
GeneIDi52696.
KEGGimmu:52696.
UCSCiuc007foy.1. mouse.

Organism-specific databases

CTDi11130.
MGIiMGI:1289227. Zwint.

Phylogenomic databases

eggNOGiNOG39831.
GeneTreeiENSGT00390000017639.
HOGENOMiHOG000293254.
HOVERGENiHBG079391.
InParanoidiQ9CQU5.
OMAiIAAKEQW.
OrthoDBiEOG783MW9.
PhylomeDBiQ9CQU5.
TreeFamiTF338101.

Enzyme and pathway databases

ReactomeiREACT_306375. Mitotic Prometaphase.
REACT_321346. Separation of Sister Chromatids.
REACT_329805. Resolution of Sister Chromatid Cohesion.

Miscellaneous databases

ChiTaRSiZwint. mouse.
NextBioi309357.
PROiQ9CQU5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQU5.
CleanExiMM_ZWINT.
GenevestigatoriQ9CQU5.

Family and domain databases

InterProiIPR029092. Zwint-1.
[Graphical view]
PANTHERiPTHR31504. PTHR31504. 1 hit.
PfamiPF15556. Zwint. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Hippocampus, Small intestine and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Mammary gland and Retina.

Entry informationi

Entry nameiZWINT_MOUSE
AccessioniPrimary (citable) accession number: Q9CQU5
Secondary accession number(s): Q3UYT8, Q91VI4, Q9D0W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.