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Q9CQU5

- ZWINT_MOUSE

UniProt

Q9CQU5 - ZWINT_MOUSE

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Protein

ZW10 interactor

Gene

Zwint

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity).By similarity

GO - Biological processi

  1. establishment of localization in cell Source: Ensembl
  2. mitotic cell cycle checkpoint Source: InterPro
  3. mitotic sister chromatid segregation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
ZW10 interactor
Alternative name(s):
ZW10-interacting protein 1
Short name:
Zwint-1
Gene namesi
Name:Zwint
Synonyms:D10Ertd749e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1289227. Zwint.

Subcellular locationi

Nucleus By similarity. Chromosomecentromerekinetochore By similarity
Note: Localizes to kinetochores from late prophase to anaphase.By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. dendrite Source: Ensembl
  3. kinetochore Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252ZW10 interactorPRO_0000066595Add
BLAST

Proteomic databases

MaxQBiQ9CQU5.
PaxDbiQ9CQU5.
PRIDEiQ9CQU5.

PTM databases

PhosphoSiteiQ9CQU5.

Expressioni

Gene expression databases

BgeeiQ9CQU5.
CleanExiMM_ZWINT.
GenevestigatoriQ9CQU5.

Interactioni

Subunit structurei

Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi206739. 19 interactions.
IntActiQ9CQU5. 21 interactions.
STRINGi10090.ENSMUSP00000020081.

Structurei

3D structure databases

ProteinModelPortaliQ9CQU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 16176Interaction with NDC80 and ZW10By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili120 – 221102Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39831.
GeneTreeiENSGT00390000017639.
HOGENOMiHOG000293254.
HOVERGENiHBG079391.
InParanoidiQ9CQU5.
OMAiIAAKEQW.
OrthoDBiEOG783MW9.
PhylomeDBiQ9CQU5.
TreeFamiTF338101.

Family and domain databases

InterProiIPR029092. Zwint-1.
[Graphical view]
PANTHERiPTHR31504. PTHR31504. 1 hit.
PfamiPF15556. Zwint. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADAEKNAVA EKNNAVATKE VLAEAAAILE PVGLQEEAEL PAKIMEEFMR
60 70 80 90 100
NSRKKDKLLC SQLQVVNFLQ TFLAQEDTEQ SPDALASEDA SRQKATETKE
110 120 130 140 150
QWKDMKATYM DHVDVIKCAL SEALPQVKEA HRKYTELQKA FEQLEAKKRV
160 170 180 190 200
LEEKLQLAQK QWVLQQKRLQ NLTKISAEVK RRRKRALEKL DGSHQELETL
210 220 230 240 250
KQQAGQEQEK LQRNQSYLQL LCSLQNKLVI SEGKAEDKDV KGRALTAKSK

SP
Length:252
Mass (Da):28,713
Last modified:June 1, 2001 - v1
Checksum:i56CF28F7493CD4E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 77MADAEKN → PTRP in AAH13559. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004305 mRNA. Translation: BAB23256.1.
AK008144 mRNA. Translation: BAB25492.1.
AK013556 mRNA. Translation: BAB28904.1.
AK075977 mRNA. Translation: BAC36090.1.
AK134380 mRNA. Translation: BAE22123.1.
BC013559 mRNA. Translation: AAH13559.1.
BC027100 mRNA. Translation: AAH27100.1.
BC034870 mRNA. Translation: AAH34870.1.
CCDSiCCDS23920.1.
RefSeqiNP_001280612.1. NM_001293683.1.
NP_001280613.1. NM_001293684.1.
NP_079911.1. NM_025635.4.
XP_006513949.1. XM_006513886.1.
XP_006513950.1. XM_006513887.1.
UniGeneiMm.62876.

Genome annotation databases

EnsembliENSMUST00000020081; ENSMUSP00000020081; ENSMUSG00000019923.
ENSMUST00000105431; ENSMUSP00000101071; ENSMUSG00000019923.
ENSMUST00000160337; ENSMUSP00000124429; ENSMUSG00000019923.
GeneIDi52696.
KEGGimmu:52696.
UCSCiuc007foy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004305 mRNA. Translation: BAB23256.1 .
AK008144 mRNA. Translation: BAB25492.1 .
AK013556 mRNA. Translation: BAB28904.1 .
AK075977 mRNA. Translation: BAC36090.1 .
AK134380 mRNA. Translation: BAE22123.1 .
BC013559 mRNA. Translation: AAH13559.1 .
BC027100 mRNA. Translation: AAH27100.1 .
BC034870 mRNA. Translation: AAH34870.1 .
CCDSi CCDS23920.1.
RefSeqi NP_001280612.1. NM_001293683.1.
NP_001280613.1. NM_001293684.1.
NP_079911.1. NM_025635.4.
XP_006513949.1. XM_006513886.1.
XP_006513950.1. XM_006513887.1.
UniGenei Mm.62876.

3D structure databases

ProteinModelPortali Q9CQU5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206739. 19 interactions.
IntActi Q9CQU5. 21 interactions.
STRINGi 10090.ENSMUSP00000020081.

PTM databases

PhosphoSitei Q9CQU5.

Proteomic databases

MaxQBi Q9CQU5.
PaxDbi Q9CQU5.
PRIDEi Q9CQU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020081 ; ENSMUSP00000020081 ; ENSMUSG00000019923 .
ENSMUST00000105431 ; ENSMUSP00000101071 ; ENSMUSG00000019923 .
ENSMUST00000160337 ; ENSMUSP00000124429 ; ENSMUSG00000019923 .
GeneIDi 52696.
KEGGi mmu:52696.
UCSCi uc007foy.1. mouse.

Organism-specific databases

CTDi 11130.
MGIi MGI:1289227. Zwint.

Phylogenomic databases

eggNOGi NOG39831.
GeneTreei ENSGT00390000017639.
HOGENOMi HOG000293254.
HOVERGENi HBG079391.
InParanoidi Q9CQU5.
OMAi IAAKEQW.
OrthoDBi EOG783MW9.
PhylomeDBi Q9CQU5.
TreeFami TF338101.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

ChiTaRSi ZWINT. mouse.
NextBioi 309357.
PROi Q9CQU5.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQU5.
CleanExi MM_ZWINT.
Genevestigatori Q9CQU5.

Family and domain databases

InterProi IPR029092. Zwint-1.
[Graphical view ]
PANTHERi PTHR31504. PTHR31504. 1 hit.
Pfami PF15556. Zwint. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Hippocampus, Small intestine and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Mammary gland and Retina.

Entry informationi

Entry nameiZWINT_MOUSE
AccessioniPrimary (citable) accession number: Q9CQU5
Secondary accession number(s): Q3UYT8, Q91VI4, Q9D0W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3