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Q9CQU5

- ZWINT_MOUSE

UniProt

Q9CQU5 - ZWINT_MOUSE

Protein

ZW10 interactor

Gene

Zwint

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase By similarity.By similarity

    GO - Biological processi

    1. establishment of localization in cell Source: Ensembl
    2. mitotic cell cycle checkpoint Source: Ensembl
    3. mitotic sister chromatid segregation Source: Ensembl

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ZW10 interactor
    Alternative name(s):
    ZW10-interacting protein 1
    Short name:
    Zwint-1
    Gene namesi
    Name:Zwint
    Synonyms:D10Ertd749e
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1289227. Zwint.

    Subcellular locationi

    Nucleus By similarity. Chromosomecentromerekinetochore By similarity
    Note: Localizes to kinetochores from late prophase to anaphase.By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytoplasm Source: Ensembl
    3. dendrite Source: Ensembl
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252ZW10 interactorPRO_0000066595Add
    BLAST

    Proteomic databases

    MaxQBiQ9CQU5.
    PaxDbiQ9CQU5.
    PRIDEiQ9CQU5.

    PTM databases

    PhosphoSiteiQ9CQU5.

    Expressioni

    Gene expression databases

    BgeeiQ9CQU5.
    CleanExiMM_ZWINT.
    GenevestigatoriQ9CQU5.

    Interactioni

    Subunit structurei

    Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi206739. 19 interactions.
    IntActiQ9CQU5. 21 interactions.
    STRINGi10090.ENSMUSP00000020081.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni86 – 16176Interaction with NDC80 and ZW10By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili120 – 221102Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39831.
    GeneTreeiENSGT00390000017639.
    HOGENOMiHOG000293254.
    HOVERGENiHBG079391.
    InParanoidiQ9CQU5.
    OMAiIAAKEQW.
    OrthoDBiEOG783MW9.
    PhylomeDBiQ9CQU5.
    TreeFamiTF338101.

    Family and domain databases

    InterProiIPR029092. Zwint-1.
    [Graphical view]
    PANTHERiPTHR31504. PTHR31504. 1 hit.
    PfamiPF15556. Zwint. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CQU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAEKNAVA EKNNAVATKE VLAEAAAILE PVGLQEEAEL PAKIMEEFMR    50
    NSRKKDKLLC SQLQVVNFLQ TFLAQEDTEQ SPDALASEDA SRQKATETKE 100
    QWKDMKATYM DHVDVIKCAL SEALPQVKEA HRKYTELQKA FEQLEAKKRV 150
    LEEKLQLAQK QWVLQQKRLQ NLTKISAEVK RRRKRALEKL DGSHQELETL 200
    KQQAGQEQEK LQRNQSYLQL LCSLQNKLVI SEGKAEDKDV KGRALTAKSK 250
    SP 252
    Length:252
    Mass (Da):28,713
    Last modified:June 1, 2001 - v1
    Checksum:i56CF28F7493CD4E8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 77MADAEKN → PTRP in AAH13559. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004305 mRNA. Translation: BAB23256.1.
    AK008144 mRNA. Translation: BAB25492.1.
    AK013556 mRNA. Translation: BAB28904.1.
    AK075977 mRNA. Translation: BAC36090.1.
    AK134380 mRNA. Translation: BAE22123.1.
    BC013559 mRNA. Translation: AAH13559.1.
    BC027100 mRNA. Translation: AAH27100.1.
    BC034870 mRNA. Translation: AAH34870.1.
    CCDSiCCDS23920.1.
    RefSeqiNP_079911.1. NM_025635.4.
    XP_006513949.1. XM_006513886.1.
    XP_006513950.1. XM_006513887.1.
    UniGeneiMm.62876.

    Genome annotation databases

    EnsembliENSMUST00000020081; ENSMUSP00000020081; ENSMUSG00000019923.
    ENSMUST00000105431; ENSMUSP00000101071; ENSMUSG00000019923.
    ENSMUST00000160337; ENSMUSP00000124429; ENSMUSG00000019923.
    GeneIDi52696.
    KEGGimmu:52696.
    UCSCiuc007foy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004305 mRNA. Translation: BAB23256.1 .
    AK008144 mRNA. Translation: BAB25492.1 .
    AK013556 mRNA. Translation: BAB28904.1 .
    AK075977 mRNA. Translation: BAC36090.1 .
    AK134380 mRNA. Translation: BAE22123.1 .
    BC013559 mRNA. Translation: AAH13559.1 .
    BC027100 mRNA. Translation: AAH27100.1 .
    BC034870 mRNA. Translation: AAH34870.1 .
    CCDSi CCDS23920.1.
    RefSeqi NP_079911.1. NM_025635.4.
    XP_006513949.1. XM_006513886.1.
    XP_006513950.1. XM_006513887.1.
    UniGenei Mm.62876.

    3D structure databases

    ProteinModelPortali Q9CQU5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206739. 19 interactions.
    IntActi Q9CQU5. 21 interactions.
    STRINGi 10090.ENSMUSP00000020081.

    PTM databases

    PhosphoSitei Q9CQU5.

    Proteomic databases

    MaxQBi Q9CQU5.
    PaxDbi Q9CQU5.
    PRIDEi Q9CQU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020081 ; ENSMUSP00000020081 ; ENSMUSG00000019923 .
    ENSMUST00000105431 ; ENSMUSP00000101071 ; ENSMUSG00000019923 .
    ENSMUST00000160337 ; ENSMUSP00000124429 ; ENSMUSG00000019923 .
    GeneIDi 52696.
    KEGGi mmu:52696.
    UCSCi uc007foy.1. mouse.

    Organism-specific databases

    CTDi 11130.
    MGIi MGI:1289227. Zwint.

    Phylogenomic databases

    eggNOGi NOG39831.
    GeneTreei ENSGT00390000017639.
    HOGENOMi HOG000293254.
    HOVERGENi HBG079391.
    InParanoidi Q9CQU5.
    OMAi IAAKEQW.
    OrthoDBi EOG783MW9.
    PhylomeDBi Q9CQU5.
    TreeFami TF338101.

    Enzyme and pathway databases

    Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    ChiTaRSi ZWINT. mouse.
    NextBioi 309357.
    PROi Q9CQU5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQU5.
    CleanExi MM_ZWINT.
    Genevestigatori Q9CQU5.

    Family and domain databases

    InterProi IPR029092. Zwint-1.
    [Graphical view ]
    PANTHERi PTHR31504. PTHR31504. 1 hit.
    Pfami PF15556. Zwint. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Hippocampus, Small intestine and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Mammary gland and Retina.

    Entry informationi

    Entry nameiZWINT_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQU5
    Secondary accession number(s): Q3UYT8, Q91VI4, Q9D0W9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3