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Q9CQU0

- TXD12_MOUSE

UniProt

Q9CQU0 - TXD12_MOUSE

Protein

Thioredoxin domain-containing protein 12

Gene

Txndc12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Possesses significant protein thiol-disulfide oxidase activity.By similarity

    Catalytic activityi

    2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.

    GO - Molecular functioni

    1. protein-disulfide reductase (glutathione) activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin domain-containing protein 12 (EC:1.8.4.2)
    Alternative name(s):
    Endoplasmic reticulum resident protein 19
    Short name:
    ER protein 19
    Short name:
    ERp19
    Thioredoxin-like protein p19
    Gene namesi
    Name:Txndc12
    Synonyms:Tlp19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1913323. Txndc12.

    Subcellular locationi

    Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 170146Thioredoxin domain-containing protein 12PRO_0000034190Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 67Redox-activePROSITE-ProRule annotation
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9CQU0.
    PaxDbiQ9CQU0.
    PRIDEiQ9CQU0.

    2D gel databases

    REPRODUCTION-2DPAGEQ9CQU0.

    PTM databases

    PhosphoSiteiQ9CQU0.

    Expressioni

    Gene expression databases

    BgeeiQ9CQU0.
    GenevestigatoriQ9CQU0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9CQU0. 6 interactions.
    MINTiMINT-4137999.
    STRINGi10090.ENSMUSP00000030296.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQU0.
    SMRiQ9CQU0. Positions 28-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi167 – 1704Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Signal

    Phylogenomic databases

    eggNOGiNOG77442.
    GeneTreeiENSGT00530000063273.
    HOGENOMiHOG000231100.
    HOVERGENiHBG107174.
    InParanoidiQ9CQU0.
    KOiK05360.
    OMAiSYKYFYT.
    OrthoDBiEOG7DNNX2.
    PhylomeDBiQ9CQU0.
    TreeFamiTF321449.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CQU0-1 [UniParc]FASTAAdd to Basket

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    MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA    50
    SGLPLMVIIH KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD 100
    EDFSPDGGYI PRILFLDPSG KVRPEIINES GNPSYKYFYV SAEQVVQGMK 150
    EAQERLTGDA FREKHFQDEL 170
    Length:170
    Mass (Da):19,049
    Last modified:June 1, 2001 - v1
    Checksum:i5B91FC9BE12C5E44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY548113 mRNA. Translation: AAS55653.1.
    AK003481 mRNA. Translation: BAB22811.1.
    AK002862 mRNA. Translation: BAB22413.1.
    BC006857 mRNA. Translation: AAH06857.1.
    CCDSiCCDS18457.1.
    RefSeqiNP_079610.1. NM_025334.3.
    UniGeneiMm.159965.

    Genome annotation databases

    EnsembliENSMUST00000030296; ENSMUSP00000030296; ENSMUSG00000028567.
    GeneIDi66073.
    KEGGimmu:66073.
    UCSCiuc008ubs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY548113 mRNA. Translation: AAS55653.1 .
    AK003481 mRNA. Translation: BAB22811.1 .
    AK002862 mRNA. Translation: BAB22413.1 .
    BC006857 mRNA. Translation: AAH06857.1 .
    CCDSi CCDS18457.1.
    RefSeqi NP_079610.1. NM_025334.3.
    UniGenei Mm.159965.

    3D structure databases

    ProteinModelPortali Q9CQU0.
    SMRi Q9CQU0. Positions 28-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CQU0. 6 interactions.
    MINTi MINT-4137999.
    STRINGi 10090.ENSMUSP00000030296.

    PTM databases

    PhosphoSitei Q9CQU0.

    2D gel databases

    REPRODUCTION-2DPAGE Q9CQU0.

    Proteomic databases

    MaxQBi Q9CQU0.
    PaxDbi Q9CQU0.
    PRIDEi Q9CQU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030296 ; ENSMUSP00000030296 ; ENSMUSG00000028567 .
    GeneIDi 66073.
    KEGGi mmu:66073.
    UCSCi uc008ubs.1. mouse.

    Organism-specific databases

    CTDi 51060.
    MGIi MGI:1913323. Txndc12.

    Phylogenomic databases

    eggNOGi NOG77442.
    GeneTreei ENSGT00530000063273.
    HOGENOMi HOG000231100.
    HOVERGENi HBG107174.
    InParanoidi Q9CQU0.
    KOi K05360.
    OMAi SYKYFYT.
    OrthoDBi EOG7DNNX2.
    PhylomeDBi Q9CQU0.
    TreeFami TF321449.

    Miscellaneous databases

    ChiTaRSi TXNDC12. mouse.
    NextBioi 320548.
    PROi Q9CQU0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQU0.
    Genevestigatori Q9CQU0.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins."
      Knoblach B., Keller B.O., Groenendyk J., Aldred S., Zheng J., Lemire B.D., Li L., Michalak M.
      Mol. Cell. Proteomics 2:1104-1119(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
      Tissue: Embryo.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiTXD12_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQU0
    Secondary accession number(s): Q53YN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3