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Protein

Proteasome maturation protein

Gene

Pomp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation (By similarity). Mediates the association of 20S preproteasome with the endoplasmic reticulum (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome maturation protein
Alternative name(s):
Proteassemblin
Protein UMP1 homolog
Short name:
mUMP1
Gene namesi
Name:Pomp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913787. Pomp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471851 – 141Proteasome maturation proteinAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9CQT5.
MaxQBiQ9CQT5.
PaxDbiQ9CQT5.
PeptideAtlasiQ9CQT5.
PRIDEiQ9CQT5.

PTM databases

iPTMnetiQ9CQT5.
PhosphoSitePlusiQ9CQT5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

By interferon gamma.1 Publication

Gene expression databases

BgeeiENSMUSG00000029649.
CleanExiMM_POMP.
ExpressionAtlasiQ9CQT5. baseline and differential.
GenevisibleiQ9CQT5. MM.

Interactioni

Subunit structurei

Constituent of preproteasomes, but not of mature 20S proteasomes. Within the preproteasome, may directly interact with PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i. Interaction with PSMB8/beta5i is controversial. Forms tetramers (By similarity).By similarity

Protein-protein interaction databases

BioGridi211543. 1 interactor.
STRINGi10090.ENSMUSP00000031654.

Family & Domainsi

Sequence similaritiesi

Belongs to the POMP/UMP1 family.Curated

Phylogenomic databases

eggNOGiKOG3061. Eukaryota.
ENOG410XUI5. LUCA.
GeneTreeiENSGT00390000010734.
HOGENOMiHOG000276894.
HOVERGENiHBG057292.
InParanoidiQ9CQT5.
KOiK11599.
OMAiGLHAPMR.
OrthoDBiEOG091G0V3C.
PhylomeDBiQ9CQT5.
TreeFamiTF323548.

Family and domain databases

InterProiView protein in InterPro
IPR008012. Ump1.
PANTHERiPTHR12828. PTHR12828. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNARGLGSEL KDSIPVAELS ASGPFESHDL LRKGFSCVKN ELLPSHPLEL
60 70 80 90 100
SEKNFQLNQD KMNFSTLRNI QGLFAPLKLQ MEFKAVQQVH RLPFLPSSNL
110 120 130 140
SLDILRGNDE TIGFEDILND PSQSELMGEP HVMVEHKLGL L
Length:141
Mass (Da):15,766
Last modified:June 1, 2001 - v1
Checksum:i5CDA8C2EB7E2D7DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52E → K in BAB29067 (PubMed:16141072).Curated1
Sequence conflicti126L → Q in BAB28250 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003439 mRNA. Translation: BAB22791.1.
AK011115 mRNA. Translation: BAB27410.1.
AK012455 mRNA. Translation: BAB28250.1.
AK013934 mRNA. Translation: BAB29067.1.
AK014296 mRNA. Translation: BAB29252.1.
AK167958 mRNA. Translation: BAE39956.1.
BC027016 mRNA. Translation: AAH27016.1.
CCDSiCCDS39402.1.
RefSeqiNP_079900.1. NM_025624.2.
UniGeneiMm.332855.

Genome annotation databases

EnsembliENSMUST00000031654; ENSMUSP00000031654; ENSMUSG00000029649.
GeneIDi66537.
KEGGimmu:66537.
UCSCiuc009aoj.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPOMP_MOUSE
AccessioniPrimary (citable) accession number: Q9CQT5
Secondary accession number(s): Q9CXV8, Q9CZL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families