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Protein

RNA-binding protein 7

Gene

Rbm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein adapters. Possible involved in germ cell RNA processing and meiosis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 7
Alternative name(s):
RNA-binding motif protein 7
Gene namesi
Name:Rbm7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914260. Rbm7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000817622 – 265RNA-binding protein 7Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei137PhosphoserineCombined sources1
Modified residuei152Omega-N-methylarginineBy similarity1
Modified residuei203PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9CQT2.
MaxQBiQ9CQT2.
PaxDbiQ9CQT2.
PRIDEiQ9CQT2.

PTM databases

iPTMnetiQ9CQT2.
PhosphoSitePlusiQ9CQT2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042396.
CleanExiMM_RBM7.
ExpressionAtlasiQ9CQT2. baseline and differential.
GenevisibleiQ9CQT2. MM.

Interactioni

Subunit structurei

Component of the nuclear exosome targeting (NEXT) complex composed of SKIV2L2/MTR4, ZCCHC8, and RBM7 that directs a subset of non-coding short-lived RNAs for exosomal degradation. Interacts with ZCCHC8 and SF3B2/SAP145. Binds to SKIV2L2/MTR4.By similarity

Protein-protein interaction databases

IntActiQ9CQT2. 2 interactors.
MINTiMINT-4131940.
STRINGi10090.ENSMUSP00000126374.

Structurei

3D structure databases

ProteinModelPortaliQ9CQT2.
SMRiQ9CQT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 87RRMPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 35ZCCHC8 bindingBy similarityAdd BLAST11
Regioni59 – 76ZCCHC8 bindingBy similarityAdd BLAST18

Phylogenomic databases

eggNOGiKOG4454. Eukaryota.
ENOG41123B7. LUCA.
GeneTreeiENSGT00870000136493.
HOGENOMiHOG000059553.
HOVERGENiHBG009324.
InParanoidiQ9CQT2.
KOiK13188.
OMAiDRHYSRE.
OrthoDBiEOG091G15TA.
PhylomeDBiQ9CQT2.
TreeFamiTF323596.

Family and domain databases

CDDicd12592. RRM_RBM7. 1 hit.
InterProiView protein in InterPro
IPR035979. RBD_domain_sf.
IPR034500. RBM7_RRM.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAAAEADR TLFVGNLETK VTEELLFELF HQAGPVIKVK IPKDKDGKLK
60 70 80 90 100
QFAFVNFKHE VSVPYAMNLL NGIKLFGRPI KIQFRSGSSH ASQDASVSYP
110 120 130 140 150
QHHVGNLSPT STSPNSYERT VGNVSPTAQM VQRSFSSPED YQRQAVMNSV
160 170 180 190 200
FRQMSYAGKF GSPHADQLGF SPSAQPHGHT FNQSSSSQWR QDALSSQRKR
210 220 230 240 250
QNSHPYLADR HYSREQRYSD HGSDYHYRGS REDFYYDDRN HDGWSHDYDN
260
RRDSSRGGKW PSSRH
Length:265
Mass (Da):30,148
Last modified:June 1, 2001 - v1
Checksum:i5D99650FD1FBF0C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti240N → D in AAH54774 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458961 mRNA. Translation: AAL60585.1.
AK005200 mRNA. Translation: BAB23878.1.
AK006755 mRNA. Translation: BAB24729.1.
AK008645 mRNA. Translation: BAB25804.1.
AK151056 mRNA. Translation: BAE30073.1.
BC054774 mRNA. Translation: AAH54774.1.
CCDSiCCDS23155.1.
RefSeqiNP_659197.2. NM_144948.5.
UniGeneiMm.76911.

Genome annotation databases

EnsembliENSMUST00000170000; ENSMUSP00000126374; ENSMUSG00000042396.
GeneIDi67010.
KEGGimmu:67010.
UCSCiuc009pic.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiRBM7_MOUSE
AccessioniPrimary (citable) accession number: Q9CQT2
Secondary accession number(s): Q3UB91, Q7TQE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot