Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methylthioribose-1-phosphate isomerase

Gene

Mri1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Methylthioribose-1-phosphate isomerase (Mri1)
  2. Methylthioribulose-1-phosphate dehydratase (Apip)
  3. Enolase-phosphatase E1 (Enoph1)
  4. Enolase-phosphatase E1 (Enoph1)
  5. 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (Adi1)
  6. no protein annotated in this organism
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei168Transition state stabilizerUniRule annotation1
Active sitei248Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-1237112 Methionine salvage pathway
UniPathwayiUPA00904; UER00874

Names & Taxonomyi

Protein namesi
Recommended name:
Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Translation initiation factor eIF-2B subunit alpha/beta/delta-like proteinUniRule annotation
Gene namesi
Name:Mri1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915123 Mri1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173261 – 369Methylthioribose-1-phosphate isomeraseAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei158Omega-N-methylarginineCombined sources1
Modified residuei366PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9CQT1
MaxQBiQ9CQT1
PaxDbiQ9CQT1
PeptideAtlasiQ9CQT1
PRIDEiQ9CQT1

PTM databases

iPTMnetiQ9CQT1
PhosphoSitePlusiQ9CQT1

Expressioni

Gene expression databases

BgeeiENSMUSG00000004996
CleanExiMM_2410018C20RIK
ExpressionAtlasiQ9CQT1 baseline and differential
GenevisibleiQ9CQT1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CQT1 2 interactors.
MINTiQ9CQT1
STRINGi10090.ENSMUSP00000122623

Structurei

3D structure databases

ProteinModelPortaliQ9CQT1
SMRiQ9CQT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1468 Eukaryota
COG0182 LUCA
GeneTreeiENSGT00390000013732
InParanoidiQ9CQT1
KOiK08963
OMAiVNVLTHC
OrthoDBiEOG091G0BA6
PhylomeDBiQ9CQT1
TreeFamiTF300852

Family and domain databases

Gene3Di1.20.120.4201 hit
HAMAPiMF_01678 Salvage_MtnA, 1 hit
InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR005251 IF-M1Pi
IPR011559 Initiation_fac_2B_a/b/d
IPR027363 M1Pi_N
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00524 eIF-2B_rel, 1 hit
TIGR00512 salvage_mtnA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEAIRYSP GSLQILDQLQ LPEHCHYEAL SSVQQASEAI RAMKVRGAPA
60 70 80 90 100
IALVGCLSLA VELRAGAGGP GLAALVAFVR DQLRLLVAAR PTAVNMARAA
110 120 130 140 150
RDLGQVAAQE AEREGATEET VRERVIRFAE DMLEKDLKDN RSIGDLGARH
160 170 180 190 200
LLEQTNPRGG KVTVLTHCNT GALATAGYGT ALGVIRSLHE MGRLEHTFCT
210 220 230 240 250
ETRPYNQGAR LTAFELVYEQ IPATLITDSM AAAAMAHRGV SAVVVGADRV
260 270 280 290 300
VANGDTANKI GTYQLAIVAK HHGVPFYVAA PSSSCDLHLE TGKEIVIEER
310 320 330 340 350
PSQELTDLNG VRIAAQGIRV WNPAFDVTPH ELITGGIITE LGVFAPEELR
360
GALSASVFSE GQTLDSPWV
Length:369
Mass (Da):39,411
Last modified:June 1, 2001 - v1
Checksum:i5DEA57F8E4AE99E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168C → L in BAC33016 (PubMed:16141072).Curated1
Sequence conflicti190E → D in BAC33016 (PubMed:16141072).Curated1
Sequence conflicti238R → Q in BAC33016 (PubMed:16141072).Curated1
Sequence conflicti291T → S in BAC33016 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010538 mRNA Translation: BAB27014.1
AK013882 mRNA Translation: BAB29034.1
AK164894 mRNA Translation: BAE37957.1
AK047287 mRNA Translation: BAC33016.1
BC025049 mRNA Translation: AAH25049.1
CCDSiCCDS22473.1
RefSeqiNP_080699.3, NM_026423.4
UniGeneiMm.278085

Genome annotation databases

EnsembliENSMUST00000126435; ENSMUSP00000122623; ENSMUSG00000004996
GeneIDi67873
KEGGimmu:67873
UCSCiuc009mmi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMTNA_MOUSE
AccessioniPrimary (citable) accession number: Q9CQT1
Secondary accession number(s): Q8BXF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome