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Protein

HAUS augmin-like complex subunit 2

Gene

Haus2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 2
Alternative name(s):
Centrosomal protein of 27 kDa
Short name:
Cep27
Gene namesi
Name:Haus2
Synonyms:Cep27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913546. Haus2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: MGI
  • Golgi apparatus Source: MGI
  • HAUS complex Source: UniProtKB
  • nucleoplasm Source: MGI
  • spindle microtubule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234HAUS augmin-like complex subunit 2PRO_0000089485Add
BLAST

Proteomic databases

MaxQBiQ9CQS9.
PaxDbiQ9CQS9.
PeptideAtlasiQ9CQS9.
PRIDEiQ9CQS9.

PTM databases

iPTMnetiQ9CQS9.
PhosphoSiteiQ9CQS9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027285.
CleanExiMM_CEP27.
ExpressionAtlasiQ9CQS9. baseline and differential.
GenevisibleiQ9CQS9. MM.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity).By similarity

Protein-protein interaction databases

BioGridi211364. 6 interactions.
IntActiQ9CQS9. 7 interactions.
STRINGi10090.ENSMUSP00000117299.

Structurei

3D structure databases

ProteinModelPortaliQ9CQS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili85 – 10521Sequence analysisAdd
BLAST
Coiled coili162 – 18221Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the HAUS2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJMS. Eukaryota.
ENOG410Y2SI. LUCA.
GeneTreeiENSGT00390000004927.
InParanoidiQ9CQS9.
KOiK16585.
OMAiMVTQEML.
OrthoDBiEOG091G100G.
PhylomeDBiQ9CQS9.
TreeFamiTF333194.

Family and domain databases

InterProiIPR028346. HAUS2.
IPR026242. HAUS2_metazoa.
[Graphical view]
PfamiPF15003. HAUS2. 1 hit.
[Graphical view]
PRINTSiPR02088. HAUSAUGMINL2.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAANPWDPA SSQTAAGLLL NHLVASGIVT KEMLDVSKKM APCFVNFSRL
60 70 80 90 100
QQISDIQAEI YQNNLELELL KLEKDTADLI HPSHLIEKCD VLQSMNNHLE
110 120 130 140 150
AVLKEKHAIR QRLLRPMCQE NLPLEAVYHR YVVHMLDLAV TFIEKFETHL
160 170 180 190 200
ETVKNSPHLD ANLKQMSKAL AKMDILVNKT EELAENILKW RELQTEISLY
210 220 230
IPKMLTEERH LHELDIVPPL PFFPKAHTET SRAK
Length:234
Mass (Da):26,839
Last modified:June 1, 2001 - v1
Checksum:i5F31E0488B17F8CC
GO
Isoform 2 (identifier: Q9CQS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:202
Mass (Da):23,623
Checksum:i5854A9CBE88C6DE6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271V → S in BAB24860 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_012224Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007106 mRNA. Translation: BAB24860.1.
AK010445 mRNA. Translation: BAB26946.1.
AK012086 mRNA. Translation: BAB28020.1.
AK012960 mRNA. Translation: BAB28570.1.
AK132300 mRNA. Translation: BAE21089.1.
AL772299 Genomic DNA. Translation: CAM15730.1.
AL772299 Genomic DNA. Translation: CAM15731.1.
BC086677 mRNA. Translation: AAH86677.1.
CCDSiCCDS16624.1. [Q9CQS9-1]
CCDS71120.1. [Q9CQS9-2]
RefSeqiNP_001277736.1. NM_001290807.1. [Q9CQS9-2]
NP_079751.1. NM_025475.3. [Q9CQS9-1]
UniGeneiMm.221900.

Genome annotation databases

EnsembliENSMUST00000110706; ENSMUSP00000106334; ENSMUSG00000027285. [Q9CQS9-2]
ENSMUST00000124187; ENSMUSP00000117299; ENSMUSG00000027285. [Q9CQS9-1]
GeneIDi66296.
KEGGimmu:66296.
UCSCiuc008lwo.2. mouse. [Q9CQS9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007106 mRNA. Translation: BAB24860.1.
AK010445 mRNA. Translation: BAB26946.1.
AK012086 mRNA. Translation: BAB28020.1.
AK012960 mRNA. Translation: BAB28570.1.
AK132300 mRNA. Translation: BAE21089.1.
AL772299 Genomic DNA. Translation: CAM15730.1.
AL772299 Genomic DNA. Translation: CAM15731.1.
BC086677 mRNA. Translation: AAH86677.1.
CCDSiCCDS16624.1. [Q9CQS9-1]
CCDS71120.1. [Q9CQS9-2]
RefSeqiNP_001277736.1. NM_001290807.1. [Q9CQS9-2]
NP_079751.1. NM_025475.3. [Q9CQS9-1]
UniGeneiMm.221900.

3D structure databases

ProteinModelPortaliQ9CQS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211364. 6 interactions.
IntActiQ9CQS9. 7 interactions.
STRINGi10090.ENSMUSP00000117299.

PTM databases

iPTMnetiQ9CQS9.
PhosphoSiteiQ9CQS9.

Proteomic databases

MaxQBiQ9CQS9.
PaxDbiQ9CQS9.
PeptideAtlasiQ9CQS9.
PRIDEiQ9CQS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110706; ENSMUSP00000106334; ENSMUSG00000027285. [Q9CQS9-2]
ENSMUST00000124187; ENSMUSP00000117299; ENSMUSG00000027285. [Q9CQS9-1]
GeneIDi66296.
KEGGimmu:66296.
UCSCiuc008lwo.2. mouse. [Q9CQS9-1]

Organism-specific databases

CTDi55142.
MGIiMGI:1913546. Haus2.

Phylogenomic databases

eggNOGiENOG410IJMS. Eukaryota.
ENOG410Y2SI. LUCA.
GeneTreeiENSGT00390000004927.
InParanoidiQ9CQS9.
KOiK16585.
OMAiMVTQEML.
OrthoDBiEOG091G100G.
PhylomeDBiQ9CQS9.
TreeFamiTF333194.

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiQ9CQS9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027285.
CleanExiMM_CEP27.
ExpressionAtlasiQ9CQS9. baseline and differential.
GenevisibleiQ9CQS9. MM.

Family and domain databases

InterProiIPR028346. HAUS2.
IPR026242. HAUS2_metazoa.
[Graphical view]
PfamiPF15003. HAUS2. 1 hit.
[Graphical view]
PRINTSiPR02088. HAUSAUGMINL2.
ProtoNetiSearch...

Entry informationi

Entry nameiHAUS2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQS9
Secondary accession number(s): A2AKH8
, A2AKI1, Q3V1R1, Q9CRI2, Q9D9D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.