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Protein

Protein transport protein Sec61 subunit beta

Gene

Sec61b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum.By similarity

GO - Molecular functioni

  • epidermal growth factor binding Source: MGI
  • poly(A) RNA binding Source: MGI
  • ribosome binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit beta
Gene namesi
Name:Sec61b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913462. Sec61b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 7069CytoplasmicSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9695Protein transport protein Sec61 subunit betaPRO_0000157255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylprolineBy similarity
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei9 – 91PhosphothreonineBy similarity
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei17 – 171PhosphoserineBy similarity
Lipidationi39 – 391S-palmitoyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9CQS8.
MaxQBiQ9CQS8.
PaxDbiQ9CQS8.
PeptideAtlasiQ9CQS8.
PRIDEiQ9CQS8.
TopDownProteomicsiQ9CQS8.

PTM databases

iPTMnetiQ9CQS8.
PhosphoSiteiQ9CQS8.
SwissPalmiQ9CQS8.

Expressioni

Gene expression databases

BgeeiQ9CQS8.
CleanExiMM_SEC61B.
ExpressionAtlasiQ9CQS8. baseline and differential.
GenevisibleiQ9CQS8. MM.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211302. 1 interaction.
IntActiQ9CQS8. 2 interactions.
MINTiMINT-1853763.
STRINGi10090.ENSMUSP00000067681.

Structurei

3D structure databases

ProteinModelPortaliQ9CQS8.
SMRiQ9CQS8. Positions 61-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3457. Eukaryota.
ENOG4111UAR. LUCA.
GeneTreeiENSGT00390000003561.
HOGENOMiHOG000211109.
HOVERGENiHBG061281.
InParanoidiQ9CQS8.
KOiK09481.
OrthoDBiEOG77M8RR.
PhylomeDBiQ9CQS8.
TreeFamiTF313144.

Family and domain databases

InterProiIPR030671. Sec61-beta/Sbh.
IPR016482. SecG/Sec61-beta/Sbh.
[Graphical view]
PANTHERiPTHR13509. PTHR13509. 1 hit.
PfamiPF03911. Sec61_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF006398. Sec61_beta_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA
60 70 80 90
GTGGMWRFYT EDSPGLKVGP VPVLVMSLLF IAAVFMLHIW GKYTRS
Length:96
Mass (Da):9,958
Last modified:January 23, 2007 - v3
Checksum:i5FAFF4197A742049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004505 mRNA. Translation: BAB23338.1.
AK008739 mRNA. Translation: BAB25868.1.
BC002089 mRNA. Translation: AAH02089.1.
BC081445 mRNA. Translation: AAH81445.1.
CCDSiCCDS38759.1.
RefSeqiNP_077133.1. NM_024171.2.
UniGeneiMm.20188.

Genome annotation databases

EnsembliENSMUST00000065678; ENSMUSP00000067681; ENSMUSG00000053317.
GeneIDi66212.
KEGGimmu:66212.
UCSCiuc008sur.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004505 mRNA. Translation: BAB23338.1.
AK008739 mRNA. Translation: BAB25868.1.
BC002089 mRNA. Translation: AAH02089.1.
BC081445 mRNA. Translation: AAH81445.1.
CCDSiCCDS38759.1.
RefSeqiNP_077133.1. NM_024171.2.
UniGeneiMm.20188.

3D structure databases

ProteinModelPortaliQ9CQS8.
SMRiQ9CQS8. Positions 61-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211302. 1 interaction.
IntActiQ9CQS8. 2 interactions.
MINTiMINT-1853763.
STRINGi10090.ENSMUSP00000067681.

PTM databases

iPTMnetiQ9CQS8.
PhosphoSiteiQ9CQS8.
SwissPalmiQ9CQS8.

Proteomic databases

EPDiQ9CQS8.
MaxQBiQ9CQS8.
PaxDbiQ9CQS8.
PeptideAtlasiQ9CQS8.
PRIDEiQ9CQS8.
TopDownProteomicsiQ9CQS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065678; ENSMUSP00000067681; ENSMUSG00000053317.
GeneIDi66212.
KEGGimmu:66212.
UCSCiuc008sur.1. mouse.

Organism-specific databases

CTDi10952.
MGIiMGI:1913462. Sec61b.

Phylogenomic databases

eggNOGiKOG3457. Eukaryota.
ENOG4111UAR. LUCA.
GeneTreeiENSGT00390000003561.
HOGENOMiHOG000211109.
HOVERGENiHBG061281.
InParanoidiQ9CQS8.
KOiK09481.
OrthoDBiEOG77M8RR.
PhylomeDBiQ9CQS8.
TreeFamiTF313144.

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiSec61b. mouse.
PROiQ9CQS8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQS8.
CleanExiMM_SEC61B.
ExpressionAtlasiQ9CQS8. baseline and differential.
GenevisibleiQ9CQS8. MM.

Family and domain databases

InterProiIPR030671. Sec61-beta/Sbh.
IPR016482. SecG/Sec61-beta/Sbh.
[Graphical view]
PANTHERiPTHR13509. PTHR13509. 1 hit.
PfamiPF03911. Sec61_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF006398. Sec61_beta_euk. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-16 AND 47-57, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiSC61B_MOUSE
AccessioniPrimary (citable) accession number: Q9CQS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.