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Protein

Protein transport protein Sec61 subunit beta

Gene

Sec61b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit beta
Gene namesi
Name:Sec61b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913462 Sec61b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 70CytoplasmicSequence analysisAdd BLAST69
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001572552 – 96Protein transport protein Sec61 subunit betaAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei9PhosphothreonineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Lipidationi39S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9CQS8
MaxQBiQ9CQS8
PaxDbiQ9CQS8
PeptideAtlasiQ9CQS8
PRIDEiQ9CQS8
TopDownProteomicsiQ9CQS8

PTM databases

iPTMnetiQ9CQS8
PhosphoSitePlusiQ9CQS8
SwissPalmiQ9CQS8

Expressioni

Gene expression databases

BgeeiENSMUSG00000053317
CleanExiMM_SEC61B
ExpressionAtlasiQ9CQS8 baseline and differential
GenevisibleiQ9CQS8 MM

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211302, 3 interactors
CORUMiQ9CQS8
IntActiQ9CQS8, 2 interactors
STRINGi10090.ENSMUSP00000067681

Structurei

3D structure databases

ProteinModelPortaliQ9CQS8
SMRiQ9CQS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3457 Eukaryota
ENOG4111UAR LUCA
GeneTreeiENSGT00390000003561
HOGENOMiHOG000211109
HOVERGENiHBG061281
InParanoidiQ9CQS8
KOiK09481
PhylomeDBiQ9CQS8
TreeFamiTF313144

Family and domain databases

InterProiView protein in InterPro
IPR030671 Sec61-beta/Sbh
IPR016482 SecG/Sec61-beta/Sbh
PANTHERiPTHR13509 PTHR13509, 1 hit
PfamiView protein in Pfam
PF03911 Sec61_beta, 1 hit
PIRSFiPIRSF006398 Sec61_beta_euk, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA
60 70 80 90
GTGGMWRFYT EDSPGLKVGP VPVLVMSLLF IAAVFMLHIW GKYTRS
Length:96
Mass (Da):9,958
Last modified:January 23, 2007 - v3
Checksum:i5FAFF4197A742049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004505 mRNA Translation: BAB23338.1
AK008739 mRNA Translation: BAB25868.1
BC002089 mRNA Translation: AAH02089.1
BC081445 mRNA Translation: AAH81445.1
CCDSiCCDS38759.1
RefSeqiNP_077133.1, NM_024171.2
UniGeneiMm.20188

Genome annotation databases

EnsembliENSMUST00000065678; ENSMUSP00000067681; ENSMUSG00000053317
GeneIDi66212
KEGGimmu:66212
UCSCiuc008sur.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSC61B_MOUSE
AccessioniPrimary (citable) accession number: Q9CQS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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