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Q9CQS5

- RIOK2_MOUSE

UniProt

Q9CQS5 - RIOK2_MOUSE

Protein

Serine/threonine-protein kinase RIO2

Gene

Riok2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei123 – 1231ATPBy similarity
    Active sitei228 – 2281Proton acceptorBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase RIO2 (EC:2.7.11.1)
    Alternative name(s):
    RIO kinase 2
    Gene namesi
    Name:Riok2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1914295. Riok2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 547547Serine/threonine-protein kinase RIO2PRO_0000213528Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei332 – 3321PhosphoserineBy similarity
    Modified residuei337 – 3371PhosphoserineBy similarity
    Modified residuei350 – 3501PhosphoserineBy similarity
    Modified residuei362 – 3621PhosphoserineBy similarity
    Modified residuei385 – 3851PhosphoserineBy similarity
    Modified residuei390 – 3901PhosphoserineBy similarity
    Modified residuei412 – 4121PhosphoserineBy similarity
    Modified residuei417 – 4171PhosphoserineBy similarity
    Modified residuei437 – 4371PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9CQS5.
    PaxDbiQ9CQS5.
    PRIDEiQ9CQS5.

    PTM databases

    PhosphoSiteiQ9CQS5.

    Expressioni

    Gene expression databases

    BgeeiQ9CQS5.
    CleanExiMM_RIOK2.
    GenevestigatoriQ9CQS5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9CQS5. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQS5.
    SMRiQ9CQS5. Positions 3-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini271 – 547277Protein kinaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.Curated

    Phylogenomic databases

    eggNOGiCOG0478.
    GeneTreeiENSGT00390000003255.
    HOGENOMiHOG000225685.
    HOVERGENiHBG056045.
    InParanoidiQ9CQS5.
    KOiK07179.
    OMAiVAKLRYM.
    OrthoDBiEOG754HP9.
    PhylomeDBiQ9CQS5.
    TreeFamiTF321400.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR018934. RIO-like_kinase.
    IPR015285. RIO2_kinase_winged_hlx_N.
    IPR018935. RIO_kinase_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01163. RIO1. 1 hit.
    PF09202. Rio2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01245. RIO1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CQS5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPCSLIAS IASLKHGGCN    50
    KILRELVKHK LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ 100
    MGVGKESDIY IVANEAGQQL ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW 150
    LYLSRLSAMK EFAYMKALYE RKFPVPKPID YNRHAVIMEL INGYPLCQIH 200
    HVEDPASVYD EAMELIVKLG NHGLIHGDFN EFNLMLDKDD HITMIDFPQM 250
    VSTSHPNAEW YFDRDVKCIR EFFMKRFSYE SELYPTFSDI RKEDSLDVEV 300
    SASGYTKEMQ ADDELLHPVG PDDKITETEE DSDFTFSDEE MLEKAKVWRS 350
    ELEKEADPAD ESGGSWCCSS TDSKQIKDGG LPEESAHVSS FEVTALSQAV 400
    EEMERQVLPH RSVTEFSEES RRTENDGQPG QRSPAGSEDC DDEPPHLIAL 450
    SSVNREFRPF RDEESMSSVT RHRTRTLSVT SAGSALSCST IPPELVKQKV 500
    KRQLTRQQKA AARRRLQKGE ANVFTKQRRE NMQNIKSSLE AASFWGD 547
    Length:547
    Mass (Da):62,490
    Last modified:June 1, 2001 - v1
    Checksum:i61A50648147B8850
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti369 – 3691S → L in AAH10781. (PubMed:15489334)Curated
    Sequence conflicti379 – 3802GG → DS in AAH10781. (PubMed:15489334)Curated
    Sequence conflicti402 – 4021E → D in AAH10781. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008385 mRNA. Translation: BAB25639.1.
    AK008451 mRNA. Translation: BAB25676.1.
    AK049232 mRNA. Translation: BAC33625.1.
    BC010781 mRNA. Translation: AAH10781.1.
    CCDSiCCDS28417.1.
    RefSeqiNP_080210.1. NM_025934.2.
    UniGeneiMm.35117.

    Genome annotation databases

    EnsembliENSMUST00000024620; ENSMUSP00000024620; ENSMUSG00000023846.
    GeneIDi67045.
    KEGGimmu:67045.
    UCSCiuc008apd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008385 mRNA. Translation: BAB25639.1 .
    AK008451 mRNA. Translation: BAB25676.1 .
    AK049232 mRNA. Translation: BAC33625.1 .
    BC010781 mRNA. Translation: AAH10781.1 .
    CCDSi CCDS28417.1.
    RefSeqi NP_080210.1. NM_025934.2.
    UniGenei Mm.35117.

    3D structure databases

    ProteinModelPortali Q9CQS5.
    SMRi Q9CQS5. Positions 3-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CQS5. 1 interaction.

    PTM databases

    PhosphoSitei Q9CQS5.

    Proteomic databases

    MaxQBi Q9CQS5.
    PaxDbi Q9CQS5.
    PRIDEi Q9CQS5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024620 ; ENSMUSP00000024620 ; ENSMUSG00000023846 .
    GeneIDi 67045.
    KEGGi mmu:67045.
    UCSCi uc008apd.2. mouse.

    Organism-specific databases

    CTDi 55781.
    MGIi MGI:1914295. Riok2.

    Phylogenomic databases

    eggNOGi COG0478.
    GeneTreei ENSGT00390000003255.
    HOGENOMi HOG000225685.
    HOVERGENi HBG056045.
    InParanoidi Q9CQS5.
    KOi K07179.
    OMAi VAKLRYM.
    OrthoDBi EOG754HP9.
    PhylomeDBi Q9CQS5.
    TreeFami TF321400.

    Miscellaneous databases

    NextBioi 323412.
    PROi Q9CQS5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQS5.
    CleanExi MM_RIOK2.
    Genevestigatori Q9CQS5.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR018934. RIO-like_kinase.
    IPR015285. RIO2_kinase_winged_hlx_N.
    IPR018935. RIO_kinase_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01163. RIO1. 1 hit.
    PF09202. Rio2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01245. RIO1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiRIOK2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQS5
    Secondary accession number(s): Q91XF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3