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Q9CQS5

- RIOK2_MOUSE

UniProt

Q9CQS5 - RIOK2_MOUSE

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Protein
Serine/threonine-protein kinase RIO2
Gene
Riok2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231ATP By similarity
Active sitei228 – 2281Proton acceptor By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIO2 (EC:2.7.11.1)
Alternative name(s):
RIO kinase 2
Gene namesi
Name:Riok2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1914295. Riok2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Serine/threonine-protein kinase RIO2
PRO_0000213528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei332 – 3321Phosphoserine By similarity
Modified residuei337 – 3371Phosphoserine By similarity
Modified residuei350 – 3501Phosphoserine By similarity
Modified residuei362 – 3621Phosphoserine By similarity
Modified residuei385 – 3851Phosphoserine By similarity
Modified residuei390 – 3901Phosphoserine By similarity
Modified residuei412 – 4121Phosphoserine By similarity
Modified residuei417 – 4171Phosphoserine By similarity
Modified residuei437 – 4371Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CQS5.
PaxDbiQ9CQS5.
PRIDEiQ9CQS5.

PTM databases

PhosphoSiteiQ9CQS5.

Expressioni

Gene expression databases

BgeeiQ9CQS5.
CleanExiMM_RIOK2.
GenevestigatoriQ9CQS5.

Interactioni

Protein-protein interaction databases

IntActiQ9CQS5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9CQS5.
SMRiQ9CQS5. Positions 3-314.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini271 – 547277Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0478.
GeneTreeiENSGT00390000003255.
HOGENOMiHOG000225685.
HOVERGENiHBG056045.
InParanoidiQ9CQS5.
KOiK07179.
OMAiVAKLRYM.
OrthoDBiEOG754HP9.
PhylomeDBiQ9CQS5.
TreeFamiTF321400.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR018934. RIO-like_kinase.
IPR015285. RIO2_kinase_winged_hlx_N.
IPR018935. RIO_kinase_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01163. RIO1. 1 hit.
PF09202. Rio2_N. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQS5-1 [UniParc]FASTAAdd to Basket

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MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPCSLIAS IASLKHGGCN    50
KILRELVKHK LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ 100
MGVGKESDIY IVANEAGQQL ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW 150
LYLSRLSAMK EFAYMKALYE RKFPVPKPID YNRHAVIMEL INGYPLCQIH 200
HVEDPASVYD EAMELIVKLG NHGLIHGDFN EFNLMLDKDD HITMIDFPQM 250
VSTSHPNAEW YFDRDVKCIR EFFMKRFSYE SELYPTFSDI RKEDSLDVEV 300
SASGYTKEMQ ADDELLHPVG PDDKITETEE DSDFTFSDEE MLEKAKVWRS 350
ELEKEADPAD ESGGSWCCSS TDSKQIKDGG LPEESAHVSS FEVTALSQAV 400
EEMERQVLPH RSVTEFSEES RRTENDGQPG QRSPAGSEDC DDEPPHLIAL 450
SSVNREFRPF RDEESMSSVT RHRTRTLSVT SAGSALSCST IPPELVKQKV 500
KRQLTRQQKA AARRRLQKGE ANVFTKQRRE NMQNIKSSLE AASFWGD 547
Length:547
Mass (Da):62,490
Last modified:June 1, 2001 - v1
Checksum:i61A50648147B8850
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691S → L in AAH10781. 1 Publication
Sequence conflicti379 – 3802GG → DS in AAH10781. 1 Publication
Sequence conflicti402 – 4021E → D in AAH10781. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008385 mRNA. Translation: BAB25639.1.
AK008451 mRNA. Translation: BAB25676.1.
AK049232 mRNA. Translation: BAC33625.1.
BC010781 mRNA. Translation: AAH10781.1.
CCDSiCCDS28417.1.
RefSeqiNP_080210.1. NM_025934.2.
UniGeneiMm.35117.

Genome annotation databases

EnsembliENSMUST00000024620; ENSMUSP00000024620; ENSMUSG00000023846.
GeneIDi67045.
KEGGimmu:67045.
UCSCiuc008apd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008385 mRNA. Translation: BAB25639.1 .
AK008451 mRNA. Translation: BAB25676.1 .
AK049232 mRNA. Translation: BAC33625.1 .
BC010781 mRNA. Translation: AAH10781.1 .
CCDSi CCDS28417.1.
RefSeqi NP_080210.1. NM_025934.2.
UniGenei Mm.35117.

3D structure databases

ProteinModelPortali Q9CQS5.
SMRi Q9CQS5. Positions 3-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CQS5. 1 interaction.

PTM databases

PhosphoSitei Q9CQS5.

Proteomic databases

MaxQBi Q9CQS5.
PaxDbi Q9CQS5.
PRIDEi Q9CQS5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024620 ; ENSMUSP00000024620 ; ENSMUSG00000023846 .
GeneIDi 67045.
KEGGi mmu:67045.
UCSCi uc008apd.2. mouse.

Organism-specific databases

CTDi 55781.
MGIi MGI:1914295. Riok2.

Phylogenomic databases

eggNOGi COG0478.
GeneTreei ENSGT00390000003255.
HOGENOMi HOG000225685.
HOVERGENi HBG056045.
InParanoidi Q9CQS5.
KOi K07179.
OMAi VAKLRYM.
OrthoDBi EOG754HP9.
PhylomeDBi Q9CQS5.
TreeFami TF321400.

Miscellaneous databases

NextBioi 323412.
PROi Q9CQS5.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQS5.
CleanExi MM_RIOK2.
Genevestigatori Q9CQS5.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR018934. RIO-like_kinase.
IPR015285. RIO2_kinase_winged_hlx_N.
IPR018935. RIO_kinase_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF01163. RIO1. 1 hit.
PF09202. Rio2_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01245. RIO1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiRIOK2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQS5
Secondary accession number(s): Q91XF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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