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Protein

Serine/threonine-protein kinase RIO2

Gene

Riok2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123ATPBy similarity1
Active sitei228Proton acceptorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIO2 (EC:2.7.11.1By similarity)
Alternative name(s):
RIO kinase 2
Gene namesi
Name:Riok2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914295. Riok2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135281 – 547Serine/threonine-protein kinase RIO2Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei362PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei390PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei433PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CQS5.
MaxQBiQ9CQS5.
PaxDbiQ9CQS5.
PeptideAtlasiQ9CQS5.
PRIDEiQ9CQS5.

PTM databases

iPTMnetiQ9CQS5.
PhosphoSitePlusiQ9CQS5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023846.
CleanExiMM_RIOK2.
ExpressionAtlasiQ9CQS5. baseline and differential.
GenevisibleiQ9CQS5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9CQS5. 3 interactors.
STRINGi10090.ENSMUSP00000024620.

Structurei

3D structure databases

ProteinModelPortaliQ9CQS5.
SMRiQ9CQS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 273Protein kinaseCuratedAdd BLAST177

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Phylogenomic databases

eggNOGiKOG2268. Eukaryota.
COG0478. LUCA.
GeneTreeiENSGT00760000119067.
HOGENOMiHOG000225685.
HOVERGENiHBG056045.
InParanoidiQ9CQS5.
KOiK07179.
PhylomeDBiQ9CQS5.
TreeFamiTF321400.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR030484. Rio2.
IPR015285. RIO2_wHTH_N.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10593:SF36. PTHR10593:SF36. 1 hit.
PfamiPF09202. Rio2_N. 1 hit.
[Graphical view]
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPCSLIAS IASLKHGGCN
60 70 80 90 100
KILRELVKHK LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ
110 120 130 140 150
MGVGKESDIY IVANEAGQQL ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW
160 170 180 190 200
LYLSRLSAMK EFAYMKALYE RKFPVPKPID YNRHAVIMEL INGYPLCQIH
210 220 230 240 250
HVEDPASVYD EAMELIVKLG NHGLIHGDFN EFNLMLDKDD HITMIDFPQM
260 270 280 290 300
VSTSHPNAEW YFDRDVKCIR EFFMKRFSYE SELYPTFSDI RKEDSLDVEV
310 320 330 340 350
SASGYTKEMQ ADDELLHPVG PDDKITETEE DSDFTFSDEE MLEKAKVWRS
360 370 380 390 400
ELEKEADPAD ESGGSWCCSS TDSKQIKDGG LPEESAHVSS FEVTALSQAV
410 420 430 440 450
EEMERQVLPH RSVTEFSEES RRTENDGQPG QRSPAGSEDC DDEPPHLIAL
460 470 480 490 500
SSVNREFRPF RDEESMSSVT RHRTRTLSVT SAGSALSCST IPPELVKQKV
510 520 530 540
KRQLTRQQKA AARRRLQKGE ANVFTKQRRE NMQNIKSSLE AASFWGD
Length:547
Mass (Da):62,490
Last modified:June 1, 2001 - v1
Checksum:i61A50648147B8850
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369S → L in AAH10781 (PubMed:15489334).Curated1
Sequence conflicti379 – 380GG → DS in AAH10781 (PubMed:15489334).Curated2
Sequence conflicti402E → D in AAH10781 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008385 mRNA. Translation: BAB25639.1.
AK008451 mRNA. Translation: BAB25676.1.
AK049232 mRNA. Translation: BAC33625.1.
BC010781 mRNA. Translation: AAH10781.1.
CCDSiCCDS28417.1.
RefSeqiNP_080210.1. NM_025934.2.
UniGeneiMm.35117.

Genome annotation databases

EnsembliENSMUST00000024620; ENSMUSP00000024620; ENSMUSG00000023852.
GeneIDi67045.
KEGGimmu:67045.
UCSCiuc008apd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008385 mRNA. Translation: BAB25639.1.
AK008451 mRNA. Translation: BAB25676.1.
AK049232 mRNA. Translation: BAC33625.1.
BC010781 mRNA. Translation: AAH10781.1.
CCDSiCCDS28417.1.
RefSeqiNP_080210.1. NM_025934.2.
UniGeneiMm.35117.

3D structure databases

ProteinModelPortaliQ9CQS5.
SMRiQ9CQS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQS5. 3 interactors.
STRINGi10090.ENSMUSP00000024620.

PTM databases

iPTMnetiQ9CQS5.
PhosphoSitePlusiQ9CQS5.

Proteomic databases

EPDiQ9CQS5.
MaxQBiQ9CQS5.
PaxDbiQ9CQS5.
PeptideAtlasiQ9CQS5.
PRIDEiQ9CQS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024620; ENSMUSP00000024620; ENSMUSG00000023852.
GeneIDi67045.
KEGGimmu:67045.
UCSCiuc008apd.2. mouse.

Organism-specific databases

CTDi55781.
MGIiMGI:1914295. Riok2.

Phylogenomic databases

eggNOGiKOG2268. Eukaryota.
COG0478. LUCA.
GeneTreeiENSGT00760000119067.
HOGENOMiHOG000225685.
HOVERGENiHBG056045.
InParanoidiQ9CQS5.
KOiK07179.
PhylomeDBiQ9CQS5.
TreeFamiTF321400.

Miscellaneous databases

PROiQ9CQS5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023846.
CleanExiMM_RIOK2.
ExpressionAtlasiQ9CQS5. baseline and differential.
GenevisibleiQ9CQS5. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR030484. Rio2.
IPR015285. RIO2_wHTH_N.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10593:SF36. PTHR10593:SF36. 1 hit.
PfamiPF09202. Rio2_N. 1 hit.
[Graphical view]
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIOK2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQS5
Secondary accession number(s): Q91XF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.