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Protein

Solute carrier family 25 member 46

Gene

Slc25a46

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 46
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914703. Slc25a46.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 123Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei167 – 187Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei202 – 222Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei258 – 278Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei314 – 334Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei382 – 402Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial outer membrane Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918291 – 418Solute carrier family 25 member 46Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei35PhosphoserineBy similarity1
Modified residuei45PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CQS4.
PaxDbiQ9CQS4.
PeptideAtlasiQ9CQS4.
PRIDEiQ9CQS4.

PTM databases

iPTMnetiQ9CQS4.
PhosphoSitePlusiQ9CQS4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024259.
CleanExiMM_SLC25A46.
GenevisibleiQ9CQS4. MM.

Interactioni

Subunit structurei

Interacts with IMMT.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053325.

Structurei

3D structure databases

ProteinModelPortaliQ9CQS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 187Solcar 1Add BLAST92
Repeati311 – 413Solcar 2Add BLAST103

Sequence similaritiesi

Contains 2 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2954. Eukaryota.
ENOG410XRFB. LUCA.
GeneTreeiENSGT00390000015874.
HOGENOMiHOG000007981.
HOVERGENiHBG059752.
InParanoidiQ9CQS4.
KOiK03454.
OMAiAHPCIVF.
OrthoDBiEOG091G05RA.
PhylomeDBiQ9CQS4.
TreeFamiTF313365.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPRRPEGFD GLGYRGGVRD DPAFGGPFHA RSFGSGTELG HWVTTPPDIP
60 70 80 90 100
GSRNLHWGEK SPSYGVPSAP PTLEGSAEEP FPGGGEGPRP GPSSEQLNRF
110 120 130 140 150
AGFGIGLASL FTENVLAHPC IVLRRQCQVN YHARHYHLTP FSIINIMYSF
160 170 180 190 200
NKTQGPRALW KGMGSTFIVQ GVTLGAEGII SEFTPLPREV SHKLNPKQIG
210 220 230 240 250
EHLLLKCLTY MVAMPFYSAS LIETVQSEII RDNTGILECV KEGIGRVIGL
260 270 280 290 300
GVPHSKRLLP LFSLIFPTVL HGVLHYIISS IIQKIVLLIL KRKTYNSHLA
310 320 330 340 350
ESTSPMQNML DAYFPELIAN FAASLCSDVI LYPLETVLHR LHIQGTRTII
360 370 380 390 400
DNTDLGYEVL PINTQYEGMR DCINTIKQEE GVFGFYKGFG AVIIQYTLHA
410
TILQITKMIY STLLQNSI
Length:418
Mass (Da):46,224
Last modified:June 1, 2001 - v1
Checksum:i621A9892D62C6CD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48D → G in BAE28241 (PubMed:16141072).Curated1
Sequence conflicti59E → G in BAE36038 (PubMed:16141072).Curated1
Sequence conflicti85G → S in AAH20087 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004625 mRNA. Translation: BAB23420.1.
AK008131 mRNA. Translation: BAB25481.1.
AK030346 mRNA. Translation: BAC26914.1.
AK031117 mRNA. Translation: BAC27260.1.
AK147936 mRNA. Translation: BAE28241.1.
AK160834 mRNA. Translation: BAE36038.1.
BC020087 mRNA. Translation: AAH20087.1.
CCDSiCCDS29110.1.
RefSeqiNP_080441.1. NM_026165.3.
UniGeneiMm.23896.

Genome annotation databases

EnsembliENSMUST00000060396; ENSMUSP00000053325; ENSMUSG00000024259.
GeneIDi67453.
KEGGimmu:67453.
UCSCiuc008ehz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004625 mRNA. Translation: BAB23420.1.
AK008131 mRNA. Translation: BAB25481.1.
AK030346 mRNA. Translation: BAC26914.1.
AK031117 mRNA. Translation: BAC27260.1.
AK147936 mRNA. Translation: BAE28241.1.
AK160834 mRNA. Translation: BAE36038.1.
BC020087 mRNA. Translation: AAH20087.1.
CCDSiCCDS29110.1.
RefSeqiNP_080441.1. NM_026165.3.
UniGeneiMm.23896.

3D structure databases

ProteinModelPortaliQ9CQS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053325.

PTM databases

iPTMnetiQ9CQS4.
PhosphoSitePlusiQ9CQS4.

Proteomic databases

MaxQBiQ9CQS4.
PaxDbiQ9CQS4.
PeptideAtlasiQ9CQS4.
PRIDEiQ9CQS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060396; ENSMUSP00000053325; ENSMUSG00000024259.
GeneIDi67453.
KEGGimmu:67453.
UCSCiuc008ehz.1. mouse.

Organism-specific databases

CTDi91137.
MGIiMGI:1914703. Slc25a46.

Phylogenomic databases

eggNOGiKOG2954. Eukaryota.
ENOG410XRFB. LUCA.
GeneTreeiENSGT00390000015874.
HOGENOMiHOG000007981.
HOVERGENiHBG059752.
InParanoidiQ9CQS4.
KOiK03454.
OMAiAHPCIVF.
OrthoDBiEOG091G05RA.
PhylomeDBiQ9CQS4.
TreeFamiTF313365.

Miscellaneous databases

PROiQ9CQS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024259.
CleanExiMM_SLC25A46.
GenevisibleiQ9CQS4. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2546_MOUSE
AccessioniPrimary (citable) accession number: Q9CQS4
Secondary accession number(s): Q3TUD3, Q3UGG7, Q8VDX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.