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Protein

H/ACA ribonucleoprotein complex subunit 3

Gene

Nop10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 3
Alternative name(s):
Nucleolar protein 10
Nucleolar protein family A member 3
snoRNP protein NOP10
Gene namesi
Name:Nop10
Synonyms:Nola3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913431. Nop10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6464H/ACA ribonucleoprotein complex subunit 3PRO_0000149002Add
BLAST

Proteomic databases

EPDiQ9CQS2.
MaxQBiQ9CQS2.
PaxDbiQ9CQS2.
PeptideAtlasiQ9CQS2.
PRIDEiQ9CQS2.
TopDownProteomicsiQ9CQS2.

PTM databases

iPTMnetiQ9CQS2.
PhosphoSiteiQ9CQS2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027133.
GenevisibleiQ9CQS2. MM.

Interactioni

Subunit structurei

Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. During assembly, the complex contains NAF1 instead of GAR1/NOLA1. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC) (By similarity).By similarity

Protein-protein interaction databases

BioGridi211277. 1 interaction.
IntActiQ9CQS2. 3 interactions.
MINTiMINT-1854127.
STRINGi10090.ENSMUSP00000028553.

Structurei

3D structure databases

ProteinModelPortaliQ9CQS2.
SMRiQ9CQS2. Positions 1-48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NOP10 family.Curated

Phylogenomic databases

eggNOGiKOG3503. Eukaryota.
COG2260. LUCA.
GeneTreeiENSGT00390000012563.
HOGENOMiHOG000159681.
HOVERGENiHBG080280.
InParanoidiQ9CQS2.
KOiK11130.
OMAiQRVTLKK.
OrthoDBiEOG091G1AP5.
PhylomeDBiQ9CQS2.
TreeFamiTF300211.

Family and domain databases

InterProiIPR007264. H/ACA_rnp_Nop10.
[Graphical view]
PANTHERiPTHR13305. PTHR13305. 1 hit.
PfamiPF04135. Nop10p. 1 hit.
[Graphical view]
SUPFAMiSSF144210. SSF144210. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLQYYLNEQ GDRVYTLKKF DPMGQQTCSA HPARFSPDDK YSRHRITIKK
60
RFKVLMTQQP RPVL
Length:64
Mass (Da):7,706
Last modified:June 1, 2001 - v1
Checksum:i62E9BCFFB27036FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004120 mRNA. Translation: BAB23180.1.
AK012875 mRNA. Translation: BAB28529.1.
BC028497 mRNA. Translation: AAH28497.1.
CCDSiCCDS38198.1.
RefSeqiNP_079679.1. NM_025403.4.
UniGeneiMm.272346.

Genome annotation databases

EnsembliENSMUST00000028553; ENSMUSP00000028553; ENSMUSG00000027133.
GeneIDi66181.
KEGGimmu:66181.
UCSCiuc008lor.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004120 mRNA. Translation: BAB23180.1.
AK012875 mRNA. Translation: BAB28529.1.
BC028497 mRNA. Translation: AAH28497.1.
CCDSiCCDS38198.1.
RefSeqiNP_079679.1. NM_025403.4.
UniGeneiMm.272346.

3D structure databases

ProteinModelPortaliQ9CQS2.
SMRiQ9CQS2. Positions 1-48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211277. 1 interaction.
IntActiQ9CQS2. 3 interactions.
MINTiMINT-1854127.
STRINGi10090.ENSMUSP00000028553.

PTM databases

iPTMnetiQ9CQS2.
PhosphoSiteiQ9CQS2.

Proteomic databases

EPDiQ9CQS2.
MaxQBiQ9CQS2.
PaxDbiQ9CQS2.
PeptideAtlasiQ9CQS2.
PRIDEiQ9CQS2.
TopDownProteomicsiQ9CQS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028553; ENSMUSP00000028553; ENSMUSG00000027133.
GeneIDi66181.
KEGGimmu:66181.
UCSCiuc008lor.2. mouse.

Organism-specific databases

CTDi55505.
MGIiMGI:1913431. Nop10.

Phylogenomic databases

eggNOGiKOG3503. Eukaryota.
COG2260. LUCA.
GeneTreeiENSGT00390000012563.
HOGENOMiHOG000159681.
HOVERGENiHBG080280.
InParanoidiQ9CQS2.
KOiK11130.
OMAiQRVTLKK.
OrthoDBiEOG091G1AP5.
PhylomeDBiQ9CQS2.
TreeFamiTF300211.

Miscellaneous databases

PROiQ9CQS2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027133.
GenevisibleiQ9CQS2. MM.

Family and domain databases

InterProiIPR007264. H/ACA_rnp_Nop10.
[Graphical view]
PANTHERiPTHR13305. PTHR13305. 1 hit.
PfamiPF04135. Nop10p. 1 hit.
[Graphical view]
SUPFAMiSSF144210. SSF144210. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOP10_MOUSE
AccessioniPrimary (citable) accession number: Q9CQS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.