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Q9CQR7

- PEN2_MOUSE

UniProt

Q9CQR7 - PEN2_MOUSE

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Protein

Gamma-secretase subunit PEN-2

Gene

Psenen

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity (By similarity).By similarity

GO - Biological processi

  1. membrane protein ectodomain proteolysis Source: HGNC
  2. Notch receptor processing Source: MGI
  3. Notch signaling pathway Source: UniProtKB-KW
  4. positive regulation of catalytic activity Source: HGNC
  5. protein processing Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Notch signaling pathway

Enzyme and pathway databases

ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_198574. Nuclear signaling by ERBB4.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.
REACT_202271. NRIF signals cell death from the nucleus.
REACT_218614. Regulated proteolysis of p75NTR.

Protein family/group databases

TCDBi9.B.47.1.1. the -secretase (-secretase) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-secretase subunit PEN-2
Alternative name(s):
Presenilin enhancer protein 2
Gene namesi
Name:Psenen
Synonyms:Pen2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1913590. Psenen.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatuscis-Golgi network membrane By similarity; Multi-pass membrane protein By similarity
Note: Predominantly located in the endoplasmic reticulum and in the cis-Golgi.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: HGNC
  2. Golgi apparatus Source: HGNC
  3. integral component of plasma membrane Source: HGNC
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Gamma-secretase subunit PEN-2PRO_0000190901Add
BLAST

Proteomic databases

MaxQBiQ9CQR7.
PaxDbiQ9CQR7.
PRIDEiQ9CQR7.

PTM databases

PhosphoSiteiQ9CQR7.

Expressioni

Gene expression databases

BgeeiQ9CQR7.
CleanExiMM_PSENEN.
GenevestigatoriQ9CQR7.

Interactioni

Subunit structurei

Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist (By similarity).By similarity

Protein-protein interaction databases

BioGridi211397. 2 interactions.
DIPiDIP-36333N.
IntActiQ9CQR7. 2 interactions.
STRINGi10090.ENSMUSP00000044682.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717LumenalSequence AnalysisAdd
BLAST
Topological domaini39 – 6022CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini82 – 10120LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PEN-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG279333.
GeneTreeiENSGT00390000016319.
HOGENOMiHOG000006914.
HOVERGENiHBG045628.
InParanoidiQ9CQR7.
KOiK06170.
OMAiILATWIT.
OrthoDBiEOG7ZSHW4.
PhylomeDBiQ9CQR7.
TreeFamiTF313116.

Family and domain databases

InterProiIPR019379. Gamma_Secretase_Asp_P_PEN2.
[Graphical view]
PfamiPF10251. PEN-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLERVSNEE KLNLCRKYYL GGFAFLPFLW LVNIFWFFRE AFLAPAYTEQ
60 70 80 90 100
SQIKGYVWRS AVGFLFWVII LATWITIFQI YRPRWGALGD YLSFTIPLGT

P
Length:101
Mass (Da):11,999
Last modified:June 1, 2001 - v1
Checksum:i6596CA2984FBCC59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002440 mRNA. Translation: BAB22102.1.
AK006284 mRNA. Translation: BAB24503.1.
AK007621 mRNA. Translation: BAB25141.1.
BC024347 mRNA. Translation: AAH24347.1.
BC081443 mRNA. Translation: AAH81443.1.
CCDSiCCDS21099.1.
RefSeqiNP_079774.1. NM_025498.2.
UniGeneiMm.86557.

Genome annotation databases

EnsembliENSMUST00000043898; ENSMUSP00000044682; ENSMUSG00000036835.
GeneIDi66340.
KEGGimmu:66340.
UCSCiuc009gez.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002440 mRNA. Translation: BAB22102.1 .
AK006284 mRNA. Translation: BAB24503.1 .
AK007621 mRNA. Translation: BAB25141.1 .
BC024347 mRNA. Translation: AAH24347.1 .
BC081443 mRNA. Translation: AAH81443.1 .
CCDSi CCDS21099.1.
RefSeqi NP_079774.1. NM_025498.2.
UniGenei Mm.86557.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211397. 2 interactions.
DIPi DIP-36333N.
IntActi Q9CQR7. 2 interactions.
STRINGi 10090.ENSMUSP00000044682.

Chemistry

BindingDBi Q9CQR7.

Protein family/group databases

TCDBi 9.B.47.1.1. the -secretase (-secretase) family.

PTM databases

PhosphoSitei Q9CQR7.

Proteomic databases

MaxQBi Q9CQR7.
PaxDbi Q9CQR7.
PRIDEi Q9CQR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043898 ; ENSMUSP00000044682 ; ENSMUSG00000036835 .
GeneIDi 66340.
KEGGi mmu:66340.
UCSCi uc009gez.1. mouse.

Organism-specific databases

CTDi 55851.
MGIi MGI:1913590. Psenen.

Phylogenomic databases

eggNOGi NOG279333.
GeneTreei ENSGT00390000016319.
HOGENOMi HOG000006914.
HOVERGENi HBG045628.
InParanoidi Q9CQR7.
KOi K06170.
OMAi ILATWIT.
OrthoDBi EOG7ZSHW4.
PhylomeDBi Q9CQR7.
TreeFami TF313116.

Enzyme and pathway databases

Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_198574. Nuclear signaling by ERBB4.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.
REACT_202271. NRIF signals cell death from the nucleus.
REACT_218614. Regulated proteolysis of p75NTR.

Miscellaneous databases

NextBioi 321375.
PROi Q9CQR7.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQR7.
CleanExi MM_PSENEN.
Genevestigatori Q9CQR7.

Family and domain databases

InterProi IPR019379. Gamma_Secretase_Asp_P_PEN2.
[Graphical view ]
Pfami PF10251. PEN-2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney, Pancreas and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Colon.

Entry informationi

Entry nameiPEN2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3