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Protein

Gamma-secretase subunit PEN-2

Gene

Psenen

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-1251985. Nuclear signaling by ERBB4.
R-MMU-193692. Regulated proteolysis of p75NTR.
R-MMU-1980148. Signaling by NOTCH3.
R-MMU-1980150. Signaling by NOTCH4.
R-MMU-205043. NRIF signals cell death from the nucleus.
R-MMU-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-MMU-3928665. EPH-ephrin mediated repulsion of cells.

Protein family/group databases

TCDBi9.B.47.1.1. the -secretase (-secretase) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-secretase subunit PEN-2
Alternative name(s):
Presenilin enhancer protein 2
Gene namesi
Name:Psenen
Synonyms:Pen2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913590. Psenen.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717LumenalSequence analysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Topological domaini39 – 6022CytoplasmicSequence analysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence analysisAdd
BLAST
Topological domaini82 – 10120LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Gamma-secretase subunit PEN-2PRO_0000190901Add
BLAST

Proteomic databases

MaxQBiQ9CQR7.
PaxDbiQ9CQR7.
PeptideAtlasiQ9CQR7.
PRIDEiQ9CQR7.
TopDownProteomicsiQ9CQR7.

PTM databases

PhosphoSiteiQ9CQR7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036835.
CleanExiMM_PSENEN.
GenevisibleiQ9CQR7. MM.

Interactioni

Subunit structurei

Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist (By similarity).By similarity

Protein-protein interaction databases

BioGridi211397. 2 interactions.
DIPiDIP-36333N.
IntActiQ9CQR7. 3 interactions.
STRINGi10090.ENSMUSP00000044682.

Structurei

3D structure databases

SMRiQ9CQR7. Positions 2-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEN-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3402. Eukaryota.
ENOG4111W09. LUCA.
GeneTreeiENSGT00390000016319.
HOGENOMiHOG000006914.
HOVERGENiHBG045628.
InParanoidiQ9CQR7.
KOiK06170.
OMAiWFFQEAF.
OrthoDBiEOG091G0X8A.
PhylomeDBiQ9CQR7.
TreeFamiTF313116.

Family and domain databases

InterProiIPR019379. Gamma_Secretase_Asp_P_PEN2.
[Graphical view]
PfamiPF10251. PEN-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLERVSNEE KLNLCRKYYL GGFAFLPFLW LVNIFWFFRE AFLAPAYTEQ
60 70 80 90 100
SQIKGYVWRS AVGFLFWVII LATWITIFQI YRPRWGALGD YLSFTIPLGT

P
Length:101
Mass (Da):11,999
Last modified:June 1, 2001 - v1
Checksum:i6596CA2984FBCC59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002440 mRNA. Translation: BAB22102.1.
AK006284 mRNA. Translation: BAB24503.1.
AK007621 mRNA. Translation: BAB25141.1.
BC024347 mRNA. Translation: AAH24347.1.
BC081443 mRNA. Translation: AAH81443.1.
CCDSiCCDS21099.1.
RefSeqiNP_079774.1. NM_025498.2.
UniGeneiMm.86557.

Genome annotation databases

EnsembliENSMUST00000043898; ENSMUSP00000044682; ENSMUSG00000036835.
ENSMUST00000207747; ENSMUSP00000146675; ENSMUSG00000036835.
GeneIDi66340.
KEGGimmu:66340.
UCSCiuc009gez.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002440 mRNA. Translation: BAB22102.1.
AK006284 mRNA. Translation: BAB24503.1.
AK007621 mRNA. Translation: BAB25141.1.
BC024347 mRNA. Translation: AAH24347.1.
BC081443 mRNA. Translation: AAH81443.1.
CCDSiCCDS21099.1.
RefSeqiNP_079774.1. NM_025498.2.
UniGeneiMm.86557.

3D structure databases

SMRiQ9CQR7. Positions 2-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211397. 2 interactions.
DIPiDIP-36333N.
IntActiQ9CQR7. 3 interactions.
STRINGi10090.ENSMUSP00000044682.

Protein family/group databases

TCDBi9.B.47.1.1. the -secretase (-secretase) family.

PTM databases

PhosphoSiteiQ9CQR7.

Proteomic databases

MaxQBiQ9CQR7.
PaxDbiQ9CQR7.
PeptideAtlasiQ9CQR7.
PRIDEiQ9CQR7.
TopDownProteomicsiQ9CQR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043898; ENSMUSP00000044682; ENSMUSG00000036835.
ENSMUST00000207747; ENSMUSP00000146675; ENSMUSG00000036835.
GeneIDi66340.
KEGGimmu:66340.
UCSCiuc009gez.1. mouse.

Organism-specific databases

CTDi55851.
MGIiMGI:1913590. Psenen.

Phylogenomic databases

eggNOGiKOG3402. Eukaryota.
ENOG4111W09. LUCA.
GeneTreeiENSGT00390000016319.
HOGENOMiHOG000006914.
HOVERGENiHBG045628.
InParanoidiQ9CQR7.
KOiK06170.
OMAiWFFQEAF.
OrthoDBiEOG091G0X8A.
PhylomeDBiQ9CQR7.
TreeFamiTF313116.

Enzyme and pathway databases

ReactomeiR-MMU-1251985. Nuclear signaling by ERBB4.
R-MMU-193692. Regulated proteolysis of p75NTR.
R-MMU-1980148. Signaling by NOTCH3.
R-MMU-1980150. Signaling by NOTCH4.
R-MMU-205043. NRIF signals cell death from the nucleus.
R-MMU-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-MMU-3928665. EPH-ephrin mediated repulsion of cells.

Miscellaneous databases

PROiQ9CQR7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036835.
CleanExiMM_PSENEN.
GenevisibleiQ9CQR7. MM.

Family and domain databases

InterProiIPR019379. Gamma_Secretase_Asp_P_PEN2.
[Graphical view]
PfamiPF10251. PEN-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEN2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.