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Protein

Gamma-secretase subunit PEN-2

Gene

Psenen

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Notch signaling pathway

Enzyme and pathway databases

ReactomeiREACT_279153. Signaling by NOTCH3.
REACT_286692. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_312443. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_314615. EPH-ephrin mediated repulsion of cells.
REACT_315710. Regulated proteolysis of p75NTR.
REACT_342872. NRIF signals cell death from the nucleus.
REACT_345101. Signaling by NOTCH4.
REACT_345486. Nuclear signaling by ERBB4.

Protein family/group databases

TCDBi9.B.47.1.1. the -secretase (-secretase) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-secretase subunit PEN-2
Alternative name(s):
Presenilin enhancer protein 2
Gene namesi
Name:Psenen
Synonyms:Pen2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913590. Psenen.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717LumenalSequence AnalysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Topological domaini39 – 6022CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Topological domaini82 – 10120LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Gamma-secretase subunit PEN-2PRO_0000190901Add
BLAST

Proteomic databases

MaxQBiQ9CQR7.
PaxDbiQ9CQR7.
PRIDEiQ9CQR7.

PTM databases

PhosphoSiteiQ9CQR7.

Expressioni

Gene expression databases

BgeeiQ9CQR7.
CleanExiMM_PSENEN.
GenevisibleiQ9CQR7. MM.

Interactioni

Subunit structurei

Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist (By similarity).By similarity

Protein-protein interaction databases

BioGridi211397. 2 interactions.
DIPiDIP-36333N.
IntActiQ9CQR7. 2 interactions.
STRINGi10090.ENSMUSP00000044682.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEN-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG279333.
GeneTreeiENSGT00390000016319.
HOGENOMiHOG000006914.
HOVERGENiHBG045628.
InParanoidiQ9CQR7.
KOiK06170.
OMAiCKKYFLI.
OrthoDBiEOG7ZSHW4.
PhylomeDBiQ9CQR7.
TreeFamiTF313116.

Family and domain databases

InterProiIPR019379. Gamma_Secretase_Asp_P_PEN2.
[Graphical view]
PfamiPF10251. PEN-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLERVSNEE KLNLCRKYYL GGFAFLPFLW LVNIFWFFRE AFLAPAYTEQ
60 70 80 90 100
SQIKGYVWRS AVGFLFWVII LATWITIFQI YRPRWGALGD YLSFTIPLGT

P
Length:101
Mass (Da):11,999
Last modified:June 1, 2001 - v1
Checksum:i6596CA2984FBCC59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002440 mRNA. Translation: BAB22102.1.
AK006284 mRNA. Translation: BAB24503.1.
AK007621 mRNA. Translation: BAB25141.1.
BC024347 mRNA. Translation: AAH24347.1.
BC081443 mRNA. Translation: AAH81443.1.
CCDSiCCDS21099.1.
RefSeqiNP_079774.1. NM_025498.2.
UniGeneiMm.86557.

Genome annotation databases

EnsembliENSMUST00000043898; ENSMUSP00000044682; ENSMUSG00000036835.
GeneIDi66340.
KEGGimmu:66340.
UCSCiuc009gez.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002440 mRNA. Translation: BAB22102.1.
AK006284 mRNA. Translation: BAB24503.1.
AK007621 mRNA. Translation: BAB25141.1.
BC024347 mRNA. Translation: AAH24347.1.
BC081443 mRNA. Translation: AAH81443.1.
CCDSiCCDS21099.1.
RefSeqiNP_079774.1. NM_025498.2.
UniGeneiMm.86557.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211397. 2 interactions.
DIPiDIP-36333N.
IntActiQ9CQR7. 2 interactions.
STRINGi10090.ENSMUSP00000044682.

Protein family/group databases

TCDBi9.B.47.1.1. the -secretase (-secretase) family.

PTM databases

PhosphoSiteiQ9CQR7.

Proteomic databases

MaxQBiQ9CQR7.
PaxDbiQ9CQR7.
PRIDEiQ9CQR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043898; ENSMUSP00000044682; ENSMUSG00000036835.
GeneIDi66340.
KEGGimmu:66340.
UCSCiuc009gez.1. mouse.

Organism-specific databases

CTDi55851.
MGIiMGI:1913590. Psenen.

Phylogenomic databases

eggNOGiNOG279333.
GeneTreeiENSGT00390000016319.
HOGENOMiHOG000006914.
HOVERGENiHBG045628.
InParanoidiQ9CQR7.
KOiK06170.
OMAiCKKYFLI.
OrthoDBiEOG7ZSHW4.
PhylomeDBiQ9CQR7.
TreeFamiTF313116.

Enzyme and pathway databases

ReactomeiREACT_279153. Signaling by NOTCH3.
REACT_286692. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_312443. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_314615. EPH-ephrin mediated repulsion of cells.
REACT_315710. Regulated proteolysis of p75NTR.
REACT_342872. NRIF signals cell death from the nucleus.
REACT_345101. Signaling by NOTCH4.
REACT_345486. Nuclear signaling by ERBB4.

Miscellaneous databases

NextBioi321375.
PROiQ9CQR7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQR7.
CleanExiMM_PSENEN.
GenevisibleiQ9CQR7. MM.

Family and domain databases

InterProiIPR019379. Gamma_Secretase_Asp_P_PEN2.
[Graphical view]
PfamiPF10251. PEN-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney, Pancreas and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Colon.

Entry informationi

Entry nameiPEN2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.