Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9CQR7

- PEN2_MOUSE

UniProt

Q9CQR7 - PEN2_MOUSE

Protein

Gamma-secretase subunit PEN-2

Gene

Psenen

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. membrane protein ectodomain proteolysis Source: HGNC
    2. Notch receptor processing Source: MGI
    3. Notch signaling pathway Source: UniProtKB-KW
    4. positive regulation of catalytic activity Source: HGNC
    5. protein processing Source: HGNC

    Keywords - Biological processi

    Notch signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199404. Signaling by NOTCH4.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_199413. Signaling by NOTCH3.
    REACT_202271. NRIF signals cell death from the nucleus.
    REACT_218614. Regulated proteolysis of p75NTR.

    Protein family/group databases

    TCDBi9.B.47.1.1. the -secretase (-secretase) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-secretase subunit PEN-2
    Alternative name(s):
    Presenilin enhancer protein 2
    Gene namesi
    Name:Psenen
    Synonyms:Pen2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1913590. Psenen.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatuscis-Golgi network membrane By similarity; Multi-pass membrane protein By similarity
    Note: Predominantly located in the endoplasmic reticulum and in the cis-Golgi.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: HGNC
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. Golgi apparatus Source: HGNC
    4. integral component of plasma membrane Source: HGNC
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 101101Gamma-secretase subunit PEN-2PRO_0000190901Add
    BLAST

    Proteomic databases

    MaxQBiQ9CQR7.
    PaxDbiQ9CQR7.
    PRIDEiQ9CQR7.

    PTM databases

    PhosphoSiteiQ9CQR7.

    Expressioni

    Gene expression databases

    BgeeiQ9CQR7.
    CleanExiMM_PSENEN.
    GenevestigatoriQ9CQR7.

    Interactioni

    Subunit structurei

    Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211397. 2 interactions.
    DIPiDIP-36333N.
    IntActiQ9CQR7. 2 interactions.
    STRINGi10090.ENSMUSP00000044682.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717LumenalSequence AnalysisAdd
    BLAST
    Topological domaini39 – 6022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini82 – 10120LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEN-2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG279333.
    GeneTreeiENSGT00390000016319.
    HOGENOMiHOG000006914.
    HOVERGENiHBG045628.
    InParanoidiQ9CQR7.
    KOiK06170.
    OMAiILATWIT.
    OrthoDBiEOG7ZSHW4.
    PhylomeDBiQ9CQR7.
    TreeFamiTF313116.

    Family and domain databases

    InterProiIPR019379. Gamma_Secretase_Asp_P_PEN2.
    [Graphical view]
    PfamiPF10251. PEN-2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CQR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLERVSNEE KLNLCRKYYL GGFAFLPFLW LVNIFWFFRE AFLAPAYTEQ    50
    SQIKGYVWRS AVGFLFWVII LATWITIFQI YRPRWGALGD YLSFTIPLGT 100
    P 101
    Length:101
    Mass (Da):11,999
    Last modified:June 1, 2001 - v1
    Checksum:i6596CA2984FBCC59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002440 mRNA. Translation: BAB22102.1.
    AK006284 mRNA. Translation: BAB24503.1.
    AK007621 mRNA. Translation: BAB25141.1.
    BC024347 mRNA. Translation: AAH24347.1.
    BC081443 mRNA. Translation: AAH81443.1.
    CCDSiCCDS21099.1.
    RefSeqiNP_079774.1. NM_025498.2.
    UniGeneiMm.86557.

    Genome annotation databases

    EnsembliENSMUST00000043898; ENSMUSP00000044682; ENSMUSG00000036835.
    GeneIDi66340.
    KEGGimmu:66340.
    UCSCiuc009gez.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002440 mRNA. Translation: BAB22102.1 .
    AK006284 mRNA. Translation: BAB24503.1 .
    AK007621 mRNA. Translation: BAB25141.1 .
    BC024347 mRNA. Translation: AAH24347.1 .
    BC081443 mRNA. Translation: AAH81443.1 .
    CCDSi CCDS21099.1.
    RefSeqi NP_079774.1. NM_025498.2.
    UniGenei Mm.86557.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211397. 2 interactions.
    DIPi DIP-36333N.
    IntActi Q9CQR7. 2 interactions.
    STRINGi 10090.ENSMUSP00000044682.

    Chemistry

    BindingDBi Q9CQR7.

    Protein family/group databases

    TCDBi 9.B.47.1.1. the -secretase (-secretase) family.

    PTM databases

    PhosphoSitei Q9CQR7.

    Proteomic databases

    MaxQBi Q9CQR7.
    PaxDbi Q9CQR7.
    PRIDEi Q9CQR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043898 ; ENSMUSP00000044682 ; ENSMUSG00000036835 .
    GeneIDi 66340.
    KEGGi mmu:66340.
    UCSCi uc009gez.1. mouse.

    Organism-specific databases

    CTDi 55851.
    MGIi MGI:1913590. Psenen.

    Phylogenomic databases

    eggNOGi NOG279333.
    GeneTreei ENSGT00390000016319.
    HOGENOMi HOG000006914.
    HOVERGENi HBG045628.
    InParanoidi Q9CQR7.
    KOi K06170.
    OMAi ILATWIT.
    OrthoDBi EOG7ZSHW4.
    PhylomeDBi Q9CQR7.
    TreeFami TF313116.

    Enzyme and pathway databases

    Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199404. Signaling by NOTCH4.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_199413. Signaling by NOTCH3.
    REACT_202271. NRIF signals cell death from the nucleus.
    REACT_218614. Regulated proteolysis of p75NTR.

    Miscellaneous databases

    NextBioi 321375.
    PROi Q9CQR7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQR7.
    CleanExi MM_PSENEN.
    Genevestigatori Q9CQR7.

    Family and domain databases

    InterProi IPR019379. Gamma_Secretase_Asp_P_PEN2.
    [Graphical view ]
    Pfami PF10251. PEN-2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney, Pancreas and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Colon.

    Entry informationi

    Entry nameiPEN2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3