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Q9CQR6

- PPP6_MOUSE

UniProt

Q9CQR6 - PPP6_MOUSE

Protein

Serine/threonine-protein phosphatase 6 catalytic subunit

Gene

Ppp6c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    A component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531Manganese 1By similarity
    Metal bindingi55 – 551Manganese 1By similarity
    Metal bindingi81 – 811Manganese 1By similarity
    Metal bindingi81 – 811Manganese 2By similarity
    Metal bindingi113 – 1131Manganese 2By similarity
    Active sitei114 – 1141Proton donorBy similarity
    Metal bindingi163 – 1631Manganese 2By similarity
    Metal bindingi237 – 2371Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: MGI

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. protein dephosphorylation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 6 catalytic subunit (EC:3.1.3.16)
    Short name:
    PP6C
    Cleaved into the following chain:
    Gene namesi
    Name:Ppp6c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1915107. Ppp6c.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Serine/threonine-protein phosphatase 6 catalytic subunitPRO_0000058878Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 305304Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processedPRO_0000424505Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9CQR6.
    PaxDbiQ9CQR6.
    PRIDEiQ9CQR6.

    PTM databases

    PhosphoSiteiQ9CQR6.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in all tissues tested with strongest expression in lung, spleen, liver, kidney and brain. Weaker expression observed in bladder, pancreas, heart and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ9CQR6.
    CleanExiMM_PPP6C.
    GenevestigatoriQ9CQR6.

    Interactioni

    Subunit structurei

    Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 and PPP6R3.By similarity

    Protein-protein interaction databases

    BioGridi212485. 1 interaction.
    IntActiQ9CQR6. 2 interactions.
    MINTiMINT-4108474.
    STRINGi10090.ENSMUSP00000028087.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQR6.
    SMRiQ9CQR6. Positions 5-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0639.
    GeneTreeiENSGT00550000074961.
    HOGENOMiHOG000172696.
    HOVERGENiHBG000216.
    InParanoidiQ9CQR6.
    KOiK15498.
    OMAiVPETSYI.
    OrthoDBiEOG74N5H2.
    PhylomeDBiQ9CQR6.
    TreeFamiTF105563.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CQR6-1 [UniParc]FASTAAdd to Basket

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    MAPLDLDKYV EIARQCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV    50
    CGDIHGQFYD LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK 100
    AKWPDRITLL RGNHESRQIT QVYGFYDECQ TKYGNANAWR YCTKVFDMLT 150
    VAALIDEQIL CVHGGLSPDI KTLDQIRTIE RNQEIPHKGA FCDLVWSDPE 200
    DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV HEGYKFMFDE 250
    KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT 300
    TPYFL 305
    Length:305
    Mass (Da):35,159
    Last modified:June 1, 2001 - v1
    Checksum:i662969DE1B2EF490
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002764 mRNA. Translation: BAB22339.1.
    AK009104 mRNA. Translation: BAB26073.1.
    AL928639 Genomic DNA. Translation: CAM24616.1.
    BC002223 mRNA. Translation: AAH02223.1.
    CCDSiCCDS16017.1.
    RefSeqiNP_077171.1. NM_024209.2.
    UniGeneiMm.389242.
    Mm.392662.

    Genome annotation databases

    EnsembliENSMUST00000028087; ENSMUSP00000028087; ENSMUSG00000026753.
    GeneIDi67857.
    KEGGimmu:67857.
    UCSCiuc008joi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002764 mRNA. Translation: BAB22339.1 .
    AK009104 mRNA. Translation: BAB26073.1 .
    AL928639 Genomic DNA. Translation: CAM24616.1 .
    BC002223 mRNA. Translation: AAH02223.1 .
    CCDSi CCDS16017.1.
    RefSeqi NP_077171.1. NM_024209.2.
    UniGenei Mm.389242.
    Mm.392662.

    3D structure databases

    ProteinModelPortali Q9CQR6.
    SMRi Q9CQR6. Positions 5-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212485. 1 interaction.
    IntActi Q9CQR6. 2 interactions.
    MINTi MINT-4108474.
    STRINGi 10090.ENSMUSP00000028087.

    PTM databases

    PhosphoSitei Q9CQR6.

    Proteomic databases

    MaxQBi Q9CQR6.
    PaxDbi Q9CQR6.
    PRIDEi Q9CQR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028087 ; ENSMUSP00000028087 ; ENSMUSG00000026753 .
    GeneIDi 67857.
    KEGGi mmu:67857.
    UCSCi uc008joi.1. mouse.

    Organism-specific databases

    CTDi 5537.
    MGIi MGI:1915107. Ppp6c.

    Phylogenomic databases

    eggNOGi COG0639.
    GeneTreei ENSGT00550000074961.
    HOGENOMi HOG000172696.
    HOVERGENi HBG000216.
    InParanoidi Q9CQR6.
    KOi K15498.
    OMAi VPETSYI.
    OrthoDBi EOG74N5H2.
    PhylomeDBi Q9CQR6.
    TreeFami TF105563.

    Miscellaneous databases

    ChiTaRSi PPP6C. mouse.
    NextBioi 325733.
    PROi Q9CQR6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQR6.
    CleanExi MM_PPP6C.
    Genevestigatori Q9CQR6.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney and Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon."
      Stefansson B., Brautigan D.L.
      J. Biol. Chem. 281:22624-22634(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPPP6_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQR6
    Secondary accession number(s): A2ASL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3