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Protein

U6 snRNA-associated Sm-like protein LSm7

Gene

Lsm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm7
Gene namesi
Name:Lsm7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913344. Lsm7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 103102U6 snRNA-associated Sm-like protein LSm7PRO_0000125580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CQQ8.
MaxQBiQ9CQQ8.
PaxDbiQ9CQQ8.
PRIDEiQ9CQQ8.

2D gel databases

REPRODUCTION-2DPAGEQ9CQQ8.

PTM databases

iPTMnetiQ9CQQ8.
PhosphoSiteiQ9CQQ8.

Expressioni

Gene expression databases

BgeeiQ9CQQ8.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CQQ8. 3 interactions.
MINTiMINT-4100620.
STRINGi10090.ENSMUSP00000072521.

Structurei

3D structure databases

ProteinModelPortaliQ9CQQ8.
SMRiQ9CQQ8. Positions 11-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1781. Eukaryota.
ENOG4111VMJ. LUCA.
GeneTreeiENSGT00510000047872.
HOGENOMiHOG000223548.
HOVERGENiHBG000513.
InParanoidiQ9CQQ8.
KOiK12626.
OMAiICPVDGM.
OrthoDBiEOG79PJRD.
PhylomeDBiQ9CQQ8.
TreeFamiTF314385.

Family and domain databases

InterProiIPR017132. Lsm7/snRNP-G.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037188. U6_snRNA_Lsm7. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG
60 70 80 90 100
TMEYMRDPDD QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFVQQ

QDT
Length:103
Mass (Da):11,636
Last modified:June 1, 2001 - v1
Checksum:i6859DC08A81AE808
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013355 mRNA. Translation: BAB28806.1.
BC027511 mRNA. Translation: AAH27511.1.
BC081444 mRNA. Translation: AAH81444.1.
AK003062 mRNA. Translation: BAB22540.1.
AK007462 mRNA. Translation: BAB25051.1.
AK012446 mRNA. Translation: BAB28245.1.
CCDSiCCDS35987.1.
RefSeqiNP_079625.1. NM_025349.2.
UniGeneiMm.379101.

Genome annotation databases

EnsembliENSMUST00000035775; ENSMUSP00000044993; ENSMUSG00000035215.
ENSMUST00000072739; ENSMUSP00000072521; ENSMUSG00000064317.
GeneIDi66094.
KEGGimmu:66094.
UCSCiuc007gez.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013355 mRNA. Translation: BAB28806.1.
BC027511 mRNA. Translation: AAH27511.1.
BC081444 mRNA. Translation: AAH81444.1.
AK003062 mRNA. Translation: BAB22540.1.
AK007462 mRNA. Translation: BAB25051.1.
AK012446 mRNA. Translation: BAB28245.1.
CCDSiCCDS35987.1.
RefSeqiNP_079625.1. NM_025349.2.
UniGeneiMm.379101.

3D structure databases

ProteinModelPortaliQ9CQQ8.
SMRiQ9CQQ8. Positions 11-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQQ8. 3 interactions.
MINTiMINT-4100620.
STRINGi10090.ENSMUSP00000072521.

PTM databases

iPTMnetiQ9CQQ8.
PhosphoSiteiQ9CQQ8.

2D gel databases

REPRODUCTION-2DPAGEQ9CQQ8.

Proteomic databases

EPDiQ9CQQ8.
MaxQBiQ9CQQ8.
PaxDbiQ9CQQ8.
PRIDEiQ9CQQ8.

Protocols and materials databases

DNASUi66094.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035775; ENSMUSP00000044993; ENSMUSG00000035215.
ENSMUST00000072739; ENSMUSP00000072521; ENSMUSG00000064317.
GeneIDi66094.
KEGGimmu:66094.
UCSCiuc007gez.1. mouse.

Organism-specific databases

CTDi51690.
MGIiMGI:1913344. Lsm7.

Phylogenomic databases

eggNOGiKOG1781. Eukaryota.
ENOG4111VMJ. LUCA.
GeneTreeiENSGT00510000047872.
HOGENOMiHOG000223548.
HOVERGENiHBG000513.
InParanoidiQ9CQQ8.
KOiK12626.
OMAiICPVDGM.
OrthoDBiEOG79PJRD.
PhylomeDBiQ9CQQ8.
TreeFamiTF314385.

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

NextBioi320614.
PROiQ9CQQ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQQ8.

Family and domain databases

InterProiIPR017132. Lsm7/snRNP-G.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037188. U6_snRNA_Lsm7. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiLSM7_MOUSE
AccessioniPrimary (citable) accession number: Q9CQQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.