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Protein

ATP synthase F(0) complex subunit B1, mitochondrial

Gene

Atp5f1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit B1, mitochondrial
Alternative name(s):
ATP synthase subunit b
Short name:
ATPase subunit b
Gene namesi
Name:Atp5f1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1100495 Atp5f1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionBy similarityAdd BLAST42
ChainiPRO_000000251443 – 256ATP synthase F(0) complex subunit B1, mitochondrialAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131N6-succinyllysineCombined sources1
Modified residuei139N6-acetyllysineCombined sources1
Modified residuei154N6-acetyllysineCombined sources1
Modified residuei162N6-acetyllysineCombined sources1
Modified residuei221N6-acetyllysineCombined sources1
Modified residuei225N6-acetyllysineCombined sources1
Modified residuei233N6-acetyllysineCombined sources1
Modified residuei244N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CQQ7
MaxQBiQ9CQQ7
PaxDbiQ9CQQ7
PeptideAtlasiQ9CQQ7
PRIDEiQ9CQQ7
TopDownProteomicsiQ9CQQ7

PTM databases

iPTMnetiQ9CQQ7
PhosphoSitePlusiQ9CQQ7
SwissPalmiQ9CQQ7

Expressioni

Gene expression databases

BgeeiENSMUSG00000000563
ExpressionAtlasiQ9CQQ7 baseline and differential
GenevisibleiQ9CQQ7 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198256, 3 interactors
IntActiQ9CQQ7, 5 interactors
MINTiQ9CQQ7
STRINGi10090.ENSMUSP00000113022

Structurei

3D structure databases

ProteinModelPortaliQ9CQQ7
SMRiQ9CQQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ATPase B chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410INNH Eukaryota
ENOG4111WYE LUCA
GeneTreeiENSGT00390000001958
HOGENOMiHOG000007163
HOVERGENiHBG050604
InParanoidiQ9CQQ7
KOiK02127
OMAiIYVINHE
OrthoDBiEOG091G0DPN
PhylomeDBiQ9CQQ7
TreeFamiTF313250

Family and domain databases

InterProiView protein in InterPro
IPR008688 ATP_synth_Bsub_B/MI25
IPR013837 ATP_synth_F0_suB
PANTHERiPTHR12733 PTHR12733, 1 hit
PfamiView protein in Pfam
PF05405 Mt_ATP-synt_B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRVVLSAA ATAAPCLKNA AALGPGVLQA TRAFHTGQPR LAPLPPLPEY
60 70 80 90 100
GGKVRLGLIP EEFFQFLYPK TGVTGPYVLG TGLSLYFLSK EIYVITPETF
110 120 130 140 150
STISVVGLIV YVIKKYGASF GEFIDKLNEE KIAQLEEVKQ SSMKQIQDAI
160 170 180 190 200
DMEKAQQALV QKRHYLFDVQ RNNIALALEV TYRERLHKAY KEVKNRLDYH
210 220 230 240 250
ISVQNMMRRK EEEHMIDWVE KHVVKSISVQ QEKETIAKCI EDLKLLAKKA

QAQPIM
Length:256
Mass (Da):28,949
Last modified:June 1, 2001 - v1
Checksum:i6B385AE4DE6CB784
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002960 mRNA Translation: BAB22481.1
AK011312 mRNA Translation: BAB27538.1
CCDSiCCDS17714.1
RefSeqiNP_033855.2, NM_009725.4
UniGeneiMm.251152

Genome annotation databases

EnsembliENSMUST00000118209; ENSMUSP00000113022; ENSMUSG00000000563
GeneIDi11950
KEGGimmu:11950
UCSCiuc008qvl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAT5F1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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