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Protein

Transmembrane protein 14C

Gene

Tmem14c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal heme biosynthesis.By similarity

GO - Biological processi

  • erythrocyte differentiation Source: MGI
  • heme biosynthetic process Source: UniProtKB-KW
  • mitochondrial transport Source: MGI
  • regulation of heme biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Heme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14C
Gene namesi
Name:Tmem14c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913404. Tmem14c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 114113Transmembrane protein 14CPRO_0000221174Add
BLAST

Proteomic databases

EPDiQ9CQN6.
MaxQBiQ9CQN6.
PaxDbiQ9CQN6.
PeptideAtlasiQ9CQN6.
PRIDEiQ9CQN6.
TopDownProteomicsiQ9CQN6.

PTM databases

iPTMnetiQ9CQN6.
PhosphoSiteiQ9CQN6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021361.
CleanExiMM_TMEM14C.
GenevisibleiQ9CQN6. MM.

Interactioni

Protein-protein interaction databases

BioGridi211255. 1 interaction.
IntActiQ9CQN6. 1 interaction.
STRINGi10090.ENSMUSP00000021790.

Structurei

3D structure databases

ProteinModelPortaliQ9CQN6.
SMRiQ9CQN6. Positions 3-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9CQN6.
OMAiHYFGFGY.
OrthoDBiEOG091G0XXJ.
PhylomeDBiQ9CQN6.
TreeFamiTF323345.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKDSGPLMP LHYFGFGYAA LVATGGIIGY AKAGSVPSLA AGLFFGGLAG
60 70 80 90 100
LGAYQLSQDP RNVWVFLATS GTLAGIMGMR FYNSGKFMPA GLIAGASLLM
110
VAKVGISLLS SPHP
Length:114
Mass (Da):11,642
Last modified:June 1, 2001 - v1
Checksum:i709C784017F5D4B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003891 mRNA. Translation: BAB23060.1.
AK008495 mRNA. Translation: BAB25700.1.
AK008878 mRNA. Translation: BAB25946.1.
AK010609 mRNA. Translation: BAB27059.1.
AK012101 mRNA. Translation: BAB28032.1.
AK019395 mRNA. Translation: BAB31700.1.
AK050688 mRNA. Translation: BAC34380.1.
BC025854 mRNA. Translation: AAH25854.1.
BC055862 mRNA. Translation: AAH55862.1.
CCDSiCCDS26470.1.
RefSeqiNP_079663.1. NM_025387.3.
XP_006517001.1. XM_006516938.2.
XP_006517002.1. XM_006516939.2.
UniGeneiMm.30005.

Genome annotation databases

EnsembliENSMUST00000021790; ENSMUSP00000021790; ENSMUSG00000021361.
GeneIDi66154.
KEGGimmu:66154.
UCSCiuc007qet.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003891 mRNA. Translation: BAB23060.1.
AK008495 mRNA. Translation: BAB25700.1.
AK008878 mRNA. Translation: BAB25946.1.
AK010609 mRNA. Translation: BAB27059.1.
AK012101 mRNA. Translation: BAB28032.1.
AK019395 mRNA. Translation: BAB31700.1.
AK050688 mRNA. Translation: BAC34380.1.
BC025854 mRNA. Translation: AAH25854.1.
BC055862 mRNA. Translation: AAH55862.1.
CCDSiCCDS26470.1.
RefSeqiNP_079663.1. NM_025387.3.
XP_006517001.1. XM_006516938.2.
XP_006517002.1. XM_006516939.2.
UniGeneiMm.30005.

3D structure databases

ProteinModelPortaliQ9CQN6.
SMRiQ9CQN6. Positions 3-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211255. 1 interaction.
IntActiQ9CQN6. 1 interaction.
STRINGi10090.ENSMUSP00000021790.

PTM databases

iPTMnetiQ9CQN6.
PhosphoSiteiQ9CQN6.

Proteomic databases

EPDiQ9CQN6.
MaxQBiQ9CQN6.
PaxDbiQ9CQN6.
PeptideAtlasiQ9CQN6.
PRIDEiQ9CQN6.
TopDownProteomicsiQ9CQN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021790; ENSMUSP00000021790; ENSMUSG00000021361.
GeneIDi66154.
KEGGimmu:66154.
UCSCiuc007qet.2. mouse.

Organism-specific databases

CTDi51522.
MGIiMGI:1913404. Tmem14c.

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9CQN6.
OMAiHYFGFGY.
OrthoDBiEOG091G0XXJ.
PhylomeDBiQ9CQN6.
TreeFamiTF323345.

Miscellaneous databases

PROiQ9CQN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021361.
CleanExiMM_TMEM14C.
GenevisibleiQ9CQN6. MM.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM14C_MOUSE
AccessioniPrimary (citable) accession number: Q9CQN6
Secondary accession number(s): Q543H6, Q9D849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.