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Protein

Transmembrane protein 14C

Gene

Tmem14c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal heme biosynthesis.By similarity

GO - Biological processi

  • erythrocyte differentiation Source: MGI
  • heme biosynthetic process Source: UniProtKB-KW
  • mitochondrial transport Source: MGI
  • regulation of heme biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Heme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14C
Gene namesi
Name:Tmem14c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913404. Tmem14c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 114113Transmembrane protein 14CPRO_0000221174Add
BLAST

Proteomic databases

EPDiQ9CQN6.
MaxQBiQ9CQN6.
PaxDbiQ9CQN6.
PRIDEiQ9CQN6.
TopDownProteomicsiQ9CQN6.

PTM databases

iPTMnetiQ9CQN6.
PhosphoSiteiQ9CQN6.

Expressioni

Gene expression databases

BgeeiQ9CQN6.
CleanExiMM_TMEM14C.
GenevisibleiQ9CQN6. MM.

Interactioni

Protein-protein interaction databases

BioGridi211255. 1 interaction.
IntActiQ9CQN6. 1 interaction.
STRINGi10090.ENSMUSP00000021790.

Structurei

3D structure databases

ProteinModelPortaliQ9CQN6.
SMRiQ9CQN6. Positions 3-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9CQN6.
OMAiHYFGFGY.
OrthoDBiEOG7NKKP0.
PhylomeDBiQ9CQN6.
TreeFamiTF323345.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKDSGPLMP LHYFGFGYAA LVATGGIIGY AKAGSVPSLA AGLFFGGLAG
60 70 80 90 100
LGAYQLSQDP RNVWVFLATS GTLAGIMGMR FYNSGKFMPA GLIAGASLLM
110
VAKVGISLLS SPHP
Length:114
Mass (Da):11,642
Last modified:June 1, 2001 - v1
Checksum:i709C784017F5D4B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003891 mRNA. Translation: BAB23060.1.
AK008495 mRNA. Translation: BAB25700.1.
AK008878 mRNA. Translation: BAB25946.1.
AK010609 mRNA. Translation: BAB27059.1.
AK012101 mRNA. Translation: BAB28032.1.
AK019395 mRNA. Translation: BAB31700.1.
AK050688 mRNA. Translation: BAC34380.1.
BC025854 mRNA. Translation: AAH25854.1.
BC055862 mRNA. Translation: AAH55862.1.
CCDSiCCDS26470.1.
RefSeqiNP_079663.1. NM_025387.3.
XP_006517001.1. XM_006516938.2.
XP_006517002.1. XM_006516939.2.
UniGeneiMm.30005.

Genome annotation databases

EnsembliENSMUST00000021790; ENSMUSP00000021790; ENSMUSG00000021361.
GeneIDi66154.
KEGGimmu:66154.
UCSCiuc007qet.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003891 mRNA. Translation: BAB23060.1.
AK008495 mRNA. Translation: BAB25700.1.
AK008878 mRNA. Translation: BAB25946.1.
AK010609 mRNA. Translation: BAB27059.1.
AK012101 mRNA. Translation: BAB28032.1.
AK019395 mRNA. Translation: BAB31700.1.
AK050688 mRNA. Translation: BAC34380.1.
BC025854 mRNA. Translation: AAH25854.1.
BC055862 mRNA. Translation: AAH55862.1.
CCDSiCCDS26470.1.
RefSeqiNP_079663.1. NM_025387.3.
XP_006517001.1. XM_006516938.2.
XP_006517002.1. XM_006516939.2.
UniGeneiMm.30005.

3D structure databases

ProteinModelPortaliQ9CQN6.
SMRiQ9CQN6. Positions 3-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211255. 1 interaction.
IntActiQ9CQN6. 1 interaction.
STRINGi10090.ENSMUSP00000021790.

PTM databases

iPTMnetiQ9CQN6.
PhosphoSiteiQ9CQN6.

Proteomic databases

EPDiQ9CQN6.
MaxQBiQ9CQN6.
PaxDbiQ9CQN6.
PRIDEiQ9CQN6.
TopDownProteomicsiQ9CQN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021790; ENSMUSP00000021790; ENSMUSG00000021361.
GeneIDi66154.
KEGGimmu:66154.
UCSCiuc007qet.2. mouse.

Organism-specific databases

CTDi51522.
MGIiMGI:1913404. Tmem14c.

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9CQN6.
OMAiHYFGFGY.
OrthoDBiEOG7NKKP0.
PhylomeDBiQ9CQN6.
TreeFamiTF323345.

Miscellaneous databases

NextBioi320792.
PROiQ9CQN6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQN6.
CleanExiMM_TMEM14C.
GenevisibleiQ9CQN6. MM.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Small intestine and Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 62-80; 87-103 AND 104-114, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTM14C_MOUSE
AccessioniPrimary (citable) accession number: Q9CQN6
Secondary accession number(s): Q543H6, Q9D849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.