Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sclerostin domain-containing protein 1

Gene

Sostdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • hair follicle morphogenesis Source: MGI
  • mammary gland bud morphogenesis Source: MGI
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cell fate commitment Source: MGI
  • negative regulation of determination of dorsal identity Source: Ensembl
  • negative regulation of myoblast differentiation Source: Ensembl
  • odontogenesis of dentin-containing tooth Source: MGI
  • pattern specification process Source: MGI
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Sclerostin domain-containing protein 1
Alternative name(s):
Ectodermal BMP inhibitor
Short name:
Ectodin
Sclerostin-like protein
Uterine sensitization-associated gene 1 protein
Short name:
USAG-1
Gene namesi
Name:Sostdc1
Synonyms:Sostl, Usag1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913292. Sostdc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003318124 – 206Sclerostin domain-containing protein 1Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi75 ↔ 133PROSITE-ProRule annotation
Disulfide bondi89 ↔ 147PROSITE-ProRule annotation
Disulfide bondi100 ↔ 163PROSITE-ProRule annotation
Disulfide bondi104 ↔ 165PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9CQN4.
PaxDbiQ9CQN4.
PRIDEiQ9CQN4.

PTM databases

PhosphoSitePlusiQ9CQN4.

Expressioni

Tissue specificityi

Highly expressed in kidney at renal collecting ducts level and weakly in brain.2 Publications

Developmental stagei

Expression was first detected at E11 throughout the surface of the embryo, and it was most intense in the head region on the surfaces of the mandibular, maxillary, and frontonasal processes. At E11.5 expression is detected in the first and second branchial arches, pharynx and metanephros. At E12-E14, expression was intense and strikingly confined to developing ectodermal organs. The vibrissae, tylotrich hair follicles, tongue papillae, and tooth germs as well as the ear auricle. Also expressed intensely in kidney epithelium in the stalk and tips of ureter as well as in the spermatic ducts in the testis. At E17.5 strong expression was restricted to kidney tubules and ameloblasts in teeth, and moderate expression was observed in hair follicles, choroids plexus of the fourth cerebral ventricle of the brain. First detected on E12.5 in interstitial cell of the testis and increased towards E14.5. On 8 dpp (day post partum) highly expression was detected in kidney and weakly in skin.3 Publications

Inductioni

Up-regulated by BMP2 and BMP7. Down-regulated by FGF4 and SHH.1 Publication

Gene expression databases

BgeeiENSMUSG00000036169.
CleanExiMM_SOSTDC1.
GenevisibleiQ9CQN4. MM.

Interactioni

Subunit structurei

Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040230.

Structurei

3D structure databases

ProteinModelPortaliQ9CQN4.
SMRiQ9CQN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 170CTCKPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the sclerostin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIVA. Eukaryota.
ENOG410YEMP. LUCA.
GeneTreeiENSGT00390000014900.
HOGENOMiHOG000252934.
HOVERGENiHBG003729.
InParanoidiQ9CQN4.
OMAiAKPAQHH.
OrthoDBiEOG091G13DX.
PhylomeDBiQ9CQN4.
TreeFamiTF353019.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR008835. Sclerostin/SOSTDC1.
PANTHERiPTHR14903. PTHR14903. 1 hit.
PfamiView protein in Pfam
PF05463. Sclerostin. 1 hit.
PROSITEiView protein in PROSITE
PS01225. CTCK_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPAIHLSL IPLLCILMRN CLAFKNDATE ILYSHVVKPV PAHPSSNSTL
60 70 80 90 100
NQARNGGRHF SSTGLDRNSR VQVGCRELRS TKYISDGQCT SISPLKELVC
110 120 130 140 150
AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG
160 170 180 190 200
STRTYKITVV TACKCKRYTR QHNESSHNFE SVSPAKPAQH HRERKRASKS

SKHSLS
Length:206
Mass (Da):23,174
Last modified:June 1, 2001 - v1
Checksum:i70D24819EB06CBC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69S → R in BAC25193 (PubMed:16141072).Curated1
Sequence conflicti80S → T in BAC25193 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY134666 mRNA. Translation: AAN08617.1.
AB059271 mRNA. Translation: BAC20332.1.
AY255635 mRNA. Translation: AAQ83297.1.
AK002240 mRNA. Translation: BAB21957.1.
AK002396 mRNA. Translation: BAB22068.1.
AK007893 mRNA. Translation: BAB25333.1.
AK007935 mRNA. Translation: BAC25193.1.
AK007967 mRNA. Translation: BAB25378.1.
BC021458 mRNA. Translation: AAH21458.1.
CCDSiCCDS25887.1.
RefSeqiNP_079588.1. NM_025312.3.
UniGeneiMm.43375.

Genome annotation databases

EnsembliENSMUST00000041407; ENSMUSP00000040230; ENSMUSG00000036169.
GeneIDi66042.
KEGGimmu:66042.
UCSCiuc007njx.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiSOSD1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQN4
Secondary accession number(s): Q8CF09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families