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Protein

Sclerostin domain-containing protein 1

Gene

Sostdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.By similarity1 Publication

GO - Biological processi

  • hair follicle morphogenesis Source: MGI
  • mammary gland bud morphogenesis Source: MGI
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cell fate commitment Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • pattern specification process Source: MGI
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Sclerostin domain-containing protein 1
Alternative name(s):
Ectodermal BMP inhibitor
Short name:
Ectodin
Sclerostin-like protein
Uterine sensitization-associated gene 1 protein
Short name:
USAG-1
Gene namesi
Name:Sostdc1
Synonyms:Sostl, Usag1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913292. Sostdc1.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 206183Sclerostin domain-containing protein 1PRO_0000033181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Disulfide bondi75 ↔ 133PROSITE-ProRule annotation
Disulfide bondi89 ↔ 147PROSITE-ProRule annotation
Disulfide bondi100 ↔ 163PROSITE-ProRule annotation
Disulfide bondi104 ↔ 165PROSITE-ProRule annotation
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9CQN4.
PRIDEiQ9CQN4.

PTM databases

PhosphoSiteiQ9CQN4.

Expressioni

Tissue specificityi

Highly expressed in kidney at renal collecting ducts level and weakly in brain.2 Publications

Developmental stagei

Expression was first detected at E11 throughout the surface of the embryo, and it was most intense in the head region on the surfaces of the mandibular, maxillary, and frontonasal processes. At E11.5 expression is detected in the first and second branchial arches, pharynx and metanephros. At E12-E14, expression was intense and strikingly confined to developing ectodermal organs. The vibrissae, tylotrich hair follicles, tongue papillae, and tooth germs as well as the ear auricle. Also expressed intensely in kidney epithelium in the stalk and tips of ureter as well as in the spermatic ducts in the testis. At E17.5 strong expression was restricted to kidney tubules and ameloblasts in teeth, and moderate expression was observed in hair follicles, choroids plexus of the fourth cerebral ventricle of the brain. First detected on E12.5 in interstitial cell of the testis and increased towards E14.5. On 8 dpp (day post partum) highly expression was detected in kidney and weakly in skin.3 Publications

Inductioni

Up-regulated by BMP2 and BMP7. Down-regulated by FGF4 and SHH.1 Publication

Gene expression databases

BgeeiENSMUSG00000036169.
CleanExiMM_SOSTDC1.
GenevisibleiQ9CQN4. MM.

Interactioni

Subunit structurei

Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040230.

Structurei

3D structure databases

ProteinModelPortaliQ9CQN4.
SMRiQ9CQN4. Positions 72-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 17096CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sclerostin family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIVA. Eukaryota.
ENOG410YEMP. LUCA.
GeneTreeiENSGT00390000014900.
HOGENOMiHOG000252934.
HOVERGENiHBG003729.
InParanoidiQ9CQN4.
OMAiAKPAQHH.
OrthoDBiEOG091G13DX.
PhylomeDBiQ9CQN4.
TreeFamiTF353019.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR008835. Sclerostin/SOSTDC1.
[Graphical view]
PANTHERiPTHR14903. PTHR14903. 1 hit.
PfamiPF05463. Sclerostin. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPAIHLSL IPLLCILMRN CLAFKNDATE ILYSHVVKPV PAHPSSNSTL
60 70 80 90 100
NQARNGGRHF SSTGLDRNSR VQVGCRELRS TKYISDGQCT SISPLKELVC
110 120 130 140 150
AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG
160 170 180 190 200
STRTYKITVV TACKCKRYTR QHNESSHNFE SVSPAKPAQH HRERKRASKS

SKHSLS
Length:206
Mass (Da):23,174
Last modified:June 1, 2001 - v1
Checksum:i70D24819EB06CBC9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691S → R in BAC25193 (PubMed:16141072).Curated
Sequence conflicti80 – 801S → T in BAC25193 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY134666 mRNA. Translation: AAN08617.1.
AB059271 mRNA. Translation: BAC20332.1.
AY255635 mRNA. Translation: AAQ83297.1.
AK002240 mRNA. Translation: BAB21957.1.
AK002396 mRNA. Translation: BAB22068.1.
AK007893 mRNA. Translation: BAB25333.1.
AK007935 mRNA. Translation: BAC25193.1.
AK007967 mRNA. Translation: BAB25378.1.
BC021458 mRNA. Translation: AAH21458.1.
CCDSiCCDS25887.1.
RefSeqiNP_079588.1. NM_025312.3.
UniGeneiMm.43375.

Genome annotation databases

EnsembliENSMUST00000041407; ENSMUSP00000040230; ENSMUSG00000036169.
GeneIDi66042.
KEGGimmu:66042.
UCSCiuc007njx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY134666 mRNA. Translation: AAN08617.1.
AB059271 mRNA. Translation: BAC20332.1.
AY255635 mRNA. Translation: AAQ83297.1.
AK002240 mRNA. Translation: BAB21957.1.
AK002396 mRNA. Translation: BAB22068.1.
AK007893 mRNA. Translation: BAB25333.1.
AK007935 mRNA. Translation: BAC25193.1.
AK007967 mRNA. Translation: BAB25378.1.
BC021458 mRNA. Translation: AAH21458.1.
CCDSiCCDS25887.1.
RefSeqiNP_079588.1. NM_025312.3.
UniGeneiMm.43375.

3D structure databases

ProteinModelPortaliQ9CQN4.
SMRiQ9CQN4. Positions 72-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040230.

PTM databases

PhosphoSiteiQ9CQN4.

Proteomic databases

PaxDbiQ9CQN4.
PRIDEiQ9CQN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041407; ENSMUSP00000040230; ENSMUSG00000036169.
GeneIDi66042.
KEGGimmu:66042.
UCSCiuc007njx.2. mouse.

Organism-specific databases

CTDi25928.
MGIiMGI:1913292. Sostdc1.

Phylogenomic databases

eggNOGiENOG410IIVA. Eukaryota.
ENOG410YEMP. LUCA.
GeneTreeiENSGT00390000014900.
HOGENOMiHOG000252934.
HOVERGENiHBG003729.
InParanoidiQ9CQN4.
OMAiAKPAQHH.
OrthoDBiEOG091G13DX.
PhylomeDBiQ9CQN4.
TreeFamiTF353019.

Miscellaneous databases

PROiQ9CQN4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036169.
CleanExiMM_SOSTDC1.
GenevisibleiQ9CQN4. MM.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR008835. Sclerostin/SOSTDC1.
[Graphical view]
PANTHERiPTHR14903. PTHR14903. 1 hit.
PfamiPF05463. Sclerostin. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOSD1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQN4
Secondary accession number(s): Q8CF09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.