Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9CQN1

- TRAP1_MOUSE

UniProt

Q9CQN1 - TRAP1_MOUSE

Protein

Heat shock protein 75 kDa, mitochondrial

Gene

Trap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei121 – 1211ATPBy similarity
    Binding sitei160 – 1601ATPBy similarity
    Binding sitei173 – 1731ATPBy similarity
    Binding sitei207 – 2071ATP; via amide nitrogenBy similarity
    Binding sitei404 – 4041ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of cellular respiration Source: UniProtKB
    2. protein folding Source: InterPro
    3. response to stress Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock protein 75 kDa, mitochondrial
    Short name:
    HSP 75
    Alternative name(s):
    TNFR-associated protein 1
    Tumor necrosis factor type 1 receptor-associated protein
    Short name:
    TRAP-1
    Gene namesi
    Name:Trap1
    Synonyms:Hsp75
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1915265. Trap1.

    Subcellular locationi

    Mitochondrion By similarity. Mitochondrion inner membrane By similarity. Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial matrix Source: UniProtKB
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6060MitochondrionBy similarityAdd
    BLAST
    Chaini61 – 706646Heat shock protein 75 kDa, mitochondrialPRO_0000013605Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei172 – 1721PhosphoserineBy similarity
    Modified residuei176 – 1761PhosphothreonineBy similarity
    Modified residuei264 – 2641N6-acetyllysine1 Publication
    Modified residuei326 – 3261N6-acetyllysine1 Publication
    Modified residuei334 – 3341N6-acetyllysineBy similarity
    Modified residuei426 – 4261N6-acetyllysine1 Publication
    Modified residuei433 – 4331N6-acetyllysine1 Publication
    Modified residuei468 – 4681N6-acetyllysineBy similarity
    Modified residuei496 – 4961PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9CQN1.
    PaxDbiQ9CQN1.
    PRIDEiQ9CQN1.

    2D gel databases

    REPRODUCTION-2DPAGEQ9CQN1.

    PTM databases

    PhosphoSiteiQ9CQN1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CQN1.
    BgeeiQ9CQN1.
    CleanExiMM_TRAP1.
    GenevestigatoriQ9CQN1.

    Interactioni

    Subunit structurei

    Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.By similarity

    Protein-protein interaction databases

    BioGridi212597. 1 interaction.
    IntActiQ9CQN1. 4 interactions.
    MINTiMINT-1861067.
    STRINGi10090.ENSMUSP00000006137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQN1.
    SMRiQ9CQN1. Positions 72-704.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heat shock protein 90 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0326.
    GeneTreeiENSGT00750000117672.
    HOGENOMiHOG000031987.
    HOVERGENiHBG103147.
    InParanoidiQ9CQN1.
    KOiK09488.
    OMAiAHDKPRY.
    OrthoDBiEOG7C8GGM.
    PhylomeDBiQ9CQN1.
    TreeFamiTF315234.

    Family and domain databases

    Gene3Di3.30.565.10. 1 hit.
    HAMAPiMF_00505. HSP90.
    InterProiIPR003594. HATPase_ATP-bd.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PANTHERiPTHR11528. PTHR11528. 1 hit.
    PfamiPF00183. HSP90. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002583. Hsp90. 1 hit.
    PRINTSiPR00775. HEATSHOCK90.
    SMARTiSM00387. HATPase_c. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CQN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACELRAVLL WGRGLQTVLR APALAGVRRG KPVLHLQKTT VQFRGPTQSL    50
    ASGISAGQLY STQAAEDKEE ESLHSIISNT EAVRGSVSKH EFQAETKKLL 100
    DIVARSLYSE KEVFIRELIS NASDALEKLR HKLVCEGQVL PEMEIHLQTD 150
    AKKGTITIQD TGIGMTQEEL VSNLGTIARS GSKAFLEALQ NQAETSSKII 200
    GQFGVGFYSA FMVADKVEVY SRSAAPESPG YQWLSDGSGV FEIAEASGVR 250
    PGTKIIIHLK SDCKDFASES RVQDVVTKYS NFVSFPLYLN GKRINTLQAI 300
    WMMDPKDISE FQHEEFYRYI AQAYDKPRFT LHYKTDAPLN IRSIFYVPEM 350
    KPSMFDVSRE LGSSVALYSR KVLIQTKAAD ILPKWLRFIR GVVDSEDIPL 400
    NLSRELLQES ALIRKLRDVL QQRLIKFFID QSKKDAEKYA KFFEDYGLFM 450
    REGIVTTAEQ DIKEDIAKLL RYESSALPAG QLTSLPDYAS RMQAGTRNIY 500
    YLCAPNRHLA EHSPYYEAMK QKHTEVLFCY EQFDELTLLH LREFDKKKLI 550
    SVETDIVVDH YKEEKFEDTS PADERLSEKE TEDLMAWMRN ALGSRVTNVK 600
    VTFRLDTHPA MVTVLEMGAA RHFLRMQQLA KTQEERAQLL QPTLEINPRH 650
    TLIKKLCQLR ESEPELAQLL VDQIYENAMI AAGLVDDPRA MVGRLNDLLV 700
    KVLEKH 706
    Length:706
    Mass (Da):80,209
    Last modified:June 1, 2001 - v1
    Checksum:i7183CE538CB36464
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002409 mRNA. Translation: BAB22078.1.
    AK010341 mRNA. Translation: BAB26865.1.
    AK088471 mRNA. Translation: BAC40374.1.
    BC022912 mRNA. Translation: AAH22912.1.
    CCDSiCCDS27914.1.
    RefSeqiNP_080784.1. NM_026508.2.
    UniGeneiMm.123366.

    Genome annotation databases

    EnsembliENSMUST00000006137; ENSMUSP00000006137; ENSMUSG00000005981.
    GeneIDi68015.
    KEGGimmu:68015.
    UCSCiuc007xzk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002409 mRNA. Translation: BAB22078.1 .
    AK010341 mRNA. Translation: BAB26865.1 .
    AK088471 mRNA. Translation: BAC40374.1 .
    BC022912 mRNA. Translation: AAH22912.1 .
    CCDSi CCDS27914.1.
    RefSeqi NP_080784.1. NM_026508.2.
    UniGenei Mm.123366.

    3D structure databases

    ProteinModelPortali Q9CQN1.
    SMRi Q9CQN1. Positions 72-704.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212597. 1 interaction.
    IntActi Q9CQN1. 4 interactions.
    MINTi MINT-1861067.
    STRINGi 10090.ENSMUSP00000006137.

    PTM databases

    PhosphoSitei Q9CQN1.

    2D gel databases

    REPRODUCTION-2DPAGE Q9CQN1.

    Proteomic databases

    MaxQBi Q9CQN1.
    PaxDbi Q9CQN1.
    PRIDEi Q9CQN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006137 ; ENSMUSP00000006137 ; ENSMUSG00000005981 .
    GeneIDi 68015.
    KEGGi mmu:68015.
    UCSCi uc007xzk.1. mouse.

    Organism-specific databases

    CTDi 10131.
    MGIi MGI:1915265. Trap1.

    Phylogenomic databases

    eggNOGi COG0326.
    GeneTreei ENSGT00750000117672.
    HOGENOMi HOG000031987.
    HOVERGENi HBG103147.
    InParanoidi Q9CQN1.
    KOi K09488.
    OMAi AHDKPRY.
    OrthoDBi EOG7C8GGM.
    PhylomeDBi Q9CQN1.
    TreeFami TF315234.

    Miscellaneous databases

    NextBioi 326204.
    PROi Q9CQN1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CQN1.
    Bgeei Q9CQN1.
    CleanExi MM_TRAP1.
    Genevestigatori Q9CQN1.

    Family and domain databases

    Gene3Di 3.30.565.10. 1 hit.
    HAMAPi MF_00505. HSP90.
    InterProi IPR003594. HATPase_ATP-bd.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    PANTHERi PTHR11528. PTHR11528. 1 hit.
    Pfami PF00183. HSP90. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002583. Hsp90. 1 hit.
    PRINTSi PR00775. HEATSHOCK90.
    SMARTi SM00387. HATPase_c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryonic stem cell, Kidney and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 391-404, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-264; LYS-326; LYS-426 AND LYS-433, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiTRAP1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQN1
    Secondary accession number(s): Q542I4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3