Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CQN1

- TRAP1_MOUSE

UniProt

Q9CQN1 - TRAP1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Heat shock protein 75 kDa, mitochondrial

Gene

Trap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211ATPBy similarity
Binding sitei160 – 1601ATPBy similarity
Binding sitei173 – 1731ATPBy similarity
Binding sitei207 – 2071ATP; via amide nitrogenBy similarity
Binding sitei404 – 4041ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. poly(A) RNA binding Source: ParkinsonsUK-UCL
  3. protein kinase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  1. negative regulation of cellular respiration Source: UniProtKB
  2. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
  3. protein folding Source: InterPro
  4. response to stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 75 kDa, mitochondrial
Short name:
HSP 75
Alternative name(s):
TNFR-associated protein 1
Tumor necrosis factor type 1 receptor-associated protein
Short name:
TRAP-1
Gene namesi
Name:Trap1
Synonyms:Hsp75
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1915265. Trap1.

Subcellular locationi

Mitochondrion By similarity. Mitochondrion inner membrane By similarity. Mitochondrion matrix By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrial inner membrane Source: UniProtKB
  3. mitochondrial intermembrane space Source: ParkinsonsUK-UCL
  4. mitochondrial matrix Source: UniProtKB
  5. mitochondrion Source: MGI
  6. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6060MitochondrionBy similarityAdd
BLAST
Chaini61 – 706646Heat shock protein 75 kDa, mitochondrialPRO_0000013605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721PhosphoserineBy similarity
Modified residuei176 – 1761PhosphothreonineBy similarity
Modified residuei264 – 2641N6-acetyllysine1 Publication
Modified residuei326 – 3261N6-acetyllysine1 Publication
Modified residuei334 – 3341N6-acetyllysineBy similarity
Modified residuei426 – 4261N6-acetyllysine1 Publication
Modified residuei433 – 4331N6-acetyllysine1 Publication
Modified residuei468 – 4681N6-acetyllysineBy similarity
Modified residuei496 – 4961PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CQN1.
PaxDbiQ9CQN1.
PRIDEiQ9CQN1.

2D gel databases

REPRODUCTION-2DPAGEQ9CQN1.

PTM databases

PhosphoSiteiQ9CQN1.

Expressioni

Gene expression databases

BgeeiQ9CQN1.
CleanExiMM_TRAP1.
ExpressionAtlasiQ9CQN1. baseline and differential.
GenevestigatoriQ9CQN1.

Interactioni

Subunit structurei

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.By similarity

Protein-protein interaction databases

BioGridi212597. 1 interaction.
IntActiQ9CQN1. 4 interactions.
MINTiMINT-1861067.
STRINGi10090.ENSMUSP00000006137.

Structurei

3D structure databases

ProteinModelPortaliQ9CQN1.
SMRiQ9CQN1. Positions 72-704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0326.
GeneTreeiENSGT00760000119253.
HOGENOMiHOG000031987.
HOVERGENiHBG103147.
InParanoidiQ9CQN1.
KOiK09488.
OMAiAHDKPRY.
OrthoDBiEOG7C8GGM.
PhylomeDBiQ9CQN1.
TreeFamiTF315234.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQN1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MACELRAVLL WGRGLQTVLR APALAGVRRG KPVLHLQKTT VQFRGPTQSL
60 70 80 90 100
ASGISAGQLY STQAAEDKEE ESLHSIISNT EAVRGSVSKH EFQAETKKLL
110 120 130 140 150
DIVARSLYSE KEVFIRELIS NASDALEKLR HKLVCEGQVL PEMEIHLQTD
160 170 180 190 200
AKKGTITIQD TGIGMTQEEL VSNLGTIARS GSKAFLEALQ NQAETSSKII
210 220 230 240 250
GQFGVGFYSA FMVADKVEVY SRSAAPESPG YQWLSDGSGV FEIAEASGVR
260 270 280 290 300
PGTKIIIHLK SDCKDFASES RVQDVVTKYS NFVSFPLYLN GKRINTLQAI
310 320 330 340 350
WMMDPKDISE FQHEEFYRYI AQAYDKPRFT LHYKTDAPLN IRSIFYVPEM
360 370 380 390 400
KPSMFDVSRE LGSSVALYSR KVLIQTKAAD ILPKWLRFIR GVVDSEDIPL
410 420 430 440 450
NLSRELLQES ALIRKLRDVL QQRLIKFFID QSKKDAEKYA KFFEDYGLFM
460 470 480 490 500
REGIVTTAEQ DIKEDIAKLL RYESSALPAG QLTSLPDYAS RMQAGTRNIY
510 520 530 540 550
YLCAPNRHLA EHSPYYEAMK QKHTEVLFCY EQFDELTLLH LREFDKKKLI
560 570 580 590 600
SVETDIVVDH YKEEKFEDTS PADERLSEKE TEDLMAWMRN ALGSRVTNVK
610 620 630 640 650
VTFRLDTHPA MVTVLEMGAA RHFLRMQQLA KTQEERAQLL QPTLEINPRH
660 670 680 690 700
TLIKKLCQLR ESEPELAQLL VDQIYENAMI AAGLVDDPRA MVGRLNDLLV

KVLEKH
Length:706
Mass (Da):80,209
Last modified:June 1, 2001 - v1
Checksum:i7183CE538CB36464
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002409 mRNA. Translation: BAB22078.1.
AK010341 mRNA. Translation: BAB26865.1.
AK088471 mRNA. Translation: BAC40374.1.
BC022912 mRNA. Translation: AAH22912.1.
CCDSiCCDS27914.1.
RefSeqiNP_080784.1. NM_026508.2.
UniGeneiMm.123366.

Genome annotation databases

EnsembliENSMUST00000006137; ENSMUSP00000006137; ENSMUSG00000005981.
GeneIDi68015.
KEGGimmu:68015.
UCSCiuc007xzk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002409 mRNA. Translation: BAB22078.1 .
AK010341 mRNA. Translation: BAB26865.1 .
AK088471 mRNA. Translation: BAC40374.1 .
BC022912 mRNA. Translation: AAH22912.1 .
CCDSi CCDS27914.1.
RefSeqi NP_080784.1. NM_026508.2.
UniGenei Mm.123366.

3D structure databases

ProteinModelPortali Q9CQN1.
SMRi Q9CQN1. Positions 72-704.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212597. 1 interaction.
IntActi Q9CQN1. 4 interactions.
MINTi MINT-1861067.
STRINGi 10090.ENSMUSP00000006137.

PTM databases

PhosphoSitei Q9CQN1.

2D gel databases

REPRODUCTION-2DPAGE Q9CQN1.

Proteomic databases

MaxQBi Q9CQN1.
PaxDbi Q9CQN1.
PRIDEi Q9CQN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006137 ; ENSMUSP00000006137 ; ENSMUSG00000005981 .
GeneIDi 68015.
KEGGi mmu:68015.
UCSCi uc007xzk.1. mouse.

Organism-specific databases

CTDi 10131.
MGIi MGI:1915265. Trap1.

Phylogenomic databases

eggNOGi COG0326.
GeneTreei ENSGT00760000119253.
HOGENOMi HOG000031987.
HOVERGENi HBG103147.
InParanoidi Q9CQN1.
KOi K09488.
OMAi AHDKPRY.
OrthoDBi EOG7C8GGM.
PhylomeDBi Q9CQN1.
TreeFami TF315234.

Miscellaneous databases

NextBioi 326204.
PROi Q9CQN1.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQN1.
CleanExi MM_TRAP1.
ExpressionAtlasi Q9CQN1. baseline and differential.
Genevestigatori Q9CQN1.

Family and domain databases

Gene3Di 3.30.565.10. 1 hit.
HAMAPi MF_00505. HSP90.
InterProi IPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
PANTHERi PTHR11528. PTHR11528. 1 hit.
Pfami PF00183. HSP90. 1 hit.
[Graphical view ]
PIRSFi PIRSF002583. Hsp90. 1 hit.
PRINTSi PR00775. HEATSHOCK90.
SMARTi SM00387. HATPase_c. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryonic stem cell, Kidney and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 391-404, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-264; LYS-326; LYS-426 AND LYS-433, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTRAP1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQN1
Secondary accession number(s): Q542I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3