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Protein
Submitted name:

60S ribosomal protein L21

Gene

Rpl21

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: MGI
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal proteinImported

Enzyme and pathway databases

ReactomeiREACT_279505. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_292264. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_302277. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_308559. Formation of a pool of free 40S subunits.
REACT_311765. Peptide chain elongation.
REACT_319670. Eukaryotic Translation Termination.
REACT_331340. SRP-dependent cotranslational protein targeting to membrane.
REACT_340387. L13a-mediated translational silencing of Ceruloplasmin expression.

Names & Taxonomyi

Protein namesi
Submitted name:
60S ribosomal protein L21Imported
Submitted name:
MCG120646Imported
Submitted name:
MCG121646, isoform CRA_aImported
Submitted name:
MCG121688Imported
Submitted name:
MCG18971Imported
Submitted name:
Ribosomal protein L21Imported
Submitted name:
Rpl21 proteinImported
Gene namesi
Name:Rpl21Imported
ORF Names:mCG_120646Imported, mCG_121646Imported, mCG_121688Imported, mCG_18971Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1278340. Rpl21.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosolic large ribosomal subunit Source: MGI
  3. membrane Source: MGI
  4. nucleolus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9CQM8.

Interactioni

Protein-protein interaction databases

MINTiMINT-4124952.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2139.
GeneTreeiENSGT00390000001293.
HOVERGENiHBG001518.
KOiK02889.
OMAiGTGTIQK.
OrthoDBiEOG7Z3F60.
TreeFamiTF314640.

Family and domain databases

Gene3Di2.30.30.70. 1 hit.
InterProiIPR001147. Ribosomal_L21e.
IPR018259. Ribosomal_L21e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR20981. PTHR20981. 1 hit.
PfamiPF01157. Ribosomal_L21e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01171. RIBOSOMAL_L21E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK
60 70 80 90 100
GMPHKCYHGK TGRVYNVTQH AVGIIVNKQV KGKILAKRIN VRIEHIKHSK
110 120 130 140 150
SRDSFLKRVK ENDQKKKEAK EKGTWVQLKR QPAPPREAHF VRTNGKEPEL
160
LEPIPYEFMA
Length:160
Mass (Da):18,579
Last modified:June 1, 2001 - v1
Checksum:i74F215B18EAFAC22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124828 Genomic DNA. No translation available.
BC086904 mRNA. Translation: AAH86904.1.
BC086905 mRNA. Translation: AAH86905.1.
BC086935 mRNA. Translation: AAH86935.1.
BC089582 mRNA. Translation: AAH89582.1.
BC090256 mRNA. Translation: AAH90256.1.
BC094410 mRNA. Translation: AAH94410.1.
BC096404 mRNA. Translation: AAH96404.1.
BC106116 mRNA. Translation: AAI06117.1.
BC138299 mRNA. Translation: AAI38300.1.
BC138300 mRNA. Translation: AAI38301.1.
AK002940 mRNA. Translation: BAB22470.1.
AK008457 mRNA. Translation: BAB25679.1.
AK018480 mRNA. Translation: BAB31230.1.
AK146440 mRNA. Translation: BAE27174.1.
AK168998 mRNA. Translation: BAE40797.1.
CH466614 Genomic DNA. Translation: EDL05813.1.
CH466614 Genomic DNA. Translation: EDL05816.1.
CH466641 Genomic DNA. Translation: EDL07492.1.
CH466570 Genomic DNA. Translation: EDL29058.1.
CH466545 Genomic DNA. Translation: EDL29396.1.
RefSeqiNP_062621.2. NM_019647.6.
XP_006504878.1. XM_006504815.2.
XP_006504879.1. XM_006504816.2.
UniGeneiMm.316592.
Mm.371575.
Mm.440507.

Genome annotation databases

EnsembliENSMUST00000035983; ENSMUSP00000041652; ENSMUSG00000041453.
ENSMUST00000075453; ENSMUSP00000106213; ENSMUSG00000041453.
ENSMUST00000099272; ENSMUSP00000106211; ENSMUSG00000041453.
GeneIDi19933.
KEGGimmu:19933.
UCSCiuc009ank.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124828 Genomic DNA. No translation available.
BC086904 mRNA. Translation: AAH86904.1.
BC086905 mRNA. Translation: AAH86905.1.
BC086935 mRNA. Translation: AAH86935.1.
BC089582 mRNA. Translation: AAH89582.1.
BC090256 mRNA. Translation: AAH90256.1.
BC094410 mRNA. Translation: AAH94410.1.
BC096404 mRNA. Translation: AAH96404.1.
BC106116 mRNA. Translation: AAI06117.1.
BC138299 mRNA. Translation: AAI38300.1.
BC138300 mRNA. Translation: AAI38301.1.
AK002940 mRNA. Translation: BAB22470.1.
AK008457 mRNA. Translation: BAB25679.1.
AK018480 mRNA. Translation: BAB31230.1.
AK146440 mRNA. Translation: BAE27174.1.
AK168998 mRNA. Translation: BAE40797.1.
CH466614 Genomic DNA. Translation: EDL05813.1.
CH466614 Genomic DNA. Translation: EDL05816.1.
CH466641 Genomic DNA. Translation: EDL07492.1.
CH466570 Genomic DNA. Translation: EDL29058.1.
CH466545 Genomic DNA. Translation: EDL29396.1.
RefSeqiNP_062621.2. NM_019647.6.
XP_006504878.1. XM_006504815.2.
XP_006504879.1. XM_006504816.2.
UniGeneiMm.316592.
Mm.371575.
Mm.440507.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4124952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035983; ENSMUSP00000041652; ENSMUSG00000041453.
ENSMUST00000075453; ENSMUSP00000106213; ENSMUSG00000041453.
ENSMUST00000099272; ENSMUSP00000106211; ENSMUSG00000041453.
GeneIDi19933.
KEGGimmu:19933.
UCSCiuc009ank.2. mouse.

Organism-specific databases

CTDi6144.
MGIiMGI:1278340. Rpl21.

Phylogenomic databases

eggNOGiCOG2139.
GeneTreeiENSGT00390000001293.
HOVERGENiHBG001518.
KOiK02889.
OMAiGTGTIQK.
OrthoDBiEOG7Z3F60.
TreeFamiTF314640.

Enzyme and pathway databases

ReactomeiREACT_279505. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_292264. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_302277. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_308559. Formation of a pool of free 40S subunits.
REACT_311765. Peptide chain elongation.
REACT_319670. Eukaryotic Translation Termination.
REACT_331340. SRP-dependent cotranslational protein targeting to membrane.
REACT_340387. L13a-mediated translational silencing of Ceruloplasmin expression.

Miscellaneous databases

NextBioi297441.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9CQM8.

Family and domain databases

Gene3Di2.30.30.70. 1 hit.
InterProiIPR001147. Ribosomal_L21e.
IPR018259. Ribosomal_L21e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR20981. PTHR20981. 1 hit.
PfamiPF01157. Ribosomal_L21e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01171. RIBOSOMAL_L21E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported and C57BL/6JImported.
    Tissue: AmnionImported, BrainImported, LungImported and Small intestineImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported and C57BL/6JImported.
    Tissue: AmnionImported, BrainImported, LungImported and Small intestineImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported and C57BL/6JImported.
    Tissue: AmnionImported, BrainImported, LungImported and Small intestineImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: BrainImported, LungImported and Small intestineImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported and C57BL/6JImported.
    Tissue: AmnionImported, BrainImported, LungImported and Small intestineImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported and C57BL/6JImported.
    Tissue: AmnionImported, BrainImported, LungImported and Small intestineImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported and Mix FVB/NImported.
    Tissue: BrainImported, HeartImported, KidneyImported, Mammary glandImported and Mammary tumor. WAP-TGF alpha model. 7 months oldImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: AmnionImported.
  11. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported and C57BL/6JImported.
    Tissue: AmnionImported, BrainImported, LungImported and Small intestineImported.
  12. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported and C57BL/6JImported.
    Tissue: AmnionImported, BrainImported, LungImported and Small intestineImported.
  13. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  15. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  16. Ensembl
    Submitted (MAY-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  17. Ensembl
    Submitted (JUN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9CQM8_MOUSE
AccessioniPrimary (citable) accession number: Q9CQM8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.