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Protein

ER lumen protein-retaining receptor 2

Gene

Kdelr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 2
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 2
Short name:
KDEL receptor 2
Gene namesi
Name:Kdelr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914163. Kdelr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 212CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941561 – 212ER lumen protein-retaining receptor 2Add BLAST212

Proteomic databases

MaxQBiQ9CQM2.
PaxDbiQ9CQM2.
PeptideAtlasiQ9CQM2.
PRIDEiQ9CQM2.

PTM databases

PhosphoSitePlusiQ9CQM2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000079111.
GenevisibleiQ9CQM2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106359.

Structurei

3D structure databases

ProteinModelPortaliQ9CQM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiQ9CQM2.
KOiK10949.
OMAiINWIWRF.
OrthoDBiEOG091G0Q1H.
PhylomeDBiQ9CQM2.
TreeFamiTF314792.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD
60 70 80 90 100
LFTSFISLYN TSMKLIYIAC SYATVYLIYM KFKATYDGNH DTFRVEFLVV
110 120 130 140 150
PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT
210
KVLKGKKLSL PA
Length:212
Mass (Da):24,454
Last modified:June 1, 2001 - v1
Checksum:i774388DAF56FEC24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278133 mRNA. Translation: CAC34585.1.
AK003515 mRNA. Translation: BAB22829.1.
AK007403 mRNA. Translation: BAB25016.1.
AK150402 mRNA. Translation: BAE29528.1.
CT010232 mRNA. Translation: CAJ18440.1.
BC007146 mRNA. Translation: AAH07146.1.
CCDSiCCDS39369.1.
RefSeqiNP_080117.1. NM_025841.4.
UniGeneiMm.181880.

Genome annotation databases

EnsembliENSMUST00000110731; ENSMUSP00000106359; ENSMUSG00000079111.
GeneIDi66913.
KEGGimmu:66913.
UCSCiuc009akh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278133 mRNA. Translation: CAC34585.1.
AK003515 mRNA. Translation: BAB22829.1.
AK007403 mRNA. Translation: BAB25016.1.
AK150402 mRNA. Translation: BAE29528.1.
CT010232 mRNA. Translation: CAJ18440.1.
BC007146 mRNA. Translation: AAH07146.1.
CCDSiCCDS39369.1.
RefSeqiNP_080117.1. NM_025841.4.
UniGeneiMm.181880.

3D structure databases

ProteinModelPortaliQ9CQM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106359.

PTM databases

PhosphoSitePlusiQ9CQM2.

Proteomic databases

MaxQBiQ9CQM2.
PaxDbiQ9CQM2.
PeptideAtlasiQ9CQM2.
PRIDEiQ9CQM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110731; ENSMUSP00000106359; ENSMUSG00000079111.
GeneIDi66913.
KEGGimmu:66913.
UCSCiuc009akh.2. mouse.

Organism-specific databases

CTDi11014.
MGIiMGI:1914163. Kdelr2.

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiQ9CQM2.
KOiK10949.
OMAiINWIWRF.
OrthoDBiEOG091G0Q1H.
PhylomeDBiQ9CQM2.
TreeFamiTF314792.

Enzyme and pathway databases

ReactomeiR-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ9CQM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079111.
GenevisibleiQ9CQM2. MM.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERD22_MOUSE
AccessioniPrimary (citable) accession number: Q9CQM2
Secondary accession number(s): Q4FK20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.