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Q9CQL7 (MOFA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MORF4 family-associated protein 1
Alternative name(s):
Protein associated with MRG of 14 kDa
Gene names
Name:Mrfap1
Synonyms:Pam14
ORF Names:MNCb-1039
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2. Ref.4 UniProtKB Q9Y605 UniProtKB Q5M820

Subcellular location

Nucleus By similarity. Cytoplasmperinuclear region By similarity. Note: Colocalizes with MORF4L1 to cell nuclei By similarity. UniProtKB Q9Y605

Tissue specificity

Widely expressed in all tissues examined and as early as 7 days during embryonic development. Ref.4

Disruption phenotype

Male mice are viable, fertile and show normal T-cell function. Ref.4

Sequence similarities

Belongs to the MORF4 family-associated protein family.

Sequence caution

The sequence BAB31978.1 differs from that shown. Reason: Frameshift at positions 115, 121 and 125.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction Ref.4. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 125125MORF4 family-associated protein 1
PRO_0000306177

Regions

Coiled coil94 – 12431 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9CQL7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7933E2FBCDAFF90E

FASTA12514,194
        10         20         30         40         50         60 
MRPLDAVELA EPEEVEVLEP EEDFEQFLLP VIHEMREDIA SLTRERGRAP ARNRGKLWEM 

        70         80         90        100        110        120 
DNMLIQIKTQ VEASEESALN HLQGAGGAEP RGPRAEKADE KAQEMAKMAE MLVQLVRRIE 


KSESS 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Blastocyst, Cecum, Dendritic cell, Embryo, Embryonic testis and Tongue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[4]"PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice."
Tominaga K., Magee D.M., Matzuk M.M., Pereira-Smith O.M.
Mol. Cell. Biol. 24:8366-8373(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB041651 mRNA. Translation: BAB93545.1.
AK009827 mRNA. Translation: BAB26527.1.
AK017832 mRNA. Translation: BAB30963.1.
AK018675 mRNA. Translation: BAB31337.1.
AK020049 mRNA. Translation: BAB31978.1. Frameshift.
AK159464 mRNA. Translation: BAE35105.1.
AK167112 mRNA. Translation: BAE39260.1.
AK170789 mRNA. Translation: BAE42029.1.
AK170909 mRNA. Translation: BAE42107.1.
AK170984 mRNA. Translation: BAE42158.1.
BC010209 mRNA. Translation: AAH10209.1.
CCDSCCDS19242.1.
RefSeqNP_080518.1. NM_026242.3.
UniGeneMm.332336.
Mm.490257.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212280. 1 interaction.
STRING10090.ENSMUSP00000067135.

PTM databases

PhosphoSiteQ9CQL7.

Proteomic databases

MaxQBQ9CQL7.
PaxDbQ9CQL7.
PRIDEQ9CQL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
GeneID67568.
KEGGmmu:67568.
UCSCuc008xfa.2. mouse.

Organism-specific databases

CTD93621.
MGIMGI:1914818. Mrfap1.

Phylogenomic databases

eggNOGNOG39174.
GeneTreeENSGT00510000048749.
HOGENOMHOG000070216.
HOVERGENHBG104090.
InParanoidQ9CQL7.
OMARATKRCE.
OrthoDBEOG7K6PXM.
PhylomeDBQ9CQL7.
TreeFamTF338232.

Gene expression databases

BgeeQ9CQL7.
CleanExMM_MRFAP1.
GenevestigatorQ9CQL7.

Family and domain databases

InterProIPR029254. MRFAP1.
[Graphical view]
PfamPF15155. MRFAP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio324933.
PROQ9CQL7.
SOURCESearch...

Entry information

Entry nameMOFA1_MOUSE
AccessionPrimary (citable) accession number: Q9CQL7
Secondary accession number(s): Q9CX68
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot