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Protein

MORF4 family-associated protein 1

Gene

Mrfap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORF4 family-associated protein 1
Alternative name(s):
Protein associated with MRG of 14 kDa
Gene namesi
Name:Mrfap1Imported
Synonyms:Pam14
ORF Names:MNCb-1039
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914818. Mrfap1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmperinuclear region By similarity

  • Note: Colocalizes with MORF4L1 to cell nuclei.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Male mice are viable, fertile and show normal T-cell function.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003061771 – 125MORF4 family-associated protein 1Add BLAST125

Proteomic databases

EPDiQ9CQL7.
MaxQBiQ9CQL7.
PaxDbiQ9CQL7.
PRIDEiQ9CQL7.

PTM databases

iPTMnetiQ9CQL7.
PhosphoSitePlusiQ9CQL7.

Expressioni

Tissue specificityi

Widely expressed in all tissues examined and as early as 7 days during embryonic development.1 Publication

Gene expression databases

BgeeiENSMUSG00000055302.
CleanExiMM_MRFAP1.
GenevisibleiQ9CQL7. MM.

Interactioni

Subunit structurei

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity1 Publication

Protein-protein interaction databases

BioGridi212280. 1 interactor.
IntActiQ9CQL7. 1 interactor.
STRINGi10090.ENSMUSP00000067135.

Structurei

3D structure databases

ProteinModelPortaliQ9CQL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 124Sequence analysisAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J03M. Eukaryota.
ENOG4111AYE. LUCA.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ9CQL7.
OMAiRGTKRCE.
OrthoDBiEOG091G10XY.
PhylomeDBiQ9CQL7.
TreeFamiTF338232.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLDAVELA EPEEVEVLEP EEDFEQFLLP VIHEMREDIA SLTRERGRAP
60 70 80 90 100
ARNRGKLWEM DNMLIQIKTQ VEASEESALN HLQGAGGAEP RGPRAEKADE
110 120
KAQEMAKMAE MLVQLVRRIE KSESS
Length:125
Mass (Da):14,194
Last modified:June 1, 2001 - v1
Checksum:i7933E2FBCDAFF90E
GO

Sequence cautioni

The sequence BAB31978 differs from that shown. Reason: Frameshift at positions 115, 121 and 125.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041651 mRNA. Translation: BAB93545.1.
AK009827 mRNA. Translation: BAB26527.1.
AK017832 mRNA. Translation: BAB30963.1.
AK018675 mRNA. Translation: BAB31337.1.
AK020049 mRNA. Translation: BAB31978.1. Frameshift.
AK159464 mRNA. Translation: BAE35105.1.
AK167112 mRNA. Translation: BAE39260.1.
AK170789 mRNA. Translation: BAE42029.1.
AK170909 mRNA. Translation: BAE42107.1.
AK170984 mRNA. Translation: BAE42158.1.
BC010209 mRNA. Translation: AAH10209.1.
CCDSiCCDS19242.1.
RefSeqiNP_080518.1. NM_026242.3.
UniGeneiMm.332336.
Mm.490257.

Genome annotation databases

EnsembliENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
GeneIDi67568.
KEGGimmu:67568.
UCSCiuc008xfa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041651 mRNA. Translation: BAB93545.1.
AK009827 mRNA. Translation: BAB26527.1.
AK017832 mRNA. Translation: BAB30963.1.
AK018675 mRNA. Translation: BAB31337.1.
AK020049 mRNA. Translation: BAB31978.1. Frameshift.
AK159464 mRNA. Translation: BAE35105.1.
AK167112 mRNA. Translation: BAE39260.1.
AK170789 mRNA. Translation: BAE42029.1.
AK170909 mRNA. Translation: BAE42107.1.
AK170984 mRNA. Translation: BAE42158.1.
BC010209 mRNA. Translation: AAH10209.1.
CCDSiCCDS19242.1.
RefSeqiNP_080518.1. NM_026242.3.
UniGeneiMm.332336.
Mm.490257.

3D structure databases

ProteinModelPortaliQ9CQL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212280. 1 interactor.
IntActiQ9CQL7. 1 interactor.
STRINGi10090.ENSMUSP00000067135.

PTM databases

iPTMnetiQ9CQL7.
PhosphoSitePlusiQ9CQL7.

Proteomic databases

EPDiQ9CQL7.
MaxQBiQ9CQL7.
PaxDbiQ9CQL7.
PRIDEiQ9CQL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
GeneIDi67568.
KEGGimmu:67568.
UCSCiuc008xfa.2. mouse.

Organism-specific databases

CTDi93621.
MGIiMGI:1914818. Mrfap1.

Phylogenomic databases

eggNOGiENOG410J03M. Eukaryota.
ENOG4111AYE. LUCA.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ9CQL7.
OMAiRGTKRCE.
OrthoDBiEOG091G10XY.
PhylomeDBiQ9CQL7.
TreeFamiTF338232.

Miscellaneous databases

PROiQ9CQL7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055302.
CleanExiMM_MRFAP1.
GenevisibleiQ9CQL7. MM.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOFA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQL7
Secondary accession number(s): Q9CX68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.