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Protein

MORF4 family-associated protein 1

Gene

Mrfap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORF4 family-associated protein 1
Alternative name(s):
Protein associated with MRG of 14 kDa
Gene namesi
Name:Mrfap1Imported
Synonyms:Pam14
ORF Names:MNCb-1039
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914818. Mrfap1.

Subcellular locationi

Nucleus By similarity. Cytoplasmperinuclear region By similarity
Note: Colocalizes with MORF4L1 to cell nuclei.By similarity

GO - Cellular componenti

  1. nucleoplasm Source: MGI
  2. nucleus Source: MGI
  3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Male mice are viable, fertile and show normal T-cell function.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125MORF4 family-associated protein 1PRO_0000306177Add
BLAST

Proteomic databases

MaxQBiQ9CQL7.
PaxDbiQ9CQL7.
PRIDEiQ9CQL7.

PTM databases

PhosphoSiteiQ9CQL7.

Expressioni

Tissue specificityi

Widely expressed in all tissues examined and as early as 7 days during embryonic development.1 Publication

Gene expression databases

BgeeiQ9CQL7.
CleanExiMM_MRFAP1.
GenevestigatoriQ9CQL7.

Interactioni

Subunit structurei

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity1 Publication

Protein-protein interaction databases

BioGridi212280. 1 interaction.
STRINGi10090.ENSMUSP00000067135.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili94 – 12431Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39174.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ9CQL7.
OMAiRATKRCE.
OrthoDBiEOG7K6PXM.
PhylomeDBiQ9CQL7.
TreeFamiTF338232.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLDAVELA EPEEVEVLEP EEDFEQFLLP VIHEMREDIA SLTRERGRAP
60 70 80 90 100
ARNRGKLWEM DNMLIQIKTQ VEASEESALN HLQGAGGAEP RGPRAEKADE
110 120
KAQEMAKMAE MLVQLVRRIE KSESS
Length:125
Mass (Da):14,194
Last modified:May 31, 2001 - v1
Checksum:i7933E2FBCDAFF90E
GO

Sequence cautioni

The sequence BAB31978.1 differs from that shown. Reason: Frameshift at positions 115, 121 and 125. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041651 mRNA. Translation: BAB93545.1.
AK009827 mRNA. Translation: BAB26527.1.
AK017832 mRNA. Translation: BAB30963.1.
AK018675 mRNA. Translation: BAB31337.1.
AK020049 mRNA. Translation: BAB31978.1. Frameshift.
AK159464 mRNA. Translation: BAE35105.1.
AK167112 mRNA. Translation: BAE39260.1.
AK170789 mRNA. Translation: BAE42029.1.
AK170909 mRNA. Translation: BAE42107.1.
AK170984 mRNA. Translation: BAE42158.1.
BC010209 mRNA. Translation: AAH10209.1.
CCDSiCCDS19242.1.
RefSeqiNP_080518.1. NM_026242.3.
UniGeneiMm.332336.
Mm.490257.

Genome annotation databases

EnsembliENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
GeneIDi67568.
KEGGimmu:67568.
UCSCiuc008xfa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041651 mRNA. Translation: BAB93545.1.
AK009827 mRNA. Translation: BAB26527.1.
AK017832 mRNA. Translation: BAB30963.1.
AK018675 mRNA. Translation: BAB31337.1.
AK020049 mRNA. Translation: BAB31978.1. Frameshift.
AK159464 mRNA. Translation: BAE35105.1.
AK167112 mRNA. Translation: BAE39260.1.
AK170789 mRNA. Translation: BAE42029.1.
AK170909 mRNA. Translation: BAE42107.1.
AK170984 mRNA. Translation: BAE42158.1.
BC010209 mRNA. Translation: AAH10209.1.
CCDSiCCDS19242.1.
RefSeqiNP_080518.1. NM_026242.3.
UniGeneiMm.332336.
Mm.490257.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212280. 1 interaction.
STRINGi10090.ENSMUSP00000067135.

PTM databases

PhosphoSiteiQ9CQL7.

Proteomic databases

MaxQBiQ9CQL7.
PaxDbiQ9CQL7.
PRIDEiQ9CQL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
GeneIDi67568.
KEGGimmu:67568.
UCSCiuc008xfa.2. mouse.

Organism-specific databases

CTDi93621.
MGIiMGI:1914818. Mrfap1.

Phylogenomic databases

eggNOGiNOG39174.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ9CQL7.
OMAiRATKRCE.
OrthoDBiEOG7K6PXM.
PhylomeDBiQ9CQL7.
TreeFamiTF338232.

Miscellaneous databases

NextBioi324933.
PROiQ9CQL7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQL7.
CleanExiMM_MRFAP1.
GenevestigatoriQ9CQL7.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported and NODImported.
    Tissue: BlastocystImported, CecumImported, Dendritic cellImported, EmbryoImported, Embryonic testisImported and TongueImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumorImported.
  4. "PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice."
    Tominaga K., Magee D.M., Matzuk M.M., Pereira-Smith O.M.
    Mol. Cell. Biol. 24:8366-8373(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiMOFA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQL7
Secondary accession number(s): Q9CX68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 2007
Last sequence update: May 31, 2001
Last modified: March 3, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.