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Q9CQL7

- MOFA1_MOUSE

UniProt

Q9CQL7 - MOFA1_MOUSE

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Protein

MORF4 family-associated protein 1

Gene

Mrfap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORF4 family-associated protein 1
Alternative name(s):
Protein associated with MRG of 14 kDa
Gene namesi
Name:Mrfap1Imported
Synonyms:Pam14
ORF Names:MNCb-1039
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1914818. Mrfap1.

Subcellular locationi

Nucleus By similarity. Cytoplasmperinuclear region By similarity
Note: Colocalizes with MORF4L1 to cell nuclei.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Male mice are viable, fertile and show normal T-cell function.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125MORF4 family-associated protein 1PRO_0000306177Add
BLAST

Proteomic databases

MaxQBiQ9CQL7.
PaxDbiQ9CQL7.
PRIDEiQ9CQL7.

PTM databases

PhosphoSiteiQ9CQL7.

Expressioni

Tissue specificityi

Widely expressed in all tissues examined and as early as 7 days during embryonic development.1 Publication

Gene expression databases

BgeeiQ9CQL7.
CleanExiMM_MRFAP1.
GenevestigatoriQ9CQL7.

Interactioni

Subunit structurei

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity1 Publication

Protein-protein interaction databases

BioGridi212280. 1 interaction.
STRINGi10090.ENSMUSP00000067135.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili94 – 12431Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39174.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ9CQL7.
OMAiRATKRCE.
OrthoDBiEOG7K6PXM.
PhylomeDBiQ9CQL7.
TreeFamiTF338232.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPLDAVELA EPEEVEVLEP EEDFEQFLLP VIHEMREDIA SLTRERGRAP
60 70 80 90 100
ARNRGKLWEM DNMLIQIKTQ VEASEESALN HLQGAGGAEP RGPRAEKADE
110 120
KAQEMAKMAE MLVQLVRRIE KSESS
Length:125
Mass (Da):14,194
Last modified:June 1, 2001 - v1
Checksum:i7933E2FBCDAFF90E
GO

Sequence cautioni

The sequence BAB31978.1 differs from that shown. Reason: Frameshift at positions 115, 121 and 125. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041651 mRNA. Translation: BAB93545.1.
AK009827 mRNA. Translation: BAB26527.1.
AK017832 mRNA. Translation: BAB30963.1.
AK018675 mRNA. Translation: BAB31337.1.
AK020049 mRNA. Translation: BAB31978.1. Frameshift.
AK159464 mRNA. Translation: BAE35105.1.
AK167112 mRNA. Translation: BAE39260.1.
AK170789 mRNA. Translation: BAE42029.1.
AK170909 mRNA. Translation: BAE42107.1.
AK170984 mRNA. Translation: BAE42158.1.
BC010209 mRNA. Translation: AAH10209.1.
CCDSiCCDS19242.1.
RefSeqiNP_080518.1. NM_026242.3.
UniGeneiMm.332336.
Mm.490257.

Genome annotation databases

EnsembliENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
GeneIDi67568.
KEGGimmu:67568.
UCSCiuc008xfa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041651 mRNA. Translation: BAB93545.1 .
AK009827 mRNA. Translation: BAB26527.1 .
AK017832 mRNA. Translation: BAB30963.1 .
AK018675 mRNA. Translation: BAB31337.1 .
AK020049 mRNA. Translation: BAB31978.1 . Frameshift.
AK159464 mRNA. Translation: BAE35105.1 .
AK167112 mRNA. Translation: BAE39260.1 .
AK170789 mRNA. Translation: BAE42029.1 .
AK170909 mRNA. Translation: BAE42107.1 .
AK170984 mRNA. Translation: BAE42158.1 .
BC010209 mRNA. Translation: AAH10209.1 .
CCDSi CCDS19242.1.
RefSeqi NP_080518.1. NM_026242.3.
UniGenei Mm.332336.
Mm.490257.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212280. 1 interaction.
STRINGi 10090.ENSMUSP00000067135.

PTM databases

PhosphoSitei Q9CQL7.

Proteomic databases

MaxQBi Q9CQL7.
PaxDbi Q9CQL7.
PRIDEi Q9CQL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068795 ; ENSMUSP00000067135 ; ENSMUSG00000055302 .
GeneIDi 67568.
KEGGi mmu:67568.
UCSCi uc008xfa.2. mouse.

Organism-specific databases

CTDi 93621.
MGIi MGI:1914818. Mrfap1.

Phylogenomic databases

eggNOGi NOG39174.
GeneTreei ENSGT00510000048749.
HOGENOMi HOG000070216.
HOVERGENi HBG104090.
InParanoidi Q9CQL7.
OMAi RATKRCE.
OrthoDBi EOG7K6PXM.
PhylomeDBi Q9CQL7.
TreeFami TF338232.

Miscellaneous databases

NextBioi 324933.
PROi Q9CQL7.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQL7.
CleanExi MM_MRFAP1.
Genevestigatori Q9CQL7.

Family and domain databases

InterProi IPR029254. MRFAP1.
[Graphical view ]
Pfami PF15155. MRFAP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported and NODImported.
    Tissue: BlastocystImported, CecumImported, Dendritic cellImported, EmbryoImported, Embryonic testisImported and TongueImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumorImported.
  4. "PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice."
    Tominaga K., Magee D.M., Matzuk M.M., Pereira-Smith O.M.
    Mol. Cell. Biol. 24:8366-8373(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiMOFA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQL7
Secondary accession number(s): Q9CX68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3