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Protein

MORF4 family-associated protein 1

Gene

Mrfap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORF4 family-associated protein 1
Alternative name(s):
Protein associated with MRG of 14 kDa
Gene namesi
Name:Mrfap1Imported
Synonyms:Pam14
ORF Names:MNCb-1039
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914818. Mrfap1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmperinuclear region By similarity

  • Note: Colocalizes with MORF4L1 to cell nuclei.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Male mice are viable, fertile and show normal T-cell function.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003061771 – 125MORF4 family-associated protein 1Add BLAST125

Proteomic databases

EPDiQ9CQL7.
MaxQBiQ9CQL7.
PaxDbiQ9CQL7.
PRIDEiQ9CQL7.

PTM databases

iPTMnetiQ9CQL7.
PhosphoSitePlusiQ9CQL7.

Expressioni

Tissue specificityi

Widely expressed in all tissues examined and as early as 7 days during embryonic development.1 Publication

Gene expression databases

BgeeiENSMUSG00000055302.
CleanExiMM_MRFAP1.
GenevisibleiQ9CQL7. MM.

Interactioni

Subunit structurei

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity1 Publication

Protein-protein interaction databases

BioGridi212280. 1 interactor.
IntActiQ9CQL7. 1 interactor.
STRINGi10090.ENSMUSP00000067135.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 124Sequence analysisAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J03M. Eukaryota.
ENOG4111AYE. LUCA.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ9CQL7.
OMAiRGTKRCE.
OrthoDBiEOG091G10XY.
PhylomeDBiQ9CQL7.
TreeFamiTF338232.

Family and domain databases

InterProiView protein in InterPro
IPR029254. MRFAP1.
PfamiView protein in Pfam
PF15155. MRFAP1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLDAVELA EPEEVEVLEP EEDFEQFLLP VIHEMREDIA SLTRERGRAP
60 70 80 90 100
ARNRGKLWEM DNMLIQIKTQ VEASEESALN HLQGAGGAEP RGPRAEKADE
110 120
KAQEMAKMAE MLVQLVRRIE KSESS
Length:125
Mass (Da):14,194
Last modified:June 1, 2001 - v1
Checksum:i7933E2FBCDAFF90E
GO

Sequence cautioni

The sequence BAB31978 differs from that shown. Reason: Frameshift at positions 115, 121 and 125.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041651 mRNA. Translation: BAB93545.1.
AK009827 mRNA. Translation: BAB26527.1.
AK017832 mRNA. Translation: BAB30963.1.
AK018675 mRNA. Translation: BAB31337.1.
AK020049 mRNA. Translation: BAB31978.1. Frameshift.
AK159464 mRNA. Translation: BAE35105.1.
AK167112 mRNA. Translation: BAE39260.1.
AK170789 mRNA. Translation: BAE42029.1.
AK170909 mRNA. Translation: BAE42107.1.
AK170984 mRNA. Translation: BAE42158.1.
BC010209 mRNA. Translation: AAH10209.1.
CCDSiCCDS19242.1.
RefSeqiNP_080518.1. NM_026242.3.
UniGeneiMm.332336.
Mm.490257.

Genome annotation databases

EnsembliENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
GeneIDi67568.
KEGGimmu:67568.
UCSCiuc008xfa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041651 mRNA. Translation: BAB93545.1.
AK009827 mRNA. Translation: BAB26527.1.
AK017832 mRNA. Translation: BAB30963.1.
AK018675 mRNA. Translation: BAB31337.1.
AK020049 mRNA. Translation: BAB31978.1. Frameshift.
AK159464 mRNA. Translation: BAE35105.1.
AK167112 mRNA. Translation: BAE39260.1.
AK170789 mRNA. Translation: BAE42029.1.
AK170909 mRNA. Translation: BAE42107.1.
AK170984 mRNA. Translation: BAE42158.1.
BC010209 mRNA. Translation: AAH10209.1.
CCDSiCCDS19242.1.
RefSeqiNP_080518.1. NM_026242.3.
UniGeneiMm.332336.
Mm.490257.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212280. 1 interactor.
IntActiQ9CQL7. 1 interactor.
STRINGi10090.ENSMUSP00000067135.

PTM databases

iPTMnetiQ9CQL7.
PhosphoSitePlusiQ9CQL7.

Proteomic databases

EPDiQ9CQL7.
MaxQBiQ9CQL7.
PaxDbiQ9CQL7.
PRIDEiQ9CQL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
GeneIDi67568.
KEGGimmu:67568.
UCSCiuc008xfa.2. mouse.

Organism-specific databases

CTDi93621.
MGIiMGI:1914818. Mrfap1.

Phylogenomic databases

eggNOGiENOG410J03M. Eukaryota.
ENOG4111AYE. LUCA.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ9CQL7.
OMAiRGTKRCE.
OrthoDBiEOG091G10XY.
PhylomeDBiQ9CQL7.
TreeFamiTF338232.

Miscellaneous databases

PROiPR:Q9CQL7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055302.
CleanExiMM_MRFAP1.
GenevisibleiQ9CQL7. MM.

Family and domain databases

InterProiView protein in InterPro
IPR029254. MRFAP1.
PfamiView protein in Pfam
PF15155. MRFAP1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOFA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQL7
Secondary accession number(s): Q9CX68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.