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Q9CQL7

- MOFA1_MOUSE

UniProt

Q9CQL7 - MOFA1_MOUSE

Protein

MORF4 family-associated protein 1

Gene

Mrfap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MORF4 family-associated protein 1
    Alternative name(s):
    Protein associated with MRG of 14 kDa
    Gene namesi
    Name:Mrfap1Imported
    Synonyms:Pam14
    ORF Names:MNCb-1039
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1914818. Mrfap1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmperinuclear region By similarity
    Note: Colocalizes with MORF4L1 to cell nuclei.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Male mice are viable, fertile and show normal T-cell function.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 125125MORF4 family-associated protein 1PRO_0000306177Add
    BLAST

    Proteomic databases

    MaxQBiQ9CQL7.
    PaxDbiQ9CQL7.
    PRIDEiQ9CQL7.

    PTM databases

    PhosphoSiteiQ9CQL7.

    Expressioni

    Tissue specificityi

    Widely expressed in all tissues examined and as early as 7 days during embryonic development.1 Publication

    Gene expression databases

    BgeeiQ9CQL7.
    CleanExiMM_MRFAP1.
    GenevestigatoriQ9CQL7.

    Interactioni

    Subunit structurei

    Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi212280. 1 interaction.
    STRINGi10090.ENSMUSP00000067135.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili94 – 12431Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39174.
    GeneTreeiENSGT00510000048749.
    HOGENOMiHOG000070216.
    HOVERGENiHBG104090.
    InParanoidiQ9CQL7.
    OMAiRATKRCE.
    OrthoDBiEOG7K6PXM.
    PhylomeDBiQ9CQL7.
    TreeFamiTF338232.

    Family and domain databases

    InterProiIPR029254. MRFAP1.
    [Graphical view]
    PfamiPF15155. MRFAP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CQL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPLDAVELA EPEEVEVLEP EEDFEQFLLP VIHEMREDIA SLTRERGRAP    50
    ARNRGKLWEM DNMLIQIKTQ VEASEESALN HLQGAGGAEP RGPRAEKADE 100
    KAQEMAKMAE MLVQLVRRIE KSESS 125
    Length:125
    Mass (Da):14,194
    Last modified:June 1, 2001 - v1
    Checksum:i7933E2FBCDAFF90E
    GO

    Sequence cautioni

    The sequence BAB31978.1 differs from that shown. Reason: Frameshift at positions 115, 121 and 125.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041651 mRNA. Translation: BAB93545.1.
    AK009827 mRNA. Translation: BAB26527.1.
    AK017832 mRNA. Translation: BAB30963.1.
    AK018675 mRNA. Translation: BAB31337.1.
    AK020049 mRNA. Translation: BAB31978.1. Frameshift.
    AK159464 mRNA. Translation: BAE35105.1.
    AK167112 mRNA. Translation: BAE39260.1.
    AK170789 mRNA. Translation: BAE42029.1.
    AK170909 mRNA. Translation: BAE42107.1.
    AK170984 mRNA. Translation: BAE42158.1.
    BC010209 mRNA. Translation: AAH10209.1.
    CCDSiCCDS19242.1.
    RefSeqiNP_080518.1. NM_026242.3.
    UniGeneiMm.332336.
    Mm.490257.

    Genome annotation databases

    EnsembliENSMUST00000068795; ENSMUSP00000067135; ENSMUSG00000055302.
    GeneIDi67568.
    KEGGimmu:67568.
    UCSCiuc008xfa.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041651 mRNA. Translation: BAB93545.1 .
    AK009827 mRNA. Translation: BAB26527.1 .
    AK017832 mRNA. Translation: BAB30963.1 .
    AK018675 mRNA. Translation: BAB31337.1 .
    AK020049 mRNA. Translation: BAB31978.1 . Frameshift.
    AK159464 mRNA. Translation: BAE35105.1 .
    AK167112 mRNA. Translation: BAE39260.1 .
    AK170789 mRNA. Translation: BAE42029.1 .
    AK170909 mRNA. Translation: BAE42107.1 .
    AK170984 mRNA. Translation: BAE42158.1 .
    BC010209 mRNA. Translation: AAH10209.1 .
    CCDSi CCDS19242.1.
    RefSeqi NP_080518.1. NM_026242.3.
    UniGenei Mm.332336.
    Mm.490257.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212280. 1 interaction.
    STRINGi 10090.ENSMUSP00000067135.

    PTM databases

    PhosphoSitei Q9CQL7.

    Proteomic databases

    MaxQBi Q9CQL7.
    PaxDbi Q9CQL7.
    PRIDEi Q9CQL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068795 ; ENSMUSP00000067135 ; ENSMUSG00000055302 .
    GeneIDi 67568.
    KEGGi mmu:67568.
    UCSCi uc008xfa.2. mouse.

    Organism-specific databases

    CTDi 93621.
    MGIi MGI:1914818. Mrfap1.

    Phylogenomic databases

    eggNOGi NOG39174.
    GeneTreei ENSGT00510000048749.
    HOGENOMi HOG000070216.
    HOVERGENi HBG104090.
    InParanoidi Q9CQL7.
    OMAi RATKRCE.
    OrthoDBi EOG7K6PXM.
    PhylomeDBi Q9CQL7.
    TreeFami TF338232.

    Miscellaneous databases

    NextBioi 324933.
    PROi Q9CQL7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQL7.
    CleanExi MM_MRFAP1.
    Genevestigatori Q9CQL7.

    Family and domain databases

    InterProi IPR029254. MRFAP1.
    [Graphical view ]
    Pfami PF15155. MRFAP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
      Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported and NODImported.
      Tissue: BlastocystImported, CecumImported, Dendritic cellImported, EmbryoImported, Embryonic testisImported and TongueImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumorImported.
    4. "PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice."
      Tominaga K., Magee D.M., Matzuk M.M., Pereira-Smith O.M.
      Mol. Cell. Biol. 24:8366-8373(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiMOFA1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQL7
    Secondary accession number(s): Q9CX68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3