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Protein

39S ribosomal protein L18, mitochondrial

Gene

Mrpl18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Ribonucleoprotein, Ribosomal protein, RNA-binding
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L18, mitochondrial
Short name:
L18mt
Short name:
MRP-L18
Gene namesi
Name:Mrpl18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914931 Mrpl18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030557? – 18039S ribosomal protein L18, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9CQL5
MaxQBiQ9CQL5
PaxDbiQ9CQL5
PeptideAtlasiQ9CQL5
PRIDEiQ9CQL5

PTM databases

PhosphoSitePlusiQ9CQL5

Expressioni

Gene expression databases

BgeeiENSMUSG00000057388
CleanExiMM_MRPL18
GenevisibleiQ9CQL5 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078123

Structurei

3D structure databases

ProteinModelPortaliQ9CQL5
SMRiQ9CQL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3333 Eukaryota
ENOG4111MCR LUCA
GeneTreeiENSGT00390000006394
HOGENOMiHOG000043958
HOVERGENiHBG001529
InParanoidiQ9CQL5
KOiK02881
OMAiSTSEWAI
OrthoDBiEOG091G0P8F
PhylomeDBiQ9CQL5
TreeFamiTF313292

Family and domain databases

Gene3Di3.30.420.80, 1 hit
InterProiView protein in InterPro
IPR005484 Ribosomal_L18
IPR036967 Ribosomal_S11_sf
PANTHERiPTHR12899 PTHR12899, 1 hit
PfamiView protein in Pfam
PF00861 Ribosomal_L18p, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRPRFWKC LSVCRKLECG FAALSTSSVP AVQPDVESKE NEAVAPEFTN
60 70 80 90 100
RNPRNLELLG VARKERGWAT VWPNREFWHR LRVVKTQHHV EAFVEHLNGQ
110 120 130 140 150
VVVSASTREW AIKKHLYSTR NVVACESIGR VLAQRCLEAG INFMVYQPTP
160 170 180
WEASSDSIKR LQNAMTESGV MLREPRRIYE
Length:180
Mass (Da):20,677
Last modified:June 1, 2001 - v1
Checksum:i7B7759EF8A5315DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29V → A in BAB26735 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003104 mRNA Translation: BAB22567.1
AK008680 mRNA Translation: BAB25828.1
AK010150 mRNA Translation: BAB26735.1
BC011425 mRNA Translation: AAH11425.1
CCDSiCCDS28396.1
RefSeqiNP_080586.1, NM_026310.3
UniGeneiMm.290166

Genome annotation databases

EnsembliENSMUST00000079121; ENSMUSP00000078123; ENSMUSG00000057388
GeneIDi67681
KEGGimmu:67681
UCSCiuc008alj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRM18_MOUSE
AccessioniPrimary (citable) accession number: Q9CQL5
Secondary accession number(s): Q9D6N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health