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Protein

Protein N-lysine methyltransferase METTL21A

Gene

Mettl21A

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei47S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei94S-adenosyl-L-methionineBy similarity1
Binding sitei125S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei143S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-MMU-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N-lysine methyltransferase METTL21A (EC:2.1.1.-)
Alternative name(s):
Methyltransferase-like protein 21A
Gene namesi
Name:Mettl21A
Synonyms:Fam119a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914349 Mettl21a

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920341 – 218Protein N-lysine methyltransferase METTL21AAdd BLAST218

Proteomic databases

EPDiQ9CQL0
MaxQBiQ9CQL0
PaxDbiQ9CQL0
PeptideAtlasiQ9CQL0
PRIDEiQ9CQL0

PTM databases

PhosphoSitePlusiQ9CQL0

Expressioni

Gene expression databases

BgeeiENSMUSG00000025956
GenevisibleiQ9CQL0 MM

Interactioni

Subunit structurei

Interacts with heat shock 70 family members; these proteins probably are methylation substrates.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050424

Structurei

3D structure databases

ProteinModelPortaliQ9CQL0
SMRiQ9CQL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 75S-adenosyl-L-methionine bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2793 Eukaryota
ENOG4111IJ0 LUCA
GeneTreeiENSGT00550000074572
HOVERGENiHBG059353
InParanoidiQ9CQL0
KOiK21804
OMAiHIYKAQR
OrthoDBiEOG091G0NXA
PhylomeDBiQ9CQL0
TreeFamiTF313206

Family and domain databases

InterProiView protein in InterPro
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVPYEESA AIGLQKFHKP LATFSFANHT IQIRQDWRQL GVAAVVWDAA
60 70 80 90 100
VVLSMYLEMG AVELRGCSAV ELGAGTGLVG IVAALLGAQV TITDRKVALE
110 120 130 140 150
FLKSNVEANL PPHIQPKAVV KELTWGQNLE SFSPGEFDLI LGADVIYLED
160 170 180 190 200
TFTDLLQTLG HLCSNNSVIL LACRIRYERD SNFLTMLERQ FTVSKVHYDP
210
EKDVHIYKAQ KRNQREDL
Length:218
Mass (Da):24,286
Last modified:June 1, 2001 - v1
Checksum:i7CAFEA691B90195A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86L → P in AAH26952 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009673 mRNA Translation: BAB26430.1
AK009675 mRNA Translation: BAB26431.1
AK009678 mRNA Translation: BAB26434.1
AK009679 mRNA Translation: BAB26435.1
AK009680 mRNA Translation: BAB26436.1
AK009682 mRNA Translation: BAB26437.1
AK011433 mRNA Translation: BAB27618.1
AK033578 mRNA Translation: BAC28371.1
BC026952 mRNA Translation: AAH26952.1
CCDSiCCDS15006.1
RefSeqiNP_080240.1, NM_025964.3
XP_006496266.1, XM_006496203.3
XP_006496267.1, XM_006496204.3
UniGeneiMm.46394

Genome annotation databases

EnsembliENSMUST00000053469; ENSMUSP00000050424; ENSMUSG00000025956
ENSMUST00000114079; ENSMUSP00000109713; ENSMUSG00000025956
GeneIDi67099
KEGGimmu:67099
UCSCiuc007bgu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMT21A_MOUSE
AccessioniPrimary (citable) accession number: Q9CQL0
Secondary accession number(s): Q8R2Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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