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Protein

RWD domain-containing protein 1

Gene

Rwdd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protects DRG2 from proteolytic degradation.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 1
Alternative name(s):
DRG family-regulatory protein 2
IH1
Gene namesi
Name:Rwdd1
Synonyms:Dfrp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913771. Rwdd1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 243242RWD domain-containing protein 1PRO_0000097541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei144 – 1441PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQK7.
MaxQBiQ9CQK7.
PaxDbiQ9CQK7.
PRIDEiQ9CQK7.

PTM databases

iPTMnetiQ9CQK7.
PhosphoSiteiQ9CQK7.

Expressioni

Gene expression databases

BgeeiQ9CQK7.
CleanExiMM_RWDD1.
GenevisibleiQ9CQK7. MM.

Interactioni

Subunit structurei

Interacts with androgen receptor (By similarity). Interacts with DRG2.By similarity1 Publication

Protein-protein interaction databases

BioGridi211532. 2 interactions.
IntActiQ9CQK7. 2 interactions.
MINTiMINT-4133533.
STRINGi10090.ENSMUSP00000019917.

Structurei

3D structure databases

DisProtiDP00587.
ProteinModelPortaliQ9CQK7.
SMRiQ9CQK7. Positions 1-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 114105RWDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni142 – 19756Interaction with DRG2Add
BLAST

Sequence similaritiesi

Belongs to the RWDD1/GIR2 family.Curated
Contains 1 RWD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4018. Eukaryota.
ENOG410XT0M. LUCA.
GeneTreeiENSGT00390000009168.
HOGENOMiHOG000237961.
HOVERGENiHBG060864.
InParanoidiQ9CQK7.
OMAiPPLWEIY.
OrthoDBiEOG779NZV.
PhylomeDBiQ9CQK7.
TreeFamiTF313662.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR032378. ZC3H15/TMA46_C.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDYGEEQRN ELEALESIYP DSFTVLSESP PSFTITVTSE AGENDETVQT
60 70 80 90 100
TLKFTYSEKY PDETPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI
110 120 130 140 150
FTLVTAVQEK LNEIVDQIKT RREEEKKQKE KEAEEAEKKL FHGTPVTIEN
160 170 180 190 200
FLSWKAKFDA ELLEIKKKRM KEEEQAGKNK LSGKQLFETD HNLDTSDIQF
210 220 230 240
LEDAGNNVEV DESLFQEMDD LELEDGEDDP DYNPVAPGSD SSD
Length:243
Mass (Da):27,785
Last modified:June 1, 2001 - v1
Checksum:i7CF857F6CC055F65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503942 mRNA. Translation: AAM27457.1.
AK003262 mRNA. Translation: BAB22678.2. Sequence problems.
AK005278 mRNA. Translation: BAB23927.1.
AK011277 mRNA. Translation: BAB27511.1.
BC062136 mRNA. Translation: AAH62136.1.
CCDSiCCDS23773.1.
RefSeqiNP_079890.1. NM_025614.3.
UniGeneiMm.28528.

Genome annotation databases

EnsembliENSMUST00000019917; ENSMUSP00000019917; ENSMUSG00000019782.
GeneIDi66521.
KEGGimmu:66521.
UCSCiuc007eun.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503942 mRNA. Translation: AAM27457.1.
AK003262 mRNA. Translation: BAB22678.2. Sequence problems.
AK005278 mRNA. Translation: BAB23927.1.
AK011277 mRNA. Translation: BAB27511.1.
BC062136 mRNA. Translation: AAH62136.1.
CCDSiCCDS23773.1.
RefSeqiNP_079890.1. NM_025614.3.
UniGeneiMm.28528.

3D structure databases

DisProtiDP00587.
ProteinModelPortaliQ9CQK7.
SMRiQ9CQK7. Positions 1-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211532. 2 interactions.
IntActiQ9CQK7. 2 interactions.
MINTiMINT-4133533.
STRINGi10090.ENSMUSP00000019917.

PTM databases

iPTMnetiQ9CQK7.
PhosphoSiteiQ9CQK7.

Proteomic databases

EPDiQ9CQK7.
MaxQBiQ9CQK7.
PaxDbiQ9CQK7.
PRIDEiQ9CQK7.

Protocols and materials databases

DNASUi66521.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019917; ENSMUSP00000019917; ENSMUSG00000019782.
GeneIDi66521.
KEGGimmu:66521.
UCSCiuc007eun.1. mouse.

Organism-specific databases

CTDi51389.
MGIiMGI:1913771. Rwdd1.

Phylogenomic databases

eggNOGiKOG4018. Eukaryota.
ENOG410XT0M. LUCA.
GeneTreeiENSGT00390000009168.
HOGENOMiHOG000237961.
HOVERGENiHBG060864.
InParanoidiQ9CQK7.
OMAiPPLWEIY.
OrthoDBiEOG779NZV.
PhylomeDBiQ9CQK7.
TreeFamiTF313662.

Miscellaneous databases

ChiTaRSiRwdd1. mouse.
NextBioi321924.
PROiQ9CQK7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQK7.
CleanExiMM_RWDD1.
GenevisibleiQ9CQK7. MM.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR032378. ZC3H15/TMA46_C.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene associated with murine thymus atrophy."
    Li C., Li Y., He W.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Thymus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.
  4. "Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2."
    Ishikawa K., Azuma S., Ikawa S., Semba K., Inoue J.
    Genes Cells 10:139-150(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DRG2, FUNCTION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiRWDD1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.