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Protein

RAD52 motif-containing protein 1

Gene

Rdm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RAD52 motif-containing protein 1
Gene namesi
Name:Rdm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913849. Rdm1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995301 – 281RAD52 motif-containing protein 1Add BLAST281

Proteomic databases

PaxDbiQ9CQK3.
PRIDEiQ9CQK3.

PTM databases

PhosphoSitePlusiQ9CQK3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000010362.
CleanExiMM_RDM1.
ExpressionAtlasiQ9CQK3. baseline and differential.
GenevisibleiQ9CQK3. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010506.

Structurei

3D structure databases

ProteinModelPortaliQ9CQK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 98RRMPROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 92Necessary for nuclear localization and for nucleolar accumulation in response to heat shockBy similarityAdd BLAST92
Regioni90 – 133Necessary for nuclear and nucleolar localizationBy similarityAdd BLAST44

Domaini

C-terminal half contains cytoplasmic retention domains as well as determinants involved in its stress-induced nucleolar accumulation.By similarity

Phylogenomic databases

eggNOGiENOG410IFY2. Eukaryota.
ENOG41123Y3. LUCA.
GeneTreeiENSGT00390000018397.
HOGENOMiHOG000015383.
HOVERGENiHBG105575.
InParanoidiQ9CQK3.
KOiK10874.
OMAiYDCRSPG.
OrthoDBiEOG091G0J48.
PhylomeDBiQ9CQK3.
TreeFamiTF101222.

Family and domain databases

CDDicd12364. RRM_RDM1. 1 hit.
InterProiView protein in InterPro
IPR035979. RBD_domain_sf.
IPR034200. RDM1_RRM.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CQK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELISFVVP TQSDKVLLVW DLSTGPPAEA LSHSLFTVFS QFGLLYSVRV
60 70 80 90 100
FPNAAVARPG FYAIIKFYSS RDAQRAQKAC DGKPLFQTSP VKVRLGTRHK
110 120 130 140 150
ALQHQAFALN SSRCQELANY YFGFSGWSKR IIKLQELSGL EDAALAVPMQ
160 170 180 190 200
KGSPQFLCAV EVVLPPYGCR SPGVGISEEP LRQLEEGQSS FLMKRKTAQK
210 220 230 240 250
LAFQAAVSDA FQKLTIVVLE SGRIAVEYRP TAEDLDARSE EELQNLIQVS
260 270 280
CSSWSQSSQR EEECLSDFSL EEEDLKLCDP H
Length:281
Mass (Da):31,235
Last modified:June 1, 2001 - v1
Checksum:i7FDB5CB5F2579CCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003135 mRNA. Translation: BAB22595.1.
AK010457 mRNA. Translation: BAB26954.1.
AL590994 Genomic DNA. Translation: CAM22639.1.
BC026811 mRNA. Translation: AAH26811.1.
BC055013 mRNA. Translation: AAH55013.1.
CCDSiCCDS25477.1.
RefSeqiNP_079930.1. NM_025654.2.
UniGeneiMm.41449.

Genome annotation databases

EnsembliENSMUST00000010506; ENSMUSP00000010506; ENSMUSG00000010362.
GeneIDi66599.
KEGGimmu:66599.
UCSCiuc007lpp.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRDM1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot