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Protein

Zinc finger HIT domain-containing protein 3

Gene

Znhit3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 42HIT-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger HIT domain-containing protein 3
Alternative name(s):
Thyroid hormone receptor interactor 3
Thyroid receptor-interacting protein 3
Short name:
TR-interacting protein 3
Short name:
TRIP-3
Gene namesi
Name:Znhit3
Synonyms:Trip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3051596 Znhit3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735521 – 151Zinc finger HIT domain-containing protein 3Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CQK1
MaxQBiQ9CQK1
PaxDbiQ9CQK1
PeptideAtlasiQ9CQK1
PRIDEiQ9CQK1

PTM databases

iPTMnetiQ9CQK1
PhosphoSitePlusiQ9CQK1

Expressioni

Tissue specificityi

Expressed in the cerebellum.1 Publication

Developmental stagei

Detected in proliferating fetal granule cell precursors at embryonic day 16.5, in proliferating and post-mitotic granule cells at postnatal days 3 and 10. Expression in cerebellar Purkinje cells is strong at postnatal days 10 and 21.1 Publication

Gene expression databases

BgeeiENSMUSG00000020526
CleanExiMM_ZNHIT3
GenevisibleiQ9CQK1 MM

Interactioni

Subunit structurei

Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction (By similarity). Interacts with NUFIP1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099484

Structurei

3D structure databases

ProteinModelPortaliQ9CQK1
SMRiQ9CQK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 42HIT-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2857 Eukaryota
ENOG41123YY LUCA
GeneTreeiENSGT00390000010822
HOGENOMiHOG000230732
HOVERGENiHBG055775
InParanoidiQ9CQK1
OMAiKCSAPYC
OrthoDBiEOG091G0VWN
PhylomeDBiQ9CQK1
TreeFamiTF324673

Family and domain databases

InterProiView protein in InterPro
IPR007529 Znf_HIT
PfamiView protein in Pfam
PF04438 zf-HIT, 1 hit
PROSITEiView protein in PROSITE
PS51083 ZF_HIT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLNCRTAV CVVCLEKPKY RCPTCRVPYC SVPCFQKHKE QCSSEARPVE
60 70 80 90 100
KRRAGPPVRS EESKDDDSSV ADFLNSDEEE DRVSLQNLKN LGESETLRSL
110 120 130 140 150
LLNPHLRQLM ISLDQGDNKA KLMRACMQEP LFVEFADCCL GIVEPSQKRD

S
Length:151
Mass (Da):17,068
Last modified:June 1, 2001 - v1
Checksum:i8047204E2072EFE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014350 mRNA Translation: BAB29291.1
AK002888 mRNA Translation: BAB22434.1
AK003721 mRNA Translation: BAB22958.1
AK004259 mRNA Translation: BAB23239.1
AL645623 Genomic DNA No translation available.
CCDSiCCDS25189.1
RefSeqiNP_001005223.1, NM_001005223.2
UniGeneiMm.379733

Genome annotation databases

EnsembliENSMUST00000103195; ENSMUSP00000099484; ENSMUSG00000020526
GeneIDi448850
KEGGimmu:448850
UCSCiuc007kre.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZNHI3_MOUSE
AccessioniPrimary (citable) accession number: Q9CQK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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