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Protein

Density-regulated protein

Gene

Denr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Density-regulated protein
Short name:
DRP
Gene namesi
Name:Denr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915434. Denr.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001306012 – 198Density-regulated proteinAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei20PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei189PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQJ6.
MaxQBiQ9CQJ6.
PaxDbiQ9CQJ6.
PeptideAtlasiQ9CQJ6.
PRIDEiQ9CQJ6.

PTM databases

iPTMnetiQ9CQJ6.
PhosphoSitePlusiQ9CQJ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023106.
CleanExiMM_DENR.
ExpressionAtlasiQ9CQJ6. baseline and differential.
GenevisibleiQ9CQJ6. MM.

Interactioni

Subunit structurei

Interacts with MCTS1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023869.

Structurei

3D structure databases

ProteinModelPortaliQ9CQJ6.
SMRiQ9CQJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 182SUI1PROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the DENR family.Curated
Contains 1 SUI1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3239. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000014349.
HOGENOMiHOG000237611.
HOVERGENiHBG005471.
InParanoidiQ9CQJ6.
OMAiSGGHDCK.
OrthoDBiEOG091G0R9X.
PhylomeDBiQ9CQJ6.
TreeFamiTF105912.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005873. Drp1.
IPR001950. SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SUPFAMiSSF55159. SSF55159. 2 hits.
TIGRFAMsiTIGR01159. DRP1. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDISESSG ADCKGDTKNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV
60 70 80 90 100
AKCRQWLEKN FPNEFAKLTV ENSPKQETGI TEGQGPVGEE EEKKKQKRGG
110 120 130 140 150
RGQIKQKKKT VPQKVTIAKI PRAKKKYVTR VCGLATFEID LKEAQRFFAQ
160 170 180 190
KFSCGASVTG EDEIIIQGDF TDDIIDVIQE KWPEVDDDSI EDLGEVKK
Length:198
Mass (Da):22,166
Last modified:April 27, 2001 - v1
Checksum:i8482AA9E13E27A10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017647 mRNA. Translation: BAB30854.1.
AK018762 mRNA. Translation: BAB31392.1.
AK135127 mRNA. Translation: BAE22432.1.
BC043922 mRNA. Translation: AAH43922.1.
CCDSiCCDS39275.1.
RefSeqiNP_080879.1. NM_026603.4.
UniGeneiMm.28549.

Genome annotation databases

EnsembliENSMUST00000023869; ENSMUSP00000023869; ENSMUSG00000023106.
GeneIDi68184.
KEGGimmu:68184.
UCSCiuc008zor.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017647 mRNA. Translation: BAB30854.1.
AK018762 mRNA. Translation: BAB31392.1.
AK135127 mRNA. Translation: BAE22432.1.
BC043922 mRNA. Translation: AAH43922.1.
CCDSiCCDS39275.1.
RefSeqiNP_080879.1. NM_026603.4.
UniGeneiMm.28549.

3D structure databases

ProteinModelPortaliQ9CQJ6.
SMRiQ9CQJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023869.

PTM databases

iPTMnetiQ9CQJ6.
PhosphoSitePlusiQ9CQJ6.

Proteomic databases

EPDiQ9CQJ6.
MaxQBiQ9CQJ6.
PaxDbiQ9CQJ6.
PeptideAtlasiQ9CQJ6.
PRIDEiQ9CQJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023869; ENSMUSP00000023869; ENSMUSG00000023106.
GeneIDi68184.
KEGGimmu:68184.
UCSCiuc008zor.1. mouse.

Organism-specific databases

CTDi8562.
MGIiMGI:1915434. Denr.

Phylogenomic databases

eggNOGiKOG3239. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000014349.
HOGENOMiHOG000237611.
HOVERGENiHBG005471.
InParanoidiQ9CQJ6.
OMAiSGGHDCK.
OrthoDBiEOG091G0R9X.
PhylomeDBiQ9CQJ6.
TreeFamiTF105912.

Miscellaneous databases

PROiQ9CQJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023106.
CleanExiMM_DENR.
ExpressionAtlasiQ9CQJ6. baseline and differential.
GenevisibleiQ9CQJ6. MM.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005873. Drp1.
IPR001950. SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SUPFAMiSSF55159. SSF55159. 2 hits.
TIGRFAMsiTIGR01159. DRP1. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDENR_MOUSE
AccessioniPrimary (citable) accession number: Q9CQJ6
Secondary accession number(s): Q3UXY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.