Q9CQJ4O35699O35729Q4FJV5Q8C1X8RING2_MOUSEE3 ubiquitin-protein ligase RING22.3.2.27RING finger protein 1BRING1bRING finger protein 2RING-type E3 ubiquitin transferase RING2Rnf2DinGRing1bMus musculusMouseEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMusRing1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain.NUCLEOTIDE SEQUENCE [MRNA]INTERACTION WITH CBX2The transcriptional landscape of the mammalian genome.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1.INTERACTION WITH RYBP AND RING1Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.INTERACTION WITH CBX2; PCGF2; PHC1; PHC2; RNF1 AND BMI1FUNCTIONSUBCELLULAR LOCATIONPolycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.FUNCTIONCATALYTIC ACTIVITYPATHWAYRing1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation.SUBCELLULAR LOCATIONMammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes.INTERACTION WITH PHC2The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA.INTERACTION WITH RYBPA tissue-specific atlas of mouse protein phosphorylation and expression.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3.FUNCTIONCATALYTIC ACTIVITYPATHWAYSUBCELLULAR LOCATIONSUBUNITINTERACTION WITH PCGF2; RYBP; RING1; PHC1; PHC3; PHC2; CBX7; CBX2 AND CBX8Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells.FUNCTIONINTERACTION WITH PHC1; PCGF2; RYBP; CBX7; CBX4; CBX2 AND BMI1TISSUE SPECIFICITYFive friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.INTERACTION WITH CHTOPThe Aurora B kinase and the Polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes.FUNCTIONINTERACTION WITH AURKBRNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy.FUNCTIONCATALYTIC ACTIVITYPATHWAYSUBCELLULAR LOCATIONMUTAGENESIS OF HIS-69PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.FUNCTIONINTERACTION WITH PCGF1; PCGF2; PCGF3; PCGF5 AND PCGF6SUBUNITStructure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-159 IN COMPLEX WITH BMI1 AND ZINC IONSFUNCTIONMONOUBIQUITINATIONSUBUNITE3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15525528, PubMed:22325148, PubMed:28596365). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals (PubMed:15525528, PubMed:28596365). May be involved in the initiation of both imprinted and random X inactivation (PubMed:15525528). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:22325148, PubMed:16710298). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:15525528, PubMed:22325148, PubMed:16710298). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:16710298). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (PubMed:15525528, PubMed:16710298). Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers (PubMed:22226355). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (PubMed:24980959).S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.Protein modification; protein ubiquitination.Component of chromatin-associated Polycomb (PcG) complexes (PubMed:22325148). Component of a number of PRC1-like complexes; these complexes contain either the polycomb group ring finger protein PCGF1, or PCGF2, or PCGF3, or BMI1, or PCGF5, or PCGF6 (PubMed:28596365, PubMed:16710298). Distinct PRC1-like complexes are composed of a RING1 subunit (RING1B or RING1A), one of the six PCGF proteins (PCGF1, PCGF2, PCGF3, BMI1, PCGF5 or PCGF6), one PHC protein (PHC1, PHC2 or PHC3) and one of the CBX proteins (CBX2, CBX4, CBX6, CBX7 or CBX8) (Probable). Part of a complex that contains RNF2, UB2D3 and BMI1; within that complex RNF2 and BMI1 form a tight heterodimer, where UB2D3 interacts only with RNF2. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (By similarity). Part of a complex that contains PCGF5, RNF2 and UBE2D3. Part of a complex that contains AUTS2, PCGF5, RNF2, CSNK2B and RYBP (By similarity). Interacts with CBX6 and CBX8 (By similarity). Interacts with PHC1, PCGF2, RYBP, CBX7, CBX4, CBX2, RNF1/RING1, BMI1 and PHC2 (PubMed:12183370, PubMed:16024804, PubMed:16710298, PubMed:19170609, PubMed:9312051, PubMed:10369680, PubMed:22325148, PubMed:22226355). Interaction with RYBP and CBX7 is mutually exclusive; both compete for the same binding site on RNF2 (PubMed:22325148). Component of repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RING1 (By similarity). Interacts with CBX2 and PHC1 (PubMed:22226355). Interacts with CHTOP (PubMed:22872859). Interacts with AURKB (PubMed:24034696). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RNF1/RING1, RNF2/RING2, MBLR, L3MBTL2 and YAF2 (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with RYBP, HIP2 and TFCP2 (By similarity). Interacts with NUPR1 (By similarity).Q9CQJ4A0A087WPF7false2Q9CQJ4P25916false17Q9CQJ4Q9QXV1false5Q9CQJ4Q61177false4Q9CQJ4Q6ZQ88false3Q9CQJ4Q6P1G2false4Q9CQJ4P23798false15Q9CQJ4Q64028false7Q9CQJ4Q9QWH1false7Q9CQJ4O35730false3Q9CQJ4Q8CCI5false8Q9CQJ4Q9WTX5false4NucleusCytoplasmChromosomeEnriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells (PubMed:12183370). The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (PubMed:12183370).Expressed in embryonic stem cells.Monoubiquitinated, by auto-ubiquitination (PubMed:16710298). Polyubiquitinated in the presence of UBE2D3 (in vitro) (By similarity).3D-structureAcetylationChromosomeCytoplasmIsopeptide bondMetal-bindingNucleusPhosphoproteinReference proteomeRepressorTranscriptionTranscription regulationTransferaseUbl conjugationUbl conjugation pathwayZincZinc-fingerHYNHSTVLTKEHKFTASGNVRMSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAVAIDPVMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK
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