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Q9CQI7

- RU2B_MOUSE

UniProt

Q9CQI7 - RU2B_MOUSE

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Protein

U2 small nuclear ribonucleoprotein B''

Gene

Snrpb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A' protein (By similarity).By similarity

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. snRNA binding Source: InterPro

GO - Biological processi

  1. mRNA splicing, via spliceosome Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_260226. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein B''
Short name:
U2 snRNP B''
Gene namesi
Name:Snrpb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:104805. Snrpb2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: Ensembl
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225U2 small nuclear ribonucleoprotein B''PRO_0000081893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei111 – 1111N6-acetyllysine1 Publication
Modified residuei151 – 1511PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CQI7.
PaxDbiQ9CQI7.
PRIDEiQ9CQI7.

PTM databases

PhosphoSiteiQ9CQI7.

Expressioni

Gene expression databases

BgeeiQ9CQI7.
CleanExiMM_SNRPB2.
ExpressionAtlasiQ9CQI7. baseline and differential.
GenevestigatoriQ9CQI7.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9CQI7. 1 interaction.
MINTiMINT-1866867.

Structurei

3D structure databases

ProteinModelPortaliQ9CQI7.
SMRiQ9CQI7. Positions 3-96, 146-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8680RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 22575RRM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RRM U1 A/B'' family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG317159.
GeneTreeiENSGT00390000007046.
HOGENOMiHOG000217519.
HOVERGENiHBG000895.
InParanoidiQ9CQI7.
KOiK11094.
OMAiINKNALE.
OrthoDBiEOG77DJ77.
PhylomeDBiQ9CQI7.
TreeFamiTF313834.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR024888. U1_snRNP_A/U2_snRNP_B''.
[Graphical view]
PANTHERiPTHR10501. PTHR10501. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQI7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG
60 70 80 90 100
QAFVIFKELG SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD
110 120 130 140 150
KEKKKEKKKA KTMEQAAAAA NKKPGQGTPN AANTQGTAAP NPQVPDYPPN
160 170 180 190 200
YILFLNNLPE ETNEMMLSML FNQFPGFKEV RLVPGRHDIA FVEFENDGQA
210 220
GAARDALQGF KITPSHAMKI TYAKK
Length:225
Mass (Da):25,323
Last modified:June 1, 2001 - v1
Checksum:i88C7A298D7FC1A0D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961N → Y in BAB28565. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005107 mRNA. Translation: BAB23823.1.
AK011274 mRNA. Translation: BAB27510.1.
AK012944 mRNA. Translation: BAB28565.1.
AK013871 mRNA. Translation: BAB29026.1.
BC026794 mRNA. Translation: AAH26794.1.
CCDSiCCDS16808.1.
RefSeqiNP_067310.1. NM_021335.3.
UniGeneiMm.1323.

Genome annotation databases

EnsembliENSMUST00000008477; ENSMUSP00000008477; ENSMUSG00000008333.
GeneIDi20639.
KEGGimmu:20639.
UCSCiuc008mqb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005107 mRNA. Translation: BAB23823.1 .
AK011274 mRNA. Translation: BAB27510.1 .
AK012944 mRNA. Translation: BAB28565.1 .
AK013871 mRNA. Translation: BAB29026.1 .
BC026794 mRNA. Translation: AAH26794.1 .
CCDSi CCDS16808.1.
RefSeqi NP_067310.1. NM_021335.3.
UniGenei Mm.1323.

3D structure databases

ProteinModelPortali Q9CQI7.
SMRi Q9CQI7. Positions 3-96, 146-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CQI7. 1 interaction.
MINTi MINT-1866867.

PTM databases

PhosphoSitei Q9CQI7.

Proteomic databases

MaxQBi Q9CQI7.
PaxDbi Q9CQI7.
PRIDEi Q9CQI7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000008477 ; ENSMUSP00000008477 ; ENSMUSG00000008333 .
GeneIDi 20639.
KEGGi mmu:20639.
UCSCi uc008mqb.1. mouse.

Organism-specific databases

CTDi 6629.
MGIi MGI:104805. Snrpb2.

Phylogenomic databases

eggNOGi NOG317159.
GeneTreei ENSGT00390000007046.
HOGENOMi HOG000217519.
HOVERGENi HBG000895.
InParanoidi Q9CQI7.
KOi K11094.
OMAi INKNALE.
OrthoDBi EOG77DJ77.
PhylomeDBi Q9CQI7.
TreeFami TF313834.

Enzyme and pathway databases

Reactomei REACT_260226. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSi Snrpb2. mouse.
NextBioi 299043.
PROi Q9CQI7.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQI7.
CleanExi MM_SNRPB2.
ExpressionAtlasi Q9CQI7. baseline and differential.
Genevestigatori Q9CQI7.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR024888. U1_snRNP_A/U2_snRNP_B''.
[Graphical view ]
PANTHERi PTHR10501. PTHR10501. 1 hit.
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiRU2B_MOUSE
AccessioniPrimary (citable) accession number: Q9CQI7
Secondary accession number(s): Q9CW35, Q9CZ66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3