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Q9CQI7

- RU2B_MOUSE

UniProt

Q9CQI7 - RU2B_MOUSE

Protein

U2 small nuclear ribonucleoprotein B''

Gene

Snrpb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A' protein By similarity.By similarity

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. protein binding Source: MGI
    3. snRNA binding Source: InterPro

    GO - Biological processi

    1. mRNA splicing, via spliceosome Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U2 small nuclear ribonucleoprotein B''
    Short name:
    U2 snRNP B''
    Gene namesi
    Name:Snrpb2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:104805. Snrpb2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: Ensembl

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225U2 small nuclear ribonucleoprotein B''PRO_0000081893Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei111 – 1111N6-acetyllysine1 Publication
    Modified residuei151 – 1511PhosphotyrosineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9CQI7.
    PaxDbiQ9CQI7.
    PRIDEiQ9CQI7.

    PTM databases

    PhosphoSiteiQ9CQI7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CQI7.
    BgeeiQ9CQI7.
    CleanExiMM_SNRPB2.
    GenevestigatoriQ9CQI7.

    Interactioni

    Subunit structurei

    Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9CQI7. 1 interaction.
    MINTiMINT-1866867.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQI7.
    SMRiQ9CQI7. Positions 3-96, 146-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 8680RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini151 – 22575RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRM U1 A/B'' family.Curated
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG317159.
    GeneTreeiENSGT00390000007046.
    HOGENOMiHOG000217519.
    HOVERGENiHBG000895.
    InParanoidiQ9CQI7.
    KOiK11094.
    OMAiINKNALE.
    OrthoDBiEOG77DJ77.
    PhylomeDBiQ9CQI7.
    TreeFamiTF313834.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR024888. U1_snRNP_A/U2_snRNP_B''.
    [Graphical view]
    PANTHERiPTHR10501. PTHR10501. 1 hit.
    PfamiPF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CQI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG    50
    QAFVIFKELG SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD 100
    KEKKKEKKKA KTMEQAAAAA NKKPGQGTPN AANTQGTAAP NPQVPDYPPN 150
    YILFLNNLPE ETNEMMLSML FNQFPGFKEV RLVPGRHDIA FVEFENDGQA 200
    GAARDALQGF KITPSHAMKI TYAKK 225
    Length:225
    Mass (Da):25,323
    Last modified:June 1, 2001 - v1
    Checksum:i88C7A298D7FC1A0D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961N → Y in BAB28565. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005107 mRNA. Translation: BAB23823.1.
    AK011274 mRNA. Translation: BAB27510.1.
    AK012944 mRNA. Translation: BAB28565.1.
    AK013871 mRNA. Translation: BAB29026.1.
    BC026794 mRNA. Translation: AAH26794.1.
    CCDSiCCDS16808.1.
    RefSeqiNP_067310.1. NM_021335.3.
    UniGeneiMm.1323.

    Genome annotation databases

    EnsembliENSMUST00000008477; ENSMUSP00000008477; ENSMUSG00000008333.
    GeneIDi20639.
    KEGGimmu:20639.
    UCSCiuc008mqb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005107 mRNA. Translation: BAB23823.1 .
    AK011274 mRNA. Translation: BAB27510.1 .
    AK012944 mRNA. Translation: BAB28565.1 .
    AK013871 mRNA. Translation: BAB29026.1 .
    BC026794 mRNA. Translation: AAH26794.1 .
    CCDSi CCDS16808.1.
    RefSeqi NP_067310.1. NM_021335.3.
    UniGenei Mm.1323.

    3D structure databases

    ProteinModelPortali Q9CQI7.
    SMRi Q9CQI7. Positions 3-96, 146-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CQI7. 1 interaction.
    MINTi MINT-1866867.

    PTM databases

    PhosphoSitei Q9CQI7.

    Proteomic databases

    MaxQBi Q9CQI7.
    PaxDbi Q9CQI7.
    PRIDEi Q9CQI7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000008477 ; ENSMUSP00000008477 ; ENSMUSG00000008333 .
    GeneIDi 20639.
    KEGGi mmu:20639.
    UCSCi uc008mqb.1. mouse.

    Organism-specific databases

    CTDi 6629.
    MGIi MGI:104805. Snrpb2.

    Phylogenomic databases

    eggNOGi NOG317159.
    GeneTreei ENSGT00390000007046.
    HOGENOMi HOG000217519.
    HOVERGENi HBG000895.
    InParanoidi Q9CQI7.
    KOi K11094.
    OMAi INKNALE.
    OrthoDBi EOG77DJ77.
    PhylomeDBi Q9CQI7.
    TreeFami TF313834.

    Miscellaneous databases

    ChiTaRSi SNRPB2. mouse.
    NextBioi 299043.
    PROi Q9CQI7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CQI7.
    Bgeei Q9CQI7.
    CleanExi MM_SNRPB2.
    Genevestigatori Q9CQI7.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR024888. U1_snRNP_A/U2_snRNP_B''.
    [Graphical view ]
    PANTHERi PTHR10501. PTHR10501. 1 hit.
    Pfami PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiRU2B_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQI7
    Secondary accession number(s): Q9CW35, Q9CZ66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3