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Protein

U2 small nuclear ribonucleoprotein B''

Gene

Snrpb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein B''
Short name:
U2 snRNP B''
Gene namesi
Name:Snrpb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104805 Snrpb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818931 – 225U2 small nuclear ribonucleoprotein B''Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111N6-acetyllysine; alternateCombined sources1
Cross-linki111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei151PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CQI7
MaxQBiQ9CQI7
PaxDbiQ9CQI7
PeptideAtlasiQ9CQI7
PRIDEiQ9CQI7

PTM databases

iPTMnetiQ9CQI7
PhosphoSitePlusiQ9CQI7

Expressioni

Gene expression databases

BgeeiENSMUSG00000008333
CleanExiMM_SNRPB2
ExpressionAtlasiQ9CQI7 baseline and differential
GenevisibleiQ9CQI7 MM

Interactioni

Subunit structurei

Identified in the spliceosome B complex. Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1. Contributes to the binding of stem loop IV of U2 snRNA with SNRPP1.By similarity

Protein-protein interaction databases

IntActiQ9CQI7, 1 interactor
MINTiQ9CQI7
STRINGi10090.ENSMUSP00000008477

Structurei

3D structure databases

ProteinModelPortaliQ9CQI7
SMRiQ9CQI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 86RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini151 – 225RRM 2PROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the RRM U1 A/B'' family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4206 Eukaryota
ENOG410XPZI LUCA
GeneTreeiENSGT00390000007046
HOGENOMiHOG000217519
HOVERGENiHBG000895
InParanoidiQ9CQI7
KOiK11094
OMAiQGFPFYN
OrthoDBiEOG091G0NFU
PhylomeDBiQ9CQI7
TreeFamiTF313834

Family and domain databases

CDDicd12478 RRM1_U2B, 1 hit
cd12481 RRM2_U2B, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034564 U2B''_RRM1
IPR034562 U2B''_RRM2
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

Q9CQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG
60 70 80 90 100
QAFVIFKELG SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD
110 120 130 140 150
KEKKKEKKKA KTMEQAAAAA NKKPGQGTPN AANTQGTAAP NPQVPDYPPN
160 170 180 190 200
YILFLNNLPE ETNEMMLSML FNQFPGFKEV RLVPGRHDIA FVEFENDGQA
210 220
GAARDALQGF KITPSHAMKI TYAKK
Length:225
Mass (Da):25,323
Last modified:June 1, 2001 - v1
Checksum:i88C7A298D7FC1A0D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196N → Y in BAB28565 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005107 mRNA Translation: BAB23823.1
AK011274 mRNA Translation: BAB27510.1
AK012944 mRNA Translation: BAB28565.1
AK013871 mRNA Translation: BAB29026.1
BC026794 mRNA Translation: AAH26794.1
CCDSiCCDS16808.1
RefSeqiNP_067310.1, NM_021335.3
UniGeneiMm.1323

Genome annotation databases

EnsembliENSMUST00000008477; ENSMUSP00000008477; ENSMUSG00000008333
GeneIDi20639
KEGGimmu:20639
UCSCiuc008mqb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRU2B_MOUSE
AccessioniPrimary (citable) accession number: Q9CQI7
Secondary accession number(s): Q9CW35, Q9CZ66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health