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Protein

Glia maturation factor beta

Gene

Gmfb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.By similarity

GO - Biological processi

  • learning Source: MGI
  • locomotory behavior Source: MGI
  • negative regulation of Arp2/3 complex-mediated actin nucleation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor beta
Short name:
GMF-beta
Gene namesi
Name:Gmfb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1927133. Gmfb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 142141Glia maturation factor betaPRO_0000214944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Post-translational modificationi

Phosphorylated; stimulated by phorbol ester.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQI3.
MaxQBiQ9CQI3.
PaxDbiQ9CQI3.
PRIDEiQ9CQI3.

PTM databases

iPTMnetiQ9CQI3.
PhosphoSiteiQ9CQI3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062014.
CleanExiMM_GMFB.
ExpressionAtlasiQ9CQI3. baseline and differential.
GenevisibleiQ9CQI3. MM.

Interactioni

Protein-protein interaction databases

BioGridi211011. 3 interactions.
IntActiQ9CQI3. 2 interactions.
STRINGi10090.ENSMUSP00000107448.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 2211Combined sources
Beta strandi30 – 367Combined sources
Beta strandi38 – 403Combined sources
Beta strandi42 – 5110Combined sources
Helixi54 – 574Combined sources
Helixi58 – 603Combined sources
Beta strandi63 – 653Combined sources
Beta strandi67 – 726Combined sources
Beta strandi86 – 916Combined sources
Helixi98 – 11417Combined sources
Beta strandi118 – 1258Combined sources
Helixi126 – 1283Combined sources
Helixi131 – 1399Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V6FNMR-A2-139[»]
ProteinModelPortaliQ9CQI3.
SMRiQ9CQI3. Positions 5-139.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CQI3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 139136ADF-HPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1736. Eukaryota.
ENOG4111RK6. LUCA.
GeneTreeiENSGT00390000008920.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiQ9CQI3.
OMAiMEEVEQF.
OrthoDBiEOG091G0YYO.
TreeFamiTF315147.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESLVVCDV AEDLVEKLRK FRFRKETHNA AIIMKIDKDE RLVVLDEELE
60 70 80 90 100
GVSPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH
Length:142
Mass (Da):16,723
Last modified:January 23, 2007 - v3
Checksum:i89D0E02A826247C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401E → K in AAG22803 (PubMed:11435704).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297220 mRNA. Translation: AAG22803.1.
AB050013 mRNA. Translation: BAB41099.1.
AK013947 mRNA. Translation: BAB29076.1.
AK013970 mRNA. Translation: BAB29092.1.
AK142014 mRNA. Translation: BAE24913.1.
BC040233 mRNA. Translation: AAH40233.1.
CCDSiCCDS36898.1.
RefSeqiNP_071306.2. NM_022023.2.
UniGeneiMm.87312.

Genome annotation databases

EnsembliENSMUST00000079314; ENSMUSP00000078293; ENSMUSG00000062014.
ENSMUST00000111817; ENSMUSP00000107448; ENSMUSG00000062014.
GeneIDi63985.
KEGGimmu:63985.
UCSCiuc007thh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297220 mRNA. Translation: AAG22803.1.
AB050013 mRNA. Translation: BAB41099.1.
AK013947 mRNA. Translation: BAB29076.1.
AK013970 mRNA. Translation: BAB29092.1.
AK142014 mRNA. Translation: BAE24913.1.
BC040233 mRNA. Translation: AAH40233.1.
CCDSiCCDS36898.1.
RefSeqiNP_071306.2. NM_022023.2.
UniGeneiMm.87312.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V6FNMR-A2-139[»]
ProteinModelPortaliQ9CQI3.
SMRiQ9CQI3. Positions 5-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211011. 3 interactions.
IntActiQ9CQI3. 2 interactions.
STRINGi10090.ENSMUSP00000107448.

PTM databases

iPTMnetiQ9CQI3.
PhosphoSiteiQ9CQI3.

Proteomic databases

EPDiQ9CQI3.
MaxQBiQ9CQI3.
PaxDbiQ9CQI3.
PRIDEiQ9CQI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079314; ENSMUSP00000078293; ENSMUSG00000062014.
ENSMUST00000111817; ENSMUSP00000107448; ENSMUSG00000062014.
GeneIDi63985.
KEGGimmu:63985.
UCSCiuc007thh.2. mouse.

Organism-specific databases

CTDi2764.
MGIiMGI:1927133. Gmfb.

Phylogenomic databases

eggNOGiKOG1736. Eukaryota.
ENOG4111RK6. LUCA.
GeneTreeiENSGT00390000008920.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiQ9CQI3.
OMAiMEEVEQF.
OrthoDBiEOG091G0YYO.
TreeFamiTF315147.

Miscellaneous databases

ChiTaRSiGmfb. mouse.
EvolutionaryTraceiQ9CQI3.
PROiQ9CQI3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062014.
CleanExiMM_GMFB.
ExpressionAtlasiQ9CQI3. baseline and differential.
GenevisibleiQ9CQI3. MM.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMFB_MOUSE
AccessioniPrimary (citable) accession number: Q9CQI3
Secondary accession number(s): Q3UQX5, Q9ERL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.