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Protein

Glia maturation factor beta

Gene

Gmfb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.By similarity

GO - Molecular functioni

GO - Biological processi

  • learning Source: MGI
  • locomotory behavior Source: MGI
  • negative regulation of Arp2/3 complex-mediated actin nucleation Source: InterPro

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor beta
Short name:
GMF-beta
Gene namesi
Name:Gmfb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1927133 Gmfb

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002149442 – 142Glia maturation factor betaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Post-translational modificationi

Phosphorylated; stimulated by phorbol ester.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQI3
MaxQBiQ9CQI3
PaxDbiQ9CQI3
PRIDEiQ9CQI3

PTM databases

iPTMnetiQ9CQI3
PhosphoSitePlusiQ9CQI3

Expressioni

Gene expression databases

BgeeiENSMUSG00000062014
CleanExiMM_GMFB
GenevisibleiQ9CQI3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211011, 5 interactors
IntActiQ9CQI3, 2 interactors
STRINGi10090.ENSMUSP00000107448

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 22Combined sources11
Beta strandi30 – 36Combined sources7
Beta strandi38 – 40Combined sources3
Beta strandi42 – 51Combined sources10
Helixi54 – 57Combined sources4
Helixi58 – 60Combined sources3
Beta strandi63 – 65Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi86 – 91Combined sources6
Helixi98 – 114Combined sources17
Beta strandi118 – 125Combined sources8
Helixi126 – 128Combined sources3
Helixi131 – 139Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V6FNMR-A2-139[»]
ProteinModelPortaliQ9CQI3
SMRiQ9CQI3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CQI3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 139ADF-HPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1736 Eukaryota
ENOG4111RK6 LUCA
GeneTreeiENSGT00390000008920
HOGENOMiHOG000175654
HOVERGENiHBG003045
InParanoidiQ9CQI3
OMAiMEEVEQF
OrthoDBiEOG091G0YYO
TreeFamiTF315147

Family and domain databases

CDDicd11283 ADF_GMF-beta_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR011171 GMF
PANTHERiPTHR11249 PTHR11249, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PIRSFiPIRSF001788 GMF-beta, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESLVVCDV AEDLVEKLRK FRFRKETHNA AIIMKIDKDE RLVVLDEELE
60 70 80 90 100
GVSPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH
Length:142
Mass (Da):16,723
Last modified:January 23, 2007 - v3
Checksum:i89D0E02A826247C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40E → K in AAG22803 (PubMed:11435704).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297220 mRNA Translation: AAG22803.1
AB050013 mRNA Translation: BAB41099.1
AK013947 mRNA Translation: BAB29076.1
AK013970 mRNA Translation: BAB29092.1
AK142014 mRNA Translation: BAE24913.1
BC040233 mRNA Translation: AAH40233.1
CCDSiCCDS36898.1
RefSeqiNP_071306.2, NM_022023.2
UniGeneiMm.87312

Genome annotation databases

EnsembliENSMUST00000079314; ENSMUSP00000078293; ENSMUSG00000062014
ENSMUST00000111817; ENSMUSP00000107448; ENSMUSG00000062014
GeneIDi63985
KEGGimmu:63985
UCSCiuc007thh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGMFB_MOUSE
AccessioniPrimary (citable) accession number: Q9CQI3
Secondary accession number(s): Q3UQX5, Q9ERL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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