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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Gene

Ndufb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Alternative name(s):
Complex I-SGDH
Short name:
CI-SGDH
NADH-ubiquinone oxidoreductase SGDH subunit
Gene namesi
Name:Ndufb5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913296. Ndufb5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4646MitochondrionBy similarityAdd
BLAST
Chaini47 – 189143NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialPRO_0000020053Add
BLAST

Proteomic databases

EPDiQ9CQH3.
MaxQBiQ9CQH3.
PaxDbiQ9CQH3.
PeptideAtlasiQ9CQH3.
PRIDEiQ9CQH3.

PTM databases

iPTMnetiQ9CQH3.
PhosphoSiteiQ9CQH3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027673.
ExpressionAtlasiQ9CQH3. baseline and differential.
GenevisibleiQ9CQH3. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi211174. 1 interaction.
IntActiQ9CQH3. 3 interactions.
MINTiMINT-1859377.
STRINGi10090.ENSMUSP00000114963.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB5 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4632. Eukaryota.
ENOG4111HCK. LUCA.
GeneTreeiENSGT00390000009980.
HOVERGENiHBG003008.
InParanoidiQ9CQH3.
KOiK03961.
OMAiYYDRRFL.
OrthoDBiEOG091G0L2T.
PhylomeDBiQ9CQH3.
TreeFamiTF313997.

Family and domain databases

InterProiIPR019173. NADH_UbQ_OxRdtase_B5_su.
[Graphical view]
PANTHERiPTHR13178. PTHR13178. 1 hit.
PfamiPF09781. NDUF_B5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMSLLQRA SVSALTALSC RRAGPRLGVG SFLTRSFPKT VAPVRHSGDH
60 70 80 90 100
GKRLFVVKPS LYYDARFLRL MKFYLMLTGI PVIIGITLVN IFIGEAELAE
110 120 130 140 150
IPEGYIPEHW EYYKHPISRW IARNFYDGPE KNYEKTLAIL QIESEKAELR
160 170 180
LKEQEVRRLM RARGDGPWYQ FPTPEKEFID HSPKATPDN
Length:189
Mass (Da):21,710
Last modified:June 1, 2001 - v1
Checksum:i8D998EA6CD683DE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018562 mRNA. Translation: BAB31277.1.
AK004372 mRNA. Translation: BAB23279.1.
AK013223 mRNA. Translation: BAB28724.1.
BC025155 mRNA. Translation: AAH25155.1.
CCDSiCCDS17300.1.
RefSeqiNP_079592.2. NM_025316.2.
UniGeneiMm.28058.

Genome annotation databases

EnsembliENSMUST00000127477; ENSMUSP00000114963; ENSMUSG00000027673.
GeneIDi66046.
KEGGimmu:66046.
UCSCiuc008owq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018562 mRNA. Translation: BAB31277.1.
AK004372 mRNA. Translation: BAB23279.1.
AK013223 mRNA. Translation: BAB28724.1.
BC025155 mRNA. Translation: AAH25155.1.
CCDSiCCDS17300.1.
RefSeqiNP_079592.2. NM_025316.2.
UniGeneiMm.28058.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211174. 1 interaction.
IntActiQ9CQH3. 3 interactions.
MINTiMINT-1859377.
STRINGi10090.ENSMUSP00000114963.

PTM databases

iPTMnetiQ9CQH3.
PhosphoSiteiQ9CQH3.

Proteomic databases

EPDiQ9CQH3.
MaxQBiQ9CQH3.
PaxDbiQ9CQH3.
PeptideAtlasiQ9CQH3.
PRIDEiQ9CQH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000127477; ENSMUSP00000114963; ENSMUSG00000027673.
GeneIDi66046.
KEGGimmu:66046.
UCSCiuc008owq.1. mouse.

Organism-specific databases

CTDi4711.
MGIiMGI:1913296. Ndufb5.

Phylogenomic databases

eggNOGiKOG4632. Eukaryota.
ENOG4111HCK. LUCA.
GeneTreeiENSGT00390000009980.
HOVERGENiHBG003008.
InParanoidiQ9CQH3.
KOiK03961.
OMAiYYDRRFL.
OrthoDBiEOG091G0L2T.
PhylomeDBiQ9CQH3.
TreeFamiTF313997.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNdufb5. mouse.
PROiQ9CQH3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027673.
ExpressionAtlasiQ9CQH3. baseline and differential.
GenevisibleiQ9CQH3. MM.

Family and domain databases

InterProiIPR019173. NADH_UbQ_OxRdtase_B5_su.
[Graphical view]
PANTHERiPTHR13178. PTHR13178. 1 hit.
PfamiPF09781. NDUF_B5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB5_MOUSE
AccessioniPrimary (citable) accession number: Q9CQH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.