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Protein
Submitted name:

Putative uncharacterized protein

Gene

Lrrk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. actin binding Source: MGI
  2. ATP binding Source: InterPro
  3. clathrin binding Source: MGI
  4. glycoprotein binding Source: MGI
  5. GTPase activator activity Source: MGI
  6. GTPase activity Source: MGI
  7. GTP binding Source: MGI
  8. GTP-dependent protein kinase activity Source: MGI
  9. identical protein binding Source: MGI
  10. ion channel binding Source: MGI
  11. kinase activity Source: MGI
  12. MAP kinase kinase activity Source: MGI
  13. peroxidase inhibitor activity Source: MGI
  14. protein homodimerization activity Source: MGI
  15. protein kinase A binding Source: MGI
  16. protein kinase activity Source: MGI
  17. protein serine/threonine kinase activity Source: MGI
  18. Rho GTPase binding Source: MGI
  19. SNARE binding Source: MGI
  20. syntaxin-1 binding Source: MGI
  21. tubulin binding Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. activation of MAPKK activity Source: MGI
  3. cellular response to dopamine Source: MGI
  4. cellular response to manganese ion Source: MGI
  5. cellular response to oxidative stress Source: MGI
  6. determination of adult lifespan Source: MGI
  7. endocytosis Source: MGI
  8. exploration behavior Source: MGI
  9. GTP catabolic process Source: MGI
  10. intracellular distribution of mitochondria Source: MGI
  11. MAPK cascade Source: MGI
  12. negative regulation of GTPase activity Source: MGI
  13. negative regulation of hydrogen peroxide-induced cell death Source: MGI
  14. negative regulation of peroxidase activity Source: MGI
  15. negative regulation of protein binding Source: MGI
  16. negative regulation of protein processing Source: MGI
  17. negative regulation of protein targeting to mitochondrion Source: MGI
  18. negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation Source: MGI
  19. neuromuscular junction development Source: MGI
  20. neuron death Source: MGI
  21. neuron projection morphogenesis Source: MGI
  22. olfactory bulb development Source: MGI
  23. peptidyl-serine phosphorylation Source: MGI
  24. peptidyl-threonine phosphorylation Source: MGI
  25. positive regulation of autophagy Source: MGI
  26. positive regulation of dopamine receptor signaling pathway Source: MGI
  27. positive regulation of GTPase activity Source: MGI
  28. positive regulation of programmed cell death Source: MGI
  29. positive regulation of protein autoubiquitination Source: MGI
  30. positive regulation of protein binding Source: MGI
  31. positive regulation of protein phosphorylation Source: MGI
  32. positive regulation of protein ubiquitination Source: MGI
  33. protein autophosphorylation Source: MGI
  34. protein phosphorylation Source: MGI
  35. reactive oxygen species metabolic process Source: MGI
  36. regulation of branching morphogenesis of a nerve Source: MGI
  37. regulation of dendritic spine morphogenesis Source: MGI
  38. regulation of locomotion Source: MGI
  39. regulation of membrane potential Source: MGI
  40. regulation of mitochondrial depolarization Source: MGI
  41. regulation of neuroblast proliferation Source: MGI
  42. regulation of neuron death Source: MGI
  43. regulation of neuron maturation Source: MGI
  44. regulation of synaptic vesicle exocytosis Source: MGI
  45. response to oxidative stress Source: MGI
  46. tangential migration from the subventricular zone to the olfactory bulb Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Lrrk2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1913975. Lrrk2.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic side of mitochondrial outer membrane Source: MGI
  4. cytosol Source: MGI
  5. dendrite Source: MGI
  6. dendrite cytoplasm Source: MGI
  7. extracellular space Source: MGI
  8. extracellular vesicular exosome Source: MGI
  9. inclusion body Source: MGI
  10. membrane raft Source: MGI
  11. mitochondrial membrane Source: MGI
  12. mitochondrion Source: MGI
  13. neuronal cell body Source: MGI
  14. neuron projection Source: MGI
  15. perikaryon Source: MGI
  16. plasma membrane Source: MGI
  17. synapse Source: MGI
  18. synaptic vesicle Source: MGI
  19. trans-Golgi network Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9CQG8.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG075871.
KOiK08844.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAIFERPI PPDTRPWYLH SAMIIYRDLK PHNVLLFTLY PNAAIIAKIA
60 70 80 90 100
DYGIAQYCCR MGIKTSEGTP GFRAPEVARG NVIYNQQADV YSFGLLLHDI
110 120 130 140 150
WTTGSRIMEG LRFPNEFDEL AIQGKLPDPV KEYGCAPWPM VEKLITKCLK
160 170 180 190 200
ENPQERPTSA QVFDILNSAE LICLMRHILI PKNIIVECMV ATNLNSKSAT
210 220 230 240 250
LWLGCGNTEK GQLSLFDLNT ERYSYEEVAD SRILCLALVH LAAEKESWVV
260 270 280 290 300
CGTQSGALLV INVEEETKRH TLEKMTDSVT CLHCNSLAKQ SKQSNFLLVG
310 320 330 340 350
TADGNLMIFE DKAVKCKGAA PLKTLHIGDV STPLMCLSES LNSSERHITW
360 370 380 390 400
GGCGTKVFSF SNDFTIQKLI ETKTNQLFSY AAFSDSNIIA LAVDTALYIA
410 420 430 440 450
KKNSPVVEVW DKKTEKLCEL IDCVHFLKEV MVKLNKESKH QLSYSGRVKA
460 470 480 490 500
LCLQKNTALW IGTGGGHILL LDLSTRRVIR TIHNFCDSVR AMATAQLGSL
510 520 530 540 550
KNVMLVLGYK RKSTEGIQEQ KEIQSCLSIW DLNLPHEVQN LEKHIEVRTE
560
LADKMRKTSV E
Length:561
Mass (Da):62,834
Last modified:June 1, 2001 - v1
Checksum:i8EB2B26C99F1D293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014886 mRNA. Translation: BAB29603.1.
AK014938 mRNA. Translation: BAB29628.1.
RefSeqiNP_080006.3. NM_025730.3.
UniGeneiMm.37558.

Genome annotation databases

GeneIDi66725.
KEGGimmu:66725.
UCSCiuc007xia.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014886 mRNA. Translation: BAB29603.1.
AK014938 mRNA. Translation: BAB29628.1.
RefSeqiNP_080006.3. NM_025730.3.
UniGeneiMm.37558.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi66725.
KEGGimmu:66725.
UCSCiuc007xia.1. mouse.

Organism-specific databases

CTDi120892.
MGIiMGI:1913975. Lrrk2.

Phylogenomic databases

HOVERGENiHBG075871.
KOiK08844.

Miscellaneous databases

NextBioi322485.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9CQG8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ9CQG8_MOUSE
AccessioniPrimary (citable) accession number: Q9CQG8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.