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Protein

Transmembrane protein 147

Gene

Tmem147

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 147
Gene namesi
Name:Tmem147
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915011. Tmem147.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Transmembrane protein 147PRO_0000271702Add
BLAST

Proteomic databases

EPDiQ9CQG6.
MaxQBiQ9CQG6.
PaxDbiQ9CQG6.
PRIDEiQ9CQG6.

PTM databases

PhosphoSiteiQ9CQG6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006315.
CleanExiMM_TMEM147.
ExpressionAtlasiQ9CQG6. baseline and differential.
GenevisibleiQ9CQG6. MM.

Interactioni

Subunit structurei

Forms a complex with NCLN and NOMO, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006478.

Structurei

3D structure databases

ProteinModelPortaliQ9CQG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3236. Eukaryota.
ENOG41101UF. LUCA.
GeneTreeiENSGT00390000013276.
HOGENOMiHOG000005667.
HOVERGENiHBG094059.
InParanoidiQ9CQG6.
OrthoDBiEOG091G0KEQ.
PhylomeDBiQ9CQG6.
TreeFamiTF314086.

Family and domain databases

InterProiIPR019164. DUF2053_membrane.
[Graphical view]
PANTHERiPTHR12869. PTHR12869. 1 hit.
PfamiPF09767. DUF2053. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLFHFGNCF ALAYFPYFIT YKCSGLSEYN AFWKCVQAGV TYLFVQLCKM
60 70 80 90 100
LFLATFFPTW EGGIYDFIGE FMKASVDVAD LIGLNLVMSR NAGKGEYKIM
110 120 130 140 150
VAALGWATAE LIMSRCIPLW VGARGIEFDW KYIQMSIDSN ISLVHYIVAS
160 170 180 190 200
AQVWMITRYD LYHTFRPAVL LLMFLSVYKA FVMETFVHLF SLGSWTALLA
210 220
RAVVTGLLAL STLALYVAVV NVHS
Length:224
Mass (Da):25,335
Last modified:June 1, 2001 - v1
Checksum:i90122835A76E53AE
GO
Isoform 2 (identifier: Q9CQG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-112: GKGEYKIMVAALGWATAELI → DASPSGWEPEALNLTGNISR
     113-224: Missing.

Note: No experimental confirmation available.
Show »
Length:112
Mass (Da):12,616
Checksum:iE39642E89E04E2B5
GO

Sequence cautioni

The sequence BAB25453 differs from that shown. Reason: Frameshift at position 221. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231H → Q in BAB25453 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei93 – 11220GKGEY…TAELI → DASPSGWEPEALNLTGNISR in isoform 2. 1 PublicationVSP_022328Add
BLAST
Alternative sequencei113 – 224112Missing in isoform 2. 1 PublicationVSP_022329Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007753 mRNA. Translation: BAB25234.1.
AK008089 mRNA. Translation: BAB25453.1. Frameshift.
AK010168 mRNA. Translation: BAB26744.1.
BC035323 mRNA. Translation: AAH35323.1.
CCDSiCCDS39890.1. [Q9CQG6-1]
RefSeqiNP_081491.2. NM_027215.2. [Q9CQG6-1]
UniGeneiMm.27499.

Genome annotation databases

EnsembliENSMUST00000006478; ENSMUSP00000006478; ENSMUSG00000006315. [Q9CQG6-1]
ENSMUST00000207779; ENSMUSP00000146550; ENSMUSG00000006315. [Q9CQG6-2]
GeneIDi69804.
KEGGimmu:69804.
UCSCiuc009gga.1. mouse. [Q9CQG6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007753 mRNA. Translation: BAB25234.1.
AK008089 mRNA. Translation: BAB25453.1. Frameshift.
AK010168 mRNA. Translation: BAB26744.1.
BC035323 mRNA. Translation: AAH35323.1.
CCDSiCCDS39890.1. [Q9CQG6-1]
RefSeqiNP_081491.2. NM_027215.2. [Q9CQG6-1]
UniGeneiMm.27499.

3D structure databases

ProteinModelPortaliQ9CQG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006478.

PTM databases

PhosphoSiteiQ9CQG6.

Proteomic databases

EPDiQ9CQG6.
MaxQBiQ9CQG6.
PaxDbiQ9CQG6.
PRIDEiQ9CQG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006478; ENSMUSP00000006478; ENSMUSG00000006315. [Q9CQG6-1]
ENSMUST00000207779; ENSMUSP00000146550; ENSMUSG00000006315. [Q9CQG6-2]
GeneIDi69804.
KEGGimmu:69804.
UCSCiuc009gga.1. mouse. [Q9CQG6-1]

Organism-specific databases

CTDi10430.
MGIiMGI:1915011. Tmem147.

Phylogenomic databases

eggNOGiKOG3236. Eukaryota.
ENOG41101UF. LUCA.
GeneTreeiENSGT00390000013276.
HOGENOMiHOG000005667.
HOVERGENiHBG094059.
InParanoidiQ9CQG6.
OrthoDBiEOG091G0KEQ.
PhylomeDBiQ9CQG6.
TreeFamiTF314086.

Miscellaneous databases

PROiQ9CQG6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006315.
CleanExiMM_TMEM147.
ExpressionAtlasiQ9CQG6. baseline and differential.
GenevisibleiQ9CQG6. MM.

Family and domain databases

InterProiIPR019164. DUF2053_membrane.
[Graphical view]
PANTHERiPTHR12869. PTHR12869. 1 hit.
PfamiPF09767. DUF2053. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM147_MOUSE
AccessioniPrimary (citable) accession number: Q9CQG6
Secondary accession number(s): Q8CI89, Q9D8F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.