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Q9CQF9

- PCYOX_MOUSE

UniProt

Q9CQF9 - PCYOX_MOUSE

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Protein

Prenylcysteine oxidase

Gene
Pcyox1, Kiaa0908
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine By similarity.

Catalytic activityi

An S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.

Cofactori

FAD By similarity.

GO - Molecular functioni

  1. chloride-transporting ATPase activity Source: Ensembl
  2. prenylcysteine oxidase activity Source: MGI

GO - Biological processi

  1. prenylated protein catabolic process Source: Ensembl
  2. prenylcysteine catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Prenylcysteine oxidase (EC:1.8.3.5)
Gene namesi
Name:Pcyox1
Synonyms:Kiaa0908
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1914131. Pcyox1.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
  2. plasma membrane Source: Ensembl
  3. very-low-density lipoprotein particle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed predictionAdd
BLAST
Chaini29 – 505477Prenylcysteine oxidasePRO_0000023300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki162 – 162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Glycosylationi196 – 1961N-linked (GlcNAc...)1 Publication
Glycosylationi323 – 3231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi353 – 3531N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9CQF9.
PaxDbiQ9CQF9.
PRIDEiQ9CQF9.

PTM databases

PhosphoSiteiQ9CQF9.

Expressioni

Gene expression databases

ArrayExpressiQ9CQF9.
BgeeiQ9CQF9.
CleanExiMM_PCYOX1.
GenevestigatoriQ9CQF9.

Interactioni

Protein-protein interaction databases

IntActiQ9CQF9. 5 interactions.
MINTiMINT-1858396.
STRINGi10090.ENSMUSP00000032065.

Structurei

3D structure databases

ProteinModelPortaliQ9CQF9.
SMRiQ9CQF9. Positions 34-111.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG73316.
GeneTreeiENSGT00390000011206.
HOGENOMiHOG000241149.
HOVERGENiHBG053532.
InParanoidiQ9CQF9.
KOiK05906.
OMAiNGIECAA.
OrthoDBiEOG7VB2F5.
PhylomeDBiQ9CQF9.
TreeFamiTF329001.

Family and domain databases

InterProiIPR010795. Prenylcys_lyase.
IPR017046. Prenylcysteine_Oxase.
[Graphical view]
PfamiPF07156. Prenylcys_lyase. 1 hit.
[Graphical view]
PIRSFiPIRSF036292. Prenylcysteine_oxidase. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQF9-1 [UniParc]FASTAAdd to Basket

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MGRFAAALVG SLFWLGLLLC GLGSLASAEP RAPPNRIAIV GAGIGGTSSA    50
YYLRKKFGKD VKIDVFEREE VGGRLATLKV QGHDYEAGGS VIHPLNLHMK 100
RFVKELGLSS VPASGGLVGV YNGKSLVFEE SSWFVINVIK LVWRYGFQSL 150
RMHMWVEDLL DKFMRIYRYQ SHDYAFSSVE KLMHAIGGDD YVRLLNQTLR 200
ENLKKAGFSE TFLNEMIAPV MKVNYGQSTD INAFVGAVSL TAADSNLWAV 250
EGGNKIVCSG LLQASSSNLI SGSVMSIEEK TRTKQTGNPT KMYEVVYKTG 300
SETHSDFYDI VLVAAPLNRK MSNITFRNFD PPIEEFNDPY QQLVTTFIKG 350
ELNSTLFSSR PKDQFGLSAI LVTDDSDMFI NSLSIVASVR QKEGPPPAVD 400
GMHVWKTFSR DILTKEQISK LFLSYDYAVR KPWLSYPHYE PPQKCPSIIL 450
HDRLYYLNGI EFAASCMEMS AIAGYNAALL AYHRWNGNED MIDQDDLYER 500
LKTEL 505
Length:505
Mass (Da):56,495
Last modified:June 1, 2001 - v1
Checksum:i9169BC4CC7D97561
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141S → T in BAC28252. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004799 mRNA. Translation: BAB23572.1.
AK004840 mRNA. Translation: BAB23607.1.
AK031585 mRNA. Translation: BAC27462.1.
AK033373 mRNA. Translation: BAC28252.1.
AK049412 mRNA. Translation: BAC33741.1.
AK145366 mRNA. Translation: BAE26391.1.
AK147190 mRNA. Translation: BAE27750.1.
AK161616 mRNA. Translation: BAE36494.1.
AK169209 mRNA. Translation: BAE40981.1.
BC028308 mRNA. Translation: AAH28308.1.
AK173058 mRNA. Translation: BAD32336.1.
CCDSiCCDS20311.1.
RefSeqiNP_080099.1. NM_025823.4.
UniGeneiMm.30849.

Genome annotation databases

EnsembliENSMUST00000032065; ENSMUSP00000032065; ENSMUSG00000029998.
GeneIDi66881.
KEGGimmu:66881.
UCSCiuc009cro.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004799 mRNA. Translation: BAB23572.1 .
AK004840 mRNA. Translation: BAB23607.1 .
AK031585 mRNA. Translation: BAC27462.1 .
AK033373 mRNA. Translation: BAC28252.1 .
AK049412 mRNA. Translation: BAC33741.1 .
AK145366 mRNA. Translation: BAE26391.1 .
AK147190 mRNA. Translation: BAE27750.1 .
AK161616 mRNA. Translation: BAE36494.1 .
AK169209 mRNA. Translation: BAE40981.1 .
BC028308 mRNA. Translation: AAH28308.1 .
AK173058 mRNA. Translation: BAD32336.1 .
CCDSi CCDS20311.1.
RefSeqi NP_080099.1. NM_025823.4.
UniGenei Mm.30849.

3D structure databases

ProteinModelPortali Q9CQF9.
SMRi Q9CQF9. Positions 34-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CQF9. 5 interactions.
MINTi MINT-1858396.
STRINGi 10090.ENSMUSP00000032065.

PTM databases

PhosphoSitei Q9CQF9.

Proteomic databases

MaxQBi Q9CQF9.
PaxDbi Q9CQF9.
PRIDEi Q9CQF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032065 ; ENSMUSP00000032065 ; ENSMUSG00000029998 .
GeneIDi 66881.
KEGGi mmu:66881.
UCSCi uc009cro.2. mouse.

Organism-specific databases

CTDi 51449.
MGIi MGI:1914131. Pcyox1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG73316.
GeneTreei ENSGT00390000011206.
HOGENOMi HOG000241149.
HOVERGENi HBG053532.
InParanoidi Q9CQF9.
KOi K05906.
OMAi NGIECAA.
OrthoDBi EOG7VB2F5.
PhylomeDBi Q9CQF9.
TreeFami TF329001.

Miscellaneous databases

NextBioi 322917.
PROi Q9CQF9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9CQF9.
Bgeei Q9CQF9.
CleanExi MM_PCYOX1.
Genevestigatori Q9CQF9.

Family and domain databases

InterProi IPR010795. Prenylcys_lyase.
IPR017046. Prenylcysteine_Oxase.
[Graphical view ]
Pfami PF07156. Prenylcys_lyase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036292. Prenylcysteine_oxidase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion, Liver, Lung and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-505.
    Tissue: Fetal brain.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 145-151; 169-193; 292-298; 328-349 AND 421-430, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-196.
    Strain: C57BL/6.
    Tissue: Plasma.
  6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-353.

Entry informationi

Entry nameiPCYOX_MOUSE
AccessioniPrimary (citable) accession number: Q9CQF9
Secondary accession number(s): Q3UHV6, Q69ZW0, Q8BZX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi