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Protein

L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Gene

Aasdhppt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN (in vitro) (By similarity).By similarity

Catalytic activityi

CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei47 – 471Coenzyme ABy similarity
Metal bindingi129 – 1291MagnesiumBy similarity
Metal bindingi181 – 1811MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-199220. Vitamin B5 (pantothenate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC:2.7.8.-)
Alternative name(s):
4'-phosphopantetheinyl transferase
Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
Short name:
AASD-PPT
Gene namesi
Name:Aasdhppt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914868. Aasdhppt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferasePRO_0000175737Add
BLAST

Proteomic databases

EPDiQ9CQF6.
MaxQBiQ9CQF6.
PaxDbiQ9CQF6.
PRIDEiQ9CQF6.

PTM databases

iPTMnetiQ9CQF6.
PhosphoSiteiQ9CQF6.

Expressioni

Gene expression databases

BgeeiQ9CQF6.
GenevisibleiQ9CQF6. MM.

Interactioni

Subunit structurei

Monomer. Interacts with FASN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053971.

Structurei

3D structure databases

ProteinModelPortaliQ9CQF6.
SMRiQ9CQF6. Positions 14-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 916Coenzyme A bindingBy similarity
Regioni108 – 1114Coenzyme A bindingBy similarity
Regioni181 – 1855Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0945. Eukaryota.
COG2091. LUCA.
GeneTreeiENSGT00390000004663.
HOGENOMiHOG000265195.
HOVERGENiHBG080822.
InParanoidiQ9CQF6.
KOiK06133.
OMAiVRWAFRC.
OrthoDBiEOG7N37F7.
PhylomeDBiQ9CQF6.
TreeFamiTF313753.

Family and domain databases

Gene3Di3.90.470.20. 2 hits.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
SUPFAMiSSF56214. SSF56214. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFPAKRLCV VPSMEGVRWA FSCGTWLPSR AEWLLAMRSI QPEEKERIGK
60 70 80 90 100
FVFARDAKAA LAGRLMIRKL VAEKLNIPWD HIRLQRTSKG KPVLAKDSLN
110 120 130 140 150
PYPNFNFNIS HQGDYAVLAA EPEVQVGIDI MKTSFPGRGS IPEFFHIMKR
160 170 180 190 200
KFTKKEWETI RSFNDEWTQL DMFYRHWALK ESFIKAIGVG LGFEMQRLEF
210 220 230 240 250
DVSPLNMDIG QVYKETCLIL DGEEEKEWAF EESKIDEHHF VAVAVRKPDG
260 270 280 290 300
SRHQNVSYQD DSKLSQRKFT ILNFNDLVAS AIPMTPEDPS FWDCFCFTEE

ILIRNGTKS
Length:309
Mass (Da):35,764
Last modified:June 1, 2001 - v1
Checksum:i928EE04A1383AE25
GO
Isoform 2 (identifier: Q9CQF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-177: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):29,085
Checksum:i8D5A6BA1F9110649
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321E → G in AAH38013 (PubMed:15489334).Curated
Sequence conflicti262 – 2621S → F in BAB25740 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei124 – 17754Missing in isoform 2. 1 PublicationVSP_016096Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007737 mRNA. Translation: BAB25224.1.
AK008554 mRNA. Translation: BAB25740.1.
AK010557 mRNA. Translation: BAB27026.1.
AK013111 mRNA. Translation: BAB28656.1.
AK018191 mRNA. Translation: BAB31116.1.
AK076099 mRNA. Translation: BAC36182.1.
AK076866 mRNA. Translation: BAC36512.1.
AK144671 mRNA. Translation: BAE26000.1.
BC038013 mRNA. Translation: AAH38013.1.
BC049851 mRNA. Translation: AAH49851.1.
CCDSiCCDS22794.1. [Q9CQF6-1]
RefSeqiNP_080552.3. NM_026276.3. [Q9CQF6-1]
XP_006509939.1. XM_006509876.2. [Q9CQF6-2]
UniGeneiMm.33970.

Genome annotation databases

EnsembliENSMUST00000051589; ENSMUSP00000053971; ENSMUSG00000025894. [Q9CQF6-1]
GeneIDi67618.
KEGGimmu:67618.
UCSCiuc009obe.2. mouse. [Q9CQF6-1]
uc009obf.2. mouse. [Q9CQF6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007737 mRNA. Translation: BAB25224.1.
AK008554 mRNA. Translation: BAB25740.1.
AK010557 mRNA. Translation: BAB27026.1.
AK013111 mRNA. Translation: BAB28656.1.
AK018191 mRNA. Translation: BAB31116.1.
AK076099 mRNA. Translation: BAC36182.1.
AK076866 mRNA. Translation: BAC36512.1.
AK144671 mRNA. Translation: BAE26000.1.
BC038013 mRNA. Translation: AAH38013.1.
BC049851 mRNA. Translation: AAH49851.1.
CCDSiCCDS22794.1. [Q9CQF6-1]
RefSeqiNP_080552.3. NM_026276.3. [Q9CQF6-1]
XP_006509939.1. XM_006509876.2. [Q9CQF6-2]
UniGeneiMm.33970.

3D structure databases

ProteinModelPortaliQ9CQF6.
SMRiQ9CQF6. Positions 14-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053971.

PTM databases

iPTMnetiQ9CQF6.
PhosphoSiteiQ9CQF6.

Proteomic databases

EPDiQ9CQF6.
MaxQBiQ9CQF6.
PaxDbiQ9CQF6.
PRIDEiQ9CQF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051589; ENSMUSP00000053971; ENSMUSG00000025894. [Q9CQF6-1]
GeneIDi67618.
KEGGimmu:67618.
UCSCiuc009obe.2. mouse. [Q9CQF6-1]
uc009obf.2. mouse. [Q9CQF6-2]

Organism-specific databases

CTDi60496.
MGIiMGI:1914868. Aasdhppt.

Phylogenomic databases

eggNOGiKOG0945. Eukaryota.
COG2091. LUCA.
GeneTreeiENSGT00390000004663.
HOGENOMiHOG000265195.
HOVERGENiHBG080822.
InParanoidiQ9CQF6.
KOiK06133.
OMAiVRWAFRC.
OrthoDBiEOG7N37F7.
PhylomeDBiQ9CQF6.
TreeFamiTF313753.

Enzyme and pathway databases

ReactomeiR-MMU-199220. Vitamin B5 (pantothenate) metabolism.

Miscellaneous databases

ChiTaRSiAasdhppt. mouse.
PROiQ9CQF6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQF6.
GenevisibleiQ9CQF6. MM.

Family and domain databases

Gene3Di3.90.470.20. 2 hits.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
SUPFAMiSSF56214. SSF56214. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo, Lung, Medulla oblongata, Pancreas, Small intestine and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Spleen and Testis.

Entry informationi

Entry nameiADPPT_MOUSE
AccessioniPrimary (citable) accession number: Q9CQF6
Secondary accession number(s): Q5U5W8, Q9CU40, Q9D827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.