ID   RM11_MOUSE              Reviewed;         192 AA.
AC   Q9CQF0; Q3TJX7;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 159.
DE   RecName: Full=Large ribosomal subunit protein uL11m {ECO:0000305};
DE   AltName: Full=39S ribosomal protein L11, mitochondrial;
DE            Short=L11mt;
DE            Short=MRP-L11;
DE   Flags: Precursor;
GN   Name=Mrpl11;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX   PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA   Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA   Watanabe K.;
RT   "Structural compensation for the deficit of rRNA with proteins in the
RT   mammalian mitochondrial ribosome. Systematic analysis of protein components
RT   of the large ribosomal subunit from mammalian mitochondria.";
RL   J. Biol. Chem. 276:21724-21736(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryonic stem cell, and Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC   Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC       which comprises a 16S rRNA and about 50 distinct proteins.
CC       {ECO:0000250|UniProtKB:Q9Y3B7}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL11 family.
CC       {ECO:0000305}.
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DR   EMBL; AB049639; BAB40844.1; -; mRNA.
DR   EMBL; AK002797; BAB22366.1; -; mRNA.
DR   EMBL; AK010329; BAB26856.1; -; mRNA.
DR   EMBL; AK167247; BAE39368.1; -; mRNA.
DR   EMBL; BC046750; AAH46750.1; -; mRNA.
DR   CCDS; CCDS29444.1; -.
DR   RefSeq; NP_079829.1; NM_025553.4.
DR   AlphaFoldDB; Q9CQF0; -.
DR   SMR; Q9CQF0; -.
DR   BioGRID; 211460; 38.
DR   ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR   STRING; 10090.ENSMUSP00000025836; -.
DR   iPTMnet; Q9CQF0; -.
DR   PhosphoSitePlus; Q9CQF0; -.
DR   EPD; Q9CQF0; -.
DR   MaxQB; Q9CQF0; -.
DR   PaxDb; 10090-ENSMUSP00000025836; -.
DR   PeptideAtlas; Q9CQF0; -.
DR   ProteomicsDB; 300518; -.
DR   Pumba; Q9CQF0; -.
DR   Antibodypedia; 30159; 364 antibodies from 30 providers.
DR   DNASU; 66419; -.
DR   Ensembl; ENSMUST00000025836.6; ENSMUSP00000025836.5; ENSMUSG00000024902.6.
DR   GeneID; 66419; -.
DR   KEGG; mmu:66419; -.
DR   UCSC; uc008gbt.2; mouse.
DR   AGR; MGI:2137215; -.
DR   CTD; 65003; -.
DR   MGI; MGI:2137215; Mrpl11.
DR   VEuPathDB; HostDB:ENSMUSG00000024902; -.
DR   eggNOG; KOG3257; Eukaryota.
DR   GeneTree; ENSGT00390000003153; -.
DR   HOGENOM; CLU_074237_1_1_1; -.
DR   InParanoid; Q9CQF0; -.
DR   OMA; CKQFNAK; -.
DR   OrthoDB; 166522at2759; -.
DR   PhylomeDB; Q9CQF0; -.
DR   TreeFam; TF313471; -.
DR   Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR   Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR   BioGRID-ORCS; 66419; 20 hits in 77 CRISPR screens.
DR   ChiTaRS; Mrpl11; mouse.
DR   PRO; PR:Q9CQF0; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q9CQF0; Protein.
DR   Bgee; ENSMUSG00000024902; Expressed in optic fissure and 261 other cell types or tissues.
DR   ExpressionAtlas; Q9CQF0; baseline and differential.
DR   GO; GO:0005743; C:mitochondrial inner membrane; NAS:ComplexPortal.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0070180; F:large ribosomal subunit rRNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR   GO; GO:0032543; P:mitochondrial translation; NAS:ComplexPortal.
DR   GO; GO:0006412; P:translation; ISO:MGI.
DR   CDD; cd00349; Ribosomal_L11; 1.
DR   Gene3D; 1.10.10.250; Ribosomal protein L11, C-terminal domain; 1.
DR   Gene3D; 3.30.1550.10; Ribosomal protein L11/L12, N-terminal domain; 1.
DR   HAMAP; MF_00736; Ribosomal_uL11; 1.
DR   InterPro; IPR000911; Ribosomal_uL11.
DR   InterPro; IPR006519; Ribosomal_uL11_bac-typ.
DR   InterPro; IPR020783; Ribosomal_uL11_C.
DR   InterPro; IPR036769; Ribosomal_uL11_C_sf.
DR   InterPro; IPR020784; Ribosomal_uL11_N.
DR   InterPro; IPR036796; Ribosomal_uL11_N_sf.
DR   NCBIfam; TIGR01632; L11_bact; 1.
DR   PANTHER; PTHR11661:SF1; 39S RIBOSOMAL PROTEIN L11, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11661; 60S RIBOSOMAL PROTEIN L12; 1.
DR   Pfam; PF00298; Ribosomal_L11; 1.
DR   Pfam; PF03946; Ribosomal_L11_N; 1.
DR   SMART; SM00649; RL11; 1.
DR   SUPFAM; SSF54747; Ribosomal L11/L12e N-terminal domain; 1.
DR   SUPFAM; SSF46906; Ribosomal protein L11, C-terminal domain; 1.
DR   Genevisible; Q9CQF0; MM.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..192
FT                   /note="Large ribosomal subunit protein uL11m"
FT                   /id="PRO_0000030444"
SQ   SEQUENCE   192 AA;  20680 MW;  9530EFA4E41A81F3 CRC64;
     MSKLSRATRT LKKPEAGGVI RSIVRAGQAI PGPPLGPILG QRGVSINQFC KEFNEKTKDI
     KEGIPLPTKI FIKPDRTFEL KIGQPTVSYF LKAAAGIEKG ARHTGKEVAG LVSLKHVYEI
     ACVKAKDDAF AMQDVPLSSV VRSIIGSARS LGIRVVKDLS AEELEAFQKE RAVFLAAQKE
     ADLAAQAEAA KK
//