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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Gene

Ergic3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Alternative name(s):
Serologically defined breast cancer antigen NY-BR-84 homolog
Gene namesi
Name:Ergic3
Synonyms:Erv46, Sdbcag84
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913616. Ergic3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence analysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence analysisAdd
BLAST
Topological domaini47 – 341295LumenalSequence analysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence analysisAdd
BLAST
Topological domaini363 – 38321CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Endoplasmic reticulum-Golgi intermediate compartment protein 3PRO_0000097641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

EPDiQ9CQE7.
MaxQBiQ9CQE7.
PaxDbiQ9CQE7.
PRIDEiQ9CQE7.

PTM databases

iPTMnetiQ9CQE7.
PhosphoSiteiQ9CQE7.
SwissPalmiQ9CQE7.

Expressioni

Tissue specificityi

Expression is particularly strong in liver, kidney and brain but is almost undetectable in heart.1 Publication

Gene expression databases

BgeeiQ9CQE7.
CleanExiMM_ERGIC3.
ExpressionAtlasiQ9CQE7. baseline and differential.
GenevisibleiQ9CQE7. MM.

Interactioni

Subunit structurei

Interacts with ERGIC1/ERGIC32.By similarity

Protein-protein interaction databases

IntActiQ9CQE7. 1 interaction.
MINTiMINT-4613510.
STRINGi10090.ENSMUSP00000006035.

Structurei

3D structure databases

ProteinModelPortaliQ9CQE7.
SMRiQ9CQE7. Positions 198-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2667. Eukaryota.
ENOG410XP7X. LUCA.
GeneTreeiENSGT00530000063113.
HOGENOMiHOG000210954.
HOVERGENiHBG105706.
InParanoidiQ9CQE7.
OMAiIFPHMPC.
OrthoDBiEOG70KGPK.
PhylomeDBiQ9CQE7.
TreeFamiTF300739.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL
60 70 80 90 100
TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE
110 120 130 140 150
HNLFKKRLDK DGVPVSSEAE RHELGKVEVT VFDPNSLDPN RCESCYGAES
160 170 180 190 200
EDIKCCNSCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ
210 220 230 240 250
VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI NMTHYIKHLS
260 270 280 290 300
FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF
310 320 330 340 350
SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA
360 370 380
IIGGMFTVAG LIDSLIYHSA RAIQKKIDLG KTT
Length:383
Mass (Da):43,208
Last modified:June 1, 2001 - v1
Checksum:i97EF08712201E0C2
GO
Isoform 2 (identifier: Q9CQE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-229: V → VHAVEI
     239-239: N → NPSDCLQ

Show »
Length:394
Mass (Da):44,402
Checksum:i44BFD6F72316DD77
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei229 – 2291V → VHAVEI in isoform 2. 1 PublicationVSP_019209
Alternative sequencei239 – 2391N → NPSDCLQ in isoform 2. 1 PublicationVSP_019210

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009350 mRNA. Translation: BAB26233.1.
AK013942 mRNA. Translation: BAB29073.1.
AK050285 mRNA. Translation: BAC34166.1.
AL833786 Genomic DNA. Translation: CAX15725.1.
BC043720 mRNA. Translation: AAH43720.1.
BC057130 mRNA. Translation: AAH57130.1.
CCDSiCCDS16959.1. [Q9CQE7-1]
RefSeqiNP_079792.1. NM_025516.4. [Q9CQE7-1]
XP_011238033.1. XM_011239731.1. [Q9CQE7-2]
UniGeneiMm.141276.

Genome annotation databases

EnsembliENSMUST00000006035; ENSMUSP00000006035; ENSMUSG00000005881. [Q9CQE7-1]
ENSMUST00000088650; ENSMUSP00000086025; ENSMUSG00000005881. [Q9CQE7-2]
GeneIDi66366.
KEGGimmu:66366.
UCSCiuc008nlx.1. mouse. [Q9CQE7-1]
uc008nly.1. mouse. [Q9CQE7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009350 mRNA. Translation: BAB26233.1.
AK013942 mRNA. Translation: BAB29073.1.
AK050285 mRNA. Translation: BAC34166.1.
AL833786 Genomic DNA. Translation: CAX15725.1.
BC043720 mRNA. Translation: AAH43720.1.
BC057130 mRNA. Translation: AAH57130.1.
CCDSiCCDS16959.1. [Q9CQE7-1]
RefSeqiNP_079792.1. NM_025516.4. [Q9CQE7-1]
XP_011238033.1. XM_011239731.1. [Q9CQE7-2]
UniGeneiMm.141276.

3D structure databases

ProteinModelPortaliQ9CQE7.
SMRiQ9CQE7. Positions 198-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQE7. 1 interaction.
MINTiMINT-4613510.
STRINGi10090.ENSMUSP00000006035.

PTM databases

iPTMnetiQ9CQE7.
PhosphoSiteiQ9CQE7.
SwissPalmiQ9CQE7.

Proteomic databases

EPDiQ9CQE7.
MaxQBiQ9CQE7.
PaxDbiQ9CQE7.
PRIDEiQ9CQE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006035; ENSMUSP00000006035; ENSMUSG00000005881. [Q9CQE7-1]
ENSMUST00000088650; ENSMUSP00000086025; ENSMUSG00000005881. [Q9CQE7-2]
GeneIDi66366.
KEGGimmu:66366.
UCSCiuc008nlx.1. mouse. [Q9CQE7-1]
uc008nly.1. mouse. [Q9CQE7-2]

Organism-specific databases

CTDi51614.
MGIiMGI:1913616. Ergic3.

Phylogenomic databases

eggNOGiKOG2667. Eukaryota.
ENOG410XP7X. LUCA.
GeneTreeiENSGT00530000063113.
HOGENOMiHOG000210954.
HOVERGENiHBG105706.
InParanoidiQ9CQE7.
OMAiIFPHMPC.
OrthoDBiEOG70KGPK.
PhylomeDBiQ9CQE7.
TreeFamiTF300739.

Miscellaneous databases

ChiTaRSiErgic3. mouse.
PROiQ9CQE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQE7.
CleanExiMM_ERGIC3.
ExpressionAtlasiQ9CQE7. baseline and differential.
GenevisibleiQ9CQE7. MM.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo, Liver and Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N-3.
    Tissue: Brain and Mammary tumor.
  4. "Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae."
    Orci L., Ravazzola M., Mack G.J., Barlowe C., Otte S.
    Proc. Natl. Acad. Sci. U.S.A. 100:4586-4591(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiERGI3_MOUSE
AccessioniPrimary (citable) accession number: Q9CQE7
Secondary accession number(s): B7ZCN9, Q6PGA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.