Q9CQE5 (RGS10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 10
Short name=RGS10

Gene names

Name:

Rgs10

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein By similarity.

Sequence similarities

Contains 1 RGS domain.

Ontologies

Keywords
Molecular function	Signal transduction inhibitor
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	axon terminus Inferred from electronic annotation. Source: Compara cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome dendritic spine Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Regulator of G-protein signaling 10		PRO_0000204208
Regions
	Domain	41 – 156	116	RGS
Amino acid modifications
	Lipidation	74	1	S-palmitoyl cysteine By similarity
Experimental info
	Sequence conflict	73	1	A → E in BAB30688. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9CQE5 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 9897860505962286	FASTA	181	21,151
	10 20 30 40 50 60 MFTRAVSRLS RKRPPSDIHD GDGSSSSGHQ SLKSTAKWAS SLENLLEDPE GVQRFREFLK 70 80 90 100 110 120 KEFSEENVLF WLACEDFKKT EDRKQMQEKA KEIYMTFLSN KASSQVNVEG QSRLTEKILE 130 140 150 160 170 180 EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD LFLKPKRTEE EEEEPPDAQT AAKRASRIYN T

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Head, Thymus and Tongue.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK009686 mRNA. Translation: BAB26440.1. AK009283 mRNA. Translation: BAB26193.1. AK017314 mRNA. Translation: BAB30688.1. AK088009 mRNA. Translation: BAC40091.1.
IPI	IPI00132450.
RefSeq	NP_080694.1. NM_026418.2.
UniGene	Mm.18635.
3D structure databases
ProteinModelPortal	Q9CQE5.
SMR	Q9CQE5. Positions 30-164.
ModBase	Search...
PTM databases
PhosphoSite	Q9CQE5.
Proteomic databases
PaxDb	Q9CQE5.
PRIDE	Q9CQE5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033133; ENSMUSP00000033133; ENSMUSG00000030844.
GeneID	67865.
KEGG	mmu:67865.
Organism-specific databases
CTD	6001.
MGI	MGI:1915115. Rgs10.
Phylogenomic databases
eggNOG	NOG271158.
GeneTree	ENSGT00700000104412.
HOGENOM	HOG000233512.
HOVERGEN	HBG013233.
InParanoid	Q9CQE5.
KO	K16449.
OMA	PKSTAKW.
OrthoDB	EOG4JM7QV.
Gene expression databases
ArrayExpress	Q9CQE5.
Bgee	Q9CQE5.
CleanEx	MM_RGS10.
Genevestigator	Q9CQE5.
GermOnline	ENSMUSG00000030844. Mus musculus.
Family and domain databases
Gene3D	1.10.196.10. 1 hit.
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	325763.
SOURCE	Search...

Entry information

Entry name

RGS10_MOUSE

Accession

Primary (citable) accession number: Q9CQE5
Secondary accession number(s): Q9D3L2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program