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Q9CQE5

- RGS10_MOUSE

UniProt

Q9CQE5 - RGS10_MOUSE

Protein

Regulator of G-protein signaling 10

Gene

Rgs10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome
    2. protein binding Source: MGI

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 10
    Short name:
    RGS10
    Gene namesi
    Name:Rgs10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1915115. Rgs10.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. cytoplasm Source: RefGenome
    3. dendritic spine Source: Ensembl
    4. neuronal cell body Source: Ensembl
    5. nucleus Source: Ensembl
    6. plasma membrane Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Regulator of G-protein signaling 10PRO_0000204208Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi74 – 741S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiQ9CQE5.
    PaxDbiQ9CQE5.
    PRIDEiQ9CQE5.

    PTM databases

    PhosphoSiteiQ9CQE5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CQE5.
    BgeeiQ9CQE5.
    CleanExiMM_RGS10.
    GenevestigatoriQ9CQE5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9CQE5. 1 interaction.
    MINTiMINT-4132285.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQE5.
    SMRiQ9CQE5. Positions 30-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 156116RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG271158.
    GeneTreeiENSGT00700000104412.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiQ9CQE5.
    KOiK16449.
    OMAiPKSTAKW.
    OrthoDBiEOG7XDBF0.
    PhylomeDBiQ9CQE5.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CQE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTRAVSRLS RKRPPSDIHD GDGSSSSGHQ SLKSTAKWAS SLENLLEDPE    50
    GVQRFREFLK KEFSEENVLF WLACEDFKKT EDRKQMQEKA KEIYMTFLSN 100
    KASSQVNVEG QSRLTEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD 150
    LFLKPKRTEE EEEEPPDAQT AAKRASRIYN T 181
    Length:181
    Mass (Da):21,151
    Last modified:June 1, 2001 - v1
    Checksum:i9897860505962286
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731A → E in BAB30688. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009686 mRNA. Translation: BAB26440.1.
    AK009283 mRNA. Translation: BAB26193.1.
    AK017314 mRNA. Translation: BAB30688.1.
    AK088009 mRNA. Translation: BAC40091.1.
    CCDSiCCDS21896.1.
    RefSeqiNP_080694.1. NM_026418.2.
    UniGeneiMm.18635.

    Genome annotation databases

    EnsembliENSMUST00000033133; ENSMUSP00000033133; ENSMUSG00000030844.
    GeneIDi67865.
    KEGGimmu:67865.
    UCSCiuc009jyw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009686 mRNA. Translation: BAB26440.1 .
    AK009283 mRNA. Translation: BAB26193.1 .
    AK017314 mRNA. Translation: BAB30688.1 .
    AK088009 mRNA. Translation: BAC40091.1 .
    CCDSi CCDS21896.1.
    RefSeqi NP_080694.1. NM_026418.2.
    UniGenei Mm.18635.

    3D structure databases

    ProteinModelPortali Q9CQE5.
    SMRi Q9CQE5. Positions 30-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CQE5. 1 interaction.
    MINTi MINT-4132285.

    PTM databases

    PhosphoSitei Q9CQE5.

    Proteomic databases

    MaxQBi Q9CQE5.
    PaxDbi Q9CQE5.
    PRIDEi Q9CQE5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033133 ; ENSMUSP00000033133 ; ENSMUSG00000030844 .
    GeneIDi 67865.
    KEGGi mmu:67865.
    UCSCi uc009jyw.1. mouse.

    Organism-specific databases

    CTDi 6001.
    MGIi MGI:1915115. Rgs10.

    Phylogenomic databases

    eggNOGi NOG271158.
    GeneTreei ENSGT00700000104412.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi Q9CQE5.
    KOi K16449.
    OMAi PKSTAKW.
    OrthoDBi EOG7XDBF0.
    PhylomeDBi Q9CQE5.
    TreeFami TF315837.

    Miscellaneous databases

    NextBioi 325763.
    PROi Q9CQE5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CQE5.
    Bgeei Q9CQE5.
    CleanExi MM_RGS10.
    Genevestigatori Q9CQE5.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head, Thymus and Tongue.

    Entry informationi

    Entry nameiRGS10_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQE5
    Secondary accession number(s): Q9D3L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3