Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type proton ATPase subunit e 1

Gene

Atp6v0e1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit e 1
Short name:
V-ATPase subunit e 1
Alternative name(s):
Vacuolar proton pump subunit e 1
Gene namesi
Name:Atp6v0e1
Synonyms:Atp6v0e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1328318. Atp6v0e.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002701962 – 81V-type proton ATPase subunit e 1Add BLAST80

Proteomic databases

PaxDbiQ9CQD8.
PRIDEiQ9CQD8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015575.
CleanExiMM_ATP6V0E.
GenevisibleiQ9CQD8. MM.

Interactioni

Subunit structurei

Composed of at least 10 subunits.

Protein-protein interaction databases

BioGridi198266. 2 interactors.
STRINGi10090.ENSMUSP00000015719.

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase e1/e2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3500. Eukaryota.
ENOG41121M0. LUCA.
GeneTreeiENSGT00390000000728.
HOGENOMiHOG000265078.
HOVERGENiHBG003974.
InParanoidiQ9CQD8.
KOiK02153.
OMAiGVVPWFI.
OrthoDBiEOG091G113P.
PhylomeDBiQ9CQD8.
TreeFamiTF300290.

Family and domain databases

InterProiIPR008389. ATPase_V0-cplx_e1/e2_su.
IPR017385. ATPase_V0-cplx_e1/e2_su_met.
[Graphical view]
PANTHERiPTHR12263. PTHR12263. 1 hit.
PfamiPF05493. ATP_synt_H. 1 hit.
[Graphical view]
PIRSFiPIRSF038097. V-ATP_synth_e1/e2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYHGLTVPL IVMSVFWGFV GLLVPWFIPK GPNRGVIITM LVTCSVCCYL
60 70 80
FWLIAILAQL NPLFGPQLKN ETIWYLKYHW P
Length:81
Mass (Da):9,340
Last modified:January 23, 2007 - v3
Checksum:i9A47F165D72B2A2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007610 mRNA. Translation: BAB25133.1.
AK013229 mRNA. Translation: BAB28727.1.
AK017760 mRNA. Translation: BAB30911.1.
AK030335 mRNA. Translation: BAC26909.1.
AK134836 mRNA. Translation: BAE22305.1.
AK159669 mRNA. Translation: BAE35273.1.
AK168015 mRNA. Translation: BAE40002.1.
BC024733 mRNA. Translation: AAH24733.1.
CCDSiCCDS28554.1.
PIRiJC7602.
RefSeqiNP_079548.1. NM_025272.2.
UniGeneiMm.22602.

Genome annotation databases

EnsembliENSMUST00000015719; ENSMUSP00000015719; ENSMUSG00000015575.
ENSMUST00000167352; ENSMUSP00000127552; ENSMUSG00000015575.
GeneIDi11974.
KEGGimmu:11974.
UCSCiuc008beh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007610 mRNA. Translation: BAB25133.1.
AK013229 mRNA. Translation: BAB28727.1.
AK017760 mRNA. Translation: BAB30911.1.
AK030335 mRNA. Translation: BAC26909.1.
AK134836 mRNA. Translation: BAE22305.1.
AK159669 mRNA. Translation: BAE35273.1.
AK168015 mRNA. Translation: BAE40002.1.
BC024733 mRNA. Translation: AAH24733.1.
CCDSiCCDS28554.1.
PIRiJC7602.
RefSeqiNP_079548.1. NM_025272.2.
UniGeneiMm.22602.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198266. 2 interactors.
STRINGi10090.ENSMUSP00000015719.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

PaxDbiQ9CQD8.
PRIDEiQ9CQD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015719; ENSMUSP00000015719; ENSMUSG00000015575.
ENSMUST00000167352; ENSMUSP00000127552; ENSMUSG00000015575.
GeneIDi11974.
KEGGimmu:11974.
UCSCiuc008beh.1. mouse.

Organism-specific databases

CTDi11974.
MGIiMGI:1328318. Atp6v0e.

Phylogenomic databases

eggNOGiKOG3500. Eukaryota.
ENOG41121M0. LUCA.
GeneTreeiENSGT00390000000728.
HOGENOMiHOG000265078.
HOVERGENiHBG003974.
InParanoidiQ9CQD8.
KOiK02153.
OMAiGVVPWFI.
OrthoDBiEOG091G113P.
PhylomeDBiQ9CQD8.
TreeFamiTF300290.

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Miscellaneous databases

PROiQ9CQD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015575.
CleanExiMM_ATP6V0E.
GenevisibleiQ9CQD8. MM.

Family and domain databases

InterProiIPR008389. ATPase_V0-cplx_e1/e2_su.
IPR017385. ATPase_V0-cplx_e1/e2_su_met.
[Graphical view]
PANTHERiPTHR12263. PTHR12263. 1 hit.
PfamiPF05493. ATP_synt_H. 1 hit.
[Graphical view]
PIRSFiPIRSF038097. V-ATP_synth_e1/e2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVA0E1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.