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Protein

V-type proton ATPase subunit e 1

Gene

Atp6v0e1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit e 1
Short name:
V-ATPase subunit e 1
Alternative name(s):
Vacuolar proton pump subunit e 1
Gene namesi
Name:Atp6v0e1
Synonyms:Atp6v0e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1328318. Atp6v0e.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 8180V-type proton ATPase subunit e 1PRO_0000270196Add
BLAST

Proteomic databases

PaxDbiQ9CQD8.

Expressioni

Gene expression databases

BgeeiQ9CQD8.
CleanExiMM_ATP6V0E.
GenevisibleiQ9CQD8. MM.

Interactioni

Subunit structurei

Composed of at least 10 subunits.

Protein-protein interaction databases

BioGridi198266. 1 interaction.
STRINGi10090.ENSMUSP00000015719.

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase e1/e2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3500. Eukaryota.
ENOG41121M0. LUCA.
GeneTreeiENSGT00390000000728.
HOGENOMiHOG000265078.
HOVERGENiHBG003974.
InParanoidiQ9CQD8.
KOiK02153.
OMAiGVVPWFI.
OrthoDBiEOG7B31QD.
PhylomeDBiQ9CQD8.
TreeFamiTF300290.

Family and domain databases

InterProiIPR008389. ATPase_V0-cplx_e1/e2_su.
IPR017385. ATPase_V0-cplx_e1/e2_su_met.
[Graphical view]
PANTHERiPTHR12263. PTHR12263. 1 hit.
PfamiPF05493. ATP_synt_H. 1 hit.
[Graphical view]
PIRSFiPIRSF038097. V-ATP_synth_e1/e2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYHGLTVPL IVMSVFWGFV GLLVPWFIPK GPNRGVIITM LVTCSVCCYL
60 70 80
FWLIAILAQL NPLFGPQLKN ETIWYLKYHW P
Length:81
Mass (Da):9,340
Last modified:January 23, 2007 - v3
Checksum:i9A47F165D72B2A2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007610 mRNA. Translation: BAB25133.1.
AK013229 mRNA. Translation: BAB28727.1.
AK017760 mRNA. Translation: BAB30911.1.
AK030335 mRNA. Translation: BAC26909.1.
AK134836 mRNA. Translation: BAE22305.1.
AK159669 mRNA. Translation: BAE35273.1.
AK168015 mRNA. Translation: BAE40002.1.
BC024733 mRNA. Translation: AAH24733.1.
CCDSiCCDS28554.1.
PIRiJC7602.
RefSeqiNP_079548.1. NM_025272.2.
UniGeneiMm.22602.

Genome annotation databases

EnsembliENSMUST00000015719; ENSMUSP00000015719; ENSMUSG00000015575.
ENSMUST00000167352; ENSMUSP00000127552; ENSMUSG00000015575.
GeneIDi11974.
KEGGimmu:11974.
UCSCiuc008beh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007610 mRNA. Translation: BAB25133.1.
AK013229 mRNA. Translation: BAB28727.1.
AK017760 mRNA. Translation: BAB30911.1.
AK030335 mRNA. Translation: BAC26909.1.
AK134836 mRNA. Translation: BAE22305.1.
AK159669 mRNA. Translation: BAE35273.1.
AK168015 mRNA. Translation: BAE40002.1.
BC024733 mRNA. Translation: AAH24733.1.
CCDSiCCDS28554.1.
PIRiJC7602.
RefSeqiNP_079548.1. NM_025272.2.
UniGeneiMm.22602.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198266. 1 interaction.
STRINGi10090.ENSMUSP00000015719.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

PaxDbiQ9CQD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015719; ENSMUSP00000015719; ENSMUSG00000015575.
ENSMUST00000167352; ENSMUSP00000127552; ENSMUSG00000015575.
GeneIDi11974.
KEGGimmu:11974.
UCSCiuc008beh.1. mouse.

Organism-specific databases

CTDi11974.
MGIiMGI:1328318. Atp6v0e.

Phylogenomic databases

eggNOGiKOG3500. Eukaryota.
ENOG41121M0. LUCA.
GeneTreeiENSGT00390000000728.
HOGENOMiHOG000265078.
HOVERGENiHBG003974.
InParanoidiQ9CQD8.
KOiK02153.
OMAiGVVPWFI.
OrthoDBiEOG7B31QD.
PhylomeDBiQ9CQD8.
TreeFamiTF300290.

Enzyme and pathway databases

ReactomeiR-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Miscellaneous databases

NextBioi280103.
PROiQ9CQD8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQD8.
CleanExiMM_ATP6V0E.
GenevisibleiQ9CQD8. MM.

Family and domain databases

InterProiIPR008389. ATPase_V0-cplx_e1/e2_su.
IPR017385. ATPase_V0-cplx_e1/e2_su_met.
[Graphical view]
PANTHERiPTHR12263. PTHR12263. 1 hit.
PfamiPF05493. ATP_synt_H. 1 hit.
[Graphical view]
PIRSFiPIRSF038097. V-ATP_synth_e1/e2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Medulla oblongata, Ovary and Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiVA0E1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.