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Q9CQD6

- SARCO_MOUSE

UniProt

Q9CQD6 - SARCO_MOUSE

Protein

Sarcolipin

Gene

Sln

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis.2 Publications

    GO - Molecular functioni

    1. enzyme regulator activity Source: InterPro

    GO - Biological processi

    1. regulation of calcium ion transport Source: UniProtKB
    2. regulation of calcium-transporting ATPase activity Source: UniProtKB
    3. regulation of relaxation of muscle Source: UniProtKB
    4. sarcoplasmic reticulum calcium ion transport Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sarcolipin
    Gene namesi
    Name:Sln
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1913652. Sln.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. sarcoplasmic reticulum Source: UniProtKB
    3. sarcoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype at 22 degrees Celsius. Increased heat-loss and failure to maintain body temperature at 4 degrees Celsius when the shivering response is prevented. Mice show increased weight gain and obesity when kept on a high-fat diet. Mice display faster muscle relaxation rates in soleus due to an increase in the affinity of ATP2A1 for Ca2+.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3131SarcolipinPRO_0000045899Add
    BLAST

    PTM databases

    PhosphoSiteiQ9CQD6.

    Expressioni

    Tissue specificityi

    Highly expressed in heart atrium, red gastrocnemius muscle and soleus. Detected at lower levels in the extensor digitorum longus muscle (at protein level).1 Publication

    Gene expression databases

    BgeeiQ9CQD6.
    CleanExiMM_SLN.
    GenevestigatoriQ9CQD6.

    Interactioni

    Subunit structurei

    Interacts with calcium ATPase ATP2A1/SERCA1.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000036950.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CQD6.
    SMRiQ9CQD6. Positions 1-31.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicBy similarity
    Topological domaini27 – 315LumenalBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2619HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sarcolipin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG140204.
    GeneTreeiENSGT00530000064724.
    HOGENOMiHOG000142457.
    HOVERGENiHBG079165.
    InParanoidiQ9CQD6.
    OrthoDBiEOG7T7GXN.
    PhylomeDBiQ9CQD6.

    Family and domain databases

    InterProiIPR008028. Sarcolipin.
    [Graphical view]
    PfamiPF05366. Sarcolipin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CQD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERSTQELFI NFTVVLITVL LMWLLVRSYQ Y                       31
    Length:31
    Mass (Da):3,808
    Last modified:June 1, 2001 - v1
    Checksum:i9B310161575EF81D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008863 mRNA. No translation available.
    AK008896 mRNA. Translation: BAB25959.1.
    AK009005 mRNA. Translation: BAB26019.1.
    AK009809 mRNA. Translation: BAB26516.1.
    BC028496 mRNA. Translation: AAH28496.1.
    CCDSiCCDS40640.1.
    RefSeqiNP_079816.1. NM_025540.2.
    UniGeneiMm.29132.

    Genome annotation databases

    EnsembliENSMUST00000048485; ENSMUSP00000036950; ENSMUSG00000042045.
    GeneIDi66402.
    KEGGimmu:66402.
    UCSCiuc009pmp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008863 mRNA. No translation available.
    AK008896 mRNA. Translation: BAB25959.1 .
    AK009005 mRNA. Translation: BAB26019.1 .
    AK009809 mRNA. Translation: BAB26516.1 .
    BC028496 mRNA. Translation: AAH28496.1 .
    CCDSi CCDS40640.1.
    RefSeqi NP_079816.1. NM_025540.2.
    UniGenei Mm.29132.

    3D structure databases

    ProteinModelPortali Q9CQD6.
    SMRi Q9CQD6. Positions 1-31.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000036950.

    PTM databases

    PhosphoSitei Q9CQD6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048485 ; ENSMUSP00000036950 ; ENSMUSG00000042045 .
    GeneIDi 66402.
    KEGGi mmu:66402.
    UCSCi uc009pmp.1. mouse.

    Organism-specific databases

    CTDi 6588.
    MGIi MGI:1913652. Sln.

    Phylogenomic databases

    eggNOGi NOG140204.
    GeneTreei ENSGT00530000064724.
    HOGENOMi HOG000142457.
    HOVERGENi HBG079165.
    InParanoidi Q9CQD6.
    OrthoDBi EOG7T7GXN.
    PhylomeDBi Q9CQD6.

    Miscellaneous databases

    ChiTaRSi SLN. mouse.
    NextBioi 321575.
    PROi Q9CQD6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQD6.
    CleanExi MM_SLN.
    Genevestigatori Q9CQD6.

    Family and domain databases

    InterProi IPR008028. Sarcolipin.
    [Graphical view ]
    Pfami PF05366. Sarcolipin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Stomach and Tongue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    3. Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
    4. Cited for: DISRUPTION PHENOTYPE, FUNCTION.

    Entry informationi

    Entry nameiSARCO_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3