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Q9CQD6

- SARCO_MOUSE

UniProt

Q9CQD6 - SARCO_MOUSE

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Protein

Sarcolipin

Gene

Sln

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis.2 Publications

GO - Molecular functioni

  1. enzyme regulator activity Source: InterPro

GO - Biological processi

  1. regulation of calcium ion transport Source: UniProtKB
  2. regulation of calcium-transporting ATPase activity Source: UniProtKB
  3. regulation of relaxation of muscle Source: UniProtKB
  4. sarcoplasmic reticulum calcium ion transport Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcolipin
Gene namesi
Name:Sln
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1913652. Sln.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. sarcoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

No visible phenotype at 22 degrees Celsius. Increased heat-loss and failure to maintain body temperature at 4 degrees Celsius when the shivering response is prevented. Mice show increased weight gain and obesity when kept on a high-fat diet. Mice display faster muscle relaxation rates in soleus due to an increase in the affinity of ATP2A1 for Ca2+.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3131SarcolipinPRO_0000045899Add
BLAST

PTM databases

PhosphoSiteiQ9CQD6.

Expressioni

Tissue specificityi

Highly expressed in heart atrium, red gastrocnemius muscle and soleus. Detected at lower levels in the extensor digitorum longus muscle (at protein level).1 Publication

Gene expression databases

BgeeiQ9CQD6.
CleanExiMM_SLN.
GenevestigatoriQ9CQD6.

Interactioni

Subunit structurei

Interacts with calcium ATPase ATP2A1/SERCA1.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036950.

Structurei

3D structure databases

ProteinModelPortaliQ9CQD6.
SMRiQ9CQD6. Positions 1-31.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicBy similarity
Topological domaini27 – 315LumenalBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2619HelicalBy similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the sarcolipin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG140204.
GeneTreeiENSGT00530000064724.
HOGENOMiHOG000142457.
HOVERGENiHBG079165.
InParanoidiQ9CQD6.
OrthoDBiEOG7T7GXN.
PhylomeDBiQ9CQD6.

Family and domain databases

InterProiIPR008028. Sarcolipin.
[Graphical view]
PfamiPF05366. Sarcolipin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQD6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30
MERSTQELFI NFTVVLITVL LMWLLVRSYQ Y
Length:31
Mass (Da):3,808
Last modified:June 1, 2001 - v1
Checksum:i9B310161575EF81D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008863 mRNA. No translation available.
AK008896 mRNA. Translation: BAB25959.1.
AK009005 mRNA. Translation: BAB26019.1.
AK009809 mRNA. Translation: BAB26516.1.
BC028496 mRNA. Translation: AAH28496.1.
CCDSiCCDS40640.1.
RefSeqiNP_079816.1. NM_025540.2.
UniGeneiMm.29132.

Genome annotation databases

EnsembliENSMUST00000048485; ENSMUSP00000036950; ENSMUSG00000042045.
GeneIDi66402.
KEGGimmu:66402.
UCSCiuc009pmp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008863 mRNA. No translation available.
AK008896 mRNA. Translation: BAB25959.1 .
AK009005 mRNA. Translation: BAB26019.1 .
AK009809 mRNA. Translation: BAB26516.1 .
BC028496 mRNA. Translation: AAH28496.1 .
CCDSi CCDS40640.1.
RefSeqi NP_079816.1. NM_025540.2.
UniGenei Mm.29132.

3D structure databases

ProteinModelPortali Q9CQD6.
SMRi Q9CQD6. Positions 1-31.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000036950.

PTM databases

PhosphoSitei Q9CQD6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048485 ; ENSMUSP00000036950 ; ENSMUSG00000042045 .
GeneIDi 66402.
KEGGi mmu:66402.
UCSCi uc009pmp.1. mouse.

Organism-specific databases

CTDi 6588.
MGIi MGI:1913652. Sln.

Phylogenomic databases

eggNOGi NOG140204.
GeneTreei ENSGT00530000064724.
HOGENOMi HOG000142457.
HOVERGENi HBG079165.
InParanoidi Q9CQD6.
OrthoDBi EOG7T7GXN.
PhylomeDBi Q9CQD6.

Miscellaneous databases

ChiTaRSi SLN. mouse.
NextBioi 321575.
PROi Q9CQD6.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQD6.
CleanExi MM_SLN.
Genevestigatori Q9CQD6.

Family and domain databases

InterProi IPR008028. Sarcolipin.
[Graphical view ]
Pfami PF05366. Sarcolipin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
  4. Cited for: DISRUPTION PHENOTYPE, FUNCTION.

Entry informationi

Entry nameiSARCO_MOUSE
AccessioniPrimary (citable) accession number: Q9CQD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3