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Protein

Sarcolipin

Gene

Sln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis.2 Publications

GO - Molecular functioni

  1. enzyme regulator activity Source: InterPro

GO - Biological processi

  1. regulation of calcium ion transport Source: UniProtKB
  2. regulation of calcium-transporting ATPase activity Source: UniProtKB
  3. regulation of relaxation of muscle Source: UniProtKB
  4. sarcoplasmic reticulum calcium ion transport Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcolipin
Gene namesi
Name:Sln
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913652. Sln.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicBy similarity
Transmembranei8 – 2619HelicalBy similarityAdd
BLAST
Topological domaini27 – 315LumenalBy similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. sarcoplasmic reticulum Source: UniProtKB
  3. sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

No visible phenotype at 22 degrees Celsius. Increased heat-loss and failure to maintain body temperature at 4 degrees Celsius when the shivering response is prevented. Mice show increased weight gain and obesity when kept on a high-fat diet. Mice display faster muscle relaxation rates in soleus due to an increase in the affinity of ATP2A1 for Ca2+.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3131SarcolipinPRO_0000045899Add
BLAST

PTM databases

PhosphoSiteiQ9CQD6.

Expressioni

Tissue specificityi

Highly expressed in heart atrium, red gastrocnemius muscle and soleus. Detected at lower levels in the extensor digitorum longus muscle (at protein level).1 Publication

Gene expression databases

BgeeiQ9CQD6.
CleanExiMM_SLN.
GenevestigatoriQ9CQD6.

Interactioni

Subunit structurei

Interacts with calcium ATPase ATP2A1/SERCA1.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036950.

Structurei

3D structure databases

ProteinModelPortaliQ9CQD6.
SMRiQ9CQD6. Positions 1-31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sarcolipin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG140204.
GeneTreeiENSGT00530000064724.
HOGENOMiHOG000142457.
HOVERGENiHBG079165.
InParanoidiQ9CQD6.
OrthoDBiEOG7T7GXN.
PhylomeDBiQ9CQD6.

Family and domain databases

InterProiIPR008028. Sarcolipin.
[Graphical view]
PfamiPF05366. Sarcolipin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MERSTQELFI NFTVVLITVL LMWLLVRSYQ Y
Length:31
Mass (Da):3,808
Last modified:June 1, 2001 - v1
Checksum:i9B310161575EF81D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008863 mRNA. No translation available.
AK008896 mRNA. Translation: BAB25959.1.
AK009005 mRNA. Translation: BAB26019.1.
AK009809 mRNA. Translation: BAB26516.1.
BC028496 mRNA. Translation: AAH28496.1.
CCDSiCCDS40640.1.
RefSeqiNP_079816.1. NM_025540.2.
UniGeneiMm.29132.

Genome annotation databases

EnsembliENSMUST00000048485; ENSMUSP00000036950; ENSMUSG00000042045.
GeneIDi66402.
KEGGimmu:66402.
UCSCiuc009pmp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008863 mRNA. No translation available.
AK008896 mRNA. Translation: BAB25959.1.
AK009005 mRNA. Translation: BAB26019.1.
AK009809 mRNA. Translation: BAB26516.1.
BC028496 mRNA. Translation: AAH28496.1.
CCDSiCCDS40640.1.
RefSeqiNP_079816.1. NM_025540.2.
UniGeneiMm.29132.

3D structure databases

ProteinModelPortaliQ9CQD6.
SMRiQ9CQD6. Positions 1-31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036950.

PTM databases

PhosphoSiteiQ9CQD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048485; ENSMUSP00000036950; ENSMUSG00000042045.
GeneIDi66402.
KEGGimmu:66402.
UCSCiuc009pmp.1. mouse.

Organism-specific databases

CTDi6588.
MGIiMGI:1913652. Sln.

Phylogenomic databases

eggNOGiNOG140204.
GeneTreeiENSGT00530000064724.
HOGENOMiHOG000142457.
HOVERGENiHBG079165.
InParanoidiQ9CQD6.
OrthoDBiEOG7T7GXN.
PhylomeDBiQ9CQD6.

Miscellaneous databases

ChiTaRSiSln. mouse.
NextBioi321575.
PROiQ9CQD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQD6.
CleanExiMM_SLN.
GenevestigatoriQ9CQD6.

Family and domain databases

InterProiIPR008028. Sarcolipin.
[Graphical view]
PfamiPF05366. Sarcolipin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
  4. Cited for: DISRUPTION PHENOTYPE, FUNCTION.

Entry informationi

Entry nameiSARCO_MOUSE
AccessioniPrimary (citable) accession number: Q9CQD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.