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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

Gene

Ndufb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Alternative name(s):
Complex I-B15
Short name:
CI-B15
NADH-ubiquinone oxidoreductase B15 subunit
Gene namesi
Name:Ndufb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1915444. Ndufb4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei88 – 105HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001188012 – 129NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei26PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQC7.
MaxQBiQ9CQC7.
PaxDbiQ9CQC7.
PRIDEiQ9CQC7.

PTM databases

iPTMnetiQ9CQC7.
PhosphoSitePlusiQ9CQC7.
SwissPalmiQ9CQC7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022820.
GenevisibleiQ9CQC7. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi212719. 1 interactor.
IntActiQ9CQC7. 4 interactors.
MINTiMINT-4103061.
STRINGi10090.ENSMUSP00000023514.

Structurei

3D structure databases

ProteinModelPortaliQ9CQC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB4 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
GeneTreeiENSGT00390000007133.
HOVERGENiHBG001159.
InParanoidiQ9CQC7.
KOiK03960.
OMAiRWVYARA.
OrthoDBiEOG091G1578.
PhylomeDBiQ9CQC7.
TreeFamiTF328761.

Family and domain databases

InterProiIPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
[Graphical view]
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiPF07225. NDUF_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSKYKPAP LATLPSTLDP AEYDVSPETR RAQVERLSIR ARLKREYLLQ
60 70 80 90 100
YNDPKRVSHI EDPALIRWTY ARSANIYPNF RPTPKNSLLG AVAGFGPLIF
110 120
WYYVFKTDRD RKERLIQEGK LDRKFNISY
Length:129
Mass (Da):15,081
Last modified:January 23, 2007 - v3
Checksum:i9E76B5087F095062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009807 mRNA. Translation: BAB26515.1.
AK018707 mRNA. Translation: BAB31358.1.
BC056229 mRNA. Translation: AAH56229.1.
CCDSiCCDS28161.1.
RefSeqiNP_080886.1. NM_026610.1.
XP_001476621.1. XM_001476571.4.
XP_001478493.1. XM_001478443.6.
UniGeneiMm.379154.
Mm.390788.

Genome annotation databases

EnsembliENSMUST00000023514; ENSMUSP00000023514; ENSMUSG00000022820.
GeneIDi100041273.
100042503.
68194.
KEGGimmu:100041273.
mmu:100042503.
mmu:68194.
UCSCiuc007zei.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009807 mRNA. Translation: BAB26515.1.
AK018707 mRNA. Translation: BAB31358.1.
BC056229 mRNA. Translation: AAH56229.1.
CCDSiCCDS28161.1.
RefSeqiNP_080886.1. NM_026610.1.
XP_001476621.1. XM_001476571.4.
XP_001478493.1. XM_001478443.6.
UniGeneiMm.379154.
Mm.390788.

3D structure databases

ProteinModelPortaliQ9CQC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212719. 1 interactor.
IntActiQ9CQC7. 4 interactors.
MINTiMINT-4103061.
STRINGi10090.ENSMUSP00000023514.

PTM databases

iPTMnetiQ9CQC7.
PhosphoSitePlusiQ9CQC7.
SwissPalmiQ9CQC7.

Proteomic databases

EPDiQ9CQC7.
MaxQBiQ9CQC7.
PaxDbiQ9CQC7.
PRIDEiQ9CQC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023514; ENSMUSP00000023514; ENSMUSG00000022820.
GeneIDi100041273.
100042503.
68194.
KEGGimmu:100041273.
mmu:100042503.
mmu:68194.
UCSCiuc007zei.1. mouse.

Organism-specific databases

CTDi4710.
MGIiMGI:1915444. Ndufb4.

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
GeneTreeiENSGT00390000007133.
HOVERGENiHBG001159.
InParanoidiQ9CQC7.
KOiK03960.
OMAiRWVYARA.
OrthoDBiEOG091G1578.
PhylomeDBiQ9CQC7.
TreeFamiTF328761.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ9CQC7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022820.
GenevisibleiQ9CQC7. MM.

Family and domain databases

InterProiIPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
[Graphical view]
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiPF07225. NDUF_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB4_MOUSE
AccessioniPrimary (citable) accession number: Q9CQC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.