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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

Gene

Ndufb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Alternative name(s):
Complex I-B15
Short name:
CI-B15
NADH-ubiquinone oxidoreductase B15 subunit
Gene namesi
Name:Ndufb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1915444. Ndufb4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei88 – 10518HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 129128NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4PRO_0000118801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei26 – 261PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQC7.
MaxQBiQ9CQC7.
PaxDbiQ9CQC7.
PRIDEiQ9CQC7.

PTM databases

iPTMnetiQ9CQC7.
PhosphoSiteiQ9CQC7.
SwissPalmiQ9CQC7.

Expressioni

Gene expression databases

BgeeiQ9CQC7.
GenevisibleiQ9CQC7. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi212719. 1 interaction.
IntActiQ9CQC7. 4 interactions.
MINTiMINT-4103061.
STRINGi10090.ENSMUSP00000023514.

Structurei

3D structure databases

ProteinModelPortaliQ9CQC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB4 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
GeneTreeiENSGT00390000007133.
HOVERGENiHBG001159.
InParanoidiQ9CQC7.
KOiK03960.
OMAiIGPLFFW.
OrthoDBiEOG70KGRC.
PhylomeDBiQ9CQC7.
TreeFamiTF328761.

Family and domain databases

InterProiIPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
[Graphical view]
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiPF07225. NDUF_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSKYKPAP LATLPSTLDP AEYDVSPETR RAQVERLSIR ARLKREYLLQ
60 70 80 90 100
YNDPKRVSHI EDPALIRWTY ARSANIYPNF RPTPKNSLLG AVAGFGPLIF
110 120
WYYVFKTDRD RKERLIQEGK LDRKFNISY
Length:129
Mass (Da):15,081
Last modified:January 23, 2007 - v3
Checksum:i9E76B5087F095062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009807 mRNA. Translation: BAB26515.1.
AK018707 mRNA. Translation: BAB31358.1.
BC056229 mRNA. Translation: AAH56229.1.
CCDSiCCDS28161.1.
RefSeqiNP_080886.1. NM_026610.1.
XP_001476621.1. XM_001476571.4.
XP_001478493.1. XM_001478443.5.
UniGeneiMm.379154.
Mm.390788.

Genome annotation databases

EnsembliENSMUST00000023514; ENSMUSP00000023514; ENSMUSG00000022820.
GeneIDi100041273.
100042503.
68194.
KEGGimmu:100041273.
mmu:100042503.
mmu:68194.
UCSCiuc007zei.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009807 mRNA. Translation: BAB26515.1.
AK018707 mRNA. Translation: BAB31358.1.
BC056229 mRNA. Translation: AAH56229.1.
CCDSiCCDS28161.1.
RefSeqiNP_080886.1. NM_026610.1.
XP_001476621.1. XM_001476571.4.
XP_001478493.1. XM_001478443.5.
UniGeneiMm.379154.
Mm.390788.

3D structure databases

ProteinModelPortaliQ9CQC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212719. 1 interaction.
IntActiQ9CQC7. 4 interactions.
MINTiMINT-4103061.
STRINGi10090.ENSMUSP00000023514.

PTM databases

iPTMnetiQ9CQC7.
PhosphoSiteiQ9CQC7.
SwissPalmiQ9CQC7.

Proteomic databases

EPDiQ9CQC7.
MaxQBiQ9CQC7.
PaxDbiQ9CQC7.
PRIDEiQ9CQC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023514; ENSMUSP00000023514; ENSMUSG00000022820.
GeneIDi100041273.
100042503.
68194.
KEGGimmu:100041273.
mmu:100042503.
mmu:68194.
UCSCiuc007zei.1. mouse.

Organism-specific databases

CTDi4710.
MGIiMGI:1915444. Ndufb4.

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
GeneTreeiENSGT00390000007133.
HOVERGENiHBG001159.
InParanoidiQ9CQC7.
KOiK03960.
OMAiIGPLFFW.
OrthoDBiEOG70KGRC.
PhylomeDBiQ9CQC7.
TreeFamiTF328761.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

NextBioi326670.
PROiQ9CQC7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQC7.
GenevisibleiQ9CQC7. MM.

Family and domain databases

InterProiIPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
[Graphical view]
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiPF07225. NDUF_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 6-40; 46-67 AND 73-85, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNDUB4_MOUSE
AccessioniPrimary (citable) accession number: Q9CQC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: January 23, 2007
Last modified: March 16, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.