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Protein

Basic leucine zipper and W2 domain-containing protein 1

Gene

Bzw1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances histone H4 gene transcription but does not seem to bind DNA directly.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper and W2 domain-containing protein 1
Gene namesi
Name:Bzw1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914132 Bzw1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546101 – 419Basic leucine zipper and W2 domain-containing protein 1Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei12PhosphoserineBy similarity1
Cross-linki368Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei411PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CQC6
MaxQBiQ9CQC6
PaxDbiQ9CQC6
PeptideAtlasiQ9CQC6
PRIDEiQ9CQC6

PTM databases

iPTMnetiQ9CQC6
PhosphoSitePlusiQ9CQC6

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000051223
CleanExiMM_BZW1
ExpressionAtlasiQ9CQC6 baseline and differential
GenevisibleiQ9CQC6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211786, 1 interactor
IntActiQ9CQC6, 1 interactor
STRINGi10090.ENSMUSP00000051935

Structurei

3D structure databases

ProteinModelPortaliQ9CQC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 414W2PROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the BZW family.Curated

Phylogenomic databases

eggNOGiKOG2297 Eukaryota
ENOG410XR08 LUCA
GeneTreeiENSGT00390000012561
HOGENOMiHOG000252932
HOVERGENiHBG080940
InParanoidiQ9CQC6
PhylomeDBiQ9CQC6
TreeFamiTF324313

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQKQQKPT LSGQRFKTRK RDEKERFDPT QFQDCIIQGL TETGTDLEAV
60 70 80 90 100
AKFLDASGAK LDYRRYAETL FDILVAGGML APGGTLADDM MRTDVCVFAA
110 120 130 140 150
QEDLETMQAF AQVFNKLIRR YKYLEKGFED EVKKLLLFLK GFSESERNKL
160 170 180 190 200
AMLTGVLLAN GTLNASILNS LYNENLVKEG VSAAFAVKLF KSWINEKDIN
210 220 230 240 250
AVAASLRKVS MDNRLMELFP ANKQSVEHFT KYFTEAGLKE LSEYVRNQQT
260 270 280 290 300
IGARKELQKE LQEQMSRGDP FKDIILYVKE EMKKNNIPEP VVIGIVWSSV
310 320 330 340 350
MSTVEWNKKE ELVAEQAIKH LKQYSPLLAA FTTQGQSELT LLLKIQEYCY
360 370 380 390 400
DNIHFMKAFQ KIVVLFYKAE VLSEEPILKW YKDAHVAKGK SVFLEQMKKF
410
VEWLKNAEEE SESEAEEGD
Length:419
Mass (Da):48,043
Last modified:June 1, 2001 - v1
Checksum:i9E952D52F5796F60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38Q → K in BAE40121 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004784 mRNA Translation: BAB23562.1
AK013980 mRNA Translation: BAB29098.1
AK076086 mRNA Translation: BAC36172.1
AK076560 mRNA Translation: BAC36393.1
AK088322 mRNA Translation: BAC40280.1
AK133973 mRNA Translation: BAE21963.1
AK151919 mRNA Translation: BAE30797.1
AK153538 mRNA Translation: BAE32075.1
AK161192 mRNA Translation: BAE36231.1
AK166247 mRNA Translation: BAE38658.1
AK167074 mRNA Translation: BAE39234.1
AK168158 mRNA Translation: BAE40121.1
BC005466 mRNA Translation: AAH05466.1
BC028865 mRNA Translation: AAH28865.1
CCDSiCCDS14971.1
RefSeqiNP_080100.1, NM_025824.3
UniGeneiMm.21848

Genome annotation databases

EnsembliENSMUST00000050552; ENSMUSP00000051935; ENSMUSG00000051223
GeneIDi66882
KEGGimmu:66882
UCSCiuc007bbq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBZW1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQC6
Secondary accession number(s): Q3THS5, Q3UZ94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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