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Protein

Basic leucine zipper and W2 domain-containing protein 1

Gene

Bzw1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances histone H4 gene transcription but does not seem to bind DNA directly.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper and W2 domain-containing protein 1
Gene namesi
Name:Bzw1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914132. Bzw1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546101 – 419Basic leucine zipper and W2 domain-containing protein 1Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei12PhosphoserineBy similarity1
Modified residuei411PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQC6.
MaxQBiQ9CQC6.
PaxDbiQ9CQC6.
PeptideAtlasiQ9CQC6.
PRIDEiQ9CQC6.

PTM databases

iPTMnetiQ9CQC6.
PhosphoSitePlusiQ9CQC6.

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000051223.
CleanExiMM_BZW1.
ExpressionAtlasiQ9CQC6. baseline and differential.
GenevisibleiQ9CQC6. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211786. 1 interactor.
IntActiQ9CQC6. 1 interactor.
STRINGi10090.ENSMUSP00000051935.

Structurei

3D structure databases

ProteinModelPortaliQ9CQC6.
SMRiQ9CQC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 414W2PROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the BZW family.Curated
Contains 1 W2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ9CQC6.
PhylomeDBiQ9CQC6.
TreeFamiTF324313.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CQC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQKQQKPT LSGQRFKTRK RDEKERFDPT QFQDCIIQGL TETGTDLEAV
60 70 80 90 100
AKFLDASGAK LDYRRYAETL FDILVAGGML APGGTLADDM MRTDVCVFAA
110 120 130 140 150
QEDLETMQAF AQVFNKLIRR YKYLEKGFED EVKKLLLFLK GFSESERNKL
160 170 180 190 200
AMLTGVLLAN GTLNASILNS LYNENLVKEG VSAAFAVKLF KSWINEKDIN
210 220 230 240 250
AVAASLRKVS MDNRLMELFP ANKQSVEHFT KYFTEAGLKE LSEYVRNQQT
260 270 280 290 300
IGARKELQKE LQEQMSRGDP FKDIILYVKE EMKKNNIPEP VVIGIVWSSV
310 320 330 340 350
MSTVEWNKKE ELVAEQAIKH LKQYSPLLAA FTTQGQSELT LLLKIQEYCY
360 370 380 390 400
DNIHFMKAFQ KIVVLFYKAE VLSEEPILKW YKDAHVAKGK SVFLEQMKKF
410
VEWLKNAEEE SESEAEEGD
Length:419
Mass (Da):48,043
Last modified:June 1, 2001 - v1
Checksum:i9E952D52F5796F60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38Q → K in BAE40121 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004784 mRNA. Translation: BAB23562.1.
AK013980 mRNA. Translation: BAB29098.1.
AK076086 mRNA. Translation: BAC36172.1.
AK076560 mRNA. Translation: BAC36393.1.
AK088322 mRNA. Translation: BAC40280.1.
AK133973 mRNA. Translation: BAE21963.1.
AK151919 mRNA. Translation: BAE30797.1.
AK153538 mRNA. Translation: BAE32075.1.
AK161192 mRNA. Translation: BAE36231.1.
AK166247 mRNA. Translation: BAE38658.1.
AK167074 mRNA. Translation: BAE39234.1.
AK168158 mRNA. Translation: BAE40121.1.
BC005466 mRNA. Translation: AAH05466.1.
BC028865 mRNA. Translation: AAH28865.1.
CCDSiCCDS14971.1.
RefSeqiNP_080100.1. NM_025824.3.
UniGeneiMm.21848.

Genome annotation databases

EnsembliENSMUST00000050552; ENSMUSP00000051935; ENSMUSG00000051223.
GeneIDi66882.
KEGGimmu:66882.
UCSCiuc007bbq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004784 mRNA. Translation: BAB23562.1.
AK013980 mRNA. Translation: BAB29098.1.
AK076086 mRNA. Translation: BAC36172.1.
AK076560 mRNA. Translation: BAC36393.1.
AK088322 mRNA. Translation: BAC40280.1.
AK133973 mRNA. Translation: BAE21963.1.
AK151919 mRNA. Translation: BAE30797.1.
AK153538 mRNA. Translation: BAE32075.1.
AK161192 mRNA. Translation: BAE36231.1.
AK166247 mRNA. Translation: BAE38658.1.
AK167074 mRNA. Translation: BAE39234.1.
AK168158 mRNA. Translation: BAE40121.1.
BC005466 mRNA. Translation: AAH05466.1.
BC028865 mRNA. Translation: AAH28865.1.
CCDSiCCDS14971.1.
RefSeqiNP_080100.1. NM_025824.3.
UniGeneiMm.21848.

3D structure databases

ProteinModelPortaliQ9CQC6.
SMRiQ9CQC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211786. 1 interactor.
IntActiQ9CQC6. 1 interactor.
STRINGi10090.ENSMUSP00000051935.

PTM databases

iPTMnetiQ9CQC6.
PhosphoSitePlusiQ9CQC6.

Proteomic databases

EPDiQ9CQC6.
MaxQBiQ9CQC6.
PaxDbiQ9CQC6.
PeptideAtlasiQ9CQC6.
PRIDEiQ9CQC6.

Protocols and materials databases

DNASUi66882.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050552; ENSMUSP00000051935; ENSMUSG00000051223.
GeneIDi66882.
KEGGimmu:66882.
UCSCiuc007bbq.1. mouse.

Organism-specific databases

CTDi9689.
MGIiMGI:1914132. Bzw1.

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ9CQC6.
PhylomeDBiQ9CQC6.
TreeFamiTF324313.

Miscellaneous databases

PROiQ9CQC6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051223.
CleanExiMM_BZW1.
ExpressionAtlasiQ9CQC6. baseline and differential.
GenevisibleiQ9CQC6. MM.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBZW1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQC6
Secondary accession number(s): Q3THS5, Q3UZ94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.