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Protein

Transmembrane protein 216

Gene

Tmem216

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.1 Publication

GO - Biological processi

  • cilium assembly Source: UniProtKB

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620912. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 216
Alternative name(s):
Thymus atrophy-related protein
Gene namesi
Name:Tmem216
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1920020. Tmem216.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189561 – 141Transmembrane protein 216Add BLAST141

Proteomic databases

PaxDbiQ9CQC4.
PRIDEiQ9CQC4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024667.
GenevisibleiQ9CQC4. MM.

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex) (PubMed:21725307). Interacts with TMEM107 (By similarity).By similarity1 Publication

Protein-protein interaction databases

CORUMiQ9CQC4.
STRINGi10090.ENSMUSP00000025569.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4502. Eukaryota.
ENOG4111ZCW. LUCA.
GeneTreeiENSGT00390000002170.
HOGENOMiHOG000008106.
HOVERGENiHBG059533.
InParanoidiQ9CQC4.
KOiK19385.
OMAiYFLLLQT.
OrthoDBiEOG091G0UR4.
PhylomeDBiQ9CQC4.

Family and domain databases

InterProiView protein in InterPro
IPR019184. Uncharacterised_TM-17.
PANTHERiPTHR13531. PTHR13531. 1 hit.
PfamiView protein in Pfam
PF09799. Transmemb_17. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRDKRLSS TPLEVLFFLN GWYYATYFLL ELLIFLYKGL LLPYPTANLV
60 70 80 90 100
LDVVMLLLYL GIEVIRLFFG TKGNLCQRKM PLGISVALTF PSAMMASYYL
110 120 130 140
LLQTYVLRLE AIMNSILLFF CGSELLLEML TLATFSSMDR I
Length:141
Mass (Da):16,160
Last modified:November 30, 2010 - v2
Checksum:i844CFD26380F0D93
GO
Isoform 2 (identifier: Q9CQC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:87
Mass (Da):9,865
Checksum:i9F574A3C8F18E7DC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402971 – 54Missing in isoform 2. 3 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332866 mRNA. Translation: AAK17992.1.
AK003740 mRNA. Translation: BAB22973.1.
AK014997 mRNA. Translation: BAB29662.1.
AC125093 Genomic DNA. No translation available.
BC052053 mRNA. Translation: AAH52053.1.
CCDSiCCDS37913.1. [Q9CQC4-2]
CCDS70934.1. [Q9CQC4-1]
RefSeqiNP_001264789.1. NM_001277860.1. [Q9CQC4-1]
NP_001264790.1. NM_001277861.1. [Q9CQC4-2]
NP_081074.1. NM_026798.3. [Q9CQC4-2]
XP_006527381.1. XM_006527318.2. [Q9CQC4-1]
XP_006527382.1. XM_006527319.3. [Q9CQC4-2]
UniGeneiMm.31236.

Genome annotation databases

EnsembliENSMUST00000025569; ENSMUSP00000025569; ENSMUSG00000024667. [Q9CQC4-2]
ENSMUST00000059582; ENSMUSP00000059878; ENSMUSG00000024667. [Q9CQC4-2]
ENSMUST00000123788; ENSMUSP00000119596; ENSMUSG00000024667. [Q9CQC4-1]
ENSMUST00000145210; ENSMUSP00000123397; ENSMUSG00000024667. [Q9CQC4-2]
ENSMUST00000154383; ENSMUSP00000115319; ENSMUSG00000024667. [Q9CQC4-1]
GeneIDi68642.
KEGGimmu:68642.
UCSCiuc008gqc.2. mouse. [Q9CQC4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTM216_MOUSE
AccessioniPrimary (citable) accession number: Q9CQC4
Secondary accession number(s): D3YUA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 30, 2010
Last modified: November 22, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome