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Protein

Colipase

Gene

Clps

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Digestion, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-192456. Digestion of dietary lipid.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:Clps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88421. Clps.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Propeptidei19 – 235Enterostatin, activation peptideSequence analysisPRO_0000005698
Chaini24 – 11390ColipasePRO_0000005699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 46PROSITE-ProRule annotation
Disulfide bondi41 ↔ 57PROSITE-ProRule annotation
Disulfide bondi45 ↔ 79PROSITE-ProRule annotation
Disulfide bondi67 ↔ 87PROSITE-ProRule annotation
Disulfide bondi81 ↔ 105PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9CQC2.
PaxDbiQ9CQC2.
PRIDEiQ9CQC2.

PTM databases

PhosphoSiteiQ9CQC2.

Expressioni

Tissue specificityi

Expressed by the pancreas.

Gene expression databases

BgeeiQ9CQC2.
CleanExiMM_CLPS.
ExpressionAtlasiQ9CQC2. baseline and differential.
GenevisibleiQ9CQC2. MM.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025062.

Structurei

3D structure databases

ProteinModelPortaliQ9CQC2.
SMRiQ9CQC2. Positions 22-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
GeneTreeiENSGT00390000012644.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiQ9CQC2.
KOiK14460.
OMAiCSAKTLY.
OrthoDBiEOG74N5K5.
PhylomeDBiQ9CQC2.
TreeFamiTF336178.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiPF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
[Graphical view]
PRINTSiPR00128. COLIPASE.
SMARTiSM00023. COLIPASE. 1 hit.
[Graphical view]
PROSITEiPS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVLVLLLV SLLAVAYAAP GPRGLIINLE DGEICLNSMQ CKSRCCQHDT
60 70 80 90 100
ILGIARCTHK AMENSECSPK TLYGIYYRCP CERGLTCEGD RSIIGAITNT
110
NYGICLDSRR SKQ
Length:113
Mass (Da):12,445
Last modified:June 1, 2001 - v1
Checksum:i9FC784631D1C413E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414676 mRNA. Translation: AAL40730.1.
AF414677 mRNA. Translation: AAL40731.1.
AF414678 Genomic DNA. Translation: AAL40732.1.
AF414679 Genomic DNA. Translation: AAL40733.1.
AK008635 mRNA. Translation: BAB25796.1.
AK008815 mRNA. Translation: BAB25909.1.
AK008834 mRNA. Translation: BAB25918.1.
AK008839 mRNA. Translation: BAB25921.1.
AK008874 mRNA. Translation: BAB25944.1.
AK008879 mRNA. Translation: BAB25947.1.
AK019047 mRNA. Translation: BAB31524.1.
AK028141 mRNA. Translation: BAC25769.1.
BC042935 mRNA. Translation: AAH42935.1.
CCDSiCCDS28581.1.
RefSeqiNP_001303994.1. NM_001317065.1.
NP_079745.1. NM_025469.3.
UniGeneiMm.21160.

Genome annotation databases

EnsembliENSMUST00000025062; ENSMUSP00000025062; ENSMUSG00000024225.
GeneIDi109791.
KEGGimmu:109791.
UCSCiuc008brf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414676 mRNA. Translation: AAL40730.1.
AF414677 mRNA. Translation: AAL40731.1.
AF414678 Genomic DNA. Translation: AAL40732.1.
AF414679 Genomic DNA. Translation: AAL40733.1.
AK008635 mRNA. Translation: BAB25796.1.
AK008815 mRNA. Translation: BAB25909.1.
AK008834 mRNA. Translation: BAB25918.1.
AK008839 mRNA. Translation: BAB25921.1.
AK008874 mRNA. Translation: BAB25944.1.
AK008879 mRNA. Translation: BAB25947.1.
AK019047 mRNA. Translation: BAB31524.1.
AK028141 mRNA. Translation: BAC25769.1.
BC042935 mRNA. Translation: AAH42935.1.
CCDSiCCDS28581.1.
RefSeqiNP_001303994.1. NM_001317065.1.
NP_079745.1. NM_025469.3.
UniGeneiMm.21160.

3D structure databases

ProteinModelPortaliQ9CQC2.
SMRiQ9CQC2. Positions 22-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025062.

PTM databases

PhosphoSiteiQ9CQC2.

Proteomic databases

MaxQBiQ9CQC2.
PaxDbiQ9CQC2.
PRIDEiQ9CQC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025062; ENSMUSP00000025062; ENSMUSG00000024225.
GeneIDi109791.
KEGGimmu:109791.
UCSCiuc008brf.1. mouse.

Organism-specific databases

CTDi1208.
MGIiMGI:88421. Clps.

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
GeneTreeiENSGT00390000012644.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiQ9CQC2.
KOiK14460.
OMAiCSAKTLY.
OrthoDBiEOG74N5K5.
PhylomeDBiQ9CQC2.
TreeFamiTF336178.

Enzyme and pathway databases

ReactomeiR-MMU-192456. Digestion of dietary lipid.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiClps. mouse.
PROiQ9CQC2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CQC2.
CleanExiMM_CLPS.
ExpressionAtlasiQ9CQC2. baseline and differential.
GenevisibleiQ9CQC2. MM.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiPF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
[Graphical view]
PRINTSiPR00128. COLIPASE.
SMARTiSM00023. COLIPASE. 1 hit.
[Graphical view]
PROSITEiPS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Zuberi A.R., Poole A.C., York B., Smith Richards B.K.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: C57BL/6J and CAST/Ei.
    Tissue: Pancreas.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.

Entry informationi

Entry nameiCOL_MOUSE
AccessioniPrimary (citable) accession number: Q9CQC2
Secondary accession number(s): Q8VHR2, Q8VHR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.