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Protein

Colipase

Gene

Clps

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Digestion, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-192456. Digestion of dietary lipid.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:Clps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88421. Clps.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Propeptidei19 – 235Enterostatin, activation peptideSequence analysisPRO_0000005698
Chaini24 – 11390ColipasePRO_0000005699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 46PROSITE-ProRule annotation
Disulfide bondi41 ↔ 57PROSITE-ProRule annotation
Disulfide bondi45 ↔ 79PROSITE-ProRule annotation
Disulfide bondi67 ↔ 87PROSITE-ProRule annotation
Disulfide bondi81 ↔ 105PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9CQC2.
PaxDbiQ9CQC2.
PeptideAtlasiQ9CQC2.
PRIDEiQ9CQC2.

PTM databases

PhosphoSiteiQ9CQC2.

Expressioni

Tissue specificityi

Expressed by the pancreas.

Gene expression databases

BgeeiENSMUSG00000024225.
CleanExiMM_CLPS.
ExpressionAtlasiQ9CQC2. baseline and differential.
GenevisibleiQ9CQC2. MM.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025062.

Structurei

3D structure databases

ProteinModelPortaliQ9CQC2.
SMRiQ9CQC2. Positions 22-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
GeneTreeiENSGT00390000012644.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiQ9CQC2.
KOiK14460.
OMAiCSAKTLY.
OrthoDBiEOG091G0Z2E.
PhylomeDBiQ9CQC2.
TreeFamiTF336178.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiPF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
[Graphical view]
PRINTSiPR00128. COLIPASE.
SMARTiSM00023. COLIPASE. 1 hit.
[Graphical view]
PROSITEiPS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVLVLLLV SLLAVAYAAP GPRGLIINLE DGEICLNSMQ CKSRCCQHDT
60 70 80 90 100
ILGIARCTHK AMENSECSPK TLYGIYYRCP CERGLTCEGD RSIIGAITNT
110
NYGICLDSRR SKQ
Length:113
Mass (Da):12,445
Last modified:June 1, 2001 - v1
Checksum:i9FC784631D1C413E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414676 mRNA. Translation: AAL40730.1.
AF414677 mRNA. Translation: AAL40731.1.
AF414678 Genomic DNA. Translation: AAL40732.1.
AF414679 Genomic DNA. Translation: AAL40733.1.
AK008635 mRNA. Translation: BAB25796.1.
AK008815 mRNA. Translation: BAB25909.1.
AK008834 mRNA. Translation: BAB25918.1.
AK008839 mRNA. Translation: BAB25921.1.
AK008874 mRNA. Translation: BAB25944.1.
AK008879 mRNA. Translation: BAB25947.1.
AK019047 mRNA. Translation: BAB31524.1.
AK028141 mRNA. Translation: BAC25769.1.
BC042935 mRNA. Translation: AAH42935.1.
CCDSiCCDS28581.1.
RefSeqiNP_001303994.1. NM_001317065.1.
NP_079745.1. NM_025469.3.
UniGeneiMm.21160.

Genome annotation databases

EnsembliENSMUST00000025062; ENSMUSP00000025062; ENSMUSG00000024225.
GeneIDi109791.
KEGGimmu:109791.
UCSCiuc008brf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414676 mRNA. Translation: AAL40730.1.
AF414677 mRNA. Translation: AAL40731.1.
AF414678 Genomic DNA. Translation: AAL40732.1.
AF414679 Genomic DNA. Translation: AAL40733.1.
AK008635 mRNA. Translation: BAB25796.1.
AK008815 mRNA. Translation: BAB25909.1.
AK008834 mRNA. Translation: BAB25918.1.
AK008839 mRNA. Translation: BAB25921.1.
AK008874 mRNA. Translation: BAB25944.1.
AK008879 mRNA. Translation: BAB25947.1.
AK019047 mRNA. Translation: BAB31524.1.
AK028141 mRNA. Translation: BAC25769.1.
BC042935 mRNA. Translation: AAH42935.1.
CCDSiCCDS28581.1.
RefSeqiNP_001303994.1. NM_001317065.1.
NP_079745.1. NM_025469.3.
UniGeneiMm.21160.

3D structure databases

ProteinModelPortaliQ9CQC2.
SMRiQ9CQC2. Positions 22-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025062.

PTM databases

PhosphoSiteiQ9CQC2.

Proteomic databases

MaxQBiQ9CQC2.
PaxDbiQ9CQC2.
PeptideAtlasiQ9CQC2.
PRIDEiQ9CQC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025062; ENSMUSP00000025062; ENSMUSG00000024225.
GeneIDi109791.
KEGGimmu:109791.
UCSCiuc008brf.1. mouse.

Organism-specific databases

CTDi1208.
MGIiMGI:88421. Clps.

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
GeneTreeiENSGT00390000012644.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiQ9CQC2.
KOiK14460.
OMAiCSAKTLY.
OrthoDBiEOG091G0Z2E.
PhylomeDBiQ9CQC2.
TreeFamiTF336178.

Enzyme and pathway databases

ReactomeiR-MMU-192456. Digestion of dietary lipid.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiClps. mouse.
PROiQ9CQC2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024225.
CleanExiMM_CLPS.
ExpressionAtlasiQ9CQC2. baseline and differential.
GenevisibleiQ9CQC2. MM.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiPF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
[Graphical view]
PRINTSiPR00128. COLIPASE.
SMARTiSM00023. COLIPASE. 1 hit.
[Graphical view]
PROSITEiPS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOL_MOUSE
AccessioniPrimary (citable) accession number: Q9CQC2
Secondary accession number(s): Q8VHR2, Q8VHR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.