Q9CQA9 (NTPCR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cancer-related nucleoside-triphosphatase homolog
Short name=NTPase
EC=3.6.1.15

Alternative name(s):
Nucleoside triphosphate phosphohydrolase

Gene names

Name:

Ntpcr

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the THEP1 NTPase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: EC nucleotide phosphatase activity Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Cancer-related nucleoside-triphosphatase homolog		PRO_0000146712
Regions
	Nucleotide binding	9 – 16	8	ATP By similarity
	Nucleotide binding	109 – 116	8	ATP By similarity
Amino acid modifications
	Modified residue	21	1	N6-acetyllysine By similarity
	Modified residue	165	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CQA9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: A6B9C6DFDFB06813	FASTA	190	20,667
	10 20 30 40 50 60 MSRHVFLTGP PGVGKTTLIQ KAIEVLQSSG LPVDGFYTQE VRQEGKRIGF DVVTLSGAQG 70 80 90 100 110 120 PLSRVGSQPL PGKPECRVGQ YVVNLDSFEQ LALPVLRNAG SSCGPKHRVC IIDEIGKMEL 130 140 150 160 170 180 FSQPFIQAVR QMLSTPGIIV VGTIPVPKGK PLALVEEIRK RRDVKVFNVT RDNRNSLLPD 190 IVAVVQSSRT

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Hippocampus, Testis and Tongue.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK006433 mRNA. Translation: BAB24586.1. AK010229 mRNA. Translation: BAB26783.1. AK010823 mRNA. Translation: BAB27206.1. AK019321 mRNA. Translation: BAB31665.1. BC025168 mRNA. Translation: AAH25168.1.
IPI	IPI00132339.
RefSeq	NP_079912.1. NM_025636.5.
UniGene	Mm.25296.
3D structure databases
ProteinModelPortal	Q9CQA9.
SMR	Q9CQA9. Positions 2-189.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9CQA9.
PTM databases
PhosphoSite	Q9CQA9.
Proteomic databases
PRIDE	Q9CQA9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034313; ENSMUSP00000034313; ENSMUSG00000031851.
GeneID	66566.
KEGG	mmu:66566.
NMPDR	fig|10090.3.peg.19470.
UCSC	uc009nyk.2. mouse.
Organism-specific databases
CTD	84284.
MGI	MGI:1913816. Ntpcr.
Phylogenomic databases
HOGENOM	HBG574935.
HOVERGEN	HBG058637.
InParanoid	Q9CQA9.
OMA	TKENRNH.
OrthoDB	EOG42FSJM.
PhylomeDB	Q9CQA9.
Gene expression databases
ArrayExpress	Q9CQA9.
Bgee	Q9CQA9.
CleanEx	MM_2310079N02RIK.
Genevestigator	Q9CQA9.
GermOnline	ENSMUSG00000031851. Mus musculus.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR004948. Nuc-triphosphatase_THEP1. [Graphical view]
KO	K06928.
Pfam	PF03266. NTPase_1. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	322018.
SOURCE	Search...

Entry information

Entry name

NTPCR_MOUSE

Accession

Primary (citable) accession number: Q9CQA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	June 1, 2001
Last modified:	November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program