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Protein

Cancer-related nucleoside-triphosphatase homolog

Gene

Ntpcr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (By similarity).By similarity

Catalytic activityi

NTP + H2O = NDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPBy similarity8
Nucleotide bindingi109 – 116ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cancer-related nucleoside-triphosphatase homolog (EC:3.6.1.15)
Short name:
NTPase
Alternative name(s):
Nucleoside triphosphate phosphohydrolase
Gene namesi
Name:Ntpcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913816 Ntpcr

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001467121 – 190Cancer-related nucleoside-triphosphatase homologAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei165N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CQA9
MaxQBiQ9CQA9
PaxDbiQ9CQA9
PeptideAtlasiQ9CQA9
PRIDEiQ9CQA9

PTM databases

PhosphoSitePlusiQ9CQA9

Expressioni

Gene expression databases

BgeeiENSMUSG00000031851
CleanExiMM_2310079N02RIK
ExpressionAtlasiQ9CQA9 baseline and differential
GenevisibleiQ9CQA9 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi211557, 1 interactor
STRINGi10090.ENSMUSP00000034313

Structurei

3D structure databases

ProteinModelPortaliQ9CQA9
SMRiQ9CQA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THEP1 NTPase family.Curated

Phylogenomic databases

eggNOGiENOG410IXTM Eukaryota
COG1618 LUCA
GeneTreeiENSGT00390000018683
HOVERGENiHBG058637
InParanoidiQ9CQA9
KOiK06928
OMAiVCIIDEI
OrthoDBiEOG091G0M7P
PhylomeDBiQ9CQA9
TreeFamiTF323592

Family and domain databases

HAMAPiMF_00796 NTPase_1, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004948 Nuc-triphosphatase_THEP1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF03266 NTPase_1, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRHVFLTGP PGVGKTTLIQ KAIEVLQSSG LPVDGFYTQE VRQEGKRIGF
60 70 80 90 100
DVVTLSGAQG PLSRVGSQPL PGKPECRVGQ YVVNLDSFEQ LALPVLRNAG
110 120 130 140 150
SSCGPKHRVC IIDEIGKMEL FSQPFIQAVR QMLSTPGIIV VGTIPVPKGK
160 170 180 190
PLALVEEIRK RRDVKVFNVT RDNRNSLLPD IVAVVQSSRT
Length:190
Mass (Da):20,667
Last modified:June 1, 2001 - v1
Checksum:iA6B9C6DFDFB06813
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006433 mRNA Translation: BAB24586.1
AK010229 mRNA Translation: BAB26783.1
AK010823 mRNA Translation: BAB27206.1
AK019321 mRNA Translation: BAB31665.1
BC025168 mRNA Translation: AAH25168.1
CCDSiCCDS22781.1
RefSeqiNP_001297617.1, NM_001310688.1
NP_079912.1, NM_025636.5
UniGeneiMm.25296

Genome annotation databases

EnsembliENSMUST00000034313; ENSMUSP00000034313; ENSMUSG00000031851
GeneIDi66566
KEGGimmu:66566
UCSCiuc009nyk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNTPCR_MOUSE
AccessioniPrimary (citable) accession number: Q9CQA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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