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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

Sdhb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Sdhb), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Sdhb), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Sdha), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Sdhb)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi95Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi100Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi103Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi115Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi188Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi191Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi194Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi198Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei203Ubiquinone; shared with DHSDBy similarity1
Metal bindingi245Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi251Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi255Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-71403. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:Sdhb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914930. Sdhb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000001035631 – 282Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineCombined sources1
Modified residuei57N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CQA3.
MaxQBiQ9CQA3.
PaxDbiQ9CQA3.
PeptideAtlasiQ9CQA3.
PRIDEiQ9CQA3.

2D gel databases

REPRODUCTION-2DPAGEQ9CQA3.

PTM databases

iPTMnetiQ9CQA3.
PhosphoSitePlusiQ9CQA3.
SwissPalmiQ9CQA3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000009863.
GenevisibleiQ9CQA3. MM.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

Protein-protein interaction databases

BioGridi212362. 2 interactors.
IntActiQ9CQA3. 5 interactors.
MINTiMINT-1860322.
STRINGi10090.ENSMUSP00000010007.

Structurei

3D structure databases

ProteinModelPortaliQ9CQA3.
SMRiQ9CQA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 1352Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST94
Domaini178 – 2084Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3049. Eukaryota.
COG0479. LUCA.
GeneTreeiENSGT00390000013558.
HOGENOMiHOG000160590.
HOVERGENiHBG005483.
InParanoidiQ9CQA3.
KOiK00235.
OMAiIDSHERM.
OrthoDBiEOG091G0EKC.
PhylomeDBiQ9CQA3.
TreeFamiTF300754.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATVGVSLK RGFPAAVLGR VGLQFQACRG AQTAAAAAPR IKKFAIYRWD
60 70 80 90 100
PDKTGDKPRM QTYEVDLNKC GPMVLDALIK IKNEVDSTLT FRRSCREGIC
110 120 130 140 150
GSCAMNINGG NTLACTRRID TDLSKVSKIY PLPHMYVIKD LVPDLSNFYA
160 170 180 190 200
QYKSIEPYLK KKDESQEGKQ QYLQSIEDRE KLDGLYECIL CACCSTSCPS
210 220 230 240 250
YWWNGDKYLG PAVLMQAYRW MIDSRDDFTE ERLAKLQDPF SVYRCHTIMN
260 270 280
CTQTCPKGLN PGKAIAEIKK MMATYKEKRA LA
Length:282
Mass (Da):31,814
Last modified:June 1, 2001 - v1
Checksum:iA8616A911427AF8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40R → K in BAB22534 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003052 mRNA. Translation: BAB22534.1.
AK003533 mRNA. Translation: BAB22842.1.
AK009660 mRNA. Translation: BAB26422.1.
AK153045 mRNA. Translation: BAE31674.1.
AK169252 mRNA. Translation: BAE41016.1.
BC013509 mRNA. Translation: AAH13509.1.
BC051934 mRNA. Translation: AAH51934.1.
CCDSiCCDS18858.1.
PIRiPT0094.
RefSeqiNP_075863.2. NM_023374.3.
UniGeneiMm.246965.

Genome annotation databases

EnsembliENSMUST00000010007; ENSMUSP00000010007; ENSMUSG00000009863.
GeneIDi67680.
KEGGimmu:67680.
UCSCiuc008vnl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003052 mRNA. Translation: BAB22534.1.
AK003533 mRNA. Translation: BAB22842.1.
AK009660 mRNA. Translation: BAB26422.1.
AK153045 mRNA. Translation: BAE31674.1.
AK169252 mRNA. Translation: BAE41016.1.
BC013509 mRNA. Translation: AAH13509.1.
BC051934 mRNA. Translation: AAH51934.1.
CCDSiCCDS18858.1.
PIRiPT0094.
RefSeqiNP_075863.2. NM_023374.3.
UniGeneiMm.246965.

3D structure databases

ProteinModelPortaliQ9CQA3.
SMRiQ9CQA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212362. 2 interactors.
IntActiQ9CQA3. 5 interactors.
MINTiMINT-1860322.
STRINGi10090.ENSMUSP00000010007.

PTM databases

iPTMnetiQ9CQA3.
PhosphoSitePlusiQ9CQA3.
SwissPalmiQ9CQA3.

2D gel databases

REPRODUCTION-2DPAGEQ9CQA3.

Proteomic databases

EPDiQ9CQA3.
MaxQBiQ9CQA3.
PaxDbiQ9CQA3.
PeptideAtlasiQ9CQA3.
PRIDEiQ9CQA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010007; ENSMUSP00000010007; ENSMUSG00000009863.
GeneIDi67680.
KEGGimmu:67680.
UCSCiuc008vnl.1. mouse.

Organism-specific databases

CTDi6390.
MGIiMGI:1914930. Sdhb.

Phylogenomic databases

eggNOGiKOG3049. Eukaryota.
COG0479. LUCA.
GeneTreeiENSGT00390000013558.
HOGENOMiHOG000160590.
HOVERGENiHBG005483.
InParanoidiQ9CQA3.
KOiK00235.
OMAiIDSHERM.
OrthoDBiEOG091G0EKC.
PhylomeDBiQ9CQA3.
TreeFamiTF300754.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.
ReactomeiR-MMU-71403. Citric acid cycle (TCA cycle).

Miscellaneous databases

ChiTaRSiSdhb. mouse.
PROiQ9CQA3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009863.
GenevisibleiQ9CQA3. MM.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDHB_MOUSE
AccessioniPrimary (citable) accession number: Q9CQA3
Secondary accession number(s): Q3TF82, Q9DC91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.