Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9CQA0

- CENPM_MOUSE

UniProt

Q9CQA0 - CENPM_MOUSE

Protein

Centromere protein M

Gene

Cenpm

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres By similarity.By similarity

    Enzyme and pathway databases

    ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein M
    Short name:
    CENP-M
    Alternative name(s):
    Proliferation-associated nuclear element protein 1
    Gene namesi
    Name:Cenpm
    Synonyms:Pane1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1913820. Cenpm.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Chromosomecentromerekinetochore By similarity
    Note: Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells. Localizes in the kinetochore domain of centromeres By similarity.By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180Centromere protein MPRO_0000058225Add
    BLAST

    Proteomic databases

    PRIDEiQ9CQA0.

    Expressioni

    Gene expression databases

    BgeeiQ9CQA0.
    CleanExiMM_CENPM.
    GenevestigatoriQ9CQA0.

    Interactioni

    Subunit structurei

    Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9CQA0. 1 interaction.
    MINTiMINT-8174100.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG25434.
    GeneTreeiENSGT00390000017504.
    HOGENOMiHOG000261677.
    HOVERGENiHBG081086.
    InParanoidiQ9CQA0.
    KOiK11505.
    OMAiEPREPPI.
    OrthoDBiEOG7R8333.
    PhylomeDBiQ9CQA0.
    TreeFamiTF328778.

    Family and domain databases

    InterProiIPR020987. Centromere_Cenp-M.
    [Graphical view]
    PfamiPF11111. CENP-M. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CQA0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVLRSMDKL PDLNRATVLL VSTEDALLQQ LAESMLKDDC ASELRVHLAN    50
    SLPLPSNVNR PRIDLIVFVI NLHSKYSLQK VEEFLQHVDS SFFLGKVCFL 100
    VTGAGQESHC SVHQNTVIKL AHTYRSPLLL CDLQVESFRA AMARRLVRIL 150
    QICAGHVPGV SALNLMSLLR SPENPPSKEL 180
    Length:180
    Mass (Da):20,039
    Last modified:June 1, 2001 - v1
    Checksum:iAA6396B75269346C
    GO
    Isoform 2 (identifier: Q9CQA0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         104-180: AGQESHCSVH...SPENPPSKEL → GGKLSCSHGA...AASSKSSHCW

    Note: No experimental confirmation available.

    Show »
    Length:168
    Mass (Da):18,344
    Checksum:i38E2649F47853431
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131L → M in BAE40163. (PubMed:16141072)Curated
    Sequence conflicti47 – 471H → N in BAE40163. (PubMed:16141072)Curated
    Sequence conflicti129 – 1291L → F in AAH09160. (PubMed:15489334)Curated
    Sequence conflicti134 – 1341Q → QK in AAH09160. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei104 – 18077AGQES…PSKEL → GGKLSCSHGAASGAHSADLR WPCARRLRAEPDVLAAEPRE PPIQGAVSITALHTFAASSK SSHCW in isoform 2. 1 PublicationVSP_020440Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY243536 mRNA. Translation: AAO62567.1.
    AY243537 mRNA. Translation: AAO62568.1.
    AK010885 mRNA. Translation: BAB27246.1.
    AK011191 mRNA. Translation: BAB27456.1.
    AK011227 mRNA. Translation: BAB27479.1.
    AK011464 mRNA. Translation: BAB27635.1.
    AK011755 mRNA. Translation: BAB27823.1.
    AK168203 mRNA. Translation: BAE40163.1.
    AK017679 mRNA. Translation: BAB30869.1.
    BC009160 mRNA. Translation: AAH09160.1.
    CCDSiCCDS27685.1. [Q9CQA0-1]
    CCDS37156.1. [Q9CQA0-2]
    RefSeqiNP_001073627.1. NM_001080158.1.
    NP_079915.1. NM_025639.4. [Q9CQA0-1]
    NP_840000.2. NM_178269.3. [Q9CQA0-2]
    UniGeneiMm.23596.

    Genome annotation databases

    EnsembliENSMUST00000089155; ENSMUSP00000086558; ENSMUSG00000068101. [Q9CQA0-2]
    ENSMUST00000089157; ENSMUSP00000086560; ENSMUSG00000068101. [Q9CQA0-1]
    GeneIDi66570.
    KEGGimmu:66570.
    UCSCiuc007wym.1. mouse. [Q9CQA0-1]
    uc007wyo.1. mouse. [Q9CQA0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY243536 mRNA. Translation: AAO62567.1 .
    AY243537 mRNA. Translation: AAO62568.1 .
    AK010885 mRNA. Translation: BAB27246.1 .
    AK011191 mRNA. Translation: BAB27456.1 .
    AK011227 mRNA. Translation: BAB27479.1 .
    AK011464 mRNA. Translation: BAB27635.1 .
    AK011755 mRNA. Translation: BAB27823.1 .
    AK168203 mRNA. Translation: BAE40163.1 .
    AK017679 mRNA. Translation: BAB30869.1 .
    BC009160 mRNA. Translation: AAH09160.1 .
    CCDSi CCDS27685.1. [Q9CQA0-1 ]
    CCDS37156.1. [Q9CQA0-2 ]
    RefSeqi NP_001073627.1. NM_001080158.1.
    NP_079915.1. NM_025639.4. [Q9CQA0-1 ]
    NP_840000.2. NM_178269.3. [Q9CQA0-2 ]
    UniGenei Mm.23596.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CQA0. 1 interaction.
    MINTi MINT-8174100.

    Proteomic databases

    PRIDEi Q9CQA0.

    Protocols and materials databases

    DNASUi 66570.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089155 ; ENSMUSP00000086558 ; ENSMUSG00000068101 . [Q9CQA0-2 ]
    ENSMUST00000089157 ; ENSMUSP00000086560 ; ENSMUSG00000068101 . [Q9CQA0-1 ]
    GeneIDi 66570.
    KEGGi mmu:66570.
    UCSCi uc007wym.1. mouse. [Q9CQA0-1 ]
    uc007wyo.1. mouse. [Q9CQA0-2 ]

    Organism-specific databases

    CTDi 79019.
    MGIi MGI:1913820. Cenpm.

    Phylogenomic databases

    eggNOGi NOG25434.
    GeneTreei ENSGT00390000017504.
    HOGENOMi HOG000261677.
    HOVERGENi HBG081086.
    InParanoidi Q9CQA0.
    KOi K11505.
    OMAi EPREPPI.
    OrthoDBi EOG7R8333.
    PhylomeDBi Q9CQA0.
    TreeFami TF328778.

    Enzyme and pathway databases

    Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    NextBioi 322034.
    PROi Q9CQA0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CQA0.
    CleanExi MM_CENPM.
    Genevestigatori Q9CQA0.

    Family and domain databases

    InterProi IPR020987. Centromere_Cenp-M.
    [Graphical view ]
    Pfami PF11111. CENP-M. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin."
      Renou J.-P., Bierie B., Miyoshi K., Cui Y., Djiane J., Reichenstein M., Shani M., Hennighausen L.
      Oncogene 22:4594-4610(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
      Strain: C57BL/6.
      Tissue: Lactating mammary gland.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and DBA/2.
      Tissue: Embryonic liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiCENPM_MOUSE
    AccessioniPrimary (citable) accession number: Q9CQA0
    Secondary accession number(s): Q3THN3, Q91VS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3