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Protein

Centromere protein M

Gene

Cenpm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-MMU-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein M
Short name:
CENP-M
Alternative name(s):
Proliferation-associated nuclear element protein 1
Gene namesi
Name:Cenpm
Synonyms:Pane1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913820. Cenpm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582251 – 180Centromere protein MAdd BLAST180

Proteomic databases

PaxDbiQ9CQA0.
PRIDEiQ9CQA0.

PTM databases

PhosphoSitePlusiQ9CQA0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000068101.
CleanExiMM_CENPM.
GenevisibleiQ9CQA0. MM.

Interactioni

Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9CQA0. 1 interactor.
MINTiMINT-8174100.
STRINGi10090.ENSMUSP00000086560.

Structurei

3D structure databases

ProteinModelPortaliQ9CQA0.
SMRiQ9CQA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5U. Eukaryota.
ENOG4111PTI. LUCA.
GeneTreeiENSGT00390000017504.
HOGENOMiHOG000261677.
HOVERGENiHBG081086.
InParanoidiQ9CQA0.
KOiK11505.
OMAiFCDLEIE.
OrthoDBiEOG091G0PZ0.
PhylomeDBiQ9CQA0.
TreeFamiTF328778.

Family and domain databases

InterProiIPR020987. Centromere_Cenp-M.
[Graphical view]
PfamiPF11111. CENP-M. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CQA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVLRSMDKL PDLNRATVLL VSTEDALLQQ LAESMLKDDC ASELRVHLAN
60 70 80 90 100
SLPLPSNVNR PRIDLIVFVI NLHSKYSLQK VEEFLQHVDS SFFLGKVCFL
110 120 130 140 150
VTGAGQESHC SVHQNTVIKL AHTYRSPLLL CDLQVESFRA AMARRLVRIL
160 170 180
QICAGHVPGV SALNLMSLLR SPENPPSKEL
Length:180
Mass (Da):20,039
Last modified:June 1, 2001 - v1
Checksum:iAA6396B75269346C
GO
Isoform 2 (identifier: Q9CQA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-180: AGQESHCSVH...SPENPPSKEL → GGKLSCSHGA...AASSKSSHCW

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):18,344
Checksum:i38E2649F47853431
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13L → M in BAE40163 (PubMed:16141072).Curated1
Sequence conflicti47H → N in BAE40163 (PubMed:16141072).Curated1
Sequence conflicti129L → F in AAH09160 (PubMed:15489334).Curated1
Sequence conflicti134Q → QK in AAH09160 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020440104 – 180AGQES…PSKEL → GGKLSCSHGAASGAHSADLR WPCARRLRAEPDVLAAEPRE PPIQGAVSITALHTFAASSK SSHCW in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243536 mRNA. Translation: AAO62567.1.
AY243537 mRNA. Translation: AAO62568.1.
AK010885 mRNA. Translation: BAB27246.1.
AK011191 mRNA. Translation: BAB27456.1.
AK011227 mRNA. Translation: BAB27479.1.
AK011464 mRNA. Translation: BAB27635.1.
AK011755 mRNA. Translation: BAB27823.1.
AK168203 mRNA. Translation: BAE40163.1.
AK017679 mRNA. Translation: BAB30869.1.
BC009160 mRNA. Translation: AAH09160.1.
CCDSiCCDS27685.1. [Q9CQA0-1]
CCDS37156.1. [Q9CQA0-2]
RefSeqiNP_001073627.1. NM_001080158.1.
NP_079915.1. NM_025639.4. [Q9CQA0-1]
NP_840000.2. NM_178269.3. [Q9CQA0-2]
UniGeneiMm.23596.

Genome annotation databases

EnsembliENSMUST00000089155; ENSMUSP00000086558; ENSMUSG00000068101. [Q9CQA0-2]
ENSMUST00000089157; ENSMUSP00000086560; ENSMUSG00000068101. [Q9CQA0-1]
GeneIDi66570.
KEGGimmu:66570.
UCSCiuc007wym.1. mouse. [Q9CQA0-1]
uc007wyo.1. mouse. [Q9CQA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243536 mRNA. Translation: AAO62567.1.
AY243537 mRNA. Translation: AAO62568.1.
AK010885 mRNA. Translation: BAB27246.1.
AK011191 mRNA. Translation: BAB27456.1.
AK011227 mRNA. Translation: BAB27479.1.
AK011464 mRNA. Translation: BAB27635.1.
AK011755 mRNA. Translation: BAB27823.1.
AK168203 mRNA. Translation: BAE40163.1.
AK017679 mRNA. Translation: BAB30869.1.
BC009160 mRNA. Translation: AAH09160.1.
CCDSiCCDS27685.1. [Q9CQA0-1]
CCDS37156.1. [Q9CQA0-2]
RefSeqiNP_001073627.1. NM_001080158.1.
NP_079915.1. NM_025639.4. [Q9CQA0-1]
NP_840000.2. NM_178269.3. [Q9CQA0-2]
UniGeneiMm.23596.

3D structure databases

ProteinModelPortaliQ9CQA0.
SMRiQ9CQA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQA0. 1 interactor.
MINTiMINT-8174100.
STRINGi10090.ENSMUSP00000086560.

PTM databases

PhosphoSitePlusiQ9CQA0.

Proteomic databases

PaxDbiQ9CQA0.
PRIDEiQ9CQA0.

Protocols and materials databases

DNASUi66570.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089155; ENSMUSP00000086558; ENSMUSG00000068101. [Q9CQA0-2]
ENSMUST00000089157; ENSMUSP00000086560; ENSMUSG00000068101. [Q9CQA0-1]
GeneIDi66570.
KEGGimmu:66570.
UCSCiuc007wym.1. mouse. [Q9CQA0-1]
uc007wyo.1. mouse. [Q9CQA0-2]

Organism-specific databases

CTDi79019.
MGIiMGI:1913820. Cenpm.

Phylogenomic databases

eggNOGiENOG410IZ5U. Eukaryota.
ENOG4111PTI. LUCA.
GeneTreeiENSGT00390000017504.
HOGENOMiHOG000261677.
HOVERGENiHBG081086.
InParanoidiQ9CQA0.
KOiK11505.
OMAiFCDLEIE.
OrthoDBiEOG091G0PZ0.
PhylomeDBiQ9CQA0.
TreeFamiTF328778.

Enzyme and pathway databases

ReactomeiR-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-MMU-68877. Mitotic Prometaphase.

Miscellaneous databases

PROiQ9CQA0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068101.
CleanExiMM_CENPM.
GenevisibleiQ9CQA0. MM.

Family and domain databases

InterProiIPR020987. Centromere_Cenp-M.
[Graphical view]
PfamiPF11111. CENP-M. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCENPM_MOUSE
AccessioniPrimary (citable) accession number: Q9CQA0
Secondary accession number(s): Q3THN3, Q91VS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.