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Q9CQA0 (CENPM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centromere protein M

Short name=CENP-M
Alternative name(s):
Proliferation-associated nuclear element protein 1
Gene names
Name:Cenpm
Synonyms:Pane1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres By similarity.

Subunit structure

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS By similarity.

Subcellular location

Nucleus. Cytoplasm. Chromosomecentromerekinetochore By similarity. Note: Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells. Localizes in the kinetochore domain of centromeres By similarity. Ref.1

Ontologies

Keywords
   Cellular componentCentromere
Chromosome
Cytoplasm
Kinetochore
Nucleus
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcondensed chromosome kinetochore

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9CQA0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9CQA0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     104-180: AGQESHCSVH...SPENPPSKEL → GGKLSCSHGA...AASSKSSHCW
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180Centromere protein M
PRO_0000058225

Natural variations

Alternative sequence104 – 18077AGQES…PSKEL → GGKLSCSHGAASGAHSADLR WPCARRLRAEPDVLAAEPRE PPIQGAVSITALHTFAASSK SSHCW in isoform 2.
VSP_020440

Experimental info

Sequence conflict131L → M in BAE40163. Ref.2
Sequence conflict471H → N in BAE40163. Ref.2
Sequence conflict1291L → F in AAH09160. Ref.3
Sequence conflict1341Q → QK in AAH09160. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AA6396B75269346C

FASTA18020,039
        10         20         30         40         50         60 
MSVLRSMDKL PDLNRATVLL VSTEDALLQQ LAESMLKDDC ASELRVHLAN SLPLPSNVNR 

        70         80         90        100        110        120 
PRIDLIVFVI NLHSKYSLQK VEEFLQHVDS SFFLGKVCFL VTGAGQESHC SVHQNTVIKL 

       130        140        150        160        170        180 
AHTYRSPLLL CDLQVESFRA AMARRLVRIL QICAGHVPGV SALNLMSLLR SPENPPSKEL 

« Hide

Isoform 2 [UniParc].

Checksum: 38E2649F47853431
Show »

FASTA16818,344

References

« Hide 'large scale' references
[1]"Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin."
Renou J.-P., Bierie B., Miyoshi K., Cui Y., Djiane J., Reichenstein M., Shani M., Hennighausen L.
Oncogene 22:4594-4610(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
Strain: C57BL/6.
Tissue: Lactating mammary gland.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and DBA/2.
Tissue: Embryonic liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY243536 mRNA. Translation: AAO62567.1.
AY243537 mRNA. Translation: AAO62568.1.
AK010885 mRNA. Translation: BAB27246.1.
AK011191 mRNA. Translation: BAB27456.1.
AK011227 mRNA. Translation: BAB27479.1.
AK011464 mRNA. Translation: BAB27635.1.
AK011755 mRNA. Translation: BAB27823.1.
AK168203 mRNA. Translation: BAE40163.1.
AK017679 mRNA. Translation: BAB30869.1.
BC009160 mRNA. Translation: AAH09160.1.
CCDSCCDS27685.1. [Q9CQA0-1]
CCDS37156.1. [Q9CQA0-2]
RefSeqNP_001073627.1. NM_001080158.1.
NP_079915.1. NM_025639.4. [Q9CQA0-1]
NP_840000.2. NM_178269.3. [Q9CQA0-2]
UniGeneMm.23596.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9CQA0. 1 interaction.
MINTMINT-8174100.

Proteomic databases

PRIDEQ9CQA0.

Protocols and materials databases

DNASU66570.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089155; ENSMUSP00000086558; ENSMUSG00000068101. [Q9CQA0-2]
ENSMUST00000089157; ENSMUSP00000086560; ENSMUSG00000068101. [Q9CQA0-1]
GeneID66570.
KEGGmmu:66570.
UCSCuc007wym.1. mouse. [Q9CQA0-1]
uc007wyo.1. mouse. [Q9CQA0-2]

Organism-specific databases

CTD79019.
MGIMGI:1913820. Cenpm.

Phylogenomic databases

eggNOGNOG25434.
GeneTreeENSGT00390000017504.
HOGENOMHOG000261677.
HOVERGENHBG081086.
InParanoidQ9CQA0.
KOK11505.
OMAEPREPPI.
OrthoDBEOG7R8333.
PhylomeDBQ9CQA0.
TreeFamTF328778.

Gene expression databases

BgeeQ9CQA0.
CleanExMM_CENPM.
GenevestigatorQ9CQA0.

Family and domain databases

InterProIPR020987. Centromere_Cenp-M.
[Graphical view]
PfamPF11111. CENP-M. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio322034.
PROQ9CQA0.
SOURCESearch...

Entry information

Entry nameCENPM_MOUSE
AccessionPrimary (citable) accession number: Q9CQA0
Secondary accession number(s): Q3THN3, Q91VS6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot