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Q9CQA0

- CENPM_MOUSE

UniProt

Q9CQA0 - CENPM_MOUSE

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Protein
Centromere protein M
Gene
Cenpm, Pane1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres By similarity.

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein M
Short name:
CENP-M
Alternative name(s):
Proliferation-associated nuclear element protein 1
Gene namesi
Name:Cenpm
Synonyms:Pane1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1913820. Cenpm.

Subcellular locationi

Nucleus. Cytoplasm. Chromosomecentromerekinetochore By similarity
Note: Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells. Localizes in the kinetochore domain of centromeres By similarity.1 Publication

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Centromere protein M
PRO_0000058225Add
BLAST

Proteomic databases

PRIDEiQ9CQA0.

Expressioni

Gene expression databases

BgeeiQ9CQA0.
CleanExiMM_CENPM.
GenevestigatoriQ9CQA0.

Interactioni

Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS By similarity.

Protein-protein interaction databases

IntActiQ9CQA0. 1 interaction.
MINTiMINT-8174100.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG25434.
GeneTreeiENSGT00390000017504.
HOGENOMiHOG000261677.
HOVERGENiHBG081086.
InParanoidiQ9CQA0.
KOiK11505.
OMAiEPREPPI.
OrthoDBiEOG7R8333.
PhylomeDBiQ9CQA0.
TreeFamiTF328778.

Family and domain databases

InterProiIPR020987. Centromere_Cenp-M.
[Graphical view]
PfamiPF11111. CENP-M. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9CQA0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVLRSMDKL PDLNRATVLL VSTEDALLQQ LAESMLKDDC ASELRVHLAN    50
SLPLPSNVNR PRIDLIVFVI NLHSKYSLQK VEEFLQHVDS SFFLGKVCFL 100
VTGAGQESHC SVHQNTVIKL AHTYRSPLLL CDLQVESFRA AMARRLVRIL 150
QICAGHVPGV SALNLMSLLR SPENPPSKEL 180
Length:180
Mass (Da):20,039
Last modified:June 1, 2001 - v1
Checksum:iAA6396B75269346C
GO
Isoform 2 (identifier: Q9CQA0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-180: AGQESHCSVH...SPENPPSKEL → GGKLSCSHGA...AASSKSSHCW

Note: No experimental confirmation available.

Show »
Length:168
Mass (Da):18,344
Checksum:i38E2649F47853431
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei104 – 18077AGQES…PSKEL → GGKLSCSHGAASGAHSADLR WPCARRLRAEPDVLAAEPRE PPIQGAVSITALHTFAASSK SSHCW in isoform 2.
VSP_020440Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131L → M in BAE40163. 1 Publication
Sequence conflicti47 – 471H → N in BAE40163. 1 Publication
Sequence conflicti129 – 1291L → F in AAH09160. 1 Publication
Sequence conflicti134 – 1341Q → QK in AAH09160. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY243536 mRNA. Translation: AAO62567.1.
AY243537 mRNA. Translation: AAO62568.1.
AK010885 mRNA. Translation: BAB27246.1.
AK011191 mRNA. Translation: BAB27456.1.
AK011227 mRNA. Translation: BAB27479.1.
AK011464 mRNA. Translation: BAB27635.1.
AK011755 mRNA. Translation: BAB27823.1.
AK168203 mRNA. Translation: BAE40163.1.
AK017679 mRNA. Translation: BAB30869.1.
BC009160 mRNA. Translation: AAH09160.1.
CCDSiCCDS27685.1. [Q9CQA0-1]
CCDS37156.1. [Q9CQA0-2]
RefSeqiNP_001073627.1. NM_001080158.1.
NP_079915.1. NM_025639.4. [Q9CQA0-1]
NP_840000.2. NM_178269.3. [Q9CQA0-2]
UniGeneiMm.23596.

Genome annotation databases

EnsembliENSMUST00000089155; ENSMUSP00000086558; ENSMUSG00000068101. [Q9CQA0-2]
ENSMUST00000089157; ENSMUSP00000086560; ENSMUSG00000068101. [Q9CQA0-1]
GeneIDi66570.
KEGGimmu:66570.
UCSCiuc007wym.1. mouse. [Q9CQA0-1]
uc007wyo.1. mouse. [Q9CQA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY243536 mRNA. Translation: AAO62567.1 .
AY243537 mRNA. Translation: AAO62568.1 .
AK010885 mRNA. Translation: BAB27246.1 .
AK011191 mRNA. Translation: BAB27456.1 .
AK011227 mRNA. Translation: BAB27479.1 .
AK011464 mRNA. Translation: BAB27635.1 .
AK011755 mRNA. Translation: BAB27823.1 .
AK168203 mRNA. Translation: BAE40163.1 .
AK017679 mRNA. Translation: BAB30869.1 .
BC009160 mRNA. Translation: AAH09160.1 .
CCDSi CCDS27685.1. [Q9CQA0-1 ]
CCDS37156.1. [Q9CQA0-2 ]
RefSeqi NP_001073627.1. NM_001080158.1.
NP_079915.1. NM_025639.4. [Q9CQA0-1 ]
NP_840000.2. NM_178269.3. [Q9CQA0-2 ]
UniGenei Mm.23596.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CQA0. 1 interaction.
MINTi MINT-8174100.

Proteomic databases

PRIDEi Q9CQA0.

Protocols and materials databases

DNASUi 66570.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089155 ; ENSMUSP00000086558 ; ENSMUSG00000068101 . [Q9CQA0-2 ]
ENSMUST00000089157 ; ENSMUSP00000086560 ; ENSMUSG00000068101 . [Q9CQA0-1 ]
GeneIDi 66570.
KEGGi mmu:66570.
UCSCi uc007wym.1. mouse. [Q9CQA0-1 ]
uc007wyo.1. mouse. [Q9CQA0-2 ]

Organism-specific databases

CTDi 79019.
MGIi MGI:1913820. Cenpm.

Phylogenomic databases

eggNOGi NOG25434.
GeneTreei ENSGT00390000017504.
HOGENOMi HOG000261677.
HOVERGENi HBG081086.
InParanoidi Q9CQA0.
KOi K11505.
OMAi EPREPPI.
OrthoDBi EOG7R8333.
PhylomeDBi Q9CQA0.
TreeFami TF328778.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 322034.
PROi Q9CQA0.
SOURCEi Search...

Gene expression databases

Bgeei Q9CQA0.
CleanExi MM_CENPM.
Genevestigatori Q9CQA0.

Family and domain databases

InterProi IPR020987. Centromere_Cenp-M.
[Graphical view ]
Pfami PF11111. CENP-M. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin."
    Renou J.-P., Bierie B., Miyoshi K., Cui Y., Djiane J., Reichenstein M., Shani M., Hennighausen L.
    Oncogene 22:4594-4610(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    Strain: C57BL/6.
    Tissue: Lactating mammary gland.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and DBA/2.
    Tissue: Embryonic liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCENPM_MOUSE
AccessioniPrimary (citable) accession number: Q9CQA0
Secondary accession number(s): Q3THN3, Q91VS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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